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Enhanced macrophage polarization induced by COX-2 inhibitor-loaded Pd octahedral nanozymes for treatment of atherosclerosis

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Chinese Chemical Letters 2023年第1期34卷 262-269页

作者： min xu Chuchu Ren yue Zhou Zbynek Heger Xiaoyang Liang Vojtech Adam Nan Li School of Pharmaceutical Science and Technology Tianjin UniversityTainjin 300072China Department of Chemistry and Biochemistry Mendel University in BrnoBrno CZ-61300Czech Republic

Inhibition of foam cell formation is considered a promising treatment method for atherosclerosis,the leading cause of cardiovascular diseases ***,currently available therapeutic strategies have shown unsatisfactory clinical ***,herein,we design aloperine(ALO)-loaded and hyaluronic acid(HA)-modified palladium(Pd)octahedral nanozymes(Pd@HA/ALO)that can synergistically scavenge reactive oxygen species(ROS)and downregulate cyclooxygenase-2(COX-2)expression to induce macrophage polarization,thus inhibiting foam cell formation to attenuate *** to the targeted effect of HA on stabilin-2 and CD44,which are overexpressed in atherosclerotic plaques,Pd@HA/ALO can actively accumulate in atherosclerotic ***,the antioxidative effects of Pd octahedral nanozymes are mediated by their intrinsic superoxide dismutase-and catalase-like activities capable of effective scavenging of *** addition,anti-inflammatory effects are mediated by controlled,on-demand near-infrared-triggered ALO release leading to inhibition of COX-2 ***,the combined therapy can promote the polarization of macrophages to the M2 subtype by upregulating Arg-1 and CD206 expression and downregulating expression of TNF-α,IL-1βand IL-6,thereby inhibiting atherosclerosis-related foam cell *** conclusion,the presented in vitro and in vivo data demonstrate that Pd@HA/ALO enhanced macrophage polarization to reduce plaque formation,identifying an attractive treatment strategy for cardiovascular disease.

关键词： Atherosclerosis COX-2 inhibitor Pd octahedral nanozyme Macrophage polarization Anti-inflammation Antioxidation

Heteroscedastic regression analysis method for mixed data

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航空动力学报 2011年第4期26卷 721-726页

作者： FU Hui-min yue Xiao-rui Research Center of Small Sample Technology Beijing University of Aeronautics and Astronautics Beijing 100191 China

The heteroscedastic regression model was established and the heteroscedastic regression analysis method was presented for mixed data composed of complete data,type-Ⅰ censored data and type-Ⅱ censored data from the location-scale *** best unbiased estimations of regression coefficients,as well as the confidence limits of the location parameter and scale parameter were ***,the point estimations and confidence limits of percentiles were ***,the traditional multiple regression analysis method which is only suitable to the complete data from normal distribution can be extended to the cases of heteroscedastic mixed data and the location-scale *** the presented method has a broad range of promising applications.

关键词： heteroscedastic regression analysis censored data performance test life prediction reliability analysis

Soundscape of the West Lake Scenic Area with profound cultural background—a case study of Evening Bell Ringing in Jingci Temple,China

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第3期14卷 219-229页

作者： Jian GE min GUO Miao yue Deptartment of Architecture Zhejiang University State Key Lab of Subtropical Building Science South China University of Technology Deptartment of Architecture and Art Zhejiang College of Construction

From the case study of Evening Bell Ringing at Nanping Hill,one of the West Lake Cultural Landscapes in Hangzhou,China,we investigated the soundscape of a scenic area with a profound cultural ***,we conducted the soundscape physical index of the area in both winter and spring seasons to analyze its objective graphical ***,we focused on people's reactions to the soundscape in order to obtain a subjective evaluation of each component in the soundscape and integrated ***,the relationship between the objective data and the subjective evaluation was ***,the impacts of the natural environment,history,and cultural factors on the evaluation of the Jingci Temple soundscape were *** was found that natural sounds,cultural sounds,and historic sounds were widely acclaimed in people's subjective feelings,which indicated the close relationships among historical and cultural background,soundscape,and natural ***,the conclusion was made that soundscape should be consistent with the local natural environment and the historical and cultural background.

关键词： Soundscape Culture Evaluation West Lake Evening Bell Ringing at Nanping Hill

Numerical Investigation on the Harbour Resonance Inside A Harbour with Lateral Cavities

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China Ocean Engineering 2024年第5期38卷 838-844页

作者： YU yue-min HUANG Xiao-hua School of Marine Science and Engineering Hainan UniversityHaikou 570228China Key Laboratory for Sustainable Utilization of Open-Sea Fishery Ministry of Agriculture and Rural AffairsGuangzhou 510300China South China Sea Fisheries Research Institute Chinese Academy of Fishery SciencesGuangzhou 510300China

Wave-induced harbour resonance is numerically investigated inside a harbour with lateral *** theoretical solutions for the amplification parameter are compared with the simulated results under varying dimensionless wave numbers in order to verify the simulation model in a rectangular harbour at a constant *** results indicate that the numerical model can correctly calculate the natural frequency and the natural wave height.A range of calculations are performed for harbour resonance with one pair of lateral cavities,two pairs of lateral cavities and three pairs of lateral cavities,*** simulated results indicate that the amplitude of the amplification parameter decreases both at the primary natural oscillation and the secondary natural oscillation,as the number of lateral cavities *** dimensionless wave number reduces as the number of lateral cavities increases both at the primary natural oscillation and the secondary natural oscillation as well.

关键词： harbour resonance lateral cavity numerical simulation amplification parameter

Electronic Structure and Visible-Light Absorption of Transition Metals(TM=Cr,Mn, Fe, Co) and Zn-Codoped SrTiO_(3): a First-Principles Study

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Chinese Physics Letters 2018年第1期35卷 72-75页

作者： yue-Qin Wang Yin Liu ming-xu Zhang Fan-Fei min School of Material Science and Engineering Anhui University of Science and TechnologyHuanian 232001 School of Mechanics and optoelectronic Physics Anhui University of Science and TechnologyHuainan 232001

First-principles calculations are performed on the influence of transition metal(TM=Cr,Mn,Fe,Co)as codopants on the electronic structure and visible-light absorption of Zn-doped Sr TiO_(3).The calculated results show that(Zn,Mn)-codoped Sr TiO_(3) requires the smallest formation energy in four codoping *** structures of the codoped systems display obvious lattice distortion,inducing a phase transition from cubic to rhombohedral after *** impurity Cr,Mn and Co 3d states appear below the bottom of conduction band and some Fe 3d states are located above the top of valence band,which leads to a significant narrowing of band gap after transition metal *** enhancement of visible-light absorption are observed in transition metals(TM=Cr,Mn,Fe,Co)and Zn codoped Sr TiO_(3) *** prediction calculations suggested that the(Zn,Mn)-and(Zn,Co)-codoped SrTiO_(3) could be the desirable visible-light photocatalysts.

关键词： Transition metals

Dependence patterns associated with the fundamental diagram:a copula function approach

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第1期11卷 18-24页

作者： Jia LI yue-ping xu Department of Ctvtl and Envzronmental Engtneermg University of Massachusetts Amherst Amherst MA 01002 USA Department of Civil Engmeermg Zhejlang Umverslty Hangzhou 310058 China)

Randomness plays a major role in the interpretation of many interesting traffic flow phenomena,such as hysteresis,capacity drop and spontaneous breakdown. The analysis of the uncertainty and reliability of traffic systems is directly associated with their random characteristics. Therefore,it is beneficial to understand the distributional properties of traffic variables. This paper focuses on the dependence relation between traffic flow density and traffic speed,which constitute the fundamental diagram (FD). The traditional model of the FD is obtained essentially through curve fitting. We use the copula function as the basic toolkit and provide a novel approach for identifying the distributional patterns associated with the FD. In particular,we construct a rule-of-thumb nonparametric copula function,which in general avoids the mis-specification risk of parametric approaches and is more efficient in practice. By applying our construction to loop detector data on a freeway,we identify the dependence patterns existing in traffic data. We find that similar modes exist among traffic states of low,moderate or high traffic densities. Our findings also suggest that highway traffic speed and traffic flow density as a bivariate distribution is skewed and highly heterogeneous.

关键词： Nonparametric copula Dependence patterns Traffic flow Loop detector

Edge-Pancyclicity and Hamiltonian Connectivity of Twisted Cubes

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Acta Mathematica Sinica,English Series 2010年第7期26卷 1315-1322页

作者： min xu School of Mathematical Sciences Beijing Normal UniversityLaboratory of Mathematics and Complex Systems Ministry of Education Beijing 100875 P. R. China

The twisted cube TQn is a variant of the hypercube Qn. It has been shown by Chang, Wang and Hsu [Topological properties of twisted cube. Information Science, 113, 147-167 （1999）] that TQn contains a cycle of every length from 4 to 2^n. In this paper, we improve this result by showing that every edge of TQn lies on a cycle of every length from 4 to 2^n inclusive. We also show that the twisted cube are Hamiltonian connected.

关键词： cycles twisted cubes hypercubes edge-pancyclicity hamiltonian connectivity

Vegetative Storage Protein with Trypsin Inhibitor Activity Occurs in Sapindus mukorassi,a Sapindaceae Deciduous Tree

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Journal of Integrative Plant Biology 2009年第4期51卷 352-359页

作者： Shi-Biao Liu xu-Chu Wang min-Jing Shi yue-Yi Chen Zheng-Hai Hu Wei-min Tian Institute of Ecology Jishou University Jishou 416000 China Key Laboratory of Rubber Biology Rubber Research Institute Chinese Academy of Tropical Agricultural Sciences Danzhou 571737 China Institute of Botany Northwest University Xi'an 710069 China

A vegetative storage protein （VSP） with trypsin inhibitor activity in a deciduous tree, Sapindus mukorassi, was characterized by means of sodium dodecyl sulfate-polyacrylamide gel electrophoresis, Western-blot, immuno-histochemical localization, light- and electro-microscopy, together with analysis of proteinase inhibitor activity of the purified VSP in vitro. There were two proteins with molecular masses of about 23 and 27 kDa in a relatively high content in the bark tissues of terminal branches of S. mukorassi in leafless periods. The proteins decreased markedly during young shoot development, indicating their role in seasonal nitrogen storage. Immuno-histochemical localization with the polyclonal antibodies raised against the 23 kDa protein demonstrated that the 23 kDa protein was the major component of protein inclusions in protein-storing cells. The protein inclusions were identified by protein-specific staining and should correspond to the electron-dense materials in different forms in the vacuoles of phloem parenchyma cells and phloem ray parenchyma cells under an electron microscope. So, the 23 kDa protein was a typical VSP in S. mukorassi. The 23 and 27 kDa proteins shared no immuno-relatedness, whereas the 23 kDa protein was immuno-related with the 22 kDa VSP in lychee and possessed trypsin inhibitor activity. The 23 kDa protein may confer dual functions： nitrogen storage and defense.

关键词： annual growth cycle Chinese soapberry immuno-localization seasonal nitrogen storage trypsin inhibitor.

Ultralight and superelastic MXene/reduced graphene oxide aerogels for electromagnetic interference shielding

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Nano Research 2025年第1期18卷 1-9页

作者： Xinfeng Zhou Yang Dai Guoyao yue Yiman Zhang Lulu Li Zhong-Zhen Yu Peng min Hao-Bin Zhang 21 State Key Laboratory of Organic-Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China Beijing Key Laboratory of Advanced Functional Polymer Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China Present address:BOE Technology Innovation Center BOE Technology Group Co.Ltd.Beijing 100176China Xi’an Modern Chemistry Research Institute Xi’an 710065China

Lightweight aerogels feature multifunctionality and a high porosity,yet accompanied with poor structure recovery under large strain *** this work,we develop an air bubble-ice crystal dual template and annealing strategy to integrate low density and high resilience for the conductive transition metal carbides/nitrides(MXene)composite *** air bubbles and ice crystals synergistically exclude the nanosheets to the gas-liquid interfaces,thereby constructing unique Y-shaped junctions and robust *** annealing process greatly enhances the interlayer *** external load,the Yshaped structures prevent the stress concentration at the junctions by transferring the forces to the skeleton for maintaining structural *** addition,the wrinkled and thick cell walls,together with the enhanced interlayer interactions,endow the aerogel with exceptional structural stability and *** a result,the MXene/reduced graphene oxide(RGO)composite aerogels exhibit superelasticity with reversible compressive strains of up to 95%.In addition,the electron bridging effect of the RGO sheets affords the aerogel to deliver excellent electromagnetic interference shielding performance,as high as 46.3 dB at 2.5 ***,the remarkable reshapeability of the aerogels allows for precise regulation of structure and performance(33.5-75.1 dB)by a simple wetting compression *** summary,this work offers helpful inspirations for developing lightweight and superelasticity aerogels for extensive applications.

关键词： lightweight superelasticity MXene aerogel electromagnetic interference shielding reshapeability