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The relationship between erectile function and complex panurethral stricture： a preliminary ,nvestigative and descriptive study

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Asian Journal of Andrology 2015年第2期17卷 315-318,I0012页

作者： Hong Xie yue-min xu Qiang Fu Ying-Long Sa YongQiao Department of Urology Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China.

The aim of this study was to evaluate erectile function in patients with panurethral stricture after urethral reconstruction. Totally, 65 patients were enrolled. Different urethral reconstructions were performed according to the details of urethral strictures. The erectile function was evaluated before and after surgery. The length and location of stricture and duration from initial diagnosis to operation were recorded. The International Index of Erectile Function-5 （IIEF-5） scores, the quality of life （QoL） scores and the maximal flow rate were obtained before and 3, 6, and 12 months after surgery. A significant improvement in QoL and maximal flow rate was observed 3, 6, and 12 months after surgery compared with those observed before surgery （P 〈 0.05）. An impairment of erectile function was observed in patients with multi-site stricture 3 months after surgery （P 〈 0.05）. Subsequently, these patients recovered 6 and 12 months after surgery. Three months after surgery, the IIEF-5 scores in patients with anterior urethral stricture were higher than those with multi-site stricture. Similar results were observed 6 and 12 months after surgery. No significant difference in age or duration from initial diagnosis to final operation was observed between patients with erectile dysfunction after surgery and patients with normal erectile function. However, a linear regressive relationship was detected between IIEF-5 scores and location of urethral stricture. Surgical reconstruction for treating panurethral strictures has limited effects on erectile function. The location of the stricture, particularly when extended to posterior urethra, was found to be associated with erectile function after surgery.

关键词： erectile dysfunction panurethral stricture urethral reconstruction

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One-stage dorsal lingual mucosal graft urethroplasty for the treatment of failed hypospadias repair

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Asian Journal of Andrology 2016年第3期18卷 467-470,I0011页

作者： Hong-Bin Li yue-min xu Qiang Fu Ying-Long Sa Jiong Zhang Hong Xie Department of Urology Shanghai Jiao Tong University Affiliated Sixth People's Hospital and Shanghai Eastern Institute for Urologic Repair and Reconstruction ShanghaiChina.

The aim of this study was to retrospectively investigate the outcomes of patients who underwent one-stage onlay or inlay urethroplasty using a lingual mucosal graft （LMG） after failed hypospadias repairs. Inclusion criteria included a history of failed hypospadias repair, insufficiency of the local skin that made a reoperation with skin flaps difficult, and necessity of an oral mucosal graft urethroplasty. Patients were excluded if they had undergone a failed hypospadias repair using the foreskin or a multistage repair urethroplasty. Between January 2008 and December 2012, 110 patients with failed hypospadias repairs were treated in our center. Of these patients, 56 underwent a one-stage onlay or inlay urethroplasty using LMG. The median age was 21.8 years （range： 4-45 years）. Of the 56 patients, one-stage onlay LMG urethroplasty was performed in 42 patients （group 1）, and a modified Snodgrass technique using one-stage inlay LMG urethroplasty was performed in 14 （group 2）. The median LMG urethroplasty length was 5.6 ± 1.6 cm （range： 4-13 cm）. The mean follow-up was 34.7 months （range： 10-58 months）, and complications developed in 12 of 56 patients （21.4%）, including urethrocutaneous fistulas in 7 （6 in group 1, 1 in group 2） and neourethral strictures in 5 （4 in group 1, 1 in group 2）. The total success rate was 78.6%. Our survey suggests that one-stage onlay or inlay urethroplasty with LMG may be an effective option to treat the patients with less available skin after failed hypospadias repairs; LMG harvesting is easy and safe, irrespective of the patient＇s age.

关键词： failed repair hypospadias lingual mucosa graft urethroplasty

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Preliminary experimental study of urethral reconstruction Nith tissue engineering and RNA interference techniques

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Asian Journal of Andrology 2013年第3期15卷 430-433页

作者： Chao Li yue-min xu Hong-Bin Li Department of Urology Sixth People's Hospital Shanghai Jiaotong University Shanghai 200233 China

This study investigated the feasibility of replacing urinary epithelial cells with oral keratinocytes and transforming growth factor-β1 （TGF-β1） small interfering RNA （siRNA）-transfected fibroblasts seeded on bladder acellular matrix graft （BAMG） in order to reconstruct tissue-engineered urethra. Constructed siRNAs, which expressed plasmids targeting TGF-β1, were transfected into rabbit fibroblasts. The effective siRNA was screened out by RT-PCR and was transfected into rabbit fibroblasts again. Synthesis of type I collagen in culture medium was measured by enzyme-linked immuno sorbent assay （ELISA）. Autologous oral keratinocytes and TGF-β1 siRNA-transfected fibroblasts were seeded onto BAMGs to obtain a tissue-engineered mucosa. The tissue-engineered mucosa was assessed morphologically and with the help of scanning electron microscopy. The TGF-β1 siRNA decreased the expression of fibroblasts synthesis type I collagen. Oral keratinocytes and TGF-β1 siRNA-transfected fibroblasts were seeded onto sterilized BAMG to obtain a tissue-engineered mucosa for urethral reconstruction. The compound graft was assessed using scanning electron microscope. Oral keratinocytes and TGF-β1 siRNA-transfected fibroblasts had a good compatibility with BAMG. The downregulation of fibroblasts synthesis type I collagen expression by constructed siRNA interfering TGF-β1 provided a potential basis for genetic therapy of urethral scar. Oral keratinocytes and TGF-β1 siRNA-transfected fibroblasts had good compatibility with BAMG and the compound graft could be a new choice for urethral reconstruction.

关键词： RNA interference tissue engineering urethral reconstruction

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Continued sustained release of VEGF by PLGA nanospheres modified BAMG stent for the anterior urethral reconstruction of rabbit

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Asian Pacific Journal of Tropical Medicine 2013年第6期6卷 481-484页

作者： Ji-Hong Wang yue-min xu Qiang Fu Lu-Jie Song Chao Li Qin Zhang ming-Kai Xie Department of Urology Affiliated Sixth People's HospitalShanghai Jiaotong University

Objective:To study the biocompatibility and neovascularization of the PLGA nanospheres wrapped with vascular endothelial growth factor(VEGF).which can improve bladder acellular matrix graft(BAMG) with local continuous release of ***:A total of 18 rabbit model (length of stenosis:3cm) with anterior urethral stricture were used as experimental animals and divided into three *** A as the control group:Simple BAMG scaffold materials for urethral *** B as the blank group:PLGA microspheres modified BAMG for urethral *** C:PLGA conjugated with VEGF and modified BAMG for the urethral *** rabbits underwent urethral angiography after 7 days,15 days,1 month and 3 months after the operation,and one rabbit in each group was sacrificed to be prepared for the organization histologic examination,HE staining,masson staining,CD31,34 and a-SAM immunohistochemical detection in the repaired ***:In group A,significant urethral restenosis occurred in two rabbits after 15 days of the operation,HE and masson staining showed a lot of collagen arranged in the repaired sites,and there were a large number of inflammatory cell infiltration,and there were also CD31,34 in the repaired sites.a-SAM microvascular tag count showed a small amount of microvascular;Croup B showed anastomotic restenosis,HE and masoon staining showed inflammatory cell infiltration and collagen deposition;Group C:urethrography showed lumen *** were a small amount of inflammatory cell infiltration after 7 and 15 days after the operation,and there were also CD31,34 in the repaired *** a-SAM microvascular tag count showed many *** the difference was ***:Anterior urethral reconstruction with sustained-release of VEGF by PLGA nanospheres modified BAMG stents can reduce postoperative *** can also reduce collagen deposition and scar formation,promote angiogenesis of the repair tissue;therefore it

关键词： Vascular endothelial growth factor PLGA nanospheres Bladder acellular matrix graft

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Long-term study of male rabbit urethral mucosa reconstruction using epidermal cell

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Asian Journal of Andrology 2008年第5期10卷 719-722页

作者： Qiang Fu Chen-Liang Deng Xiao-Fei Song yue-min xu Department of Urology Shanghai 6^th People＇s Hospital Shanghai Jiao Tong University Shanghai 200233 China Shanghai Tissue Engineering Research and Development Center Shanghai 200011 China

Aim： To investigate the transformation of characteristics of epidermal cells from foreskin which were used to reconstruct male rabbit anterior urethra in combination with acellular collagen matrices. Methods： In three rabbits, autologous foreskin epidermal cells were isolated, expanded in vitro, and seeded （inoculated） onto a tubular acellular collagen matrix, acquired from allogeneic rabbit bladder submucosa. A urethral mucosal defect was created, and urethral reconstruction was performed with the tubular acellular collagen matrix seeded with epidermal cells. Results： On gross examination at 12 months following the procedure, the mucosa of the urethral grafts appeared lubricous and smooth. Urethrography showed that a wide urethral caliber had been maintained without any sign of strictures. Histological examination showed a transitional cell layer in the graft without evidence of a margin between the graft and the host tissue at 12 months postoperatively. Conclusion： Epidermal cells seeded onto acellular collagen matrices can be successfully used to reconstruct urethras that have defects and are transformed to transitional epithelial cells.

关键词： urethral stricture tissue engineering foreskin epidermal

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Evaluation of erectile function after urethral reconstruction:a prospective study

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Asian Journal of Andrology 2009年第2期11卷 209-214页

作者： Hong Xie yue-min xu Xiao-Lin xu Yin-Long Sa Deng-Long Wu Xin-Chi Zhang Department of Urology Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233China

We conducted a prospective study of erectile dysfunction(ED)after urethral reconstructive surgery,using the 5-item International Index of Erectile Function(IIEF-5),the Sexual Life Quality Questionnaire(SLQQ)and the Quality of Life Questionnaire(QoLQ).Between January 2003 and July 2007,125 male patients with urethral strictures underwent urethroplasty,and pre-and post-surgery erectile function was assessed using these three questionnaires.A formula to predict the probability of ED after urethroplasty was *** 3 months post-operatively,there was a significant decrease in IIEF-5(16.57±7.98)and SLQQ scores(28.71±14.84)compared with pre-operative scores(P<0.05).However,the IIEF-5 scores rebounded at 6 months post-operatively(17.22±8.41).Logistical regression analysis showed that the location of the urethral stricture,the recurrence of strictures and the choice of surgical technique were predictive of the post-operative occurrence of *** study identified the clinical risk factors for ED after *** urethral stricture and end-to-end anastomosis were found to have a strong relationship with erectile *** logistical model derived in this study may be applied to clinical decision algorithms for patients with urethral strictures.

关键词： erectile dysfunction urethroplasty urethral stricture

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Effects of mesoscale gravity waves on sporadic E simulated by a one-dimensional dynamic model

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Earth and Planetary Physics 2025年第1期9卷 1-9页

作者： xu Zhou ZeZhong Li XinAn yue LiBo Liu Key Laboratory of Earth and Planetary Physics/Heilongjiang Mohe National Geophysical Observatory/Beijing National Observatory of Space Environment Institute of Geology and GeophysicsChinese Academy of Sciences(CAS)Beijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China CAS Center for Excellence in Comparative Planetology/CAS Key Laboratory of Geospace Environment/Mengcheng National Geophysical Observatory University of Science and Technology of ChinaHefei 230026China

In addition to being driven by tidal winds,the sporadic E(Es)layers are modulated by gravity waves(GWs),although the effects are not yet comprehensively *** this article,we discuss the effects of mesoscale GWs on the Es layers determined by using a newly developed model,MISE-1D(one-dimensional Model of Ionospheric Sporadic E),with low numerical dissipation and high *** by the wind fields resolved by the high-resolution version of the Whole Atmosphere Community Climate Model with thermosphere and ionosphere extension(WACCM-X),the MISE-1D simulation revealed that GWs significantly influence the evolution of the Es layer above 100 km but have a very limited effect at lower *** effects of GWs are diverse and complex,generally including the generation of fluctuating wavelike structures on the Es layer with frequencies similar to those of the *** mesoscale GWs can also cause increases in the density of Es layers,or they can disperse or diffuse the Es layers and increase their *** addition,the presence of GWs is a key factor in sustaining the Es layers in some cases.

关键词： sporadic E ion tidal layer gravity waves numerical simulation

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Long-term study of male rabbit urethral mucosa reconstruction using epidermal cell

Long-term study of male rabbit urethral mucosa reconstructio...

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第十五届全国泌尿外科学术会议

作者： Qiang Fu, Chen-liang Deng, Xiao-fei Song, yue-min xu Department of Urology, Shanghai 6th hospital, Shanghai 200233

Objective: To investigate the transformation in characteristics of epidermal cells from foreskin which were used to reconstruct male rabbit anterior urethra in combination with acellular collagen matrix. Materials and Methods: In three rabbits, autologous foreskin epidermal cells were isolated, expanded in vitro, and seeded (inoculated) onto a tubular acellular collagen matrix,

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Treatment of prolonged penile strangulation:a case report and review of the literature

Treatment of prolonged penile strangulation:a case report an...

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华东六省一市泌尿外科学术年会暨2011年浙江省泌尿外科、男科学学术年会

作者： Department of Urology,Affiliated Sixth People' s Hospital, Shanghai Jiaotong University,Shanghai 200233,China. Chao Li yue-min xu Rong Chen

Introduction:Entrapment or strangulation of the penis is a rare emergency situation that can lead to a wide range of vascular and mechanical *** aim of this article is to present our experience dealing with penile strangulation. Methods:A 22-year-old man presented to the emergency department with a steel hoop entrapment on his penis for 5 *** constricting steel hoop was 20 mm in external diameter,17 mm in internal *** cut off the steel hoop a motor-operated emery wheel machine was used to make intermittent cutting at two points of the hoop,and removed it from the *** of the serious injury of the skin of the root of penis,an intermediate split thickness thigh skin graft was used to repair the skin loss.A review of the literature is also summarized in this *** treatment options and outcomes are also evaluated. Results:The patient was discharged 27 days later with a satisfactory *** strangulation,though uncommon,can be challenging to *** the constricting devices involved are very variable,the clinician needs to be creative in his attempts to extricate the foreign bodies,and industrial strength devices should be deployed if necessary. Conclusion:Penile strangulation is an unusual clinical condition and the consequences can be severe. The choice of method for removal depends upon type,size,incarceration time,trauma grade,and availability of the *** treatment is essential to avoid the potential complications of ischemic necrosis and autoamputation.

关键词： Treatment of prolonged penile strangulation:a case report and review of the literature

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Inhibition of the cGAS–STING pathway:contributing to the treatment of cerebral ischemia-reperfusion injury

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Neural Regeneration Research 2025年第7期20卷 1900-1918页

作者： Hang Yang Yulei Xia yue Ma mingtong Gao Shuai Hou Shanshan xu Yanqiang Wang School of Clinical Medicine Shandong Second Medical UniversityWeifangShandong ProvinceChina Department of Emergency The Affiliated Hospital of Weifang Medical UniversityWeifangShandong ProvinceChina Department of Neurology Ⅱ The Affiliated Hospital of Weifang Medical UniversityWeifangShandong ProvinceChina

The cGAS–STING pathway plays an important role in ischemia-reperfusion injury in the heart,liver,brain,and kidney,but its role and mechanisms in cerebral ischemia-reperfusion injury have not been systematically ***,we outline the components of the cGAS–STING pathway and then analyze its role in autophagy,ferroptosis,cellular pyroptosis,disequilibrium of calcium homeostasis,inflammatory responses,disruption of the blood–brain barrier,microglia transformation,and complement system activation following cerebral ischemia-reperfusion *** further analyze the value of cGAS–STING pathway inhibitors in the treatment of cerebral ischemia-reperfusion injury and conclude that the pathway can regulate cerebral ischemia-reperfusion injury through multiple *** of the cGAS–STING pathway may be helpful in the treatment of cerebral ischemia-reperfusion injury.

关键词： calcium homeostasis cellular autophagy cerebral ischemia-reperfusion injury cGAS–STING pathway ferroptosis gut–brain–microbiota axis inflammatory light chain 3 microglial cells Syntaxin-17 protein

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