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The role of intravitreal ranubizumab in the treatment of familial exudative vitreoretinopathy of stage 2 or greater

International Journal of Ophthalmology(English edition) 2018年第6期11卷 976-980页

作者： yue-zhu lu Guang-Da Deng Jing-Hua Liu Hong Yan The First Clinical College of Chongqing Medical University Chongqing 400016 China Department of Opthalmology Beijing Tongren Hospital Capital University of Medical Sience Beijing 100730 China Department of Ophthalmology the First Affiliated Hospital of Chongqing Medical University Chongqing 400016 China

AIM： To evaluate the role of intravitreal ranubizumab （IVR） in the treatment of familial exudative vitreoretinopathy （FEVR） of stage 2 or greater either as primary or an ajunct to conventional treatments. METHODS： Retrospective, non-controlled clinical study. Thirty patients （37 eyes） diagnosed with FEVR were enrolled. Twenty patients （66.67%） were male and 10 patients （33.33%） were female. Age ranged from 0.4 to 35 years old （median 3y）. IVR was used either as primary or as a combined therapy according to the retinal neovasuclar activities. The follow up ranged from 1 to 57mo with mean 16.73±15.73 （median 11）mo. The treatment effect of retinal neovasuclar activites were recorded as well as the ocular and systemic side effects. RESULTS： Among 30 patients （37 eyes）, 10 eyes received single IVR, 1 eye received 2 injections. Three eyes were treated with IVR and simutanous laser photocoagulation. Laser indirect ophthalmoscopy （LIO） was applied in 5 eyes 1mo after the primary IVR. Seven eyes were treated surgically following the primary IVR due to persistent retinal neovasuclar activities and retinal traction. IVR was used as combined treatment with vitrectomy in 11 eyes. Retinal neovascular regression was notified 1mo following the primary IVR in all eyes. Neither systemic nor ocular complications were recorded. CONCluSION： IVR may be an effective modality in the treatment of FEVR either as primary or as an ajunct to the conventional therapies. The long term effect and safty of IVR still need further research.

关键词： familial exudative vitreoretinopathy anti-vascular endothelial growth factor treatment

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Unnecessity of lymph node regression evaluation for predicting gastric adenocarcinoma outcome after neoadjuvant chemotherapy

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World Journal of Gastrointestinal Oncology 2019年第1期11卷 48-58页

作者： yue-lu zhu Yong-Kun Sun Xue-Min Xue Jiang-Ying yue Lin Yang Li-Yan Xue Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Pathology Esophageal Carcinoma Hospital of Linzhou

BACKGROUND Neoadjuvant chemotherapy has been applied worldwide to improve the survival of patients with gastric adenocarcinoma(GAC). The evaluation of histological regression in primary tumors is valuable for predicting prognosis. However, the prognostic effect of regression change in lymph nodes(LNs) remains *** To confirm whether the evaluation of regression change in LNs could predict the prognosis of GAC patients who received neoadjuvant chemotherapy followed by *** In this study, we evaluated the histological regression of resected LNs from 192 GAC patients(including those with esophagogastric junction adenocarcinoma)treated with neoadjuvant chemotherapy. We classified regression change and residual tumor in LNs into four groups:(A) true negative LNs with no evidence of a preoperative therapy effect,(B) no residual metastasis but the presence of regression change in LNs,(C) residual metastasis with regression change in LNs,and(D) metastasis with minimal or no regression change in LNs. Correlations between regression change and residual tumor groups in LNs and regression change in the primary tumor, as well as correlations between regression change in LNs and clinicopathological characteristics, were analyzed. The prognostic effect of regression change and residual tumor groups in LNs was also *** We found that regression change and residual tumor groups in LNs were significantly correlated with regression change in the primary tumor, tumor differentiation, ypT stage, ypN stage, ypTNM stage, lymph-vascular invasion,perineural invasion and R0 resection status. Regression change and residual tumor groups in LNs were statistically significant using univariate Cox proportional hazards analysis, but were not independent predictors. For patients who had no residual tumor in LNs, the 5-year overall survival(OS) rates were 67.5% in Group A and 67.4% in Group B. For the patients who had residual tumors in LNs, the 5-year OS rates were 28.

关键词： Gastric cancer Neoadjuvant chemotherapy Lymph nodes Regression Residual tumor Regression change

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Synergistic BrΦnsted/Lewis acid catalyzed atroposelective synthesis of aryl-β-naphthol

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Chinese Chemical Letters 2025年第1期36卷 293-298页

作者： Jiajun lu Zhehui Liao Tongxiang Cao Shifa zhu Key Laboratory of Functional Molecular Engineering of Guang-dong Province School of Chemistry and Chemical EngineeringSouth China University of TechnologyGuangzhou 510640China School of Chemistry and Chemical Engineering Zhejiang Sci-Tech UniversityHangzhou 310018China State Key Laboratory of Elemento-Organic Chemistry Nankai UniversityTianjin 300071China

Axially chiral binaphthol have achieved great success in asymmetric *** toα-binaphthol,axially chiral aryl-β-naphthol are far less ***,we report a method of asymmetric catalysis to constructβ-naphthol with up to 99%yield,95.5:4.5 enantiomeric ratio,using alkynyl esters as precursors and chiral phosphonic acid(CPA)/Lewis acid as *** steps involve oxygen transfer and de novo arene formation to set up the chiral ***,this methodology provides a versatile platform for structurally divergent synthesis of atroposelectiveβ-naphthol analogs,which are widely found in bioactive molecules and asymmetric catalysts.

关键词： Synergistic catalysis Atropisomerism Aryl-β-naphthol Enantioselectivity Tandem reaction

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Spatio-temporal patterns and climatic drivers of spring phenology in eight forest communities across the north-south transitional zone of China

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Journal of Geographical Sciences 2025年第1期35卷 17-38页

作者： zhu Wenbin lu Yu Institute of Geographic Sciences and Natural Resources Research CASBeijing100101China School of Geographical Science Nanjing University of Information Science&TechnologyNanjing210044China

The Qinba Mountains are climatically and ecologically recognized as the north-south transitional zone of *** of its phenology is critical for comprehending the response of vegetation to climatic *** retrieved the start of spring phenology(SOS)of eight forest communities from the MODIS products and adopted it as an indicator for spring *** analysis,partial correlation analysis,and GeoDetector were employed to reveal the spatio-temporal patterns and climatic drivers of *** results indicated that the SOS presented an advance trend from 2001 to 2020,with a mean rate of−0.473 d yr^(−1).The SOS of most forests correlated negatively with air temperature(TEMP)and positively with precipitation(PRE),suggesting that rising TEMP and increasing PRE in spring would forward and delay SOS,*** dominant factors influencing the sensitivity of SOS to climatic variables were altitude,forest type,and latitude,while the effects of slope and aspect were relatively *** response of SOS to climatic factors varied significantly in space and among forest communities,partly due to the influence of altitude,slope,and aspect.

关键词： spring phenology climatic drivers altitude forest communities lag effect Qinba Mountains

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Impact of neoadjuvant chemoradiotherapy on the local recurrence and distant metastasis pattern of locally advanced rectal cancer: a propensity score-matched analysis

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Chinese Medical Journal 2021年第18期134卷 2196-2204页

作者： Liang Yu Tian-Lei Xu Lin Zhang Shuo-Hao Shen yue-lu zhu Hui Fang Hai-Zeng Zhang Department of Colorectal Surgery National Cancer Centre/National Clinical Research Centre for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Lab of Molecular Oncology National Cancer Centre/National Clinical Research Centre for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Pathology National Cancer Centre/National Clinical Research Centre for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Radiation Oncology National Cancer Centre/National Clinical Research Centre for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Background:Previous studies have demonstrated different predominant sites of distant metastasis between patients with and without neoadjuvant chemoradiotherapy(NCRT).This study aimed to explore whether NCRT could influence the metastasis pattern of rectal cancer through a propensity score-matched ***:In total,1296 patients with NCRT or post-operative chemoradiotherapy(PCRT)were enrolled in this study between January 2008 and December *** score matching was used to correct for differences in baseline characteristics between the two *** propensity score matching,the metastasis pattern,including metastasis sites and timing,was compared and ***:After propensity score matching,there were 408 patients in the PCRT group and 245 patients in the NCRT *** significantly reduced local recurrence(4.1%vs.10.3%,P=0.004),but not distant metastases(28.2%vs.27.9%,P=0.924)compared with *** both the NCRT and PCRT groups,the most common metastasis site was the lung,followed by the *** NCRT group developed local recurrence and distant metastases later than the PCRT group(median time:29.2[18.8,52.0]months vs.18.7[13.3,30.0]months,Z=–2.342,P=0.019;and 21.2[12.2,33.8]vs.16.4[9.3,27.9]months,Z=–1.765,P=0.035,respectively).The distant metastases occurred mainly in the 2nd year after surgery in both the PCRT group(39/114,34.2%)and NCRT group(21/69,30.4%).However,20.3%(14/69)of the distant metastases appeared in the 3rd year in the NCRT group,while this number was only 13.2%(15/114)in the PCRT ***:The predominant site of distant metastases was the lung,followed by the liver,for both the NCRT group and PCRT *** did not influence the predominant site of distant metastases,but the NCRT group developed local recurrence and distant metastases later than the PCRT *** follow-up strategy for patients with NCRT should be adjusted and a longer intensive follow-up is needed.

关键词： Locally advanced rectal cancer Metastases pattern Neoadjuvant chemoradiotherapy Propensity score matching

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Profile of Dr. Jiaojun zhu

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Science China(Life Sciences) 2025年第2期68卷 311-313页

作者： zhu, Jiaojun

Dr. Jiaojun zhu is the director general of Institute of Applied Ecology(IAE), Chinese Academy of Sciences(CAS)(2018 to present). He received his B.S. degree in Forest Science from Shenyang Agricultural University, China in July 1987, and subsequently joined Institute of Forestry and Soil, CAS(now known as the IAECAS) to pursue his M.S. degree in *** graduation, he served as a research assistant and an associate research fellow in the IAE-CAS from 1990 to 1996.

关键词： Forest pursue assistant

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“One stone, two birds”: Salt template enabling porosity engineering and single metal atom coordinating toward high-performance zinc-ion capacitors

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Journal of Energy Chemistry 2025年第1期100卷 637-645页

作者： Chunliu zhu Huanyu Liang Ping Li Chenglong Qiu Jingyi Wu Jingwei Chen Weiqian Tian yue zhu Zhi Li Huanlei Wang School of Materials Science and Engineering Ocean University of ChinaQingdao 266100ShandongChina Department of Chemical and Materials Engineering University of AlbertaAlberta T6G 2V4EdmontonCanada

Zinc-ion hybrid capacitors (ZIHCs) have received increasing attention as energy storage devices owing to their low cost,high safety,and environmental ***,their progress has been hampered by low energy and power density,as well as unsatisfactory long-cycle stability,mainly due to the lack of suitable electrode *** this context,we have developed manganese single atoms implanted in nitrogen-doped porous carbon nanosheets (MnSAs/NCNs) using a metal salt template method as cathodes for *** metal salt serves a dual purpose in the synthesis process:It facilitates the uniform dispersion of Mn atoms within the carbon matrix and acts as an activating agent to create the porous *** applied in ZIHCs,the MnSAs/NCNs electrode demonstrates exceptional performance,including a high capacity of 203 m Ah g^(-1),an energy density of 138 Wh kg^(-1)at 68 W kg^(-1),and excellent cycle stability with 91%retention over 10,000 *** calculations indicate that the introduced Mn atoms modulate the local charge distribution of carbon materials,thereby improving the electrochemical *** work demonstrates the significant potential of carbon materials with metal atoms in zinc-ion hybrid capacitors,not only in enhancing electrochemical performance but also in providing new insights and methods for developing high-performance energy storage devices.

关键词： Zinc ion hybrid capacitors Cathodes Carbon materials Heteroatoms Single atoms

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TavWA1 is critical for wheat growth by modulating cell morphology and arrangement

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Journal of Integrative Plant Biology 2025年第1期67卷 71-86页

作者： Guowei Chang yue Li Lei Peng Chuncai Shen Yipeng lu Wan Teng Yangyang Liu Yingchun Wang Weiqi zhu Cuimin Liu Xue He Yiping Tong Xueqiang Zhao Key Laboratory of Seed Innovation Institute of Genetics and Developmental BiologyThe Innovative Academy of Seed DesignChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Plant Molecular Physiology Institute of BotanyChinese Academy of SciencesBeijing 100093China State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Zhaoxian Experiment Station Shijiazhuang Academy of Agricultural and Forestry SciencesZhaoxian 515300China

Plant growth is determined by the production of cells and initiation of new *** genes that control cell number and cell size is of great significance for understanding plant growth *** this study,we characterized two wheat mutants,ah and dl,with abnormal *** ah mutant is a naturally occurring variant characterized by severe dwarfism,increased tiller number,and reduced grain length,while the dl mutant is derived from an ethyl methane sulfonate(EMS)-mutagenized population and exhibits smaller grain size and slightly reduced plant *** analyses revealed abnormal cell number,cell morphology and arrangement in the stems and leaves of the ah mutant,along with reduced cell length in the grains of the dl ***-based cloning identified that both mutants carry mutations in the same gene TavWA1-7D,which encodes a protein with a von Willebrand factor A(vWA)*** ah mutant harbors a 174-bp insertion in the 1,402-bp coding sequence(CDS)of TavWA1-7D,causing premature termination of protein translation,while the dl mutant contains a Glu420Lys *** the TavWA1-7D ahthrough clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated nuclease 9-mediated genome editing leads to a severe dwarfism *** C-terminus of the protein is crucial for its correct subcellular localization and interaction,supporting its critical role for TavWA1-7D *** analysis showed that the dwarf phenotype of the ah mutant is associated with impaired photosynthesis,ribosome function,and nucleosome ***,TavWA1-7D interacts with an E3 ligase,Ta VIP1-3B,the expression levels of which are elevated in both *** and knockout studies of TaVIP1-3B demonstrated its negative regulatory role in cell length and grain ***,our findings suggest that TavWA1-7D plays a vital role in regulating wheat growth and yield-related traits,with the dl mutant's short grain phen

关键词： grain size severe dwarf TaVIP1 TavWA1 wheat

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Status analysis on sputtering and erosion evaluation methods of ion optic systems

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Chinese Journal of Aeronautics 2025年第1期38卷 254-270页

作者： Long MIAO Tongxun YANG Zhengxi zhu Chang lu Zhiwen WU Ningfei WANG School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China Chongqing Innovation Center Beijing Institute of TechnologyChongqing 404100China Advanced Aerospace Power and Energy Research Center Beijing Institute of TechnologyZhuhai 519088China

In the past few decades,ion engines have been widely used in deep-space propulsion and satellite *** aim of extending the thruster lifetime is still one of the most important parts during the design stage of ion *** one of the core components of ion engine,the grid assembly of ion optic systems may experience long-term ion sputtering in extreme electro-thermal environments,which will eventually lead to its structural and electron-backstreaming *** this paper,the current studies of the grid assembly erosion process are systematically analyzed from the aspects of sputtering damage process of grid materials,numerical simulations,and measurements of erosion characteristics of grid *** advantages and disadvantages of various erosion prediction models are highlighted,and the key factors and processes affecting the prediction accuracy of grid assembly erosion patterns are *** different types of experimental methods of grid assembly erosion patterns are *** analysis in this paper is of great importance for selecting the sputter-resistant grid materials,as well as establishing the erosion models and measurement methods to accurately determine the erosion rate and failure modes of grid ***,the working conditions and structure parameters of ion optic systems could be optimized based on erosion models to promote the ion engine lifetime.

关键词： Electric propulsion Ion optic systems Sputtering yield Erosion characteristics Erosion pattern measurement Lifetime evaluation

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Multiphoton photoredox catalysis enables selective hydrodefluorinations

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Chinese Chemical Letters 2025年第2期36卷 366-372页

作者： Jiaqi Jia Kathiravan Murugesan Chen zhu Huifeng yue Shao-Chi Lee Magnus Rueping KAUST Catalysis Center KCC King Abdullah University of Science and Technology

Late-stage modification of complex molecules via site-selective hydrodefluorination is a challenging endeavor. The selective activation of carbon-fluorine(C–F) bonds in the presence of multiple C–F bonds is of importance in organic synthesis and drug discovery. Herein, we describe the activation of C-F bonds via multiphoton photoredox catalysis to selectively produces a series of hydrodefluorinated compounds by simply tuning the reaction conditions. Moreover, this protocol was successfully applied to the late-stage functionalization of different drug-derivatives and the corresponding mono-, di-, and tri-defluorinated products were obtained in good to excellent yields. A detailed mechanistic investigation provides insight into the unprecedented hydrodefluorination pathway.

关键词： C-F bond activation Multiphoton Photoredox catalysis Site-selectivity Trifluoroacetamide

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