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HCSP-Net:A Novel Model of Age-Related Macular Degeneration Classification Based on Color Fundus Photography

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Computers, Materials & Continua 2024年第4期79卷 391-407页

作者： cheng Wan Jiani Zhao Xiangqian hong Weihua Yang Shaochong Zhang College of Electronic and Information Engineering/College of Integrated Circuits Nanjing University of Aeronautics and AstronauticsNanjing211106China Shenzhen Eye Institute Shenzhen Eye HospitalJinan UniversityShenzhen518040China

Age-related macular degeneration(AMD)ranks third among the most common causes of *** the most conventional and direct method for identifying AMD,color fundus photography has become prominent owing to its consistency,ease of use,and good quality in extensive clinical *** this study,a convolutional neural network(CSPDarknet53)was combined with a transformer to construct a new hybrid model,*** hybrid model was employed to tri-classify color fundus photography into the normal macula(NM),dry macular degeneration(DMD),and wet macular degeneration(WMD)based on clinical classification manifestations,thus identifying and resolving AMD as early as possible with color fundus *** further enhance the performance of this model,grouped convolution was introduced in this study without significantly increasing the number of ***-Net was validated using an independent test *** average precision of HCSPNet in the diagnosis of AMD was 99.2%,the recall rate was 98.2%,the F1-Score was 98.7%,the PPV(positive predictive value)was 99.2%,and the NPV(negative predictive value)was 99.6%.Moreover,a knowledge distillation approach was also adopted to develop a lightweight student network(SCSP-Net).The experimental results revealed a noteworthy enhancement in the accuracy of SCSP-Net,rising from 94%to 97%,while remarkably reducing the parameter count to a quarter of *** attribute positions SCSP-Net as a highly suitable candidate for the deployment of resource-constrained devices,which may provide ophthalmologists with an efficient tool for diagnosing AMD.

关键词： Computer-aided diagnosis deep learning age-related macular degeneration transformer

Main controlling factor and mechanism of gas-in-place content of the Lower Cambrian shale from different sedimentary facies in the western Hubei area, South China

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Petroleum Science 2024年第3期21卷 1488-1507页

作者： Gang Li Xian-Ming Xiao Bo-Wei cheng Chen-Gang Lu yue Feng Dong-Sheng Li School of Energy Resources China University of Geosciences(Beijing)Beijing100083China Frontiers Science Center for Deep-time Digital Earth China University of Geosciences(Beijing)Beijing100083 China

The Lower Cambrian shale gas in the western Hubei area,South China has a great resource prospect,but the gas-in-place(GIP)content in different sedimentary facies varies widely,and the relevant mechanism has been not well *** the present study,two sets of the Lower Cambrian shale samples from the Wells YD4 and YD5 in the western Hubei area,representing the deep-water shelf facies and shallowwater platform facies,respectively,were investigated on the differences of pore types,pore structure and methane adsorption capacity between them,and the main controlling factor and mechanism of their methane adsorption capacities and GIP contents were *** results show that the organic matter(OM)pores in the YD4 shale samples are dominant,while the inorganic mineral(IM)pores in the YD5 shale samples are primary,with underdeveloped OM *** pore specific surface area(SSA)and pore volume(PV)of the YD4 shale samples are mainly from micropores and mesopores,respectively,while those of the YD5 shale samples are mainly from micropores and macropores,*** methane adsorption capacity of the YD4 shale samples is significantly higher than that of the YD5 shale samples,with a maximum absolute adsorption capacity of 3.13 cm^(3)/g and 1.31 cm^(3)/g in average,*** with the shallow-water platform shale,the deep-water shelf shale has a higher TOC content,a better kerogen type and more developed OM pores,which is the main mechanism for its higher adsorption *** GIP content models based on two samples with a similar TOC content selected respectively from the Wells YD4 and YD5 further indicate that the GIP content of the deep-water shelf shale is mainly 34 m^(3)/t within a depth range of 1000—4000 m,with shale gas exploration and development potential,while the shallow-water platform shale has normally a GIP content of<1 m^(3)/t,with little shale gas *** the geological and geochemical conditions of shale gas formation a

关键词： Lower Cambrian shale Deep-water shelf facies Shallow-waterplat form facies Pore structure Methane adsorption Gas-in-place content Controlling factor

Thermoelectric transport properties of p-type Bi2Se3-Sb2Se3-In2Se3 high entropy compounds

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Rare Metals 2024年第7期43卷 3415-3421页

作者： Feng Jiang cheng-Liang Xia Yong-Bin Zhu Jun Li yue Chen Wei-Shu Liu Department of Materials Science and Engineering Southern University of Science and Technology Department of Mechanical Engineering The University of Hong Kong Guangdong Provincial Key Laboratory of Functional Oxide Materials and Devices Southern University of Science and Technology

The introduction of entropy concept into thermoelectric materials recently has attracted broad ***,we showed the phase diagram of the ternary systems of *** the high entropy compounds （HECs）,we have identified an in... 详细信息

关键词： Selenium compounds

An Innovative Coupled Common-Node Discrete Element Method-Smoothed Particle Hydrodynamics Model Developed with LS-DYNA and Its Applications

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China Ocean Engineering 2024年第3期38卷 467-482页

作者： SHEN Zhong-xiang WANG Wen-qing XU cheng-yue LUO Jia-xin LIU Ren-wei School of Naval Architecture and Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212100China College of Harbor Coastal and Offshore EngineeringHohai UniversityNanjing 210098China

In this study,a common-node DEM-SPH coupling model based on the shared node method is proposed,and a fluid–structure coupling method using the common-node discrete element method-smoothed particle hydrodynamics(DS-SPH)method is developed using LS-DYNA *** DEM and SPH are established on the same node to create common-node DEM-SPH particles,allowing for fluid–structure *** simulations of various scenarios,including water entry of a rigid sphere,dam-break propagation over wet beds,impact on an ice plate floating on water and ice accumulation on offshore structures,are *** interaction between DS particles and SPH fluid and the crack generation mechanism and expansion characteristics of the ice plate under the interaction of structure and fluid are also *** results are compared with available data to verify the proposed coupling ***,the simulation results demonstrated that controlling the cutoff pressure of internal SPH particles could effectively control particle splashing during ice crushing failure.

关键词： common-node DEM-SPH fluid-structure interaction discrete element method smoothed particle hydrodynamics

Towards experimental studying the airborne sound insulation of light frame walls with staggered studs

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Science China(Technological Sciences) 2024年第7期67卷 2230-2243页

作者： ZHANG YuCai yue Kong XIE YiFan cheng XiangYu SHI XinLei WU Peng ZHAO Hui College of Civil Engineering Nanjing Tech UniversityNanjing 211800China Key Laboratory of Architectural Acoustic Environment of Anhui Higher Education Institutes Hefei 230601China Nanjing Gongda Construction Technology Co.Ltd. Nanjing 211800China

Light frame walls(LFWs) serve as common partition walls in prefabricated buildings due to their lightweight nature, costeffectiveness, energy efficiency, and adaptability for rapid on-site assembly. However, their acoustic insulation capability is hindered by issues such as sound bridges, resonance, and coincidence dips, resulting in inadequate sound insulation. This study aims to propose LFW designs with superior acoustic insulation suitable for practical engineering while meeting prevailing national standards. Nine full-scale LFW configurations were subjected to laboratory testing to evaluate the impact of staggered stud arrangements, stud types, and incorporation of compounded materials. The tests were performed between 100 and 5000 Hz,and the sound pressure level and reverberation time at 1/3 octave band were measured and used to calculate the weighted sound insulation index(Rw). Results demonstrated that the outlined design modifications significantly enhanced the sound insulation of the LFW. These modifications effectively mitigate the influence of sound bridges while addressing resonance and coincidence dips inherent in the wall system. Particularly noteworthy was the superior sound insulation achieved by staggered-stud LFWs with compounded materials, surpassing that of autoclaved lightweight concrete walls commonly used in prefabricated constructions despite having lesser thickness and surface density. Rwvalues increased from 43 to 54 dB compared to conventional LFWs, translating to a notable elevation in airborne sound insulation level from 4 to 7 as an internal separation component,meeting the requisite standards for most applications.

关键词： light frame wall staggered stud airborne sound insulation weighted sound insulation index

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Searching for plant NLR immune receptors conferring resistance to potyviruses

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The Crop Journal 2024年第1期12卷 28-44页

作者： Xin hong Shufen Li Xiaofei cheng Haijian Zhi Jinlong Yin Kai Xu Jiangsu Key Laboratory for Microbes and Functional Genomics Jiangsu Engineering and Technology Research Center for MicrobiologyCollege of Life SciencesNanjing Normal UniversityNanjing 210023JiangsuChina College of Plant Protection Northeast Agricultural UniversityHarbin 150030HeilongjiangChina National Center for Soybean Improvement National Key Laboratory for Crop Genetics and Germplasm EnhancementKey Laboratory of Biology and Genetic Improvement of Soybean-Ministry of AgricultureNanjing Agricultural UniversityNanjing 210095JiangsuChina

To fight against invasion by pathogens,plants have evolved an elaborate innate immune system,of which the nucleotide-binding domain leucine-rich repeat-containing receptor(NLR)acts as the sensor and immune ***,comprising one of the largest genera of plant viruses,cause severe crop yield losses *** crop resistance to potyviruses can be used in breeding and plant transgenesis to control disease *** review summarizes achievements in mapping and cloning NLR genes conferring dominant resistance against potyvirus in the families Fabaceae,Solanaceae,Brassicaceae,and *** compares mechanisms of potyviral protein recognition and downstream signaling employed by NLRs and discusses strategies for exploiting NLRs to better control diseases caused by potyviruses.

关键词： NLR Potyvirus resistance Genetic diversity Mapping Engineer

Intelligent representation method of image flatness for cold rolled strip

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Journal of Iron and Steel Research(International) 2024年第5期31卷 1177-1195页

作者： Yang-huan Xu Dong-cheng Wang hong-min Liu Bo-wei Duan National Engineering Research Center for Equipment and Technology of Cold Strip Rolling Yanshan UniversityQinhuangdao066004HebeiChina National Key Laboratory of Metal Forming Technology and Heavy Equipment China National Heavy Machinery Research Institute Co.Ltd.Xi’an710018ShaanxiChina State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao066004HebeiChina

Real flatness images are the bases for flatness detection based on machine vision of cold rolled *** characteristics of a real flatness image are analyzed,and a lightweight strip location detection(SLD)model with deep semantic segmentation networks is *** interference areas in the real flatness image can be eliminated by the SLD model,and valid information can be *** this basis,the concept of image flatness is proposed for the first *** image flatness representation(IFAR)model is established on the basis of an autoencoder with a new *** optimal structure of the bottleneck layer is 16×16×4,and the IFAR model exhibits a good representation ***,interpretability analysis of the representation factors is carried out,and the difference and physical meaning of the representation factors for image flatness with different categories are *** flatness with new defect morphologies(bilateral quarter waves and large middle waves)that are not present in the original dataset are generated by modifying the representation factors of the no wave ***,the SLD and IFAR models are used to detect and represent all the real flatness images on the test *** average processing time for a single image is 11.42 ms,which is suitable for industrial *** research results provide effective methods and ideas for intelligent flatness detection technology based on machine vision.

关键词： Cold rolled strip Image flatness Location detection Representation learning Bottleneck layer

Graphene as adsorbent for highly efficient extraction of modified nucleosides in urine prior to liquid chromatography-tandem mass spectrometry analysis

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Chinese Chemical Letters 2024年第4期35卷 490-495页

作者： cheng Guo Xiaoxiao Zhang Xiujuan hong Yiqiu Hu Lingna Mao Kezhi Jiang Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Cancer Center Zhejiang UniversityHangzhou 310058China Key Laboratory of Organosilicon Chemistry and Material Technology College of Material Chemistry and Chemical EngineeringHangzhou Normal UniversityHangzhou 311121China Department of General Practice The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China

RNA modifications have been involved in numerous biological processes, and aberrations of these modifications are tightly associated with various diseases including cancer. Herein, we developed graphenebased solid-phase extraction and robust ultra performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS) combined with stable isotope-dilution for simultaneous enrichment and accurate determination of 17 modified nucleosides in human urine. We found graphene could effectively adsorb various modified nucleosides in human urine samples. With this method, we identified and quantified these modified nucleosides in urine samples collected from lung cancer patients and healthy *** revealed that the levels of 12 modified nucleosides were all diminished in urine from lung cancer patients, compared with healthy controls. It is worth noting that we demonstrated, for the first time, the presence of 5,2-O-dimethyluridine(m~5U_m) in human urine. Together, we established a robust analytical method for simultaneous determinations of 17 modified nucleosides in human urine, and our results revealed a close correlation between the concentrations of urinary modified nucleosides and the occurrence of lung cancer, implying the potential applications of these modified nucleosides as noninvasive biomarkers for the early detection of lung cancer. Moreover, this study will stimulate future investigations on the regulatory roles of RNA modifications in the initiation and progression of lung cancer.

关键词： Mass spectrometry RNA modification Modified nucleosides Graphene Biomarker Urine

Thermodynamics of charged black holes in Maxwell-dilaton-massive gravity

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Chinese Physics C 2024年第7期48卷 232-243页

作者：岳瑞宏钱凯强刘博邹德成 Center for Gravitation and Cosmology College of Physical Science and TechnologyYangzhou UniversityYangzhou 225009China School of Physics Northwest UniversityXi'an 710127China School of Physics and Information Science Shaanxi University of Science and TechnologyXi'an 710021China College of Physics and Communication Electronics Jiangxi Normal UniversityNanchang 330022China

Considering the nonminimal coupling of the dilaton field to the massive graviton field in Maxwelldilaton-massive gravity,we obtain a class of analytical solutions of charged black holes,which are neither asymptotically flat nor(A)*** calculated thermodynamic quantities,such as mass,temperature,and entropy,verify the validity of the first law of black hole ***,we further investigate the critical behaviors of these black holes in the grand canonical and canonical ensembles and find a novel critical phenomenon never before observed,known as the"reverse"reentrant phase transition with a tricritical *** implies that the system undergoes a novel"SBH-LBH-SBH"phase transition process and is the reverse of the"LBH-SBH-LBH"process observed in reentrant phase transitions.

关键词： Maxwell-dilaton-massive gravity charged black hole reverse reentrant phase transition VdW-like phase transitions