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World Journal of Pediatrics 2017年第3期13卷 274-277页

作者： yue-bin zhang Zhi-Gang Gao Qi-Xing Xiong Li-Feng zhang Dou-Te Cai Jia-bin Cai Department of General Surgery Children's Hospital Zhejiang University School of MedicineHangzhouChina

Background:Several clinical reports have been published on complications resulting from swallowing multiple magnetic foreign *** study aimed to summarize the clinical experience of managing children who swallowed multiple magnetic foreign ***:We reviewed the clinical records of five children who swallowed multiple magnetic foreign bodies and were admitted to our hospital during June 2012 to June *** of the patients' presentation,imaging studies,complications and treatment were ***:All five children suffered from gastrointestinal perforation and intestinal *** magnetic foreign bodies caused local bowel wall tissue ischemia necrosis and perforation as well as other complications associated with fistula *** magnets were finally removed by laparotomy ***:If magnetic foreign bodies cannot be removed by endoscopy,an operation is suggested as soon as possible to avoid serious complications.

关键词： children gastrointestinal perforation intestinal obstruction magnetic foreign bodies

Polarization of the dielectronic recombination satellites including the generalized Breit interaction effects

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原子与分子物理学报 2006年第B4期23卷 21-25页

作者： WU Ze-qing LI yue-ming DUAN bin zhang Hong Institute of Applied Physics and Computational Mathematics. Laboratory of Computational Physics P. O. Box 8009-57 Beijing 100088 P.R. China）

The polarizations of dielectronic recombination satellite lines for hydrogenlike F to U ions are calculated including the generalized Breit interaction(GBI). The calculated values of the asymmetry parameter are compared with other theoretical results and good agreements are obtained for all lines except for those from the level 2s2p3P1. The GBI effects on the polarization become much stronger as the atomic number increases. However, for different lines, the GBI effects on the polarization are different.

关键词：偏振 GBI 电子重组理论结构原子结构

Preliminary identification of key miRNAs, signaling pathways, and genes associated with Hirschsprung's disease by analysis of tissue microRNA expression profiles

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World Journal of Pediatrics 2017年第5期13卷 489-495页

作者： Zhi-Gang Gao Qing-Jiang Chen Min Shao Yun-Zhong Qian Li-Feng zhang yue-bin zhang Qi-Xing Xiong Pediatric General Surgery Department The Children's HospitalZhejiang University School of MedicineHangzhouChina International Medical Center The First Affiliated HospitalZhejiang UniversitySchool of MedicineHangzhouChina

Background:Hirschsprung's disease (HSCR) is a congenital gut motility disorder of infants,and if left untreated,it is fatal to the affected *** study aimed to identify key microRNAs (miRNAs),signaling pathways and genes involved in the pathogenesis of ***:The miRNA microarray dataset GSE77296 was *** colon tissue samples were available:six from HSCR patients and three matched control *** expressed miRNAs (DEMs) were identified after data *** genes of the selected upregulated and downregulated DEMs were *** addition,functional enrichment analyses for the selected DEMs and target genes were ***,interaction networks between the DEMs and target genes were ***:A total of 162 DEMs (73 upregulated and 89 downregulated) were obtained.A total of 2511 DEM-target gene pairs for the 40 selected DEMs were identified,including 1645 pairs for the upregulated DEMs and 866 pairs for the downregulated *** upregulated DEM miR-141-3p and down-regulated DEM miR-30a-3p were identified as key miRNAs by Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment and network ***,KEGG pathway enrichment analysis revealed that pathways in cancer and the mitogen-activated protein kinase (MAPK) signaling pathway were key *** key genes frizzled class receptor 3 (FZD3) and docking protein 6 (DOK6) were obtained through the DEM-target gene interaction ***:Two key miRNAs (miR-141-3p and miR-30a-3p),the MAPK signaling pathway and two key genes (FZD3 and DOK6) were implicated in the pathogenesis of HSCR.

关键词： differentially expressed microRNA docking protein 6 frizzled class receptor 3 Hirschsprung's disease mitogen-activated protein kinase signaling pathway

Management of foreign bodies ingestion in children

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World Journal of Pediatrics 2022年第12期18卷 854-860页

作者： Qing-Jiang Chen Lin-Yan Wang Yi Chen Jia-Jin Xue yue-bin zhang Li-Feng zhang Yun-Zhong Qian Qi-Xing Xiong Zhi-Gang Gao Department of Pediatric General Surgery National Center for Clinical Medicine of Children’s Health and DiseaseChildren’s HospitalZhejiang University School of MedicineNational Children’s Regional Medical Center3333 Binsheng RoadBinjiang DistrictHangzhou310052China

Foreign bodies(FBs)ingestion in children is one of the common presentations to the emergency *** majority of FBs ingestion occurs in children younger than 3 years,with males showing a slight predominance[1].Although most FBs pass through the gastrointestinal tract spontaneously,some FBs need urgent medical intervention and even surgical management owing to the complications of obstruction or perforation and a potential risk to children’s health[2].Therefore,timely diagnosis and rational treatment are crucial for reducing FBs ***,optimal indications and/or timing of surgery remain *** this study,we discussed the characteristics of FBs ingestion in children and summarized our experience in its management.

关键词： diagnosis younger children

Preliminary exploration of animal models of congenital choledochal cysts

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World Journal of Gastroenterology 2024年第10期30卷 1420-1430页

作者： Shu-Hao zhang yue-bin zhang Duo-Te Cai Tao Pan Ken Chen Yi Jin Wen-Juan Luo Zong-Wei Huang Qing-Jiang Chen Zhi-Gang Gao Department of General Surgery Children’s HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina

BACKGROUND Various animal models have been used to explore the pathogenesis of choledochal cysts(CCs),but with little convincing *** surgical techniques can achieve satisfactory outcomes for treatment of ***,recent studies have focused more on clinical issues rather than basic ***,we need appropriate animal models to further basic *** To establish an appropriate animal model that may contribute to the investigation of the pathogenesis of *** Eighty-four specific pathogen-free female Sprague-Dawley rats were randomly allocated to a surgical group,sham surgical group,or control group.A rat model of CC was established by partial ligation of the bile *** reliability of the model was confirmed by measurements of serum biochemical indices,morpho-logy of common bile ducts of the rats as well as molecular biology experiments in rat and human *** Dilation classified as mild(diameter,≥1 mm tobin,direct bilirubin,and total bile acids were significantly elevated in the surgical group as compared to the control group 7 d after surgery,while direct bilirubin,total bilirubin,and gamma-glutamyltransferase were further increased 14 d after *** of the biochemical indices gradually decreased to normal ranges 28 d after *** protein expression trend of signal transducer and activator of transcription 3 in rat model was consistent with the human CC *** The model of partial ligation of the bile duct of juvenile rats could morphologically simulate the cystic or fusiform CC,which may contribute to investigating the pathogenesis of CC.

关键词： Choledochal cyst Animal model Partial ligation Cystic and fusiform dilation Juvenile rats

THE SELF-STATISTICAL REGULARITY OF THE APERIODIC AND CONSERVATIVE DYNAMICAL SYSTEM

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中国科学A辑(英文版) 1986年第9期 927-940页

作者：岳曾元张彬 Department of Geophysics Peking University Peking University

A typical nonlinear and aperiodic conservative dynamical system, the process of coin flapping without air drag and collision dissipation, is investigated in a detailed way. It is found that this deterministic process under given initial conditions shows definite 'self-statistical regularity' during a very long time. The Poincare recurrence period in this process and its dependence on the 'accuracy' of recurrence are calculated.

关键词： regularity stationary Poincare recurrence collision conservative deterministic dynamical infinitely degenerate

A Standard Time Resolution Detecting System for TOF-PET

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近代物理研究所和兰州重离子加速器实验室年报：英文版 2008年第1期 31-32页

作者： Chen Jinda Xu Hushan Guo Zhongyan Chen Ruofu Hu Zhenguo Tang bin yue Ke zhang Xueheng Yu Yuhong

Recent Advances in Artificial Sensory Neurons:Biological Fundamentals,Devices,Applications,and Challenges

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Nano-Micro Letters 2025年第3期17卷 168-216页

作者： Shuai Zhong Lirou Su Mingkun Xu Desmond Loke bin Yu Yishu zhang Rong Zhao Guangdong Institute of Intelligence Science and Technology HengqinZhuhai 519031People’s Republic of China College of Integrated Circuits Zhejiang UniversityHangzhou 3112000People’s Republic of China ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou 310027People’s Republic of China Department of Science Mathematics and TechnologySingapore University of Technology and DesignSingapore 487372Singapore Department of Precision Instruments Tsinghua UniversityBeijing 100084People’s Republic of China Center for Brain‑Inspired Computing Research Tsinghua UniversityBeijing 100084People’s Republic of China IDG/McGovern Institute for Brain Research Tsinghua UniversityBeijing 100084People’s Republic of China

Spike-based neural networks,which use spikes or action potentialsto represent information,have gained a lot of attention because of their high energyefficiency and low power *** fully leverage its advantages,convertingthe external analog signals to spikes is an essential *** including analog-to-digital converters or ring oscillators,and sensorssuffer from high power and area *** efforts are devoted to constructingartificial sensory neurons based on emerging devices inspired by the biologicalsensory *** can simultaneously perform sensing and spike conversion,overcoming the deficiencies of traditional sensory *** review summarizesand benchmarks the recent progress of artificial sensory *** starts with thepresentation of various mechanisms of biological signal transduction,followed bythe systematic introduction of the emerging devices employed for artificial ***,the implementations with different perceptual capabilitiesare briefly outlined and the key metrics and potential applications are also ***,we highlight the challenges and perspectives for the future development of artificial sensory neurons.

关键词： Artificial intelligence Emerging devices Artificial sensory neurons Spiking neural networks Neuromorphic sensing

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基于相关主题模型的程序网络自动构建与分析

电子学报 2017年第5期45卷 1052-1056页

作者：孙小兵刘湘月李斌张伟佳扬州大学信息工程学院江苏扬州225127 南京大学计算机软件新技术国家重点实验室江苏南京210023

程序理解的目的在于获得足够的软件系统信息,以适用于人理解的形式展现出来,辅助开发人员对软件的理解.本文通过使用相关主题模型,为软件系统类层次的代码文件建立程序网络,并可视化展示整个软件系统的相关结构和功能,辅助开发者理解整... 详细信息

程序理解的目的在于获得足够的软件系统信息,以适用于人理解的形式展现出来,辅助开发人员对软件的理解.本文通过使用相关主题模型,为软件系统类层次的代码文件建立程序网络,并可视化展示整个软件系统的相关结构和功能,辅助开发者理解整个程序代码.该技术综合考虑了软件代码中的结构性信息和内容性信息,所建立的程序网络可帮助开发者更好的理解程序的语法依赖关系和语义功能相关关系.实验验证了建立的程序网络具有较好的准确性以及可以为指定的类推荐相关类.

关键词：程序理解相关主题模型程序网络

Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury

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Neural Regeneration Research 2025年第10期20卷 2955-2968页

作者： Wei zhang Yubao Lu Ruoqi Shen Yingjie Wu Chenrui Liu Xingxing Fang Liangming zhang bin Liu Limin Rong Department of Spine Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina National Medical Products Administration(NMPA)Key Laboratory for Quality Research and Evaluation of Cell Products GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Quality Control of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Engineering and Technology Research of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina

Microglia,the resident monocyte of the central nervous system,play a crucial role in the response to spinal cord ***,the precise mechanism remains *** investigate the molecular mechanisms by which microglia regulate the neuroinflammatory response to spinal cord injury,we performed single-cell RNA sequencing dataset analysis,focusing on changes in microglial *** found that the MG1 subpopulation emerged in the acute/subacute phase of spinal cord injury and expressed genes related to cell pyroptosis,sphingomyelin metabolism,and neuroinflammation at high ***,we established a mouse model of contusive injury and performed intrathecal injection of siRNA and molecular inhibitors to validate the role of ceramide synthase 5 in the neuroinflammatory responses and pyroptosis after spinal cord ***,we established a PC12-BV2 cell co-culture system and found that ceramide synthase 5 and pyroptosis-associated proteins were highly expressed to induce the apoptosis of neuron *** ceramide synthase 5 expression in a mouse model of spinal cord injury effectively reduced ***,ceramide synthase 5-induced pyroptosis was dependent on activation of the NLRP3 signaling *** ceramide synthase 5 expression in microglia in vivo reduced neuronal apoptosis and promoted recovery of neurological ***2g7 formed a“bridge”between sphingolipid metabolism and ceramide synthase 5-mediated cell death by inhibiting the NLRP3 signaling ***,these findings suggest that inhibiting ceramide synthase 5 expression in microglia after spinal cord injury effectively suppressed microglial pyroptosis mediated by NLRP3,thereby exerting neuroprotective effects.

关键词： ceramide synthase 5 gasdermin D microglia neuroinflammation NLRP3 nuclear factor kappa B Pla2g7 pyroptosis sphingomyelin metabolism spinal cord injury