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Effects of yue-Bi-tang on water metabolism in severe acute pancreatitis rats with acute lung-kidney injury

World Journal of Gastroenterology 2020年第43期26卷 6810-6821页

作者： Jing Hu Yu-Mei Zhang Yi-Fan Miao Lv Zhu Xiao-Lin Yi Huan Chen Xi-Jing Yang Mei-Hua Wan Wen-Fu tang Department of Integrative Medicine West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Traditional Chinese Medicine Xiang’an Hospital of Xiamen UniversityXiamen 361101Fujian ProvinceChina Animal Experiment Center West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND The complications acute lung injury and acute kidney injury caused by severe inflammation are the main reasons of high mortality of severe acute pancreatitis(SAP).These two complications can both lead to water metabolism and acid-base balance disorders,which could act as additional critical factors affecting the disease ***(AQPs),which can regulate the transmembrane water transport,have been proved to participate in the pathophysiological process of SAP and the associated complications,such as acute lung injury and acute kidney ***,exploring herbs that can effectively regulate the expression of AQP in SAP could benefit the prognosis of this *** To determine whether yue-Bi-tang(YBT)can regulate the water metabolism in rats with severe acute pancreatitis via regulating the expression of *** Sprague-Dawley rats were randomly divided into three groups,sham operation group(SOG),model group(MG),and treatment group(TG).SAP was induced with 3.5%sodium taurocholate in the MG and *** in the TG were administered with YBT while SOG and MG rats were given the same volume of *** and tissue samples were harvested to detect serum inflammatory cytokines,histopathological changes,malondialdehyde and superoxide dismutase in the lung,and protein and mRNA expression of kidney injury molecule-1,α-smooth muscle actin,and vimentin in the kidney,and AQP1 and 4 in the lung,pancreas,and *** The serum interleukin-10,tumor necrosis factorα,and creatinine levels were higher in the MG than in the *** necrosis factorαlevel in the TG was lower than that in the *** level in lung tissues was higher than in the *** pathological scores and edema scores of the pancreas,lung,and kidney tissues in the MG were all higher than those in the SOG and *** protein expression of AQP4 in lung tissues and AQP1 in kidney tissues in the MG were higher than those in the SOG and *** expression of vimentin was s

关键词： yue-Bi-tang Aquaporins Sever acute pancreatitis Acute lung injury Acute kidney injury Water metabolism

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The First Report of Thermochemical Sulfate Reduction Reaction in the Upper Paleozoic Carbonate Rocks of Southeastern Ordos Basin

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Acta Geologica Sinica(English Edition) 2016年第6期90卷 2277-2278页

作者： tang yue tang Dazhen DU Zhili School of Energy Resources China University of Geosciences Oil & Gas Survey China Geological Survey

Thermochemical sulfate reduction （TSR） is the reaction between anhydrite and petroleum fluids at elevated temperatures to produce H2S and CO2. TSR has been studied in many sedimentary basins such as China＇s Sichuan and Tarim basins because it has a profound impact on the commercial viability of petroleum resources, with HzS typically being undesirable.

关键词： TSR The First Report of Thermochemical Sulfate Reduction Reaction in the Upper Paleozoic Carbonate Rocks of Southeastern Ordos Basin

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重视早发性肝内胆管癌的研究

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临床肝胆病杂志 2025年第12期40卷 2345-2350页

作者：覃德龙陈家璐唐玥李宗龙汤朝晖全志伟上海交通大学医学院附属新华医院普通外科上海 200092

肝内胆管癌（ICC）是一种高度恶性的胆道肿瘤，其中早发性ICC（EOICC）是指确诊年龄≤50岁的ICC，但通常具有更晚的临床分期、更显著的生物学侵袭性。目前EOICC的发病率正在迅速增长，但其研究仍处于早期阶段。现有的研究表明EOICC具有... 详细信息

肝内胆管癌（ICC）是一种高度恶性的胆道肿瘤，其中早发性ICC（EOICC）是指确诊年龄≤50岁的ICC，但通常具有更晚的临床分期、更显著的生物学侵袭性。目前EOICC的发病率正在迅速增长，但其研究仍处于早期阶段。现有的研究表明EOICC具有与晚发ICC显著不同的流行病学、临床和分子学特征。因此，重视EOICC高危因素及发病机制等方面的研究对于EOICC的早识别、早诊断以及针对性治疗具有重要意义。由于EOICC患者年龄较轻、身体状况较佳，可耐受风险更大的医疗干预措施，采取更积极的个体化诊疗方案，因此患者可能获得与晚发ICC相似甚至更好的生存预后。然而，EOICC的分子学特征与ICC显著不同，现有的靶向药物可能不适用于EOICC患者，晚期EOICC患者系统治疗面临巨大挑战。EOICC的临床和基础研究整体滞后，需要进一步深入阐明EOICC的人群特征及其发病因素，进而推动建立适合EOICC群体的预防及诊疗规范。

关键词：胆管上皮癌早发性肿瘤流行病学体征和症状基因表达谱

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A conservative distribution of tridomain NDP-heptose synthetases in actinobacteria

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Science China(Life Sciences) 2022年第5期65卷 1014-1023页

作者： yue tang Wei tang Min Wang Zhilong Zhang Yihua Chen State Key Laboratory of Microbial Resources and CAS Key Laboratory of Microbial Physiological and Metabolic Engineering Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

Heptoses are important structural components of Gram-negative bacterium cell wall and participate in bacterial colonization,infection,and immune *** knowledge of NDP-heptose originating from D-sedoheptulose 7-phosphate in Grampositive bacterium remains ***,in silico analysis suggested that the special tridomain NDP-heptose synthetases with isomerase,kinase,and nucleotidyltransferase activities are conservatively distributed in Actinobacteria class of Gram-positive *** characterization of the tridomain proteins from different strains showed that they are involved in ADPD-glycero-β-D-manno-heptose biosynthesis despite the unexpected discovery of kinase activities deficient in some *** presence of three types of NDP-heptose synthetases in Gram-positive bacterium suggests that it is also a rich source of heptoses and the heptose moieties may play important roles in *** work updates the understanding of NDP-heptose biosynthesis in Gram-positive bacterium and lays a solid foundation for further physiological function explorations.

关键词： tridomain NDP-heptose synthetase NDP-heptose biosynthesis widespread distribution Gram-positive bacterium

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Performance experiment and numerical prediction on the optimization design of the micro-sized water turbine for the hose reel irrigator

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International Journal of Agricultural and Biological Engineering 2018年第5期11卷 108-115页

作者： Lingdi tang Shouqi Yuan yue tang Haofang Yan Research Center of Fluid Machinery Engineering and Technology Jiangsu UniversityZhenJiang 212013China

In order to significantly improve the efficiency of driving water turbine used in hose reel irrigator,a new water turbine structure was proposed by the method of performance test and numerical *** internal flow characteristics of original water turbine were analyzed,and it was found that unreasonable design of main flow passage components such as inlet,outlet and runner could not effectively translated pressure energy of upper stream into impact kinetic energy of blade,and gave rise to low energy conversion efficiency of water *** inadequate internal flow and uneven pressure distribution were also not conducive to energy conversion *** a new structure of water turbine structure was presented,in which the inlet has a tangential nozzle jet and the outlet is in axial *** computational analysis showed that the nozzle jet at the inlet of the new water turbine runner,which makes jet flow mainly concentrate in the impacted blade passage,can reduce the loss of flow kinetic *** axial outflow increases the distance of inflow in the runner,which is more conducive to the runner blades *** experiments on both original and new water turbines showed that the highest efficiency of the new turbine is almost 20 percentages higher than that of the original turbine,and the new turbine is nearly triple output power over the original *** internal flow characteristic analysis and the performance experiment were conducted to assess the feasibility of the replacement of the original water turbine by the new water turbine.

关键词： micro-sized water turbine hose reel irrigator optimization design experimental study numerical analysis

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Coalbed Methane Enrichment Regularity and Major Control Factors in the Xishanyao Formation in the Western Part of the Southern Junggar Basin

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Acta Geologica Sinica(English Edition) 2020年第2期94卷 485-500页

作者： YUAN Yuan SHAN Yansheng tang yue CAO Daiyong China University of Mining&Technology Beijing 100083China China Geological Survey Oil and Gas SurveyBeijing 100083China

There are abundant coal and coalbed methane(CBM)resources in the Xishanyao Formation in the western region of the southern Junggar Basin,and the prospects for CBM exploration and development are *** promote the exploration and development of the CBM resources of the Xishanyao Formation in this area,we studied previous coalfield survey data and CBM geological exploration ***,we analyzed the relationships between the gas content and methane concentration *** seam thickness,burial depth,coal reservoir physical characteristics,hydrogeological conditions,and roof and floor *** addition,we briefly discuss the main factors influencing CBM ***,we found that the coal strata of the Xishanyao Formation in the study area are relatively simple in structure,and the coal seam has a large thickness and burial depth,as well as moderately good roof and floor *** hydrogeological conditions and coal reservoir physical characteristics are also conducive to the enrichment and a high yield of *** believe that the preservation of CBM resources in the study area is mainly controlled by the structure,burial depth,and hydrogeological ***,on the basis of the above results,the coal seam of the Xishanyao Formation in the synclinal shaft and buried at depths of 700-1000 m should be the first considered for development.

关键词： coalbed methane enrichment regularity major control factors Xishanyao Formation western area of the southern Junggar Basin

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Influence of two polyphenols on the structure and lubrication of salivary pellicle:An in vitro study on astringency mechanism

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Friction 2022年第1期10卷 167-178页

作者： Lei LEI yue tang Jing ZHENG Genlei MA Zhongrong ZHOU Tribology Research Institute Key Laboratory of Advanced Technologies of MaterialsMinistry of EducationSouthwest Jiaotong UniversityChengdu 610031China

This study investigated the influence of two polyphenols on the structure and lubrication of the salivary pellicle,aiming to extend the understanding of astringency *** salivary pellicle was prepared by the adsorption of human whole saliva on the enamel ***-astringency catechin and high-astringency tannic acid were used as *** changes induced by the two polyphenols in the structure and lubrication of the salivary pellicle were examined using quartz crystal microbalance with dissipation(QCM-D)and nano-indentation/scratch *** salivary pellicle suffers from changes in structure and physical properties owing to protein dehydration and protein-polyphenol complexation when encountering polyphenolic molecules,causing increases in the roughness and contact angle but a decrease in the load-bearing ***,the lubrication performance of the salivary pellicle is impaired,leading to an increase and fluctuation of the friction *** intensity of astringency has a strong positive correlation with the water contact angle,surface roughness,and friction coefficient of the salivary *** summary,astringency is a tactile perception driven by the roughness and wettability of the salivary pellicle rather than oral lubrication,and increased intraoral friction is an inevitable consequence of *** findings of this study will help promote and assist the objective evaluation of astringency.

关键词： salivary impaired string

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Methyl tertiary-butyl ether inhibits THP-1 macrophage cholesterol efflux in vitro and accelerates atherosclerosis in ApoE-deficient mice in vivo

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Journal of Environmental Sciences 2021年第3期33卷 236-247页

作者： Qidong Ren Xinni Xie yue tang Qing Hu Yuguo Du State Key Laboratory of Environmental Chemistry and Eco-Toxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China School of Environmental Science and Engineering Southern University of Science and TechnologyShenzhen 518055China

The biosafety of methyl tertiary-butyl ether(MTBE),mainly used as a gasoline additive,has long been a contentious *** addition to its routine toxicities,MTBE has been demonstrated to disrupt glucose and lipid metabolism and contribute to the development of type2 diabetes as well as *** one of the morbidities related to dyslipidemia,atherosclerosis is worthy of being investigated under MTBE *** foam cells derived from macrophages play pivotal roles during atherosclerosis development,we studied the effects of MTBE on macrophages in vitro and assessed the effect of MTBE on atherosclerosis plaque formation with the ApoE^(-/-)mouse model in uiuo for the first *** results demonstrated that exposure to MTBE at environmentally relevant concentrations decreased the expression of ABCA1 and ABCG1,which are responsible for macrophage cholesterol efflux,at both mRNA and protein levels in THP-1 ***,treatment with MTBE inhibited the transport of cholesterol from macrophages to High-density ***^(-/-)mice exposed to MTBE at environmentally relevant concentrations(100,1000μg/kg)displayed significant increases in lesion area in the aorta and aortic root compared to vehicletreated *** analysis indicated that MTBE exposure enhanced the macrophagespecific marker Mac-2 contents within plaques in the aortic root,implying that MTBE could promote macrophage-derived foam cell formation and thus accelerate atherosclerosis plaque *** for the first time demonstrated the pro-atherogenic effect of MTBE via eliciting disruption of macrophage cholesterol efflux and accelerating foam cell formation and atherosclerosis plaque development.

关键词： Methyl tertiary–butyl ether(MTBE) macrophage cholesterol efflux ApoE^(-/-)mouse Atherosclerosis

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On Modeling Drilling Load in Lunar Regolith Simulant

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Chinese Journal of Mechanical Engineering 2018年第1期31卷 41-52页

作者： Qi-Quan Quan Chong-Bin Chen Zong-Quan Deng Jun-yue tang De-Wei tang State Key Laboratory of Robotics and System Harbin Institute of Technology

Drilling and coring, as effective ways to obtain lunar regolith along the longitudinal direction, are widely applied in the lunar sampling field. Conventionally, modeling of drill-soil interaction was divided into soil cutting and screw conveyance processes, ignoring the differences in soil mechanical properties between them. To improve the modeling accuracy, a hypothesis that divides the drill-soil interaction into four parts: cuttings screw conveyance, cuttings extruding, cuttings bulldozing, and in situ simulant cutting, is proposed to establish a novel model based on the passive earth pressure theory. An iterative numerical calculation method is developed to predict the drilling loads. A drilling and coring testbed is developed to conduct experimental tests. Drilling experiments indicate that the drilling loads calculated by the proposed model match well the experimental results. The proposed research provides the instructions to adopt a suitable drilling strategy to match the rotary and penetrating motions, to increase the safety and reliability of drilling control in lunar sampling missions.

关键词： Lunar regolith drilling Lunar regolith simulant Drill-simulant interaction Screw conveyance

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MOTION OF TRACER PARTICLES IN A CENTRIFUGAL PUMP AND ITS TRACKING CHARACTERISTICS

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Journal of Hydrodynamics 2012年第5期24卷 785-793页

作者： LI Ya-lin YUAN Shou-qi tang yue YUAN Jian-ping Research Center of Fluid Machinery Engineering and Technology Jiangsu University Zhenjiang 212013 China

The Basset-Boussinesq-Oseen （BBO） equation can be used for most flows to trace the motion of a particle, but in a centrifugal pump, among the forces that act on the particles, one should also include those due to the impeller rotation, as additional effects. This paper firstly reviews various approximations of the BBO equation for the motion of dispersion particles in a viscous fluid. Then based on the motion equation for particles in low Reynolds number centrifugal pumps, a formula for calculating the tracking characteristics of tracer particles is deduced through the Fourier integral transformation. After that the deviations of the particle motion from the fluid motion, as predicted by the various approximations, are discussed and compared. At last, with an emphasis on the Particle Image Velocimetry （PIV） results, the tracking characteristics of particles are estimated. Also, advantages and disadvantages of different tracer particles are discussed and suitable tracer particles for application in PIV studies for flow fields in centrifugal pumps are suggested.

关键词： tracer particles equations of motion tracking characteristics centrifugal pump Particle Image Velocimetry (PIV)

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