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Journal of Control and Decision 2024年第1期11卷 50-59页

作者： yue-ming Wang Yuan-Xin Li Department of Science Liaoning University of TechnologyJinzhouPeople’s Republic of China

In this article,an adaptive security control scheme is presented for cyber-physical systems(CPSs)suffering from false data injection(FDI)attacks and time-varying state constraints.Firstly,an adaptive bound estimation mechanism is introduced in the backstepping control design to mitigate the effect of FDI attacks.Secondly,to solve the unknown sign time-varying statefeedback gains aroused by the FDI attacks,a type of Nussbaum function is employed in the adaptive security control.Then,by constructing a barrier Lyapunov function,it can be ensured that all signals of controlled system are bounded and the time-varying state constraints are not transgressed.Finally,the provided simulation examples demonstrate the effectiveness of the proposed controller.

关键词： Neural networks backstepping technology false data injection(FDI)attacks nonlinear cyber-physical systems controls

Postoperative accurate pain assessment of children and artificial intelligence: A medical hypothesis and planned study

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World Journal of Clinical Cases 2024年第4期12卷 681-687页

作者： Jian-ming yue Qi Wang Bin Liu Leng Zhou Department of Anesthesiology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

Although the pediatric perioperative pain management has been improved in recent years,the valid and reliable pain assessment tool in perioperative period of children remains a challenging task.Pediatric perioperative pain management is intractable not only because children cannot express their emotions accurately and objectively due to their inability to describe physiological characteristics of feeling which are different from those of adults,but also because there is a lack of effective and specific assessment tool for children.In addition,exposure to repeated painful stimuli early in life is known to have short and long-term adverse sequelae.The short-term sequelae can induce a series of neurological,endocrine,cardiovascular system stress related to psychological trauma,while long-term sequelae may alter brain maturation process,which can lead to impair neurodevelopmental,behavioral,and cognitive function.Children’s facial expressions largely reflect the degree of pain,which has led to the developing of a number of pain scoring tools that will help improve the quality of pain mana-gement in children if they are continually studied in depth.The artificial inte-lligence(AI)technology represented by machine learning has reached an unprecedented level in image processing of deep facial models through deep convolutional neural networks,which can effectively identify and systematically analyze various subtle features of children’s facial expressions.Based on the construction of a large database of images of facial expressions in children with perioperative pain,this study proposes to develop and apply automatic facial pain expression recognition software using AI technology.The study aims to improve the postoperative pain management for pediatric population and the short-term and long-term quality of life for pediatric patients after operational event.

关键词： Pediatric Perioperative pain Assessment tool Facial expression Machine learning Artificial intelligence

Ti_(3)C_(2)T_(x)/SnO_(2)P–N heterostructure construction boosts room-temperature detecting formaldehyde

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Rare Metals 2024年第1期43卷 267-279页

作者： yue Zhang ming-yue Wang Xiao-Guang San Yan-Bai Shen Guo-Sheng Wang Lei Zhang Dan Meng College of Chemical Engineering Shenyang University of Chemical TechnologyShenyang 110142China Institute for Superconducting and Electronic Materials(ISEM) Australian Institute for Innovative Materials(AIIM)University ofWollongongWollongongNSW2500Australia College of Resources and Civil Engineering Northeastern UniversityShenyang 110819China

Formaldehyde is a common atmospheric pollutant produced in industrial production and daily life.However,the traditional semiconductor formaldehyde gas sensor cannot work at room temperature,which limits its practical application.Therefore,developing high-performance gas sensors for rapidly and accurately detecting formaldehyde at room temperature is an important topic.In this study,Ti_(3)C_(2)Tx/SnO_(2)heterostructures were constructed,which could selectively detect formaldehyde at room temperature with a response value of 29.16%(10×10^(-6)).In addition,the sensor shows a remarkable theoretical detection limit of 5.09×10^(-9)and good longterm stability.Density functional theory(DFT)simulations reveal that SnO_(2)nano spheres provide the majority of adsorption sites that strongly interact with formaldehyde.Meanwhile,Ti_(3)C_(2)T_(x)acting as a conductive layer facilitates the transfer of charge carriers so that they show a sensing response to formaldehyde at room temperature.Moreover,the formation of p-n heterostructures between SnO_(2)and Ti_(3)C_(2)T_(x)boosts the Schottky barrier at the interface,which is the critical factor in enhancing the sensing properties by turning the Schottky barrier upon introducing formaldehyde gas.This perspective is expected to provide instructive guidance for utilizing MXene/metal oxide nanocomposites to improve the gas sensing performance at room temperature.

关键词： Ti_(3)C_(2)T_(x)/SnO_(2)nanocomposites p-n heterostructures Formaldehyde sensing Room temperature DFT calculations

Effects of dietary intervention on human diseases:molecular mechanisms and therapeutic potential

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1389-1422页

作者： Yu-Ling Xiao yue Gong Ying-Jia Qi Zhi-ming Shao Yi-Zhou Jiang Key Laboratory of Breast Cancer in Shanghai Department of Breast SurgeryFudan University Shanghai Cancer CenterShanghaiChina Department of Oncology Shanghai Medical CollegeFudanUniversityShanghai200032China

Diet,serving as a vital source of nutrients,exerts a profound influence on human health and disease progression.Recently,dietary interventions have emerged as promising adjunctive treatment strategies not only for cancer but also for neurodegenerative diseases,autoimmune diseases,cardiovascular diseases,and metabolic disorders.These interventions have demonstrated substantial potential in modulating metabolism,disease trajectory,and therapeutic responses.Metabolic reprogramming is a hallmark of malignant progression,and a deeper understanding of this phenomenon in tumors and its effects on immune regulation is a significant challenge that impedes cancer eradication.Dietary intake,as a key environmental factor,can influence tumor metabolism.Emerging evidence indicates that dietary interventions might affect the nutrient availability in tumors,thereby increasing the efficacy of cancer treatments.However,the intricate interplay between dietary interventions and the pathogenesis of cancer and other diseases is complex.Despite encouraging results,the mechanisms underlying diet-based therapeutic strategies remain largely unexplored,often resulting in underutilization in disease management.In this review,we aim to illuminate the potential effects of various dietary interventions,including calorie restriction,fasting-mimicking diet,ketogenic diet,protein restriction diet,high-salt diet,high-fat diet,and high-fiber diet,on cancer and the aforementioned diseases.We explore the multifaceted impacts of these dietary interventions,encompassing their immunomodulatory effects,other biological impacts,and underlying molecular mechanisms.This review offers valuable insights into the potential application of these dietary interventions as adjunctive therapies in disease management.

关键词： diseases metabolism potential

Reflective ultrathin light-sheet microscopy with isotropic 3D resolutions

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Photonics Research 2024年第2期12卷 271-281页

作者： yue WANG DASHAN DONG WENKAI YANG RENXI HE ming LEI KEBIN SHI State Key Laboratory for Mesoscopic Physics Department of PhysicsPeking UniversityBeijing 100871China State Key Laboratory of Membrane Biology School of Life Sciencesand Biomedical Pioneering Innovation Center(BIOPIC)Peking UniversityBeijing 100871China School of Physics Xi’an Jiaotong UniversityXi’an 710049China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China Peking University Yangtze Delta Institute of Optoelectronics Nantong 226010China

Light-sheet fluorescence microscopy(LSFM)has played an important role in bio-imaging due to its advantages of high photon efficiency,fast speed,and long-term imaging capabilities.The perpendicular layout between LSFM excitation and detection often limits the 3D resolutions as well as their isotropy.Here,we report on a reflective type light-sheet microscope with a mini-prism used as an optical path reflector.The conventional high NA objectives can be used both in excitation and detection with this design.Isotropic resolutions in 3D down to300 nm could be achieved without deconvolution.The proposed method also enables easy transform of a conventional fluorescence microscope to high performance light-sheet microscopy.

关键词： resolution excitation light

Pathogenesis of chronic enteropathy associated with the SLCO2A1 gene:Hypotheses and conundrums

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World Journal of Gastroenterology 2024年第19期30卷 2505-2511页

作者： Zhi-Xin Xie yue Li Ai-ming Yang Dong Wu Qiang Wang State Key Laboratory of Complex Severe and Rare Diseases Department of GastroenterologyPeking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Department of Clinical Medicine Peking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100730China

Chronic enteropathy associated with the SLCO2A1 gene(CEAS)is a complex gastroenterological condition characterized by multiple ulcers in the small intestine with chronic bleeding and protein loss.This review explores the potential mechanisms underlying the pathogenesis of CEAS,focusing on the role of SLCO2A1-encoded prostaglandin transporter OATP2A1 and its impact on prostaglandin E2(PGE2)levels.Studies have suggested that elevated PGE2 levels contribute to mucosal damage,inflammation,and disruption of the intestinal barrier.The effects of PGE2 on macrophage activation and Maxi-Cl channel functionality,as well as its interaction with nonsteroidal anti-inflammatory drugs play crucial roles in the progression of CEAS.Understanding the balance between its protective and pro-inflammatory effects and the complex interactions within the gastrointestinal tract can shed light on potential therapeutic targets for CEAS and guide the development of novel,targeted therapies.

关键词： SLCO2A1 Prostaglandin E2 Chronic enteropathy associated with the SLCO2A1 gene Small intestine Macrophage

Effect of austenitizing condition on mechanical properties,microstructure and precipitation behavior of AISI H13 steel

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Journal of Iron and Steel Research(International) 2024年第1期31卷 143-156页

作者： An-gang Ning Yang Liu Rui Gao Stephen yue ming-bo Wang Han-jie Guo College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan030024ShanxiChina Department of Mining and Materials Engineering McGill UniversityMontrealQCH3A 0C5Canada ASSAB Tooling Technology(Chongqing)Co. Ltd.Chongqing401120China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China

The effects of austenitizing temperature(1223,1303,and 1373 K)and holding time(1-1500 s)on the microstructure,mechanical properties,and precipitation behavior of the H13 hot work die steel were investigated.The results indicate a softening phenomenon when H13 steel is austenitized at 1303 K beyond 900 s and 1373 K beyond 600 s,respectively.For the sample held for 1200 s,the tensile strength is found capable of reaching up to 2.2 GPa when quenched from a temperature above 1303 K.Meanwhile,prior-austenite grain size increases with the increase in austenitizing temperature.The kinetic behavior of the precipitates(mainly MC-type carbides)in H13 steel could be elaborated through the principles set forth by the Arrhenius and Avrami equations.Finally,the comprehensive strengthening of the H13 steel was discussed in detail.The results show that the activation energy of the transformed fraction of carbides is higher than that of the diffusion process for common alloying elements(Cr,V,Mo,and Ni)found in the austenite.This suggests that it would be difficult for precipitates to dissolve into the matrix when H13 steel is austenitized at high temperatures.With the increasing austenitizing temperature,the precipitation fraction decreases,and the dislocation density increases.The dislocation strengthening is regarded as the dominant strengthening contributed to yield strength in as-quenched H13 steel.

关键词： H13 steel Austenitizing Mechanical property Precipitation behavior Comprehensive strengthening

Conventional and micro scale finite element modeling for metal cutting process:A review

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Chinese Journal of Aeronautics 2024年第2期37卷 199-232页

作者： Le WANG Caixu yue Xianli LIU ming LI Yongshi XU Steven Y.LIANG Key Laboratory of Advanced Manufacturing and Intelligent Technology Ministry of EducationHarbin University of Science and TechnologyHarbin 150080China George W.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlanta 30332USA

The metal cutting process is accompanied by complex stress field,strain field,temperature field.The comprehensive effects of process parameters on chip morphology,cutting force,tool wear and residual stress are complex and inter-connected.Finite element method(FEM)is considered as an effective method to predict process variables and reveal microscopic physical phenomena in the cutting process.Therefore,the finite element(FE)simulation is used to research the conventional and micro scale cutting process,and the differences in the establishment of process variable FE simulation models are distinguished,thereby improving the accuracy of FE simulation.The reliability and effectiveness of FE simulation model largely depend on the accuracy of the simulation method,constitutive model,friction model,damage model in describing mesh element,the dynamic mechanical behavior of materials,the tool-chip-workpiece contact process and the chip formation mechanism.In this paper,the FE models of conventional and micro process variables are comprehensively and up-to-date reviewed for different materials and machining methods.The purpose is to establish a FE model that is more in line with the real cutting conditions,and to provide the possibility for optimizing the cutting process variables.The development direction of FE simulation of metal cutting process is discussed,which provides guidance for future cutting process modeling.

关键词： Conventional and micro scale Finite element simulation Metal cutting process Micro cutting Modeling

Mutational landscape of TP53 and CDH1 in gastric cancer

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 276-283页

作者： Hong-Qiao Cai Li-yue Zhang Li-ming Fu Bin Xu Yan Jiao Department of Hepatobiliary and Pancreatic Surgery General Surgery CenterThe First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Critical Care Medicine The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Traditional Chinese Medicine The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

In this editorial we comment on an article published in a recent issue of the World J Gastrointest Surg.A common gene mutation in gastric cancer(GC)is the TP53 mutation.As a tumor suppressor gene,TP53 is implicated in more than half of all tumor occurrences.TP53 gene mutations in GC tissue may be related with clinical pathological aspects.The TP53 mutation arose late in the progression of GC and aided in the final switch to malignancy.CDH1 encodes E-cadherin,which is involved in cell-to-cell adhesion,epithelial structure maintenance,cell polarity,differentiation,and intracellular signaling pathway modulation.CDH1 mutations and functional loss can result in diffuse GC,and CDH1 mutations can serve as independent prognostic indicators for poor prognosis.GC patients can benefit from genetic counseling and testing for CDH1 mutations.Demethylation therapy may assist to postpone the onset and progression of GC.The investigation of TP53 and CDH1 gene mutations in GC allows for the investigation of the relationship between these two gene mutations,as well as providing some basis for evaluating the prognosis of GC patients.

关键词： TP53 CDH1 Gastric cancer Gene mutation Methylation

The Role of Renewable Protocatechol Acid in Epoxy Coating Modification: Significantly Improved Antibacterial and Adhesive Properties

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Chinese Journal of Polymer Science 2024年第1期42卷 63-72,I0008页

作者： ming-Xuan Chen Jin-yue Dai Li-yue Zhang Shuai-Peng Wang Jing-Kai Liu Yong-Gang Wu Xin-Wu Ba Xiao-Qing Liu School of Chemistry and Materials Science Hebei UniversityBaoding 071000China Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China Key Laboratory of Marine Materials and Related Technologies Chinese Academy of SciencesNingbo 315201China

It is of great significance to design epoxy coatings with superior antibacterial properties and high adhesive properties, as well as excellent processing, superior durability, and high transparency. However, it is still a challenge because of the common complex design and synthesis. Herein, the bio-based monomer protocatechuic acid(PCA) was used as raw material, the catechol structure with high bonding and antibacterial properties was introduced into the flexible alkane segment of ethylene glycol diglycidyl ether(EGDE) through an efficient, and green method, and it was cured with isophorone diamine(IPDA) to prepare corresponding thermosets. The cured resins exhibited excellent allaround qualities, particularly in bonding and antibacterial. When 30% PCA was added to pure epoxy resin, the adhesion between substrate and coating increased from 4.40 MPa to 13.60 MPa and the antibacterial rate of coating against E. coli and S. aureus could approach 100%. All of this is due to the fact that the catechol structure present in PCA has the ability to interact with various substrates and alter the permeability of bacterial cell membranes. The architecture of this method offers a fresh approach to dealing with the issues of challenging raw material selection and complex synthesis techniques.

关键词： Epoxy coatings Thermosets Catechol structure Antibacterial High adhesion