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Apoptosis-enhanced ferroptosis therapy of pancreatic carcinoma through PAmaM dendrimer-iron(Ⅲ)complex-based plasmid delivery

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Science China Chemistry 2022年第4期65卷 778-788页

作者： Wenjing ma yue gao Zhijun Ouyang Yu Fan Hongwei Yu Mengsi Zhan Han Wang Xiangyang Shi Mingwu Shen State Key Laboratory for Modification of Chemical Fibers and Polymer materials Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative MedicineCollege of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai 201620China Department of Radiology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China

The development of promising strategies to improve the treatment efficacy of pancreatic carcinoma still remains to be a challenging *** report here the development of a new dendrimer-based nanomedicine formulation to tackle pancreatic carcinoma through apoptosis-enhanced ferroptosis *** this article,G5 dendrimers were partially modified with a Fe(Ⅲ)chelator hydroxyquinoline-2-carboxylic acid(8-HQC)on their periphery,entrapped with gold nanoparticles(Au NPs)within their internal cavities,and chelated with Fe(Ⅲ).The thus created dendrimer-entrapped Au NPs(Fe-Au DENP-HQC)with an Au core size of 1.9 nm and 20.0 Fe(Ⅲ)ions complexed per dendrimer are stable,have a pH-dependent Fe(Ⅲ)release profile,and can generate reactive oxygen species under the tumor microenvironment(TME)and effectively compact plasmid DNA encoding p53 protein to form polyplexes with a hydrodynamic size of 143.9 nm and a surface potential of 33.6 *** show that cancer cells treated with the created Fe-Au DENP-HQC/p53 polyplexes can be more significantly inhibited through vector-mediated chemodynamic therapy(CDT)effect via Fe(Ⅲ)-induced Fenton reaction and the p53 gene delivery-boosted cell apoptosis and oxidative stress in the TME than single-mode CDT and gene *** investigations using a xenografted tumor model validated the effectiveness of apoptosis-enhanced ferropotosis therapy through the downregulation of GPX-4 and SLC7A11proteins,upregulation of p53 and PTEN proteins,as well as histological ***,the dendrimer nanoplatform enabled tumor fluorescence imaging through gene delivery-mediated enhanced green fluorescent protein *** Fe(Ⅲ)-complexed dendrimer vector system may be developed as a promising theranostic nanoplatform for ferroptosis or ferroptosis-based combination therapy of other cancer types.

关键词： dendrimers ferroptosis gene delivery pancreatic carcinoma fluorescence imaging

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Syntheses and Structural Characterizations of η~5-2,4-Cyclopentadien-1-yl Di-carbonyliron Heteronuclear Bi-Metallic Complexes

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Chemical Research in Chinese Universities 2001年第1期17卷 63-68页

作者： gao Jin sheng ma Zhong guo YE Ling BU Wei ming ma Dong sheng YU Chang hua GE yue FAN Yu guo Department of Chemistry Heilongjiang UniversityHarbin 150080P.R.China Key Laboratory of Supramolecular Structure and Spectroscopy Jilin UniversityChangchun 130023P.R.China

The novel complexes, Cp(CO) 2FeTiCp 2Cl(1) and Cp(CO) 2FeSn(CH 2CMe 2Ph) 3(2), were synthesized and characterized by means of elemental analyses and IR spectra, Cp(CO) 2FeSn· (CH 2CMe 2Ph) 3 was additionally characterized by X ray crystal structure analysis. The results of the elemental analyses are in good agreement with the theoretical values. The IR spectra show the existence of η 5 2,4 cyclopentadien 1 yl, carbonyl and methyl groups in the title complexes. The above experimental results show that the M-M bond exists in Cp(CO) 2FeSn· (CH 2Me 2Ph) 3, while the existence of the M-M bond in Cp(CO) 2FeTiCp 2Cl is highly possible, too. Both the two complexes are rather stable towards air and moisture, easily soluble in tetrahydrofuran and toluene, while their solubilities are greatly different in n hexane.

关键词： Metal metal bond Heteronuclear bimetallic complex Synthesis Characterization Crystal structure

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Molecular epigenetic mechanisms for the memory of temperature stresses in plants

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Journal of Genetics and Genomics 2022年第11期49卷 991-1001页

作者： Zhaoxu gao yue Zhou yuehui He State Key Laboratory of Protein and Plant Gene Research School of Advanced Agricultural SciencesPeking-Tsinghua Center for Life SciencesPeking UniversityBeijing 100871China Peking University Institute of Advanced Agricultural Sciences WeifangShandong 261325China

The sessile plants encounter various stresses;some are prolonged,whereas some others are *** is crucial for plant growth and development,and plants often encounter adverse high temperature fluctuations(heat stresses)as well as prolonged cold exposure such as seasonal temperature drops in winter when grown in temperate *** plants can remember past temperature stresses to get adapted to adverse local temperature changes to ensure survival and/or reproductive ***,we summarize chromatin-based mechanisms underlying acquired thermotolerance or thermomemory in plants and review recent progresses on molecular epigenetic understanding of‘remembering of prolonged cold in winter’or vernalization,a process critical for various over-wintering plants to acquire competence to flower in the coming *** addition,perspectives on future study in temperature stress memories of economically-important crops are discussed.

关键词： Heat stress Thermomemory Cold memory Vernalization Chromatin modification Epigenetics

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Stepwise Crystalline Structural Transformation in 0D Hybrid Antimony Halides with Triplet Turn-on and Color-Adjustable Luminescence Switching

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Research 2023年第4期2023卷 485-497页

作者： Jian-Qiang Zhao yue-Yu ma Xue-Jie Zhao Yu-Jia gao Zi-Yan Xu Pan-Chao Xiao Cheng-Yang yue Xiao-Wu Lei School of Chemistry Chemical Engineer and MaterialsJining UniversityQufuShandong 273155P.R.China

Intelligent stimuli-responsive fluorescence materials are extremely pivotal for fabricating luminescent turn-on switching in solid-state photonic integration technology,but it remains a challenging objective for typical 3-dimensional(3D)perovskite ***,by fine-tuning the accumulation modes of metal halide components to dynamically control the carrier characteristics,a novel triple-mode photoluminescence(PL)switching was realized in 0D metal halide through stepwise single-crystal to single-crystal(SC-SC)***,a family of 0D hybrid antimony halides was designed to exhibit three distinct types of PL performance including nonluminescent[Ph_(3)EtP]_(2)Sb_(2)Cl_(8)(1),yellowemissive[Ph3EtP]2SbCl5·EtOH(2),and red-emissive[Ph_(3)EtP]_(2)SbCl_(5)(3).Upon stimulus of ethanol,1 was successfully converted to 2 through SC-SC transformation with enhanced PL quantum yield from~0%to 91.50%acting as“turn-on”luminescent ***,reversible SC-SC and luminescence transformation between 2 and 3 can be also achieved in the ethanol impregnation-heating process as luminescence vapochromism *** a consequence,a new triple-model turn-on and coloradjustable luminescent switching of off-onI-onII was realized in 0D hybrid ***,wide advanced applications were also achieved in anti-counterfeiting,information security,and optical logic *** novel photon engineering strategy is expected to deepen the understanding of dynamic PL switching mechanism and guide development of new smart luminescence materials in cutting-edge optical switchable device.

关键词： luminescence halide Transformation

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Preparation and utilization of wheat straw anionic sorbent for the removal of nitrate from aqueous solution

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Journal of Environmental Sciences 2007年第11期19卷 1305-1310页

作者： WANG Yu gao Bao-yu yue Wen-wen yue Qin-yan School of Environmental Science and Engineering Shandong University Jinan 250100 China Environmental Monitoring Center of Shandong Province Jinan 250013 China

In order to reduce the impact of eutrophication caused by agricultural residues （i.e., excess nitrate） in aqueous solution, economic and effective anionic sorbents are required. In this article, we prepared anionic sorbent using wheat straw. Its structural characteristics and adsorption properties for nitrate removal from aqueous solution were investigated. The results indicate that the yield of the prepared anionic sorbent, the total exchange capacity, and the maximum adsorption capacity were 350%, 2.57 mEq/g, and 2.08 mmol/g, respectively. The Freundlich isotherm mode is more suitable than the Langmuir mode and the adsorption process accords with the first order reaction kinetic rate equation. When multiple anions （SO4^2-, H2PO4^-, NO3^-, and NO2^-） were present, the isotherm mode of prepared anionic sorbent for nitrate was consistent with Freundlich mode; however, the capacity of nitrate adsorption was reduced by 50%. In alkaline solutions, about 90% of adsorbed nitrate ions could be desorbed from prepared anionic sorbent. The results of this study confirmed that the wheat straw anionic sorbent can be used as an excellent nitrate sorbent that removes nitrate from aqueous solutions.

关键词： adsorption anionic sorbent nitrate thermodynamic wheat straw (MWS) adsorption adsorption kinetics raw wheat straw (RWS) modified

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Hypergraph Computation

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Engineering 2024年第9期40卷 188-201页

作者： yue gao Shuyi Ji Xiangmin Han Qionghai Dai School of Software Tsinghua UniversityBeijing 100084China

Practical real-world scenarios such as the Internet,social networks,and biological networks present the challenges of data scarcity and complex correlations,which limit the applications of artificial *** graph structure is a typical tool used to formulate such correlations,it is incapable of modeling highorder correlations among different objects in systems;thus,the graph structure cannot fully convey the intricate correlations among *** with the aforementioned two challenges,hypergraph computation models high-order correlations among data,knowledge,and rules through hyperedges and leverages these high-order correlations to enhance the ***,hypergraph computation achieves collaborative computation using data and high-order correlations,thereby offering greater modeling *** particular,we introduce three types of hypergraph computation methods:①hypergraph structure modeling,②hypergraph semantic computing,and③efficient hypergraph *** then specify how to adopt hypergraph computation in practice by focusing on specific tasks such as three-dimensional(3D)object recognition,revealing that hypergraph computation can reduce the data requirement by 80%while achieving comparable performance or improve the performance by 52%given the same data,compared with a traditional data-based method.A comprehensive overview of the applications of hypergraph computation in diverse domains,such as intelligent medicine and computer vision,is also ***,we introduce an open-source deep learning library,DeepHypergraph(DHG),which can serve as a tool for the practical usage of hypergraph computation.

关键词： High-order correlation Hypergraph structure modeling Hypergraph semantic computing Efficient hypergraph computing Hypergraph computation framework

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Synchronous removal of CuO nanoparticles and Cu2+ by polyaluminum chloride-Enteromorpha polysaccharides: Effect of Al species and pH

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Journal of Environmental Sciences 2020年第2期32卷 1-11页

作者： Yuanxia Luo Baoyu gao Jie Wang Qinyan yue Shandong Key Laboratory of Water Pollution Control and Resource Reuse School of Environmental Science and EngineeringShandong University266000 QingdaoChina

Copper oxide nanomaterials have been extensively applied and can have serious impacts when discharged into the aquatic environment, especially when complexed with humic acid(HA) to form composite *** an innovative recycled coagulant aid,Enteromorpha polysaccharides(Ep) were associated with polyaluminum chloride(PACl)(denoted as PACl-Ep) to simultaneously remove CuO nanoparticles, Cu2+and HA in this *** influence of different Al species coagulants(AlCl3, PAClb and PAClc) and water pH on coagulation performance, floc properties and reaction mechanisms was investigated in *** showed that in the three PACl-Ep systems, PAClb-Ep gave the highest removal efficiencies for turbidity and Cu2+, and the best UV254 removal effect was reached by using *** contents of Alb and Alc contributed to great coagulation performance because of their stronger bridging and sweeping *** all the Al species coagulants, alkalescent conditions were more conducive to removing Cu and HA compared to acidic ***, smaller and more agminated flocs with great recovery ability were formed by PAClb-Ep and PAClc-Ep systems(bridging and enmeshment effects cooperated with the chelated reticular structure formed by the Ep and Al species).Similarly,due to the increased hydrolysis and hydroxide precipitates, flocs formed under the condition of alkalescence were smaller, denser and stronger compared with weakly acidic conditions.

关键词： Al species Enteromorpha polysaccharides Polyaluminum chloride 27Al nuclear magnetic resonance Simultaneous removal

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Visual information quantification for object recognition and retrieval

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Science China(Technological Sciences) 2021年第12期64卷 2618-2626页

作者： CHENG JiaLiang BIE Lin ZHAO XiBin gao yue School of Software Tsinghua UniversityBeijing 100084China

The rapid development of computer vision has led to an increasing amount of 3 D data,such as multiple views and point clouds,which are widely used in 3 D object recognition and ***,the quality of 3 D data is the most crucial factor that directly affects the performance of 3 D ***,how to evaluate the 3 D data quality,especially the multi-view data quality,is still an open *** tackle this issue,we propose an entropy-based multi-view information quantification model(MV-Info model)to quantitatively evaluate the multi-view data *** proposed MV-Info model consists of hierarchical data module,feature generation module,and quantitative calculation ***,it considers the information entropy theory for more reasonable quantification *** our method,how much information we can observe from a group of views can be quantified,which can be used to support 3 D recognition and *** also designed a series of experiments to evaluate the effectiveness of the proposed *** experimental results demonstrate the rationality and validity of the proposed model.

关键词： information quantification multi-view data 3D object computer vision

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Novel method of gait switching in six-legged robot walking on continuous-nondifferentiable terrain by utilizing stability and interference criteria

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Science China(Technological Sciences) 2020年第12期63卷 2527-2540页

作者： maO LiHeng TIAN Yuan gao Feng ZHAO yue State Key Laboratory of Mechanical System and Vibration Department of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

Continuous-nondifferentiable terrains are extremely challenging for the environment adaption of six-legged robots. Previous researches have focused on gait planning methods to improve inherent ability of legged robots to walk over moderate ***,most six-legged robots utilize relatively monotonic gait so that they still cannot well adapt tough terrains. As a result,the current legged robots easily get stuck and fall when encountering continuous-nondifferentiable terrains,such as ***,a method of gait switching is proposed so that six-legged robots can flexibly generate multiple gaits to adapt complex terrains. This study investigated the relationship between six-legged robot gait topologies and physical constraints,such as robot stability and robot-terrain interference. The proposed gait switcher can generate 0-6,1-5,2-4 and 3-3 gaits,which is instructed by the stability and interference criteria. Simulations and experiments were performed on a novel six-legged robot Hexa-XIII that succeeded climbing stairs over 45°. The effectiveness of the gait switching method is validated by the experiment results.

关键词： six-legged robot continuous-nondifferentiable terrain gait switching method stability criteria interference criteria

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Human exploitation of carnivores in Pleistocene China: A case study of the faunal remains from Shuidonggou Locality 7

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Science China Earth Sciences 2020年第1期63卷 132-144页

作者： Shuangquan ZHANG yue ZHANG Shuwen PEI Xing gao Key Laboratory for Vertebrate Evolution and Human Origins Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijing 100044China CAS Center for Excellence in Life and Paleoenvironment Beijing 100044China University of Chinese Academy of Sciences Beijing 100049China

Hominin-animal interactions at Pleistocene archaeological sites have been the main subject of research during human evolution. However, in contrast to that of ungulates, little is known about the evidence of human processing of carnivore species in this time interval of China. In this paper, we present the first case report of an interactive relationship between carnivore species and hunter-gathers in Pleistocene China, based mainly on a detailed taphonomic study of the faunal remains from Shuidonggou Locality 7. It seems highly probable that hominins butchered some individuals of carnivores and roasted bone elements with adhering meat at the site;whereas it’s equally feasible that these animals were exploited by hominins mainly for their pelt or fur. In either way, evidence from the site indicates novel strategies in adaptive behaviors adopted by Late Pleistocene foragers in harsh environments of Northwest China.

关键词： Shuidonggou locality 7(SDG7) Upper Palaeolithic Cut marks Burned bones Taphonomy Northwest China

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