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Targeting capabilities of engineered extracellular vesicles for the treatment of neurological diseases

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Neural Regeneration Research 2025年第11期20卷 3076-3094页

作者： Xinyu Yang Xiangyu gao Xiaofan Jiang Kangyi yue Peng Luo Department of Neurosurgery Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina

Recent advances in research on extracellular vesicles have significantly enhanced their potential as therapeutic agents for neurological *** to their therapeutic properties and ability to cross the blood–brain barrier,extracellular vesicles are recognized as promising drug delivery vehicles for various neurological conditions,including ischemic stroke,traumatic brain injury,neurodegenerative diseases,glioma,and ***,the clinical application of natural extracellular vesicles is hindered by their limited targeting ability and short clearance from the *** address these limitations,multiple engineering strategies have been developed to enhance the targeting capabilities of extracellular vesicles,thereby enabling the delivery of therapeutic contents to specific tissues or ***,this review aims to highlight the latest advancements in natural and targeting-engineered extracellular vesicles,exploring their applications in treating traumatic brain injury,ischemic stroke,Parkinson's disease,Alzheimer's disease,amyotrophic lateral sclerosis,glioma,and ***,we summarized recent clinical trials involving extracellular vesicles and discussed the challenges and future prospects of using targeting-engineered extracellular vesicles for drug delivery in treating neurological *** review offers new insights for developing highly targeted therapies in this field.

关键词： Alzheimer's disease amyotrophic lateral sclerosis engineered extracellular vesicles glioma ischemic stroke neurological diseases Parkinson's disease psychosis targeted drug delivery traumatic brain injury

Upcycling of polyethylene terephthalate to1,4-cyclohexanedimethanol in water

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Science China Chemistry 2025年

作者： Shuhui Fang Zhiwen gao Xinrui Shi Min Zhang Wei Zhang yue Liu State Key Laboratory of Petroleum Molecular & Process Engineering Shanghai Key Laboratory of Green Chemistry and Chemical ProcessesSchool of Chemistry and Molecular Engineering East China Normal University Engineering Center for Sustainable Carbon Science and Technology East China Normal University Institute of Eco-Chongming

The recycling of waste polyethylene terephthalate（PET）, an extensively used polymer as plastic and fiber materials, has become an urgent topic due to the rapid generation and accumulation of plastic waste into the environment. Current chemical recycling approaches to depolymerize and convert PET into 1,4-cyclohexanedimethanol（CHDM）, an important chemical in the production of advanced polyesters, predominantly use organic solvents, such as alcohols or dioxane. Herein, we developed an environmentally friendly and economically viable pathway for converting PET to CHDM using water as the solvent. In this process, PET is sequentially hydrolyzed in water, hydrogenated to 1,4-cyclohexane dicarboxylic acid（CHDA）, and then reduced to CHDM. The PET conversion rate is self-enhanced in aqueous medium via acid-catalyzed hydrolysis by the generated CHDA intermediate. A Pd-based catalyst（e.g., Pd/C） selectively hydrogenates the arene ring of the PET monomer, terephthalic acid intermediate, and a Ru-Sn/C bimetallic catalyst reduces its COOH to CH2OH group. At optimized reaction conditions, a complete conversion of PET and 80.1% yield of CHDM are obtained. Alternatively, this approach can also efficiently produce CHDA from PET, with a yield up to 86.4%.

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Unlocking the stable interface in aqueous zinc-ion battery with multifunctional xylose-based electrolyte additives

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Journal of Energy Chemistry 2025年第1期100卷 770-778页

作者： Xiaoqin Li Jian Xiang Lu Qiu Xiaohan Chen Yinkun Zhao Yujue Wang Qu yue Taotao gao Wenlong Liu Dan Xiao Zhaoyu Jin Panpan Li Institute for Advanced Study Chengdu University School of Mechanical Engineering Chengdu University College of Food and Biological Engineering Chengdu University Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China College of materials Science and Engineering Sichuan University

The growth of dendrites and the side reactions occurring at the Zn anode pose significant challenges to the commercialization of aqueous Zn-ion batteries（AZIBs）. These challenges arise from the inherent conflict between mass transfer and electrochemical kinetics. In this study, we propose the use of a multifunctional electrolyte additive based on the xylose（Xylo） molecule to address these issues by modulating the solvation structure and electrode/electrolyte interface, thereby stabilizing the Zn anode. The introduction of the additive alters the solvation structure, creating steric hindrance that impedes charge transfer and then reduces electrochemical kinetics. Furthermore, in-situ analyses demonstrate that the reconstructed electrode/electrolyte interface facilitates stable and rapid Zn2+ion migration and suppresses corrosion and hydrogen evolution reactions. As a result, symmetric cells incorporating the Xylo additive exhibit significantly enhanced reversibility during the Zn plating/stripping process, with an impressively long lifespan of up to 1986 h, compared to cells using pure ZnSO4electrolyte. When combined with a polyaniline cathode, the full cells demonstrate improved capacity and long-term cyclic stability. This work offers an effective direction for improving the stability of Zn anode via electrolyte design, as well as highperformance AZIBs.

关键词： Solvation

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骨科学领域组织透明化技术的应用与展望

中国组织工程研究 2025年第15期29卷 3227-3234页

作者：高阳高原马炳江岳辉石永新牡丹江医学院黑龙江省牡丹江市157011 深圳大学附属华南医院广东省深圳市518111 深圳市光明区人民医院广东省深圳市518106

背景:骨组织作为高度矿化且结构复杂的结缔组织,在维持生物体形态和功能中扮演关键角色,传统的成像技术难以满足对其深入观察的需求。组织透明化技术的出现使得研究者能够更加清晰地观察到骨内的细微结构,如骨小梁、骨髓腔以及与骨组织... 详细信息

背景:骨组织作为高度矿化且结构复杂的结缔组织,在维持生物体形态和功能中扮演关键角色,传统的成像技术难以满足对其深入观察的需求。组织透明化技术的出现使得研究者能够更加清晰地观察到骨内的细微结构,如骨小梁、骨髓腔以及与骨组织相互作用的神经和血管网络,为骨科学的研究和临床应用开辟了新的视角。目的:旨在全面梳理组织透明化技术在骨科学领域的应用,并探讨其在骨组织结构与功能研究、疾病机制解析以及治疗策略创新中的潜力,同时对其创新点进行展望。方法:检索覆盖中国知网和PubMed数据库,英文检索词为“tissue clearing,tissue optical,bone”等,中文检索词为“组织透明化、骨、骨缺损”等,结合布尔逻辑以优化检索策略。纳入与组织透明化技术和骨科学研究直接相关的期刊论文和学位论文,排除关联性不强、重复或数据不完整的文献。最终纳入82篇文献进行分析,关注点包括透明化技术的效能、应用范围及对骨科学研究的贡献。结果与结论:①组织透明化技术在骨结构分析、骨代谢研究、骨肿瘤的病理学特征、骨折愈合过程、骨感染的机制研究以及骨移植和植入物材料的生物相容性评价等多个领域均展现出其独特的应用优势;②该技术的应用不仅加速了骨科学领域的基础研究进展,也为临床治疗提供了新的策略和方法,其在骨科学研究领域具有广阔的应用前景。

关键词：组织透明化技术骨科学三维成像骨组织生物医学成像

Future vehicles: learnable wheeled robots

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Science China(Information Sciences) 2020年第9期63卷 255-262页

作者： Deyi LI Nan ma yue gao Academy of Military Science Beijing Key Laboratory of Information Service Engineering Beijing Union University College of Robotics Beijing Union University School of Software Tsinghua University

As one of the important signs of the third wave of artificial intelligence, wheeled robots not only inherit knowledge but also learn independently, which brings about to learnable wheeled robots that use a driving brain to achieve data-driven control and learning. Presently, most existing technologies for selfdriving vehicles can learn positively from the benchmark drivers to guarantee safe driving. However, in many unpredicted situations, such as rollover, human drivers often cause the behavior of irrational subconscious on account of human emotions like panic. In this paper, we propose a learnable wheeled robot using the driving brain by taking the rollover as an example, which is the most serious and dangerous situation in dynamic vehicle operations. Then, based on the analysis of rollover accidents, we utilize the driving brain reversely and conduct negative learning, materializing, and condensing the group intelligence of accident experts, to solve the problem of the lack of individual intelligence in emergencies and further promote real-time response to other dangerous conditions, such as puncture for self-driving vehicles.

关键词： wheeled robots driving brain swarm intelligence negative learning data-driven self-learning

Potential role of hippocampal neurogenesis in spinal cord injury induced post-trauma depression

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Neural Regeneration Research 2024年第10期19卷 2144-2156页

作者： Ying ma yue Qiao Xiang gao Spinal Cord and Brain Injury Research Group Stark Neuroscience Research InstituteIndianapolisINUSA Department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA Department of Neurology Shengjing Hospital of China Medical UniversityShenyangLiaoning ProvinceChina

It has been reported both in clinic and rodent models that beyond spinal cord injury directly induced symptoms, such as paralysis, neuropathic pain, bladder/bowel dysfunction, and loss of sexual function, there are a variety of secondary complications, including memory loss, cognitive decline, depression, and Alzheimer's disease. The largescale longitudinal population-based studies indicate that post-trauma depression is highly prevalent in spinal cord injury patients. Yet, few basic studies have been conducted to address the potential molecular mechanisms. One of possible factors underlying the depression is the reduction of adult hippocampal neurogenesis which may come from less physical activity, social isolation, chronic pain, and elevated neuroinflammation after spinal cord injury. However, there is no clear consensus yet. In this review, we will first summarize the alteration of hippocampal neurogenesis post-spinal cord injury. Then, we will discuss possible mechanisms underlie this important spinal cord injury consequence. Finally, we will outline the potential therapeutic options aimed at enhancing hippocampal neurogenesis to ameliorate depression.

关键词： antidepressants chronic pain depression exercise hippocampal neurogenesis inflammation inhibition neuroinflammation physical activity deficits social isolation spinal cord injury

Comprehensive tensile properties improved by deep cryogenic treatment prior to aging in friction-stir-welded 2198 Al-Li alloy

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Rare Metals 2024年第10期43卷 5403-5409页

作者： Jian-Qiu Sun yue ma Chong gao Hong-Yun Luo School of materials Science and Engineering Beihang UniversityBeijing 100191China Chinalco Research Institute of Science and Technology Beijing 100082China

In order to improve the comprehensive mechanical properties,deep cryogenic treatment(DCT)prior to aging was carried out on friction-stir-welded(FSW)2198 Al-Li alloy;afterward,the microstructure and tensile properties were characterized by means of optical microscopy(OM),transmission electron microscopy(TEM)and tensile *** results show that FSW 2198 alloy through DCT prior to aging(DAT)possesses superior tensile properties than conventional aging treatment(AT)The microstructural analysis reveals that DAT alloy exhibits a finer grain structure,since DCT might effectively alleviate the residual stress in FSW 2198 alloy and thus decrease the driving force for grain coarsening in subsequent aging ***,DCT generates dislocation multiplication,which provides more preferential nucleation sites for T1(Al_(2)CuLi)phase during subsequent aging treatment,resulting in high-density fine T1 phases and thin precipitate-free zone within DAT *** reasonable microstructure leads to DAT alloy possessing better strength-ductility combination compared to AT alloy.

关键词： Al-Li alloy Friction stir welding Deep cryogenic treatment Tensile properties

Deep Learning-Based Spectrum Sensing in Space-Air-Ground Integrated Networks

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Journal of Communications and Information Networks 2021年第1期6卷 82-90页

作者： Ruifan Liu Yuan ma Xingjian Zhang yue gao College of Electronic and Information Engineering Shenzhen UniversityShenzhen 518060China Peng Cheng Laboratory Shenzhen 518052China Institute for Communication Systems University of SurreySurrey GU27XHU.K.

To complement terrestrial connections,the space-air-ground integrated network(SAGIN)has been proposed to provide wide-area connections with improved quality of experience(QoE).Spectrum management is an important issue in SAGIN due to the explosive proliferation of wireless devices and *** the progress on enabling dynamic spectrum access shows promise in advancing increased spectrum sharing,the issue of reliable spectrum sensing under low signal-to-noise ratio(SNR)remains one of the key challenges faced by the spectrum *** artificial intelligence can provide wireless networks intelligence through learning and data mining,deep learning-based spectrum sensing is proposed in order to improve the spectrum sensing performance,where a deep neural network-based detection framework is built to extract features in a data-driven way based on the covariance matrix of the received *** eliminate the impact of noise uncertainty,a blind threshold setting scheme is proposed without using the system prior *** analyses on simulated and real-world signals show that the detection performance of the proposed scheme is improved under a low SNR regime.

关键词： space-air-ground integrated network spectrum sensing deep learning convolutional neural network

Texture evolution behavior and anisotropy of 2A97 Al-Li alloy during recrystallization at elevated temperature

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Rare Metals 2023年第9期42卷 3139-3149页

作者： Dong Wang Chong gao Hong-Yun Luo Yong-Hong Yang yue ma School of materials Science and Engineering Beihang UniversityBeijing100191China China Alco Research Institute of Science and Technology Beijing100082China Xi’an Aerospace Propulsion Institute Xi’an National Civil Aerospace Industrial BaseXi’an710100China

2A97 Al-Li alloy was cold-rolled to 2 mm and then thermally exposed at different temperatures for 1 h and at 723 K for different time,*** texture evolution behavior and the anisotropy of 2A97 Al-Li alloy were *** result shows that the{001}and{011}textures are the dominant recrystallization ***{124}texture is the final recrystallization *** case of low-temperature thermal exposure(473,573 K),the{011}texture is aggregated to the{112}and{123}*** the recrystallization at 723 K,the{001},{111}and{011}textures are the intermediate transition grain *** concurrent precipitation of Al_(20)Cu_(2)Mn_(3)and Al_(3)Zr results in the occurrence of unusually sharp{011}and{001}texture components during *** alloy with both recrystallization and deformation texture possesses the smallest anisotropic,and the texture is the direct reason that results in the anisotropy.

关键词： Al-Li alloy 2A97 Crystallographic texture Texture evolution Anisotropy