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Association of tumor budding with clinicopathological features and prognostic value in stage iii-iV colorectal cancer

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World Journal of Gastroenterology 2024年第2期30卷 158-169页

作者： yue-Hao Luo Zhe-cheng Yan Jia-Ying Liu Xin-Yi Li Ming Yang Jun Fan Bo Huang cheng-Gong Ma Xiao-Na Chang Xiu Nie Department of Pathology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina

BACKGROUND Tumor budding(TB)has emerged as a promising independent prognostic biomarker in colorectal cancer(CRC).The prognostic role of TB has been extensively studied and currently affects clinical decision making in patients with stage i and ii ***,existing prognostic studies on TB in stage iii CRC have been confined to small retrospective cohort ***,this study investigated the correlation among TB categories,clinicopathological features,and prognosis in stage iii-iV CRC to further enhance the precision and individualization of treatment through refined prognostic risk *** To analyze the relationship between TB categories and clinicopathological characteristics and assess their prognostic value in stage iii-iV CRC to further refine the prognostic risk stratification of stage iii-iV *** The clinical data of 547 CRC patients were collected for this retrospective *** at the front edge of the tumor buds was counted according to the 2016 international Tumor Budding Consensus Conference *** Multivariate Cox proportional hazards regression analysis demonstrated that chemotherapy(P=0.004),clinical stage iV(Pional lymph node metastases(P=0.004),left-sided colonic cancer(P=0.040),and Bd 2-3(P=0.002)were independent prognostic factors in patients with stage iii-iV ***,the density of tumor infiltrating lymphocytes was higher in Bd 1 than in Bd 2-3,both in the tumor stroma and its invasive *** TB has an independent predictive prognostic value in patients with stage iii-iV *** is recommended to complete the TB report of stage iii-iV CRC cases in the standardized pathological report to further refine risk stratification.

关键词： Tumor budding Tumor infiltrating lymphocytes Colorectal cancer Survival analysis Prognosis

Effects of plants-associated microbiota on cultivation and quality of Chinese herbal medicines

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Chinese Herbal Medicines 2024年第2期16卷 190-203页

作者： yue Ouyang Qiqing cheng Chunsong cheng Ziyu Tang Yufeng Huang Eyu Tan Shaofeng Ma Xinheng Lin Ying Xie Hua Zhou Guangdong Provincial Hospital of Chinese Medicine Guangdong Provincial Academy of Chinese Medical SciencesState Key Laboratory of Dampness Syndrome of Chinese MedicineSecond Affiliated Hospital of Guangzhou University of Chinese MedicineGuangdong-Hong Kong-Macao Joint Lab on Chinese Medicine and Immune Disease ResearchGuangzhou 510006China Faculty of Chinese Medicine Macao University of Science and TechnologyMacao 999078China School of Pharmacy Hubei University of Science and TechnologyXianning 437100China Key Laboratory of Plant Ex-situ Conservation and Research Center of Resource Plant Lushan Botanical GardenChinese Academy of SciencesJiujiang 332900China Jiangmen Wuyi Hospital of Traditional Chinese Medicine Jiangmen 529020China Joint Laboratory for Translational Cancer Research of Chinese Medicine Ministry of EducationGuangzhou University of Chinese MedicineGuangzhou 510006China

Microbial resource influences the life activities of medicinal plants from several ***,rhizosphere microorganisms,and other environmental microorganisms play essential roles in medicinal plant growth and development,plant yield,and clinical *** microbiota can influence the biosynthesis of active compounds in medicinal plants by stimulating specific metabolic *** induce host plants to improve their resistance to environmental stresses by accumulating secondary *** can interact with their host plants to produce long-term,targeted selection results and improve their ability to adapt to the *** to the interdependence and interaction between microorganisms and medicinal plants,Chinese herbal medicines(CHMs)quality is closely related to the associated *** review summarizes the relationship between medicinal plants and their associated microorganisms,including their species,distribution,life activities,and *** can aid in quality control,improve the efficacy of medicinal plants,and provide markers for identifying the origin and storage time of ***,a comprehensive understanding of the relationship between microorganisms and medicinal plants will help to control the quality of CHMs from different perspectives.

关键词： Chinese herbal medicines endophytes environmental microorganisms microbiota rhizosphere microorganisms

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Lactobacillus plantarum and quercetin synergistically ameliorate hyperuricemia through targeting multiple pathways

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Food Science and Human Wellness 2024年

作者： Lin-Yan Zhu Meng-yue Zhang Juan-cheng Yi-Xuan Zhang School of Life Science and Biopharmaceutics， Shenyang Pharmaceutical University

Hyperuricemia is a prevalent metabolic disorder resulting from dysregulation of purine metabolism， often accompanied by inflammation. it is characterized by an abnormal elevation in uric acid levels. in our investigation， the combined treatment with Lactobacillus plantarum DY1 and quercetin suppressed the activity of xanthine oxidase and adenosine deaminase， decreased the levels of uric acid， TNF-α and iL-β， downregulated gene expression of URAT1 and GLUT9， and upregulated OAT1 and ABCG2. The combination increased the abundance of Lactobacillus and decreased the abundance of norank＿f＿norank＿o＿Clostridia＿UCG-014 and Roseburia. Metabolomics analysis revealed that the combination of probiotics and quercetin exhibited distinct metabolic pathways compared to their individual administrations. When compared to probiotics alone， the combination led to alterations in glutathione metabolism (oxidized glutathione and glutathione) as well as sphingolipid metabolism (sphingosine and sphinganine). When compared to quercetin alone， the combination resulted in variations in tryptophan metabolism (indole-3-acetamide， 5-hydroxy-L-tryptophan， indoleacetaldehyde， 3-(3-indolyl)-2-oxopropanoic acid， 3-indoleacetic acid and 3-methylindole) along with purine metabolism (UA， xanthosine， cAMP， ADP and adenosine monophosphate). The subsequent fecal microbiota transplantation proved that the effect of the combination on reducing uric acid levels was mediated by the gut microbiota. Therefore， this new combination can be considered a promising adjuvant therapy capable of synergistically alleviating hyperuricemia.

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基于YOLO v5+DeepSORT算法的羊群游走同步群体决策行为研究

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农业机械学报 2024年第6期55卷 229-236页

作者：刘成岳训山东农业大学信息科学与工程学院泰安271018

随着畜牧养殖智能化监控技术的产业化应用,进一步提升畜禽养殖的分类施策精细化管理,成为现代畜牧业精细高效养殖管理的新需求。采用固定机位、多角度视频采集技术,实时记录羊群牧食过程中的游走行为;针对羊群游走视频中易出现遮挡的复... 详细信息

随着畜牧养殖智能化监控技术的产业化应用,进一步提升畜禽养殖的分类施策精细化管理,成为现代畜牧业精细高效养殖管理的新需求。采用固定机位、多角度视频采集技术,实时记录羊群牧食过程中的游走行为;针对羊群游走视频中易出现遮挡的复杂情况,设计了基于YOLO v5模型的羊群多目标检测模型,羊群游走过程中的多目标实时跟踪识别率可达90.63%;采用羊群游走多目标轨迹跟踪DeepSORT算法,通过提取羊目标的深度表观特征,计算出羊群游走轨迹和变化节拍规律。结果表明,羊的游走过程通常为慢走、快走和疾走3种方式,单只羊的游走过程通常是不固定的随机组合。在中大规模羊群中,由于亲缘关系结构的复杂性,羊群往往分化为多个小群体,这使得从整体上观察和分析羊群行为变得异常困难。为此,聚焦于小规模羊群进行研究,通过羊群散列、聚集和同步3个游走过程分析,初步验证了羊群游走节拍周期上的同步现象。

关键词：羊群群体决策同步智慧畜牧目标跟踪 YOLO v5 DeepSORT

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Room-temperature ferromagnetism and piezoelectricity in metalfree 2D semiconductor crystalline carbon nitride

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Nano Research 2024年第6期17卷 5670-5679页

作者： Yong Wang Dingyi Yang Wei Xu Yongjie Xu Yu Zhang Zixuan cheng Yizhang Wu Xuetao Gan Wei Zhong Yan Liu Genquan Han yue Hao Wide Bandgap Semiconductor Technology Disciplines State Key Laboratory School of MicroelectronicsAcademy of Advanced Interdisciplinary ResearchXidian UniversityXi’an 710071China Emerging Device and Chip Laboratory Hangzhou Institute of TechnologyXidian UniversityHangzhou 311200China iNRS Centre for Energy Materials and Telecommunications1650 Boul.Lionel BouletVarennesQC J3X 1P7Canada National Laboratory of Solid State Microstructures Collaborative Innovation Center of Advanced Microstructures and Jiangsu Provincial Key Laboratory for NanotechnologyNanjing UniversityNanjing 210093China School of Education Jiangsu Open UniversityNanjing 210036China Department of Physics Shaanxi University of Science and TechnologyXi’an 710021China Department of Applied Physical Sciences The University of North Carolina at Chapel HillChapel HillNC 27514USA Key Laboratory of Light Field Manipulation and information Acquisition Ministry of Industry and Information Technologyand Shaanxi Key Laboratory of Optical Information TechnologySchool of Physical Science and TechnologyNorthwestern Polytechnical UniversityXi'an 710129 China

Two-dimensional(2D)materials that combine ferromagnetic,semiconductor,and piezoelectric properties hold significant potential for both fundamental research and spin electronic ***,the majority of reported 2D ferromagnetic-semiconductor-piezoelectric materials rely on d-electron systems,which limits their practical applications due to a Curie temperature lower than room temperature(RT).Here,we report a high-crystallinity carbon nitride(CCN)material based on sp-electrons using a chemical vapor deposition *** exhibits a band gap of 1.8 eV and has been confirmed to possess substantial in-plane and out-of-plane ***,we acquired clear evidences of ferromagnetic behavior at room *** structural characterizations combined with theoretical calculations reveal that incorporating structural oxygen into the highly ordered heptazine structure causes partial substitution of nitrogen sites,which is primarily responsible for generating room-temperature ferromagnetism and *** a result,the strain in wrinkles can effectively modulate the domain behavior and piezoelectric potential at room *** addition of RT ferromagnetic-semiconductor-piezoelectric material based on sp-electrons to the family of two-dimensional materials opens up numerous possibilities for novel applications in fundamental research and spin electronic devices.

关键词： crystallinity carbon nitride room-temperature ferromagnetism piezoelectricity magnetic force microscopy density functional theory(DFT)calculations

Application of wastewater-based epidemiological monitoring of COViD-19 for disease surveillance in the city

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Frontiers of Environmental Science & Engineering 2024年第8期18卷 81-87页

作者： Heng Chen Zhenhua Chen Liwen Hu Fengzhu Tang Dan Kuang Jiayi Han Yao Wang Xiao Zhang yue cheng Jiantong Meng Rong Lu Lan Zhang chengdu Workstation for Emerging infectious Disease Control and Prevention Chinese Academy of Medical SciencesChengdu 610047China chengdu Center for Disease Control and Prevention Chengdu 610047China National Key Laboratory of intelligent Tracking and Forecasting for infectious Diseases Beijing 100050China National institute of Environmental Health Chinese Center for Disease Control and PreventionBeijing 100050China

Wastewater-based surveillance serves as a supplementary approach to clinical surveillance of COViD-19 during the *** study aimed to track the prevalence of the disease and the viral genetic variability through wastewater-based surveillance in the post-epidemic *** January to December 2023,samples were collected from the influent lines of two wastewater treatment plants(WWTPs),concentrated using PEG8000,and subjected to detection of the target genes ORF 1ab and N of SARS-CoV-2 via reverse transcriptional quantitative PCR(RT-qPCR).For next-generation sequencing(NGS),high-quality samples from both wastewater and clinical patients were *** analysis were performed using R software to evaluate the correlation between the SARSCoV-2 RNA concentrations in wastewater and positive rate of reported cases,indicating a positive *** diversity patterns of SARS-CoV-2 in wastewater resembled those in the patient source based on Principal Coordinates Analysis(PCoA)with three clusters for different *** rise of RNA concentration in wastewater indicates the growth of cases and the emergence of new variants,serving as an early warning of potential viral mutations,disease outbreaks even possible ***,the genomic surveillance of wastewater could help identify new variants that may not be captured through population monitoring,especially when sample sizes are ***,surveillance of SARS-CoV-2 in municipal wastewater has emerged as a reliable,earlywarning monitoring system for COViD-19 in the post-epidemic era.

关键词： Wastewater-based epidemiology Monitoring COViD-19 Post-epidemic era

Bone morphogenetic protein-6 suppresses TGF-β_(2)-induced epithelial-mesenchymal transition in retinal pigment epithelium

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international Journal of Ophthalmology(English edition) 2024年第4期17卷 646-652页

作者： Xuan Liu Ming Liu Meng Ji Bo Ma Yu-Cen Hou Xin-yue Yao Qiao-Chu cheng Li Chen Department of Ophthalmology the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Ophthalmology Xi’an No.1 HospitalXi’an 710000Shaanxi ProvinceChina Shaanxi institute of Ophthalmology Xi’an 710000Shaanxi ProvinceChina Department of Ophthalmology Ankang Hospital of Traditional Chinese MedicineAnkang 725000Shaanxi ProvinceChina

AiM:To evaluate the effect of bone morphogenetic protein-6(BMP-6)on transforming growth factor(TGF)-β_(2)-induced epithelial-mesenchymal transition(EMT)in retinal pigment epithelium(RPE).METHODS:Adult retinal pigment epithelial cell line(ARPE-19)were randomly divided into control,TGF-β_(2)(5μg/L),and BMP-6 small interfering RNA(siRNA)*** cell morphology was observed by microscopy,and the cell migration ability were detected by Transwell *** EMT-related indexes and BMP-6 protein levels were detected by Western ***,a BMP-6 overexpression plasmid was constructed and RPE cells were divided into the control group,TGF-β_(2)+empty plasmid group,BMP-6 overexpression group,and TGF-β_(2)+BMP-6 overexpression *** EMT-related indexes and extracellular regulated protein kinases(ERK)protein levels were ***:Compared with the control group,the migration of RPE cells in the TGF-β_(2) group was significantly ***-β_(2) increased the protein expression levels ofα-smooth muscle actin(α-SMA),fibronectin and vimentin but significantly decreased the protein levels of E-cadherin and BMP-6(Pin ***,the migration of RPE cells in the BMP-6 siRNA group was also significantly ***-6 siRNA increased the protein expression levels ofα-SMA,fibronectin and vimentin but significantly decreased the protein expression levels of E-cadherin(Pion of BMP-6 inhibited the migration of RPE cells induced by TGF-β_(2) and prevented TGF-β_(2) from affecting EMT-related biomarkers(PiON:BMP-6 prevents the EMT in RPE cells induced by TGF-β_(2),which may provide a theoretical basis for the prevention and treatment of proliferative vitreoretinopathy.

关键词： bone morphogenetic protein-6 epithelialmesenchymal transition transforming growth factor-β_(2) retinal pigment epithelial cells cell migration

Effect of slow shot speed on externally solidified crystal,porosity and tensile property in a newly developed high-pressure die-cast Al-Si alloy

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China Foundry 2024年第1期21卷 11-19页

作者： Wen-ning Liu Wei Zhang Peng-yue Wang Yi-xian Liu Xiang-yi Jiao Ao-xiang Wan cheng-gang Wang Guo-dong Tong Shou-mei Xiong School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials Processing Technology Tsinghua UniversityBeijing 100084Beijing China FAW Group Co. Ltd.Changchun 130013China China FAW Foundry Co. Ltd.Changchun 130013China

The effect of slow shot speed on externally solidified crystal(ESC),porosity and tensile property in a newly developed high-pressure die-cast Al-Si alloy was investigated by optical microscopy(OM),scanning electron microscopy(SEM)and laboratory computed tomography(CT).Results showed that the newly developed AlSi9MnMoV alloy exhibited improved mechanical properties when compared to the AlSi10MnMg *** AlSi9MnMoV alloy,which was designed with trace multicomponent additions,displays a notable grain refining effect in comparison to the AlSi10MnMg *** elements Ti,Zr,V,Nb,B promote heterogeneous nucleation and reduce the grain size of primaryα-*** a lower slow shot speed,the large ESCs are easier to form and gather,developing into the dendrite net and *** an increase in slow shot speed,the size and number of ESCs and porosities significantly *** addition,the distribution of ESCs is more dispersed and the net-shrinkage *** tensile property is greatly improved by adopting a higher slow shot *** ultimate tensile strength is enhanced from 260.31 MPa to 290.31 MPa(increased by 11.52%),and the elongation is enhanced from 3.72%to 6.34%(increased by 70.52%).

关键词： hypoeutectic Al-Si alloy high pressure die casting porosity externally solidified crystal tensile property

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Energy band modulation of N-doped rutile/anatase TiO_(2) photoanode promoting charge separation toward prominent photoelectrochemical performance

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Rare Metals 2024年第8期43卷 3784-3797页

作者： Juan Gao Shi-Xuan Wang Jia-Le Deng Ping-Ping Wei Fu-Zhang Chen Ling-cheng Zheng yue-Qin Wang Yang Li Yin Liu Gang He School of Mechanics and Photoelectric Physics Anhui University of Science and TechnologyHuainan 232001China School of Materials Science and Engineering Anhui UniversityHefei230039China Tianneng Battery(Wuhu)Co. Ltd.Wuhu 241000China School of Materials Science and Engineering Anhui University of Science and TechnologyHuainan 232001China

To solve the problem of high photogenerated carrier recombination rate and low photoelectric conversion efficiency of TiO_(2)-based materials,a simple N-doped anatase/rutile TiO_(2) heterophase nanorod film was designed by a low-temperature hydrothermal method in this *** enhanced separation and transport of photogenerated charges were facilitated by the smaller contact barrier and appropriate band matching between anatase TiO_(2)nanoparticles and rutile TiO_(2) *** introduction of N doping in anatase TiO_(2) resulted in an upward shift of the valence band and a narrowing of the band gap,consequently enhancing the efficiency of visible light *** combination of the heterophase junction and N-doping exhibited a synergistic effect,effectively suppressing the recombination of photogenerated charges and enhancing the photoelectric conversion efficiency of the *** AM 1.5G irradiation,the photocurrent density(J)of the A-TO(N)@R-TONR photoanode reached2.19 mA·cm^(-2)(V_(RHE,1.23 eV)).Additionally,the incident photon-electron conversion efficiency(iPCE)and the charge injection efficiency(η)reached 81.4%and 51.6%at320 ***,the J,iPCE,andηvalues of the A-TO(N)@R-TONR photoanode were 2.96,2.1 and 3.2times those of pure R-TONR photoanode,*** work presents a rational strategy for designing efficient TiO_(2)-based photoanodes.

关键词： TiO_(2) Heterophase junction Photoanode

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