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implementation planning for lung cancer screening in China

Precision Clinical Medicine 2019年第1期2卷 13-44页

作者： yue i.cheng Michael P.A.Davies Dan Liu Weimin Li John K.Field Lung Cancer Research Group Department of Molecular and Clinical Cancer MedicineInstitute of Translational MedicineUniversity of LiverpoolWilliam Henry Duncan Building6 West Derby StreetLiverpool L78TXUnited Kingdom Department of Respiratory and Critical Care Medicine West China HospitalSichuan UniversityChengdu 610041China

Lung cancer is the leading cause of cancer-related deaths in China,with over 690000 lung cancer deaths estimated in *** mortality has increased about five-fold from the mid-1970s to the *** cancer lowdose computerized tomography(LDCT)screening in smokers was shown to improve survival in the US National Lung Screening Trial,and more recently in the European NELSON ***,although the predominant risk factor,smoking contributes to a lower fraction of lung cancers in China than in the UK and ***,it is necessary to establish Chinese-specific screening *** have been 23 associated programmes completed or still ongoing in China since the 1980s,mainly after 2000;and one has recently been ***,their entry criteria are not *** of the Chinese programmes have reported preliminary results only,which demonstrated a different high-risk subpopulation of lung cancer in *** concerning LDCT screening implementation is based on results of randomized controlled trials outside *** screening programmes combining tobacco control would produce more *** recruitment(***-based selection),screening protocol,nodule management and costeffectiveness are discussed in *** China,the high-risk subpopulation eligible for lung cancer screening has not as yet been confirmed,as all the risk parameters have not as yet been *** evidence on best practice for implementation of lung cancer screening has been accumulating in other countries,further research in China is urgently required,as China is now facing a lung cancer epidemic.

关键词： lung cancer China screening recommendation low-dose computerized tomography risk factor tobacco control pulmonary nodule management

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On the global smooth solutions of 3D incompressible Hall-MHD equations

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 319-327页

作者： yue Gao-cheng SUN Wen-da School of Mathematics Nanjing University of Aeronautics and AstronauticsNanjing 211106China

The present paper is devoted to the well-posedness issue for the 3D incompressible Hall-MHD system obtained from kinetic models. Our analysis strongly relies on the use of the Fourier analysis. We establish the global existence of smooth solutions for a class of large initial data, this result implies the initial velocity and magnetic field can be arbitrarily large.

关键词： 3D Hall-MHD well-posedness Fourier analysis

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Effects of surface energy and substrate on modulus determination of biological films by conical indentation

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Science China(Technological Sciences) 2024年第6期67卷 1757-1764页

作者： DiNG yue Li.cheng-Ya NiU XinRui WANG Gang-Feng Department of Engineering Mechanics SVLXi’an Jiaotong UniversityXi’an710049China Department of Mechanical Engineering City University of Hong KongHong Kong SAR999077China

Micro-/nano-indentation has become prevalent in evaluating the mechanical characteristics of biological samples,such as cells and ***,the existing contact models describing conical indentation ignore the joint effects of surface energy and substrate,and consequently cannot accurately extract the Young's modulus of biological samples deposited on *** finite element methods,we examine the conical indentation of biological films on substrates while taking surface energy into *** on the dimensional analysis,the explicit relationship between load and indentation depth is achieved for films with their moduli varying from 0.001 to 100 times that of the *** the classical Sneddon's model was employed to analyze the load-depth data,the measured modulus could reach 18 times the real modulus for films on harder substrates,but only 4%of the real modulus for films on softer ***,in micro-/nano-indentations,neglecting the contribution of surface energy would result in an overestimation of the Young's modulus of films depending on the contact *** analytical expression provided here can be utilized to precisely deduce the mechanical characteristics of biological films deposited on substrate from the load and indentation depth data of a conical indentation.

关键词： biological film surface effect substrate effect indentation

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investigation of stress distribution and damage behavior caused by forced installation of a composite bolted joint with a hole-location error

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Chinese Journal of Aeronautics 2024年第1期37卷 201-217页

作者： Chinan LiU Yuan Li Yi.cheng An’an ZHAO Kunpeng DU yue SHi Ximing Li Hui.cheng School of Mechanical Engineering Northwestern Polytechnical UniversityXi’an 710072China AViC Xi’an Aircraft industry Group Company LTD Xi’an 710089China

in this paper,the influence of forced installation caused by a hole-location error on the 3D stress distribution and damage of a composite bolted joint is *** analytical model of stress distributed on composite holes is promoted,in view of non-uniform extrusion caused by forced *** first,non-uniform extrusion of the hole edge caused by forced installation is *** to the contact state,expression of hole deformation is ***,based on Hertz theory,the maximum extrusion load is obtained with help of deformation *** constructing an elastic foundation beam model,3D stress distributed on a hole could be analyzed according to the extrusion ***,stress distribution predicted by the above analytical method is compared with that provided by FE considering composite ***,a forced installation experiment is carried out to analyze the damage distribution of the *** show that a central-symmetrically distributed stress is introduced by the hole-location *** an increment of the error,strength of composite decreases due to extrusion ***,stress presents a concave distribution on the *** the hole-location error exceeding 3%,stress decreases gradually due to failure of *** of holes does not exhibit a centrosymmetric *** damage is mainly distributed on the entrance of the hole at the lower sheet.

关键词： Hole-location error Composite joint Forced installation Stress distribution Damage

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Top Five Stories of the Cellular Landscape and Therapies of Atherosclerosis:Current Knowledge and Future Perspectives

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Current Medical Science 2024年第1期44卷 1-27页

作者： Qi PAN cheng CHEN yue-jin YANG State Key Laboratory of Cardiovascular Disease Department of CardiologyFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100037China

Atherosclerosis(AS)is characterized by impairment and apoptosis of endothelial cells,continuous systemic and focal inflammation and dysfunction of vascular smooth muscle cells,which is documented as the traditional cellular ***,the mechanisms appear much more complicated than we thought since a bulk of studies on efferocytosis,transdifferentiation and novel cell death forms such as ferroptosis,pyroptosis,and extracellular trap were *** of novel pathological cellular landscapes provides a large number of therapeutic *** the other side,the unsatisfactory therapeutic effects of current treatment with lipid-lowering drugs as the cornerstone also restricts the efforts to reduce global AS *** cell-or nanoparticle-based strategies spurred a lot of attention due to the attractive therapeutic effects and minimized adverse *** the complexity of pathological changes of AS,attempts to develop an almighty medicine based on single mechanisms could be theoretically *** this review,the top stories in the cellular landscapes during the initiation and progression of AS and the therapies were summarized in an integrated perspective to facilitate efforts to develop a multi-targets strategy and fill the gap between mechanism research and clinical *** future challenges and improvements were also discussed.

关键词： atherosclerosis transdifferentiation extracellular traps efferocytosis stem cell nanoparticles

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Pd(i)-catalyzed ring-opening arylation of cyclopropyl-α-aminoamides:Access toα-ketoamide peptidomimetics

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Chinese Chemical Letters 2024年第6期35卷 320-326页

作者： yue Sun Liming Yang Yaohang cheng Guanghui An Guangming Li School of Chemistry and Materials Science Heilongjiang UniversityHarbin 150080China

We report the unprecedent Pd(i)catalyzed ring-opening arylation of cyclopropyl-α-*** protocol allows facile access to biologically important α-ketoamide-containing oligopeptides and even more challenging peptide-natural product *** selectivity was achieved by introduction of special unnatural amino acids,which also meets the requisite of bioorthogonal *** investigations reveals a distinct domino radical ring-opening process through Pd(i)catalysis.

关键词： Pd(i)catalysis Ring-opening arylation Domino reactions Oligopeptides Late-stage functionalization

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Status of biomarker development for frontotemporal dementia and amyotrophic lateral sclerosis

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Neural Regeneration Research 2024年第10期19卷 2117-2118页

作者： yue Yang Qi.cheng Jianqun Gao Woojin Scott Kim Brain and Mind Centre&School of Medical Sciences The University of SydneySydneyNSWAustralia Department of Neurology and Neurophysiology Liverpool HospitalSydneyNSWAustralia Stroke and Neurology Research Group Ingham Institute for Applied Medical ResearchSydneyNSWAustralia Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation ShanghaiChina Clinical Research Center for Anesthesiology and Perioperative Medicine ShanghaiChina Translational Research institute of Brain and Brain-Like intelligence Shanghai Fourth People’s HospitalSchool of MedicineTongji UniversityShanghaiChina

Frontotemporal dementia(FTD) and amyotrophic lateral sclerosis(ALS) are neurodegenerative diseases that belong to the same disease spectrum,with overlapping of genetic and pathological *** mutations in TARDBP,C9ORF72,... 详细信息

关键词： amyotrophic sclerosis diseases

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Exercise-induced adaptation of neurons in the vertebrate locomotor system

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Journal of Sport and Health Science 2024年第2期13卷 160-171页

作者： yue Dai Yi.cheng Renkai Ge Ke Chen Liming Yang Key Lab of Adolescent Health Assessment and Exercise intervention of Ministry of Education College of Physical Education and Health CareEast China Normal UniversityShanghai 200241China Shanghai Key Laboratory of Multidimensional information Processing School of Communication and Electronic EngineeringEast China Normal UniversityShanghai 200241China School of Physical Education and Health Care East China Jiaotong UniversityNanchang 330013China Key Laboratory of High Confidence Software Technologies of Ministry of Education School of Computer SciencePeking UniversityBeijing 100871China

Vertebrate neurons are highly dynamic cells that undergo several alterations in their functioning and physiologies in adaptation to various external *** particular,how these neurons respond to physical exercise has long been an area of active *** of the vertebrate locomotor system’s adaptability suggest multiple mechanisms are involved in the regulation of neuronal activity and properties during *** this brief review,we highlight recent results and insights from the field with a focus on the following mechanisms:(a)alterations in neuronal excitability during acute exercise;(b)alterations in neuronal excitability after chronic exercise;(c)exercise-induced changes in neuronal membrane properties via modulation of ion channel activity;(d)exercise-enhanced dendritic plasticity;and(e)exercise-induced alterations in neuronal gene expression and protein *** hope is to update the community with a cellular and molecular understanding of the recent mechanisms underlying the adaptability of the vertebrate locomotor system in response to both acute and chronic physical exercise.

关键词： Dendritic plasticity Excitability Exercise ion channel modulation Neuron adaptation

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Regulating the oxidation state of Pd to enhance the selective hydrogenation for 5-hydroxymethylfurfural

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Chinese Journal of Chemical Engineering 2024年第8期72卷 60-68页

作者： Xin Li yue Ma Xuning Wang Jianguo Wu Dong Cao Daojian cheng State Key Laboratory of Organic-inorganic Composites and College of Chemical Engineering Beijing University of Chemical TechnologyBeijing 100029China

The highly selective hydrogenation of 5-hydroxymethylfurfural to 2,5-dihydroxymethylfuran is an important reaction in the field of biomass hydrogenation,because it is a bridge between biomass resources and chemical ***,we precisely constructed carbon nitride supported Pd-based catalysts by a simple impregnation-reduction *** changing the reduction temperature,catalysts with different oxidation state could be precisely ***,the important correlation between the ratio of Pd^(0)/Pd^(2+)and catalytic activity is revealed during the selective hydrogenation of *** Pd/g—C_(3)N_(4)—300 catalyst with a Pd^(0)/Pd^(2+)ratio of 3/2 showed the highest catalytic activity,which could get 96.9%5-hydroxymethylfurfural conversion and 90.3%2,5-dihydroxymethylfuran *** density functional theory calculation revealed that the synergistic effect between Pd0and Pd2+in Pd/g—C_(3)N_(4)—300 system could boost the adsorption of the substrate and the dissociation of *** this work,we highlight the important correlation between metal oxidation state and catalytic activity,which provides valuable insights for the rational design of precious metal catalysts for hydrogenation reactions.

关键词： Pd/g-C_(3)N_(4) Selective hydrogenation 5-hydroxymethylfurfural 2,5-dihydroxymethylfuran Oxidation state

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Anti-Spoofing:integrated information Authentication of BeiDou-ⅡCivil Navigation Message

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China Communications 2024年第9期21卷 242-261页

作者： Wu Zhijun Liang cheng Zhang Yun Liu Rusen yue Meng School of Safety Science and Engineering Civil Aviation University of ChinaTianjin 300300China School of Electronic information and Automation Civil Aviation University of ChinaTianjin 300300China Dalian Air Traffic Management Station of Civil Aviation of China Dalian 116000China

The BeiDou-Ⅱcivil navigation message(BDⅡ-CNAV)is transmitted in an open environment and no information integrity protection measures are ***,the BDⅡ-CNAV faces the threat of spoofing attacks,which can lead to wrong location reports and time *** order to deal with this threat,we proposed a scheme of anti-spoofing for BDⅡ-CNAV based on integrated information *** scheme generates two type authentication information,one is authentication code information(ACi),which is applied to confirm the authenticity and reliability of satellite time information,and the other is signature information,which is used to authenticate the integrity of satellite location information and other *** authentication information is designed to embed into the reserved bits in BDⅡ-CNAV without changing the frame *** order to avoid authentication failure caused by public key error or key error,the key or public key prompt information(KPKPi)are designed to remind the receiver to update both keys in *** results indicate that the scheme can successfully detect spoofing attacks,and the authentication delay is less than 1%of the transmission delay,which meets the requirements of BDⅡ-CNAV information authentication.

关键词： anti-spoofing authentication BeiDou-ii civil navigation message(BDii-CNAV) signature spoofing attack

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