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Hypidone hydrochloride(YL-0919)ameliorates functional deficits after traumatic brain injury in mice by activating the sigma-1 receptor for antioxidation

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Neural Regeneration Research 2025年第8期20卷 2325-2336页

作者： Yafan Bai Hui Ma yue zhang Jinfeng Li Xiaojuan Hou Yixin Yang Guyan Wang Yunfeng Li Department of Anesthesiology Beijing Tongren HospitalCapital Medical UniversityBeijingChina Beijing Institute of Basic Medical Sciences BeijingChina Hebei North University ZhangjiakouHebei ProvinceChina Beijing Institute of Pharmacology and Toxicology State Key Laboratory of Toxicology and Medical CountermeasuresBeijing Key Laboratory of NeuropsychopharmacologyBeijingChina

Traumatic brain injury involves complex pathophysiological mechanisms,among which oxidative stress significantly contributes to the occurrence of secondary *** this study,we evaluated hypidone hydrochloride(YL-0919),a self-developed antidepressant with selective sigma-1 receptor agonist properties,and its associated mechanisms and targets in traumatic brain *** experiments to assess functional deficits were followed by assessment of neuronal damage through histological analyses and examination of blood-brain barrier permeability and brain ***,we investigated the antioxidative effects of YL-0919 by assessing the levels of traditional markers of oxidative stress in vivo in mice and in vitro in HT22 ***,the targeted action of YL-0919 was verified by employing a sigma-1 receptor antagonist(BD-1047).Our findings demonstrated that YL-0919 markedly improved deficits in motor function and spatial cognition on day 3 post traumatic brain injury,while also decreasing neuronal mortality and reversing blood-brain barrier disruption and brain ***,YL-0919 effectively combated oxidative stress both in vivo and in *** protective effects of YL-0919 were partially inhibited by *** results indicated that YL-0919 relieved impairments in motor and spatial cognition by restraining oxidative stress,a neuroprotective effect that was partially reversed by the sigma-1 receptor antagonist ***-0919 may have potential as a new treatment for traumatic brain injury.

关键词： antidepressant drug blood-brain barrier cognitive function hypidone hydrochloride(YL-0919) neurological function nuclear factor-erythroid 2 related factor 2 oxidative stress sigma-1 receptor superoxide dismutase traumatic brain injury

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The shifts of precipitation phases and their impacts

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Science China Earth Sciences 2025年

作者： Xuemei LI Tao CHE Yuanlong TANG Huan'e DUAN Guigang WANG Xu zhang Chuanming YANG Jun WU yue zhang Lanhai LI Faculty of Geomatics Lanzhou Jiaotong University National-Local Joint Engineering Research Center of Technologies and Applications for National Geographic State Monitoring Key Laboratory of Science and Technology in Surveying & Mapping Gansu Province Key Laboratory of Cryospheric Science and Frozen Soil Engineering Heihe Remote Sensing Experimental Research StationNorthwest Institute of Eco-Environment and Resources Chinese Academy of Sciences Xinjiang Key Laboratory of Water Cycle and Utilization in Arid Zone Xinjiang Institute of Ecology and Geography Chinese academy of Sciences Tianshan Snow Cover and Avalanche Observation and Research Station of Xinjiang

Precipitation comes in various phases, including rainfall, snowfall, sleet, and hail. Shifts of precipitation phases, as well as changes in precipitation amount, intensity, and frequency, have significant impacts on regional climate, hydrology,ecology, and the energy balance of the land-atmosphere system. Over the past century, certain progress has been achieved in aspects such as the observation, discrimination, transformation, and impact of precipitation phases. Mainly including:since the1980s, studies on the observation, formation mechanism, and prediction of precipitation phases have gradually received greater attention and reached a certain scale. The estimation of different precipitation phases using new detection theories and methods has become a research focus. Avariety of discrimination methods or schemes, such as the potential thickness threshold method of the air layer, the temperature threshold method of the characteristic layer, and the near-surface air temperature threshold method,have emerged one after another. Meanwhile, comparative studies on the discrimination accuracy and applicability assessment of multiple methods or schemes have also been carried out simultaneously. In recent years, the shift of precipitation from solid to liquid (SPSL) in the mid-to-high latitudes of the Northern Hemisphere has become more pronounced due to global warming and human activities. It leads to an increase in rain-on-snow (ROS) events and avalanche disasters, affecting the speed, intensity, and duration of spring snow-melting, accelerating sea ice and glacier melting, releasing carbon from permafrost, altering soil moisture, productivity, and phenological characteristics of ecosystems, and thereby affecting their structures, processes, qualities, and service functions. Although some progress has been made in the study of precipitation phases, there remains considerable research potential in terms of completeness of basic data, reliability of discrimination schemes,

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从领域到属性:亲环境行为测量的问题及建议

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心理科学进展 2025年第1期33卷 163-175页

作者：张玥董艺佳蒋奖华北电力大学经济与管理学院北京102206 香港城市大学社会与行为科学系香港北京师范大学心理学部应用实验心理北京市重点实验室心理学国家级实验教学示范中心(北京师范大学)北京100875

已有研究开发了大量的亲环境行为测量工具,涉及量表、个体行为范式和群体博弈范式,其中大多数测量工具是基于行为领域设计,节约、出行、垃圾处理、消费和公域行为是5个最常被提及的领域。现有依据行为领域的亲环境行为测量方式存在标准... 详细信息

已有研究开发了大量的亲环境行为测量工具,涉及量表、个体行为范式和群体博弈范式,其中大多数测量工具是基于行为领域设计,节约、出行、垃圾处理、消费和公域行为是5个最常被提及的领域。现有依据行为领域的亲环境行为测量方式存在标准化程度低及测量结果推广性受限的问题,这主要是由于缺少对行为属性这一行为决定性特征的关注。未来研究应基于行为属性选用和开发标准化测量工具,并选取多种真实行为作为效标进行效度检验。

关键词：亲环境行为行为领域行为属性测量

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黄河干流实测径流量演变特征及影响因素分析

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水土保持研究 2025年第2期32卷 1-13,23页

作者：高海燕张悦兰州财经大学统计与数据科学学院兰州730020 兰州工商学院经济学院兰州730101

[目的]全面揭示黄河流域径流演变机理,为进一步探讨流域水资源管理和可持续发展提供科学依据。[方法]在函数型数据视角下,利用相平面图、主微分分析方法以及基函数拟合法探究了2002—2022年黄河干流实测径流量的趋势性、突变性、周期性... 详细信息

[目的]全面揭示黄河流域径流演变机理,为进一步探讨流域水资源管理和可持续发展提供科学依据。[方法]在函数型数据视角下,利用相平面图、主微分分析方法以及基函数拟合法探究了2002—2022年黄河干流实测径流量的趋势性、突变性、周期性和季节变动特征,并采用函数型聚类方法分析了主要水文站径流量的差异性。同时,利用累积量斜率变化分析法定量计算了气候变化和人类活动对径流变化的影响贡献率,并通过建立多元函数型线性回归模型估计了气候变化和人类活动与径流量之间的响应关系。[结果]实测径流量呈增加趋势,周期性显著,在2004年、2008年、2013年、2017年、2021年发生突变,季节特征明显;黄河干流12个主要水文站可聚为3类,各水文站不同年代径流量空间分布差异性显著;降水量、气温、耗水量等气候变化和人类活动显著影响实测径流量。[结论]近20年来黄河干流实测径流量呈增加趋势,各水文站在空间分布上特征明显,实测径流量受气候变化和人类活动的显著影响。

关键词：函数型数据分析黄河流域实测径流量

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日粮中添加枯草芽孢杆菌对高氧气调包装猪肉蛋白质和脂质氧化的影响

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食品科学 2025年第1期46卷 142-148页

作者：张悦于江刘飞张玉玉张一敏毛衍伟山东农业大学食品科学与工程学院山东泰安271018 山东省农业科学院畜牧兽医研究所农业农村部畜禽生物组学重点实验室山东济南250100

为探究日粮添加枯草芽孢杆菌对猪肉抗氧化能力以及高氧气调包装贮藏期间猪肉肉色、蛋白质氧化、脂质氧化和感官品质的影响,选取对照组(只饲喂基础日粮)和处理组(基础日粮添加枯草芽孢杆菌)的三元杂交(杜洛克×长白×大约克)猪各6只,屠... 详细信息

为探究日粮添加枯草芽孢杆菌对猪肉抗氧化能力以及高氧气调包装贮藏期间猪肉肉色、蛋白质氧化、脂质氧化和感官品质的影响,选取对照组(只饲喂基础日粮)和处理组(基础日粮添加枯草芽孢杆菌)的三元杂交(杜洛克×长白×大约克)猪各6只,屠宰后取背最长肌测定抗氧化酶活性,其余背最长肌样品进行高氧气调包装,4℃冷库贮藏,分别在0、5、10、15、20?d测定肉色、丙二醛(malondialdehyde,MDA)、羰基和巯基含量,并进行感官评价。结果表明:与对照组相比,处理组能够显著提高超氧化物歧化酶、谷胱甘肽过氧化物酶和过氧化氢酶活性(P<0.05),增强猪肉的抗氧化能力;日粮中添加枯草芽孢杆菌可以显著改善高氧气调包装猪肉的肉色(P<0.05);在低温贮藏期间,处理组能够显著降低MDA含量(P<0.05),抑制高氧气调包装猪肉的脂肪氧化;日粮中添加枯草芽孢杆菌能够显著抑制高氧气调包装猪肉的蛋白质氧化、羰基的生成和巯基损失(P<0.05),同时显著提高猪肉打开包装前的颜色和打开包装后的总体喜爱度评分(P<0.05)。综上,在日粮中添加枯草芽孢杆菌可提高猪肉的抗氧化能力、改善猪肉在高氧气调包装中的肉色、抑制蛋白质和脂质氧化,提高猪肉的食用品质。

关键词：枯草芽孢杆菌猪肉抗氧化能力脂质氧化蛋白质氧化

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Recent progress in metal-organic frameworks(Part II—material application)

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Science China Chemistry 2025年

作者： Jiandong Pang Wentao Jiang Xue-Wen zhang Hao-Long Zhou Yuxiu Sun Wei Gong Bin Wang Fuyin Ma Linwei He Long Chen Qiang Chen He-Qi Zheng Yuanjing Cui Wen-Jie Shi Chao zhang Mei Wang yue-Biao zhang Jie-Peng zhang Chongli Zhong Yong Cui Shuao Wang Jian-Rong Li Guodong Qian Tong-Bu Lu Huan Pang Xian-He Bu Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology School of Chemistry and Chemical Engineering Yangzhou University School of Materials Science and Engineering Nankai University School of Physical Science and Technology ShanghaiTech University MOE Key Laboratory of Bioinorganic and Synthetic Chemistry GBRCE for Functional Molecular Engineering School of Chemistry IGCMESun Yat-sen University Department of Chemistry Shantou University School of Chemical Engineering and Technology Tiangong University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences Soochow University College of Materials Science & Engineering Beijing University of Technology State Key Laboratory of Silicon and Advanced Semiconductor Materials Cyrus Tang Center for Sensor Materials and ApplicationsSchool of Materials Science & Engineering Zhejiang University

As a class of functional crystalline porous materials, metal-organic frameworks(MOFs) gained rapid development in the past three decades and a large number of MOFs with ordered structures, high surface areas, and functionalized channels have been investigated. MOFs and MOF-derived/composite materials show great potential in many application fields. In this review, we discussed the main applications of MOFs and MOF-derived/composite materials in small molecule storage, separation, luminescence, sensing, multitype catalysis, and energy storage. In addition, challenges and problems in the future research of MOFsrelated fields are also discussed.

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Interior-collapsing mechanism by hydrothermal process of the MgAl_(2)O_(4)/MgO porous ceramic

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Journal of Advanced Ceramics 2022年第5期11卷 814-824页

作者： Yao YAO yue zhang Key Laboratory of Aerospace Materials and Performance(Ministry of Education) School of Materials Science and EngineeringBeihang UniversityBeijing 100191China

Ceramic core is a critical component in the super-alloy turbine blade *** our previous work,a novel multi-phase MgAl_(2)O_(4)/MgO porous ceramic was prepared for this *** most important property was that it crumbled completely after hydrothermal treatment in just pure water,due to the hydration of *** this work,the hydration process of the MgO embedded in the inert matrix was investigated in *** collapse behaved as an interior destruction without any bulk expansion of the *** hydration percentage was the only factor related to the *** morphology of hydration product indicated that the reaction advanced in particular *** on the finite element analysis for the expansion effect on the porous structure,the interiorcollapsing mechanism was *** the hydration process,the MgO grains exerted pressure to the surrounding matrix and induced the collapse in the adjacent *** process took place throughout the ***,the sample crumbled completely to the *** bulk dilatation was detected before the powdering,indicating that the collapse process would not exert pressure *** the alloy blade would not be damaged during the removal of the ceramic *** was also predicted that the decrease in the MgO grain size was beneficial to the water-collapsibility.

关键词： ceramic cores porous structure MgO hydration interior-collapsing mechanism

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股权回购型对赌协议的基本原理与效力认定

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江苏商论 2025年第1期 107-111页

作者：张跃辉中国银行股份有限公司菏泽分行山东菏泽274002

以股权回购为常见形式的对赌协议,是一种具有商业惯例因素并符合企业经营内在逻辑的投资工具,属于狭义的非典型合同,背后的学理基础在于诚实信用原则。中国关于股权回购型对赌协议的规范性文件通常认可其法律效力,其中包括但不限于纪要... 详细信息

以股权回购为常见形式的对赌协议,是一种具有商业惯例因素并符合企业经营内在逻辑的投资工具,属于狭义的非典型合同,背后的学理基础在于诚实信用原则。中国关于股权回购型对赌协议的规范性文件通常认可其法律效力,其中包括但不限于纪要对司法审判的影响。既往司法实践对于协议的效力认定经历了两个阶段的发展:第一阶段在于认定协议的合法性,“华工案”的裁判思路反映出对双方当事人交易的自主意愿的尊重。第二阶段是协议的可执行性问题,一方面需要结合资本维持和清偿能力标准判断协议的可履行性;另一方面在具体的履行程序上,协议双方当事人也要事先做好周密安排。

关键词：对赌协议股权回购投资效力可履行性

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Calculation of high-temperature insulation parameters and heat transfer behaviors of multilayer insulation by inverse problems method

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Chinese Journal of Aeronautics 2014年第4期27卷 791-796页

作者： Huang Can zhang yue Key Laboratory of Aerospace Materials and Performance (Ministry of Education) School of Materials Science and Engineering Beihang University

In the present paper, a numerical model combining radiation and conduction for porous materials is developed based on the finite volume method. The model can be used to investigate high-temperature thermal insulations which are widely used in metallic thermal protection systems on reusable launch vehicles and high-temperature fuel cells. The effective thermal conductivities（ECTs） which are measured experimentally can hardly be used separately to analyze the heat transfer behaviors of conduction and radiation for high-temperature insulation. By fitting the effective thermal conductivities with experimental data, the equivalent radiation transmittance, absorptivity and reflectivity, as well as a linear function to describe the relationship between temperature and conductivity can be estimated by an inverse problems method. The deviation between the calculated and measured effective thermal conductivities is less than 4%. Using the material parameters so obtained for conduction and radiation, the heat transfer process in multilayer thermal insulation（MTI） is calculated and the deviation between the calculated and the measured transient temperatures at a certain depth in the multilayer thermal insulation is less than 6.5%.

关键词： Effective thermal conductivity Fibrous insulation Finite volume methodHeat transfer Multilayer thermal insulation Radiation

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Status and prospects of intermediate temperature solid oxide fuel cells

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Journal of University of Science and Technology Beijing 2008年第1期15卷 84-90页

作者： Bangwu Liu yue zhang Department of Materials Physics School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China Key Laboratory of New Energy Materials and Technologies University of Science and Technology Beijing Beijing 100083 China

Compared with conventional electric power generation systems, the solid oxide fuel cell （SOFC） has many advantages because of its unique features. High temperature SOFC has been successfully developed to its commercial applications, but it still faces many problems which hamper large-scale commercial applications of SOFC. To reduce the cost of SOFC, intermediate temperature solid oxide fuel cell （IT-SOFC） is presently under rapid development. The status of IT-SOFC was reviewed with emphasis on discussion of their component materials. 2008 University of Science and Technology Beijing. All rights reserved.

关键词： solid oxide fuel cell (SOFC) intermediate temperature solid oxide fuel cell (IT-SOFC) component materials commercial applications

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