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Diversity and geographical distribution of haptophyte Phaeocystis in the Chinese seas based on metabarcoding analysis

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Journal of Oceanology and Limnology 2023年第6期41卷 2197-2207页

作者： Qingshang SONG yue xue Yanying ZHANG Jiehui YIN Pingping SHEN Ocean School Yantai UniversityYantai 264005China

Phaeocystis is an important bloom-forming species and over 100 blooms have occurred since 1997 along the Chinese coasts,while only the species P.globosa was described.In this project,a total of 246 phytoplankton samples collected from the Bohai Sea,the Yellow Sea,and the East China Sea in April 2021 were analyzed to evaluate the species diversity and geographical distribution of the genus Phaeocystis based on metabarcoding 18S r DNA sequence.Four described Phaeocystis species were recognized,including P.globosa,P.pouchetii,P.jahnii,and P.cordata,and each has distinguished geographical distribution characteristics.P.globosa was the most widespread and abundant species,and P.pouchetii was found in the Bohai Sea and the northern Yellow Sea with substantially elevated abundance.P.cordata was also a widespread species,but its abundance was relatively low,while P.jahnii gathered only in the southeastern East China Sea.Water temperature,phosphate as well as ammonium contents were found to be associated with the abundance of P.globosa,P.pouchetii,and P.jahnii significantly.Moreover,two uncharacterized Phaeocystis species were detected in the Chinese seas,indicating the diversity of the genus remains underestimated worldwide.

关键词： Haptophyta Phaeocystis species diversity distribution Chinese seas amplicon sequence variant

Design of weak current measurement system and research on temperature impact

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Nuclear Science and Techniques 2024年第4期35卷 46-56页

作者： Chu-Xiang Zhao San-Gang Li Rong-Rong Su Li Yang Ming-Zhe Liu Qing-yue xue Shan Liao Zhi Zhou Qing-Shan Tan Xian-Guo Tuo Yi Cheng College of Nuclear Technology and Automation Engineering Chengdu University of Technology1#DongsanluErxianqiaoChengdu 610059China Applied Nuclear Technology in Geosciences Key Laboratory of Sichuan Province Chengdu University of Technology1#DongsanluErxianqiaoChengdu 610059China University of Science and Technology of China Hefei 230026China School of Physics and Electronic Engineering Sichuan University of Science and EngineeringZigong 643000China

A dedicated weak current measurement system was designed to measure the weak currents generated by the neutron ionization chamber.This system incorporates a second-order low-pass filter circuit and the Kalman filtering algorithm to effectively filter out noise and minimize interference in the measurement results.Testing conducted under normal temperature conditions has demonstrated the system's high precision performance.However,it was observed that temperature variations can affect the measurement performance.Data were collected across temperatures ranging from -20 to 70℃,and a temperature correction model was established through linear regression fitting to address this issue.The feasibility of the temperature correction model was confirmed at temperatures of -5 and 40℃,where relative errors remained below 0.1% after applying the temperature correction.The research indicates that the designed measurement system exhibits excellent temperature adaptability and high precision,making it particularly suitable for measuring weak currents.

关键词： Weak current measurement system Neutron ionization chamber Kalman filter algorithm Temperature correction model

全内关节镜下外侧韧带加强术治疗慢性踝关节外侧旋转不稳定的临床效果分析

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中华外科杂志 2024年第6期62卷 581-590页

作者：罗信薛冲陈杰薛越冯仕明徐州医科大学徐州临床学院徐州市中心医院运动医学科徐州221009

目的比较全内关节镜下Broström-Gould术和Broström术治疗慢性踝关节外侧旋转不稳定(CLRAI)的临床效果。方法本研究为回顾性队列研究。回顾性分析2021年1月至2022年12月徐州市中心医院骨科收治的106例CLRAI患者的临床及影像学资料。男性5... 详细信息

目的比较全内关节镜下Broström-Gould术和Broström术治疗慢性踝关节外侧旋转不稳定(CLRAI)的临床效果。方法本研究为回顾性队列研究。回顾性分析2021年1月至2022年12月徐州市中心医院骨科收治的106例CLRAI患者的临床及影像学资料。男性55例,女性51例,年龄(32.6±8.2)岁(范围:16~50岁)。患者均采用全内关节镜下治疗,按照韧带修复方式不同,分为Broström-Gould术组(54例)和Broström术组(52例)。术后3、6、12个月采用踝关节内翻应力试验和踝关节前抽屉试验检查踝关节稳定情况,并观察患者步态。采用美国足踝外科协会踝与后足评分(AOFAS-AH)和Karlsson踝关节功能评分(KAFS)评价踝关节功能;采用Tegner评分评估患者运动水平;采用足与踝关节预后评分(FAOS)(包含症状、疼痛、日常活动、运动、生活质量5项评分)评估患者日常活动能力。数据比较采用独立样本t检验、重复测量方差分析、LSD-t多重比较、χ^(2)检验或Mann-Whitney U检验。结果两组患者均顺利完成手术,切口均一期愈合,未出现感染,神经、血管损伤等并发症。术后3、6、12个月所有患者获得随访,踝关节内翻应力试验和踝关节前抽屉试验检查结果均为阴性,患者均恢复正常步态,无踝关节机械性不稳定及功能性不稳定,无患者接受翻修手术。重复测量方差分析结果显示,Broström-Gould术组和Broström术组患者术后AOFAS-AH、Tegner、KAFS、FAOS评分均较术前明显提高(P值均<0.01)。两组患者Tegner评分和FAOS中的运动评分,组间变化趋势的差异有统计学意义(F=18.839,P<0.01;F=8.169,P=0.005)。LSD-t多重比较发现术后3、6、12个月随访时,Broström-Gould组的Tegner评分[3个月:(3.7±0.5)分比(3.3±0.5)分,LSD-t=-3.980,P<0.01;6个月:(4.4±0.6)分比(3.8±0.7)分,LSD-t=-4.792,P<0.01;12个月:(5.8±0.9)分比(5.1±1.0)分,LSD-t=-3.889,P<0.01]和FAOS中的运动评分[3个月:(82.5±3.7)分比(79.3±3.8)分,LSD-t=-4.316,P<0.01;6个月:(88.5±4.9)分比(85.7±3.8)分,LSD-t=-3.312,P=0.001;12个月:(90.1±4.3)分比(88.2±5.1)分,LSD-t=-2.112,P=0.037]均高于Broström组,差异均有统计学意义。结论全内关节镜下Broström-Gould术和Broström术治疗CLRAI可在一定程度上恢复踝关节的稳定性,提高踝关节功能,但前者在患者运动功能恢复时间和运动能力恢复程度方面可能优于前者。

关键词：踝关节关节不稳定性踝关节外侧旋转不稳定外侧韧带关节镜 Broström-Gould术 Broström术

FXYD3 enhances IL-17A signaling to promote psoriasis by competitively binding TRAF3 in keratinocytes

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Cellular & Molecular Immunology 2023年第3期20卷 292-304页

作者： Wenjuan Yang Rukun He Hao Qu Wenwen Lian yue xue Tao Wang Wenlong Lin Peishuo Zhu Meng Xia Lihua Lai Qingqing Wang Institute of Immunology Zhejiang University School of Medicine310058 HangzhouChina Liangzhu Laboratory Zhejiang University Medical Center1369 West Wenyi Road311121 HangzhouChina Department of Orthopedic Surgery The Second Affiliated HospitalZhejiang University School of Medicine310009 HangzhouChina Department of Pharmacology Zhejiang University School of Medicine310058 HangzhouChina

Psoriasis is a common chronic inflammatory skin disease characterized by inflammatory cell infiltration and epidermal hyperplasia.However,the regulatory complexity of cytokine and cellular networks still needs to be investigated.Here,we show that the expression of FXYD3,a member of the FXYD domain-containing regulators of Na+/K+ATPases family,is significantly increased in the lesional skin of psoriasis patients and mice with imiquimod(IMQ)-induced psoriasis.IL-17A,a cytokine important for the development of psoriatic lesions,contributes to FXYD3 expression in human primary keratinocytes.FXYD3 deletion in keratinocytes attenuated the psoriasis-like phenotype and inflammation in an IMQ-induced psoriasis model.Importantly,FXYD3 promotes the formation of the IL-17R-ACT1 complex by competing with IL-17R for binding to TRAF3 and then enhances IL-17A signaling in keratinocytes.This promotes the activation of the NF-κB and MAPK signaling pathways and leads to the expression of proinflammatory factors.Our results clarify the mechanism by which FXYD3 serves as a mediator of IL-17A signaling in keratinocytes to form a positive regulatory loop to promote psoriasis exacerbation.Targeting FXYD3 may serve as a potential therapeutic approach in the treatment of psoriasis.

关键词： FXYD3 TRAF3 IL-17signaling Keratinocytes Psoriasis

秦岭中段不同恢复阶段弃耕农田植物多样性变化及其驱动因素

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环境科学 2024年第2期45卷 992-1003页

作者：闫成龙薛悦王艺菲康海斌王得祥西北农林科技大学林学院杨凌712100 南京大学地理与海洋科学学院南京210008

植被恢复过程往往伴随着显著的地上植物多样性的变化,探讨枯落物养分-土壤养分-酶活性化学计量对地上植被变化的驱动机制,对于维持区域生物多样性保护和生态稳定至关重要.以秦岭不同恢复年限(1、8、16、31和50 a)的典型弃耕农田为研究对... 详细信息

植被恢复过程往往伴随着显著的地上植物多样性的变化,探讨枯落物养分-土壤养分-酶活性化学计量对地上植被变化的驱动机制,对于维持区域生物多样性保护和生态稳定至关重要.以秦岭不同恢复年限(1、8、16、31和50 a)的典型弃耕农田为研究对象,通过野外调查分析了植被恢复过程中植物群落多样性的变化特征,测定了枯落物养分、土壤养分、β-1,4-葡萄糖苷酶(BG)、纤维二糖水解酶(CBH)、β-1,4-N-乙酰基氨基葡萄糖苷酶(NAG)、亮氨酸氨基肽酶(LAP)和酸性磷酸酶(AP)这5种胞外酶活性等指标,探讨了植被恢复过程中枯落物养分、土壤养分和酶活性化学计量比的变化特征及其对植物多样性变化的驱动机制.结果表明:植物群落多样性指数随植被恢复年限增加均呈先减小后增大的趋势,在恢复16 a时最小;主成分分析结果表明,植被恢复不同年限植物群落多样性指数及枯落物-土壤-酶化学计量特征之间有显著区别,植物群落多样性指数与枯落物碳磷比及枯落物氮磷比具有强烈的正相关关系,而与土壤酶碳磷比(EEA C∶P)具有明显的负相关关系;冗余分析结果表明EEA C∶P对植被恢复过程中植物多样性变化的解释率最高,为25.93%,其次为土壤全磷(TP),解释率为5.94%,是调控植物多样性变化的关键因子.综上所述,秦岭中段弃耕农田植被恢复后期植物种类和数量明显增多,土壤环境的变化影响了微生物的代谢活动从而改变了酶活性,枯落物-土壤-土壤胞外酶通过反馈与调节对群落环境和植物多样性产生影响,EEA C∶P和TP是植被恢复过程中地上植物多样性变化的主要驱动因素.

关键词：植被恢复植物多样性生态化学计量学土壤胞外酶土壤养分枯落物养分

MicroRNA-33/33^(*) inhibit the activation of MAVS through AMPK in antiviral innate immunity

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Cellular & Molecular Immunology 2021年第6期18卷 1450-1462页

作者： Danhui Liu Qinchun Tan Jie Zhu Yuanyuan Zhang yue xue Yinjing Song Yang Liu Qingqing Wang Lihua Lai Institute of Immunology Zhejiang University School of MedicineHangzhou310058China Department of Clinical Laboratory Zhejiang HospitalHangzhou310030China The Children’s Hospital of Zhejiang University School of Medicine Hangzhou310052China Department of Pharmacology Zhejiang University School of MedicineHangzhou310058China

Innate immunity plays a prominent role in the host defense against pathogens and must be precisely regulated.As vital orchestrators in cholesterol homeostasis,microRNA-33/33*have been widely investigated in cellular metabolism.However,their role in antiviral innate immunity is largely unknown.Here,we report that VSV stimulation decreased the expression of miR-33/33*through an IFNAR-dependent manner in macrophages.Overexpression of miR-33/33*resulted in impaired RIG-I signaling,enhancing viral load and lethality whereas attenuating type I interferon production both in vitro and in vivo.In addition,miR-33/33*specifically prevented the mitochondrial adaptor mitochondrial antiviral-signaling protein(MAVS)from forming activated aggregates by targeting adenosine monophosphate activated protein kinase(AMPK),subsequently impeding the mitophagy-mediated elimination of damaged mitochondria and disturbing mitochondrial homeostasis which is indispensable for efficient MAVS activation.Our findings establish miR-33/33*as negative modulators of the RNA virus-triggered innate immune response and identify a previously unknown regulatory mechanism linking mitochondrial homeostasis with antiviral signaling pathways.

关键词： microRNA-33/33^(*) type I interferon MAVS AMPKα mitophagy

2012—2023年天津市托幼机构卫生消毒质量监测分析

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中国消毒学杂志 2024年第3期41卷 186-188页

作者：纪学悦费春楠宋佳天津市疾病预防控制中心天津300011

目的了解天津市托幼机构卫生消毒质量状况。方法通过回顾性调查,对2012—2023年天津市部分托幼机构卫生消毒质量状况进行分析与评价。结果该市托幼机构卫生消毒质量监测覆盖率由2012年的13.89%,扩大到2023年的28.40%,平均覆盖率为24.... 详细信息

目的了解天津市托幼机构卫生消毒质量状况。方法通过回顾性调查,对2012—2023年天津市部分托幼机构卫生消毒质量状况进行分析与评价。结果该市托幼机构卫生消毒质量监测覆盖率由2012年的13.89%,扩大到2023年的28.40%,平均覆盖率为24.35%。室内空气、工作人员手和物体表面平均合格率分别为89.51%、89.17%和90.58%。组合监测项目(室内空气+物体表面+工作人员手+餐饮具)消毒质量合格率范围在37.65%~67.18%。公办与民办托幼机构各项消毒质量合格率无统计学差异(P>0.05)。结论天津市托幼机构消毒质量监测覆盖范围扩大,但组合监测项目消毒质量合格率偏低。

关键词：托幼机构卫生消毒质量监测

中职制造类专业学生学习投入对其职业认同的影响——基于领悟社会支持的中介作用

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职业教育研究 2024年第4期 67-73页

作者：林克松薛悦歌西南大学重庆400715

我国制造业在迈向高质量发展阶段后面临人才紧缺的发展困境,职业院校承担着培养制造业技术技能人才的关键任务。研究以10省、自治区、直辖市83所中职学校10 608名制造类专业学生为对象,通过相关量表调查了解学生学习投入、领悟社会支持... 详细信息

我国制造业在迈向高质量发展阶段后面临人才紧缺的发展困境,职业院校承担着培养制造业技术技能人才的关键任务。研究以10省、自治区、直辖市83所中职学校10 608名制造类专业学生为对象,通过相关量表调查了解学生学习投入、领悟社会支持和职业认同的主要特点及相关性关系。基于变量关系,研究认为提升中职制造类专业学生职业认同感还需从校企双方协同育人目标入手,同步创新人才培养模式,多方合力构建起系统全面的人才培养支持体系和权益监督保障体系,重塑技能社会文化生态,使学生产生持久的职业认同感。

关键词：制造类专业中职学生学习投入职业认同领悟社会支持

基于RUSLE模型和地理探测器的鄂西南土壤侵蚀脆弱性评价

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水土保持学报 2024年第1期38卷 91-103页

作者：杨严攀田培沈晨竹平耀东贾婷惠乐雪黄建武华中师范大学地理过程分析与模拟湖北省重点实验室武汉430079 华中师范大学城市与环境科学学院武汉430079

[目的]水土流失是鄂西南突出的生态问题,合理评估该区域的土壤侵蚀脆弱性,并探究其驱动机制是采取有效水土保持措施的前提。[方法]从人地耦合系统视角分析自然和社会经济因素对鄂西南土壤侵蚀的影响,从暴露度、敏感性和适应能力3个方面... 详细信息

[目的]水土流失是鄂西南突出的生态问题,合理评估该区域的土壤侵蚀脆弱性,并探究其驱动机制是采取有效水土保持措施的前提。[方法]从人地耦合系统视角分析自然和社会经济因素对鄂西南土壤侵蚀的影响,从暴露度、敏感性和适应能力3个方面构建了鄂西南土壤侵蚀脆弱性评价指标体系,并采用综合赋权法确定指标权重。[结果](1)2010—2020年鄂西南土壤侵蚀脆弱性总体上呈现先降低后升高的趋势,强烈及以上强度的土壤侵蚀脆弱性呈现零星的碎片化分布格局,且主要集中在鄂西南的中南部和东部宜昌市辖区的西部地区;(2)研究区敏感性最高的区域集中在海拔800~1500 m,敏感性在坡度25°~35°最大,并呈现出向两侧递减的趋势,当坡度>15°时,较高及以上敏感性面积急剧增加;(3)较高及以上土壤侵蚀脆弱性高于土壤侵蚀强度,较低及以下土壤侵蚀脆弱性低于土壤侵蚀强度,土壤侵蚀脆弱性与土壤侵蚀强度存在协同变化趋势;(4)土壤侵蚀脆弱性的分布格局是多因素协同作用造成的,地理探测器的分析表明坡度、植被覆盖度、教育质量和城镇化率对土壤侵蚀脆弱性的解释力较强。[结论]未来需要高度重视对坡度>15°地区植被覆盖的保护,并通过提高当地的教育质量,加强水土保持的宣传力度,提升当地居民的水土保持意识。

关键词：鄂西南土壤侵蚀脆弱性 RUSLE模型地理探测器时空变化