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Journal of Genetics and Genomics 2024年第1期51卷 61-74页

作者： Cheng Ji yue ou Wangjianfei Yu Jiaxin Lv Fanmiao Zhang Huashan Li Zeyun Gu Jiayuan Li Zhaomin Zhong Han Wang Center for Circadian Clocks Soochow UniversitySuzhouJiangsu 215123China School of Biology and Basic Medical Sciences Suzhou Medical CollegeSoochow UniversitySuzhouJiangsu 215123China

Thyroid-stimulating hormone(TSH)is important for the thyroid gland,development,growth,and *** in TSH production or the thyrotrope cells within the pituitary gland cause congenital hypothyroidism(CH),resulting in growth retardation and neurocognitive *** human TSH is known to display rhythmicity,the molecular mechanisms underlying the circadian regulation of TSH and the effects of TSH-thyroid hormone(TH)signaling on the circadian clock remain *** we show that TSH,thyroxine(T4),triiodothyronine(T3),and tshba display rhythmicity in both larval and adult zebrafish and tshba is regulated directly by the circadian clock via both E′-box and *** tshba^(−/−)mutants manifest congenital hypothyroidism,with the characteristics of low levels of T_(4)and T_(3)and growth *** or overexpression of tshba alters the rhythmicity of locomotor activities and expression of core circadian clock genes and hypothalamic-pituitary-thyroid(HPT)axis-related ***,TSH-TH signaling regulates clock2/npas2 via the thyroid response element(TRE)in its promoter,and transcriptome analysis reveals extensive functions of Tshba in ***,our results demonstrate that zebrafish tshba is a direct target of the circadian clock and in turn plays critical roles in circadian regulation along with other functions.

关键词： Thyroid-stimulating hormone subunitβa (tshba) Thyroid hormone Circadian rhythm TALEN Zebrafish

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司法解释进入行政执法的理论逻辑

行政法学研究 2024年第1期 168-176页

作者：陈越瓯吉林大学法学院吉林长春130012

相较于在司法系统内部的权威性地位,司法解释对于行政执法的效力尚不明确。针对我国现行法律解释体制以法律解释权力的配置为中心的现状,在司法解释能否进入行政执法的问题上,理论上存在基于法律解释工作安排的权力分工障碍、基于专业... 详细信息

相较于在司法系统内部的权威性地位,司法解释对于行政执法的效力尚不明确。针对我国现行法律解释体制以法律解释权力的配置为中心的现状,在司法解释能否进入行政执法的问题上,理论上存在基于法律解释工作安排的权力分工障碍、基于专业知识储备的权力能力障碍和基于权力配置原则的权力性质障碍。通过对实践中行政机关自发援引司法解释现象的经验分析,只有权力性质障碍构成司法解释进入行政执法的真正阻碍。确定司法解释外部效力之范围和强度的前提,是在功能主义的国家权力配置原则下重构司法解释权和行政解释权之间的关系。依据法律解释体制提供统一法律指引的功能目标和社会主义法律传统对国家机构间关系的定位,在现行法律解释体制下,司法解释权和行政解释权之间应当形成一种对等结构,在这种权力结构中,司法解释具有一定程度的外部效力。司法解释虽然不构成行政执法的直接依据,但对行政机关具有可反驳的规范性拘束力。

关键词：司法解释行政执法法律解释权功能主义国家机构

面向管道焊缝渗透检测机器人的管道定位与规划方法

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科学技术与工程 2024年第17期24卷 7168-7176页

作者：李彰欧越陈建文徐阳樊继壮赵杰中核武汉核电运行技术股份有限公司武汉430200 核动力运行研究所武汉430074 中国核工业集团核工业特种机器人工程技术研究中心武汉430200 哈尔滨工业大学机电学院哈尔滨150000

为了实现核电设施管路的自动化焊缝检测作业,在降低人工作业安全风险的同时提高工作效率,提出了一种集喷涂、喷擦、刷涂、擦洗、环境感知和场景建模的机器人自主作业软件系统及相关算法。分析作业机器人的工作环境和功能需求,进行机械... 详细信息

为了实现核电设施管路的自动化焊缝检测作业,在降低人工作业安全风险的同时提高工作效率,提出了一种集喷涂、喷擦、刷涂、擦洗、环境感知和场景建模的机器人自主作业软件系统及相关算法。分析作业机器人的工作环境和功能需求,进行机械臂和感知模块的选型,制定三维建模和参数辨识方案,搭建焊缝检测作业系统;提出了一种基于机器人感知到的视觉和深度信息进行场景建模的算法,该算法可以输出检测关到作业面的位置、三维模型以及作业区域范围;提出了一种基于三维重构模型和作业区域范围进行作业轨迹规划的算法,并搭建了仿真平台验证运动轨迹的正确性;开展了管道定位与三维重构实验以及轨迹规划实验,实验的结果证明,提出的管道定位方法能够实现精确的点云数据采集和高精度的管道参数辨识,机械臂能够实现准确性高、连续性好的运动,满足管道焊缝检测作业的要求。

关键词：焊缝检测三维点云表面建模运动规划

High-efficiency inspecting method for mobile robots based on task planning for heat transfer tubes in a steam generator

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机械工程前沿:英文版 2023年第2期18卷 161-175页

作者： Biying XU Xuehe ZHANG yue ou Kuan ZHANG Zhenming XING Hegao CAI Jie ZHAO Jizhuang FAN State Key Laboratory of Robotics and System Harbin Institute of TechnologyHarbin 150001China

Many heat transfer tubes are distributed on the tube plates of a steam generator that requires periodic inspection by *** inspection robots are usually involved in issues:Robots with manipulators need complicated installation due to their fixed base;tube mobile robots suffer from low running efficiency because of their structural *** there are thousands of tubes to be checked,task planning is essential to guarantee the precise,orderly,and efficient inspection *** in-service robots check the task tubes using row-by-row and column-bycolumn *** leads to unnecessary inspections,resulting in a long shutdown and affecting the regular operation of a nuclear power ***,this paper introduces the structure and control system of a dexterous robot and proposes a task planning *** method proceeds into three steps:task allocation,base position search,and sequence *** allocate the task regions,this method calculates the tool work matrix and proposes a criterion to evaluate a *** then all tasks contained in the sub-region are considered globally to search the base ***,we apply an improved ant colony algorithm for base sequence planning and determine the inspection orders according to the planned *** validated the optimized algorithm by conducting task planning experiments using our robot on a tube *** results show that the proposed method can accomplish full task coverage with few repetitive or redundant inspections and it increases the efficiency by 33.31% compared to the traditional planning algorithms.

关键词： steam generator transfer tubes mobile robot dexterous structure task planning efficient inspection

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兰科植物与共生真菌互作关系的研究进展

分子植物育种 2024年第8期22卷 2778-2784页

作者：谢泰祥郑清冬王艺兰琳英徐艳芳欧悦姚亚合艾叶福建农林大学园林学院兰科植物保护与利用国家林业与草原局重点实验室福州350002

兰科植物的种子细小,是所有被子植物中最小种子类型之一,只具备一种不被胚乳包围且小而不发达的胚,在其生命周期的整个过程中,特别是在营养资源匮乏的早期阶段,对共生真菌的依赖性非常强。共生真菌与兰科植物形成菌根联合共生体为种子... 详细信息

兰科植物的种子细小,是所有被子植物中最小种子类型之一,只具备一种不被胚乳包围且小而不发达的胚,在其生命周期的整个过程中,特别是在营养资源匮乏的早期阶段,对共生真菌的依赖性非常强。共生真菌与兰科植物形成菌根联合共生体为种子萌发、原球茎生长发育、幼苗分化以及成年植株生殖生长提供所需的营养物质。本研究对兰科植物共生真菌的研究历程与概况、菌根互作关系、多样性与专一性、促生作用以及应用前景等方面进行了综述,并在此基础上进行展望,以期为兰科植物野生资源保育与开发、人工栽培生产以及生防菌与菌肥研发等研究提供参考。

关键词：兰科植物共生真菌多样性与专一性促生作用

Knockdown of HE4 suppresses tumor growth and invasiveness in lung adenocarcinoma through regulation of EGFR signaling

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Oncology Research 2024年第6期32卷 1119-1128页

作者： yue ZHANG WENYU YANG XIAOWANG HAN yue QIAO HAITAO WANG TING CHEN TIANYING LI WEN-BIN ou Department of Biopharmaceutics College of Life Sciences and MedicineZhejiang Provincial Key Laboratory of Silkworm Bioreactor and BiomedicineZhejiang Sci-Tech UniversityHangzhou310018China Department of Thoracic Surgery Zhejiang Provincial People’s HospitalHangzhou310014China

It has been shown that the high expression of human epididymis protein 4(HE4)in most lung cancers is related to the poor prognosis of patients,but the mechanism of pathological transformation of HE4 in lung cancer is still *** current study is expected to clarify the function and mechanism of HE4 in the occurrence and metastasis of lung adenocarcinoma(LUAD).Immunoblotting evaluated HE4 expression in lung cancer cell lines and biopsies,and through analysis of The Cancer Genome Atlas(TCGA)*** HE4 overexpression was demonstrated in LUAD,but not in lung squamous cell carcinoma(LUSC),indicating that HE4 can serve as a biomarker to distinguish between LUAD and ***4 knockdown significantly inhibited cell growth,colony formation,wound healing,and invasion,and blocked the G1-phase of the cell cycle in LUAD cell lines through inactivation of the EGFR signaling downstream including PI3K/AKT/mTOR and RAF/MAPK *** first-line EGFR inhibitor gefitinib and HE4 shRNA had no synergistic inhibitory effect on the growth of lung adenocarcinoma cells,while the third-line EGFR inhibitor osimertinib showed additive anti-proliferative ***,we provided evidence that HE4 regulated EGFR expression by transcription regulation and protein interaction in *** findings suggest that HE4 positively modulates the EGFR signaling pathway to promote growth and invasiveness in LUAD and highlight that targeting HE4 could be a novel strategy for LUAD treatment.

关键词： Lung adenocarcinoma Human epididymis protein 4 Epidermal growth factor receptor Biomarker Targeted therapies

High-density lipoprotein regulates angiogenesis by affecting autophagy via miRNA-181a-5p

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Science China(Life Sciences) 2024年第2期67卷 286-300页

作者： Bi-Ang Kang Hua-Ming Li Ya-Ting Chen Meng-Jie Deng Yan Li yue-Ming Peng Jian-Jun Gao Zhi-Wei Mo Jia-Guo Zhou Zhi-Jun ou Jing-Song ou Division of Cardiac Surgery Cardiovascular Diseases InstituteThe First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases Guangzhou 510080China NHC key Laboratory of Assisted Circulation(Sun Yat-sen University) Guangzhou 510080China Guangdong Provincial Engineering and Technology Center for Diagnosis and Treatment of Vascular Diseases Guangzhou 510080China Division of Vascular Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Department of Pharmacology Cardiac and Cerebral Vascular Research CenterZhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Division of Hypertension and Vascular Diseases Department of CardiologyCardiovascular Diseases InstituteThe First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Guangdong Provincial Key Laboratory of Brain Function and Disease Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China

We previously demonstrated that normal high-density lipoprotein(nHDL)can promote angiogenesis,whereas HDL from patients with coronary artery disease(d HDL)is dysfunctional and impairs *** plays a critical role in angiogenesis,and HDL regulates ***,it is unclear whether n HDL and d HDL regulate angiogenesis by affecting *** cells(ECs)were treated with n HDL and d HDL with or without an autophagy ***,endothelial nitric oxide synthase(e NOS)expression,miRNA expression,nitric oxide(NO)production,superoxide anion(O2^(·-))generation,EC migration,and tube formation were evaluated.n HDL suppressed the expression of miR-181a-5p,which promotes autophagy and the expression of e NOS,resulting in NO production and the inhibition of O2^(·-)generation,and ultimately increasing in EC migration and tube formation.d HDL showed opposite effects compared to n HDL and ultimately inhibited EC migration and tube *** found that autophagy-related protein 5(ATG5)was a direct target of ***5 silencing or miR-181a-5p mimic inhibited n HDL-induced autophagy,e NOS expression,NO production,EC migration,tube formation,and enhanced O2^(·-)generation,whereas overexpression of ATG5 or miR-181a-5p inhibitor reversed the above effects of d ***5 expression and angiogenesis were decreased in the ischemic lower limbs of hypercholesterolemic low-density lipoprotein receptor null(LDLr^(-/-))mice when compared to C57BL/6 ***5 overexpression improved angiogenesis in ischemic hypercholesterolemic LDLr^(-/-)*** together,nHDL was able to stimulate autophagy by suppressing miR-181a-5p,subsequently increasing e NOS expression,which generated NO and promoted *** contrast,d HDL inhibited angiogenesis,at least partially,by increasing miR-181a-5p expression,which decreased autophagy and e NOS expression,resulting in a decrease in NO production and an increase in O2^(·-)*** findings reveal a nov

关键词： high-density lipoprotein angiogenesis autophagy ATG5 miRNA endothelial nitric oxide synthase

Compression and stretching of ring vortex in a bulk nonlinear medium

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Chinese Physics B 2024年第2期33卷 264-270页

作者：来娴静蔡晓鸥邵雅斌王悦悦 Department of Basic Science Zhejiang Shuren UniversityHangzhou 310015China School of Sciences Zhejiang A&F UniversityHangzhou 311300China

We explore the nonlinear gain coupled Schrödinger system through the utilization of the variables separation method and ansatz *** employing these approaches,we generate hierarchies of explicit dissipative vector vortices(DVVs)that possess diverse vorticity *** fundamental characteristics of the DVVs are examined,encompassing amplitude profiles,energy fluxes,parameter effects,as well as linear and dynamic stability.

关键词： vector optical vortices dissipative nonlinear gain

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湖南多花黄精快速繁殖体系的建立

湖南农业科学 2024年第5期 7-12页

作者：唐铭鑫符天昊杨韬坛沈子豪龚海健欧跃红刘叶蔓宁露云湖南中医药大学湖南长沙410208 娄底市知方生物科技有限公司湖南娄底417000

该研究分别以叶片、根状茎、芽以及种子为外植体,基于前人研究对培养基配方进行优化,共确定了21种培养基配方,从中筛选适用于湖南多花黄精的最佳萌发培养基、最佳增殖培养基以及最佳生根培养基配方,建立了湖南多花黄精快速繁殖体系。结... 详细信息

该研究分别以叶片、根状茎、芽以及种子为外植体,基于前人研究对培养基配方进行优化,共确定了21种培养基配方,从中筛选适用于湖南多花黄精的最佳萌发培养基、最佳增殖培养基以及最佳生根培养基配方,建立了湖南多花黄精快速繁殖体系。结果表明:以当年采收的种子为外植体,消毒后纵切再接种培养效果较好;最佳萌发培养基配方为:B5+1.0 mg/L 6-BA+0.5 mg/L KT+30 g/L蔗糖+6.0 g/L琼脂+2.0 mg/L GA_(3);最佳增殖培养基配方为:MS+4.0 mg/L 6-BA+0.2 mg/L NAA+30 g/L蔗糖+6.5 g/L琼脂;最佳生根培养基配方为:1/2 MS+1.0 mg/L NAA+30 g/L蔗糖+6.5 g/L琼脂。该研究为湖南多花黄精组培苗的生产奠定了坚实的理论基础,为进一步扩大多花黄精的人工种植规模提供了技术支撑。

关键词：多花黄精组织培养萌发增殖生根

信息集群理论视域下重特大事件数字档案资源整合的障碍及对策

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档案学研究 2023年第5期 64-72页

作者：刘婧欧月华中师范大学档案馆武汉430079 华中师范大学信息管理学院武汉430079

重特大事件数字档案资源整合对于推进国家治理体系和治理能力现代化具有重要意义,信息集群理论可以为相关研究提供新的视角。本文根据信息集群的分层理念,从组织导向的宏观层、资源导向的中观层、数据导向的微观层进行剖析,针对重特大... 详细信息

重特大事件数字档案资源整合对于推进国家治理体系和治理能力现代化具有重要意义,信息集群理论可以为相关研究提供新的视角。本文根据信息集群的分层理念,从组织导向的宏观层、资源导向的中观层、数据导向的微观层进行剖析,针对重特大事件数字档案资源整合面临机制滞后导致机构各自为政、归属分散衍生档案资源孤岛、平台割裂弱化数据利用价值的障碍,提出重特大事件数字档案资源整合对策:构建基于机构集群的协同机制,形成基于全宗集群的有机整体,开展基于数据集群的汇交工作。

关键词：信息集群理论重特大事件档案数字档案资源整合