检索结果-南通市图书馆

Polydopamine-mediated graphene oxide and nanohydroxyapatite-incorporated conductive scaffold with an immunomodulatory ability accelerates periodontal bone regeneration in diabetes

在线全文

学校读者我要写书评

暂无评论

Bioactive Materials 2022年第12期7卷 213-227页

作者： Yazhen Li Lu Yang yue hou Zhenzhen Zhang Miao Chen Maoxia Wang Jin Liu Jun Wang Zhihe Zhao Chaoming Xie Xiong Lu State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesDepartment of OrthodonticsWest China Hospital of StomatologySichuan UniversityChengduSichuan610041China Key Lab of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong UniversityChengduSichuan610031China State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesDepartment of Oral ImplantologyWest China Hospital of StomatologySichuan UniversityChengduSichuan610041China Lab for Aging Research and National Clinical Research Center for Geriatrics West China HospitalSichuan UniversityChengduSichuan610041China

Regenerating periodontal bone tissues in the aggravated inflammatory periodontal microenvironment under diabetic conditions is a great ***,a polydopamine-mediated graphene oxide(PGO)and hydroxyapatite nanoparticle(PHA)-incorporated conductive alginate/gelatin(AG)scaffold is developed to accelerate periodontal bone regeneration by modulating the diabetic inflammatory *** confers the scaffold with osteoinductivity and PGO provides a conductive pathway for the *** conductive scaffold promotes bone regeneration by transferring endogenous electrical signals to cells and activating Ca2+***,the scaffold with polydopamine-mediated nanomaterials has a reactive oxygen species(ROS)-scavenging ability and anti-inflammatory *** also exhibits an immunomodulatory ability that suppresses M1 macrophage polarization and activates M2 macrophages to secrete osteogenesis-related cytokines by mediating glycolytic and RhoA/ROCK pathways in *** scaffold induces excellent bone regeneration in periodontal bone defects of diabetic rats because of the synergistic effects of good conductive,ROS-scavenging,anti-inflammatory,and immunomodulatory *** study provides fundamental insights into the synergistical effects of conductivity,osteoinductivity,and immunomodulatory abilities on bone regeneration and offers a novel strategy to design immunomodulatory biomaterials for treatment of immune-related diseases and tissue regeneration.

关键词： Polydopamine Graphene oxide Conductive scaffold ROS-Scavenging Macrophage polarization

Intranasal insulin ameliorates neurological impairment after intracerebral hemorrhage in mice

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第1期17卷 210-216页

作者： Yuan Zhu Yi Huang Jin Yang Rong Tu Xin Zhang Wei-Wei He Chang-yue hou Xiao-Ming Wang Ju-Ming Yu Guo-Hui Jiang Department of Neurology Affiliated Hospital of North Sichuan Medical CollegeNanchongSichuan ProvinceChina Institute of Neurological Diseases North Sichuan Medical CollegeNanchongSichuan ProvinceChina Department of Intensive Care Unit Affiliated Hospital of North Sichuan Medical CollegeNanchongSichuan ProvinceChina

In Alzheimer’s disease and ischemic stroke,intranasal insulin can act as a neuroprotective ***,whether intranasal insulin has a neuroprotective effect in intracerebral hemorrhage and its potential mechanisms remain poorly *** this study,a mouse model of autologous blood-induced intracerebral hemorrhage was treated with 0.5,1,or 2 IU insulin via intranasal delivery,twice per day,until 24 or 72 hours after *** with saline treatment,1 IU intranasal insulin treatment significantly reduced hematoma volume and brain edema after cerebral hemorrhage,decreased blood-brain barrier permeability and neuronal degeneration damage,reduced neurobehavioral deficits,and improved the survival rate of *** levels of p-AKT and p-GSK3βwere significantly increased in the perihematoma tissues after intranasal insulin *** findings suggest that intranasal insulin therapy can protect the neurological function of mice after intracerebral hemorrhage through the AKT/GSK3βsignaling *** study was approved by the Ethics Committee of the North Sichuan Medical College of China(approval ***(A)2019(01))on January 7,2019.

关键词： AKT blood-brain barrier brain edema glycogen synthase kinase-3 hematoma insulin intracerebral hemorrhage intranasal insulin neurological impairment neuronal degeneration neuroprotection

Inhibition of the cGAS–STING pathway:contributing to the treatment of cerebral ischemia-reperfusion injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 1900-1918页

作者： Hang Yang Yulei Xia yue Ma Mingtong Gao Shuai hou Shanshan Xu Yanqiang Wang School of Clinical Medicine Shandong Second Medical UniversityWeifangShandong ProvinceChina Department of Emergency The Affiliated Hospital of Weifang Medical UniversityWeifangShandong ProvinceChina Department of Neurology Ⅱ The Affiliated Hospital of Weifang Medical UniversityWeifangShandong ProvinceChina

The cGAS–STING pathway plays an important role in ischemia-reperfusion injury in the heart,liver,brain,and kidney,but its role and mechanisms in cerebral ischemia-reperfusion injury have not been systematically ***,we outline the components of the cGAS–STING pathway and then analyze its role in autophagy,ferroptosis,cellular pyroptosis,disequilibrium of calcium homeostasis,inflammatory responses,disruption of the blood–brain barrier,microglia transformation,and complement system activation following cerebral ischemia-reperfusion *** further analyze the value of cGAS–STING pathway inhibitors in the treatment of cerebral ischemia-reperfusion injury and conclude that the pathway can regulate cerebral ischemia-reperfusion injury through multiple *** of the cGAS–STING pathway may be helpful in the treatment of cerebral ischemia-reperfusion injury.

关键词： calcium homeostasis cellular autophagy cerebral ischemia-reperfusion injury cGAS–STING pathway ferroptosis gut–brain–microbiota axis inflammatory light chain 3 microglial cells Syntaxin-17 protein

Multifunctional sulfur-immobilizing GO/MXene aerogels for highly-stable and long-cycle-life lithium-sulfur batteries

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2023年第8期42卷 2577-2591页

作者： Wen-Hao Yang Zhi-Cong Ni Dan You Ji-yue hou Bing-Nan Deng Rong-Wei Huang Shi-Gang Sun Jin-Bao Zhao Xue Li Yi-Yong Zhang Ying-Jie Zhang Key Laboratory of Advanced Battery Materials of Yunnan Province College of Metallurgical and Energy EngineeringKunming University of Science and TechnologyKunming oouuyocnina State Key Laboratory of Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy MaterialsCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China

Lithium-sulfur batteries are a promising candidate for next-generation energy storage due to their high theoretical energy ***,S insulation and the lithium polysulfide intermediate’s shuttle effect greatly hinder its practical *** this paper,a three-dimensional porous graphene oxide(GO)/MXene(Ti_(3)C_(2)T_(x))(GM)aerogel is designed and applied to a lithium-sulfur battery to settle the problem *** this strategy,two-dimensional(2D)GO sheets and highly conductive MXene nanosheets are integrated to form a 3D porous aerogel structure,creating a 3D conductive network and large polar surfaces,which can simultaneously achieve fast Li-ion/electron transport,strong chemical anchoring sulfur,and promot redox reactions between poly ***,the cathode shows excellent sulfur utilization and cycle *** prepared GM electrode battery has been tested for nearly nine months at 0.1C,providing the high initial capacity of 1255.62 mAh·g^(-1)and maintaining615.7 mAh·g^(-1)after 450 cycles.

关键词： Lithium-sulfur battery Aerogel Graphene oxide(GO) Ti_(3)C_(2)T_(x) Multifunction

在线全文

学校读者我要写书评

暂无评论

一个三维非线性系统的混沌运动及其控制

控制理论与应用 2009年第4期26卷 395-399页

作者：袁地侯越安阳师范学院物理学系河南安阳455000

通过数值计算、理论推导分析了一个三维类Lorenz混沌系统的基本动力学特性,并通过数值仿真、相图、Poincare截面图和功率谱研究了这个系统的混沌行为.然后,构建一个受控系统并利用Lyapunov指数谱、分叉图分析了该系统混沌吸引子的形成机... 详细信息

通过数值计算、理论推导分析了一个三维类Lorenz混沌系统的基本动力学特性,并通过数值仿真、相图、Poincare截面图和功率谱研究了这个系统的混沌行为.然后,构建一个受控系统并利用Lyapunov指数谱、分叉图分析了该系统混沌吸引子的形成机制,通过对控制参数的改变,系统的混沌运动可以得到有效控制。

关键词：类Lorenz系统混沌控制参数形成机制

Dihydrophenanthrene Derivatives with Anti-neuroinflammatory Activity from Bletilla striata

在线全文

学校读者我要写书评

暂无评论

Dihydrophenanthrene Derivatives with Anti-neuroinflammatory ...

Chemical constituents from leaves of Jatropha curcas

中国化学会第十二届全国天然有机化学学术会议

作者： Di Zhou yue hou Ning Li School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal University College of Life and Health Sciences Northeastern University

Dihydrophenanthrene derivatives,a subtype of phenanthrenoid,mainly exist in Orchidaceae family,which attracted our attention because of their diverse structures and significant anti-inflammatory *** neuroinflammation inhibitory effect assay screened out the ethyl acetate extract of the tubers of Bletilla striata,rich in dihydrophenanthrenes,as an effective *** phytochemical research of the effective extract was carried out and 27 new dihydrophenanthrenes,among which seven ones were isolated for the first time and ten pairs of atropisomers were first resoluted and identified by chiral HPLC and calculated ECD spectra,together with 19 known components were ***,their anti-neuroinflammatory activities and cytotoxicities were evaluated employing LPS-induced microglial *** a result,six dihydrophenanthrenes displayed significant inhibitory effects against NO production in over-activated BV2 cells with IC values of 15.21,17.92,22.07,11.96,0.96 and 1.87 μM,respectively(positive control,minocycline,27.23 μM),which suggesting them to be potential neuroinflammatory inhibitors for therapy of neurodegenerative *** addition,a preliminary SARs between dihydrophenanthrenes and the inhibitory effects of neuroinflammation was discussed briefly.

关键词： Bletilla striata dihydrophenanthrenes anti-neuroinflammation

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Chinese Herbal Medicines 2023年第3期15卷 463-469页

作者： Yingjie Wang Di Zhou Xiaolin Bai Qingqi Meng Haihui Xie Guojiang Wu Gang Chen yue hou Ning Li School of Traditional Chinese Materia Medica Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning ProvinceKey Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang CityShenyang Pharmaceutical UniversityShenyang 110016China Tasly Northeast Modern TCM Resources Co. Ltd.Benxi 117204China College of Life and Health Sciences Northeastern UniversityShenyang 110004China South China Botanical Garden Chinese Academy of SciencesGuangzhou 510650China

Objective:To investigate the chemical constituents from the leaves of Jatropha curcas and evaluate their inhibition on lipopolysaccharide(LPS)-activated BV-2 microglia ***:The n-BuOH extract of the leaves of *** was isolated by macroporous adsorption resin,silica gel,ODS,column chromatography and semi-preparative *** structures of the compounds were identified by MS,NMR,ECD,and other spectroscopic *** addition,anti-neuroinflammatory effects of isolated compounds were evaluated by measuring the production of nitric oxide(NO)in overactivated BV-2 ***:Seventeen compounds,including(7R,8S)-crataegifin A-4-O-β-D-glucopyranoside(1),(8R,8’R)-arctigenin(2),arctigenin-4’-O-β-D-glucopyranoside(3),(-)-syringaresinol(4),syringaresinol-4’-O-β-Dglucopyranoside(5),(-)-pinoresinol(6),pinoresinol-4’-O-β-D-glucopyranoside(7),buddlenol D(8),(2R,3R)-dihydroquercetin(9),(2S,3S)-epicatechin(10),(2R,3S)-catechin(11),isovitexin(12),naringenin-7-O-β-D-glucopyranoside(13),chamaejasmin(14),neochamaejasmin B(15),isoneochamaejasmin A(16),and tomentin-5-O-β-D-glucopyranoside(17)were isolated and *** 2,4and 8 significantly inhibited the release of NO in BV-2 microglia activated by LPS,with IC50values of18.34,29.33 and 26.30μmol/L,***:Compound 1 is a novel compound,and compounds 2,3,8,14–17 are isolated from Jatropha genus for the first *** addition,the lignans significantly inhibited NO release and the inhibitory activity was decreased after glycosylation.

关键词： anti-neuroinflammation flavonoid Jatropha curcas L. lignans

用于红外气体检测的多通池温度、压强控制系统研制

在线全文

学校读者我要写书评

暂无评论

红外与激光工程 2020年第10期49卷 96-102页

作者：侯月黄克谨北京化工大学信息科学与技术学院北京100029

为了实现CO2气体同位素的高性能检测,研制了高精度、高稳定性的多通池温度、压强控制系统。采用柔性PCB作为加热片包覆圆柱形多通池。考虑到温度控制系统的加热速率,外层包覆保温棉作为隔热装置,使得整个温度控制系统能实现快速加热,且... 详细信息

为了实现CO2气体同位素的高性能检测,研制了高精度、高稳定性的多通池温度、压强控制系统。采用柔性PCB作为加热片包覆圆柱形多通池。考虑到温度控制系统的加热速率,外层包覆保温棉作为隔热装置,使得整个温度控制系统能实现快速加热,且能够保持温度的长时间稳定。采用铂电阻PT1000温度传感器对多通池温度进行精确采集,主控制器通过PWM信号,调控柔性PCB加热膜的发热功率,从而实现温度的闭环控制。压强控制系统方面,采用压强传感器连接于多通池前、后端,检测多通池内部气压,主控制器通过PWM信号,调控多通池前、后端比例阀导通状态,从而实现压强的闭环控制。结果表明,温度控制范围为18.48~42℃,温度控制精度为±0.08℃。多通池压强为60 Torr(1 Torr≈133.322 Pa)时,控制精度为±0.04 Torr。该系统为红外CO2气体同位素的高性能检测提供可靠保障。

关键词：红外气体检测 CO2同位素多通池温度压强控制加热膜比例阀

在线全文

学校读者我要写书评

暂无评论

民国外交官学历背景之量化分析

安徽史学 2005年第1期 62-67页

作者：岳谦厚山西大学历史系山西太原030006

本文通过对民国时期外交官学历状况的量化分析 ,认为国内外高等教育 ,特别是留学教育 ,成为民国外交官学历出身的主途 ,这既反映了中国近代外交集团精英化的建构特征 ,又为民国外交政策的发展走向增加了诸多变数。

关键词：民国外交官学历背景专业化