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digital measuring the ocular morphological parameters of guinea pig eye in vivo with Python

International Journal of Ophthalmology(English edition) 2024年第2期17卷 239-246页

作者： yue di Zhong-Bao Qiao Hai-Yun Ye Xin-yue Li Wen-Ting Luo Wang-Yi Fang Tong Qiao Department of Ophthalmology Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200062China

AIM:To quantitatively measure ocular morphological parameters of guinea pig with Python technology.METHODS:Thirty-six eyeballs of eighteen 3-weekold guinea pigs were measured with keratometer and photographed to obtain the horizontal,coronal,and sagittal planes respectively.The corresponding photo pixels-actual length ratio was acquired by a proportional scale.The edge coordinates were identified artificially by ginput function.Circle and conic curve fitting were applied to fit the contour of the eyeball in the sagittal,coronal and horizontal view.The curvature,curvature radius,eccentricity,tilt angle,corneal diameter,and binocular separation angle were calculated according to the geometric principles.Next,the eyeballs were removed,canny edge detection was applied to identify the contour of eyeball in vitro.The results were compared between in vivo and in vitro.RESULTS:Regarding the corneal curvature and curvature radius on the horizontal and sagittal planes,no significant differences were observed among results in vivo,in vitro,and the keratometer.The horizontal and vertical binocular separation angles were 130.6°±6.39°and 129.8°±9.58°respectively.For the corneal curvature radius and eccentricity in vivo,significant differences were observed between horizontal and vertical planes.CONCLUSION:The Graphical interface window of Python makes up the deficiency of edge detection,which requires too much definition in Matlab.There are significant differences between guinea pig and human beings,such as exotropic eye position,oblique oval eyeball,and obvious discrepancy of binoculus.This study helps evaluate objectively the ocular morphological parameters of small experimental animals in emmetropization research.

关键词： ocular morphological parameters guinea pig digital measurement Python

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Surgical treatment of Pitt-Hopkins syndrome associated with strabismus and early-onset myopia:Two case reports

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World Journal of Clinical Cases 2022年第34期10卷 12734-12741页

作者： Ying Huang yue di Xiao-Xiao Zhang Xin-yue Li Wang-Yi Fang Tong Qiao Department of Ophthalmology Shanghai Children's HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 200062China

BACKGROUND Pitt-Hopkins syndrome(PTHS;MIM#610954)is a rare genetic neurological disorder.Myopia and strabismus have been reported in approximately 50%of PTHS patients.No studies have reported details about the required surgery for PTHS with strabismus and early-onset myopia.Here,we retrospectively reviewed the surgical management of two patients with PTHS combined with strabismus and/or early-onset myopia.CASE SUMMARY A 5-year-old girl presented with congenital esotropia and left eye myopia,and the second girl was a 5-year-old girl who presented with intermittent exotropia.Genetic testing performed on both patients showed a mutation in transcription factor 4,which is a diagnostic marker of PTHS.The first girl underwent bilateral medial rectus recession combined with posterior scleral reinforcement(PSR)in the left eye and the second patient underwent bilateral lateral rectus recession strabismus surgery.We made key innovations in surgical timing and strategy,and the results were satisfactory.The combination of strabismus and PSR surgery is an innovative strategy for patients with both strabismus and early-onset myopia.CONCLUSION Early treatment of strabismus and myopia positively influence motor development and should be included in rehabilitation programs for patients with PTHS.

关键词： Pitt-Hopkins syndrome Transcription factor 4 Strabismus Myopia Surgery Case report

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基于床层传热的皮江法炼镁过程优化

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东北大学学报（自然科学版） 2024年第4期45卷 523-529页

作者：傅大学狄跃忠王耀武东北大学多金属共生矿生态化冶金教育部重点实验室辽宁沈阳110819 东北大学冶金学院辽宁沈阳110819 福建省长汀金龙稀土有限公司福建龙岩366300

球团在还原罐内传热导致的温度梯度是限制皮江法还原反应的关键因素.本文采用数值方法研究了球团尺寸、装料方式、还原罐外壁温度等因素对床层温度分布、还原率分布的影响.结果表明:在球团直径为22.3 mm、还原时间相同时能够获得最大的... 详细信息

球团在还原罐内传热导致的温度梯度是限制皮江法还原反应的关键因素.本文采用数值方法研究了球团尺寸、装料方式、还原罐外壁温度等因素对床层温度分布、还原率分布的影响.结果表明:在球团直径为22.3 mm、还原时间相同时能够获得最大的还原率;生产过程中应尽量提高还原罐外壁温度;床层中心区域温度低,还原反应速率慢,反应滞后;通过中心留空的方法能够有效缩短还原周期,提高原料利用率;以单位体积、单位时间镁的产量为依据,对于内径为270 mm的还原罐,当中心留空区域的直径小于27 mm时,可获得最大生产效率.

关键词：镁皮江法真空硅热还原数值仿真传热

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抗炎通腑方对脓毒症急性肺损伤大鼠mtDNA-STING-NLRP3信号通路的影响

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中国急救医学 2024年第4期44卷 323-329页

作者：霍雁岳迪上海市同仁医院、上海交通大学医学院附属同仁医院中医科上海200336

目的探讨抗炎通腑方对脓毒症急性肺损伤(ALI)大鼠的影响及作用机制。方法将35只大鼠随机分为正常组、模型组、地塞米松(DEX)组、中药(TCM)组和TCM+DEX组,每组7只。分别给予相应药物灌胃、造模。酶联免疫吸附实验(ELISA)法检测白细胞介素... 详细信息

目的探讨抗炎通腑方对脓毒症急性肺损伤(ALI)大鼠的影响及作用机制。方法将35只大鼠随机分为正常组、模型组、地塞米松(DEX)组、中药(TCM)组和TCM+DEX组,每组7只。分别给予相应药物灌胃、造模。酶联免疫吸附实验(ELISA)法检测白细胞介素(IL)-6、IL-1β、IL-18、肿瘤坏死因子-α(TNF-α)含量及血清中巨噬细胞计数;采用实时荧光定量多聚核苷酸链式反应(RT-qPCR)和蛋白免疫印迹(Western blot)检测肺组织中干扰素基因刺激因子(STING)、磷酸化干扰素基因刺激因子(P-STING)、NOD样受体热蛋白结构域相关蛋白3(NLRP3)、凋亡相关斑点样蛋白信使核糖核酸(ASC mRNA)和相关蛋白的表达水平。测定肺组织湿/干比(W/D),观察肺组织病理学改变。检测肺组织中巨噬细胞表达情况。结果与正常组比较,各组指标显著升高;与模型组比较,DEX组、TCM组及TCM+DEX组各指标均显著降低。与模型组比较,TCM+DEX组改变最为明显,肺组织损伤改善,W/D值(4.77±0.29 vs.3.78±0.48)及巨噬细胞计数(13.39±2.06 vs.7.09±1.42)均降低(P<0.05),IL-6(152.51±22.27 vs.58.92±13.53)、IL-1β(126.19±10.02 vs.45.69±6.67)、IL-18(59.12±6.31 vs.31.75±4.23)及TNF-α(126.57±8.25 vs.49.59±8.12)水平均降低(P均<0.01),肺组织中线粒体DNA(mtDNA)损伤及释放、P-STING(0.32±0.03 vs.0.16±0.03)、STING mRNA(19.24±2.70 vs.0.32±0.16)、NLRP3 mRNA(20.03±5.06 vs.1.20±0.04)、ASC mRNA(16.96±4.31 vs.3.41±2.52)和相关蛋白的表达均降低(P<0.01)。结论抗炎通腑方可能通过调控mtDNA-STING-NLRP3信号通路减轻脓毒症ALI大鼠的炎症。

关键词：抗炎通腑方 STING-NLRP3信号通路脓毒症急性肺损伤(ALI) 炎症地塞米松巨噬细胞计数

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Edge detection and mathematic fitting for corneal surface with Matlab software

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International Journal of Ophthalmology(English edition) 2017年第3期10卷 336-342页

作者： yue di Mei-Yan Li Tong Qiao Na Lu Department of Ophthalmology Shanghai Children’s HospitalShanghai Jiaotong University Department of Ophthalmology Eye & ENT Hospital Fudan Unversity Department of Radiology Huashan Hospital NorthFudan University

AIM：To select the optimal edge detection methods to identify the corneal surface,and compare three fitting curve equations with Matlab software. METHODS：Fifteen subjects were recruited. The corneal images from optical coherence tomography（OCT）were imported into Matlab software. Five edge detection methods（Canny,Log,Prewitt,Roberts,Sobel）were used to identify the corneal surface. Then two manual identifying methods（ginput and getpts）were applied to identify the edge coordinates respectively. The differences among these methods were compared. Binomial curve（y=Ax2＋Bx＋C）,Polynomial curve [p（x）=p1xn＋p2x（n-1）＋....＋pnx＋pn＋1] and Conic section（Ax2＋Bxy＋Cy2＋Dx＋Ey＋F=0）were used for curve fitting the corneal surface respectively. The relative merits among three fitting curves were analyzed. Finally,the eccentricity（e）obtained by corneal topography and conic section were compared with paired t-test. RESULTS：Five edge detection algorithms all had continuous coordinates which indicated the edge of the corneal surface. The ordinates of manual identifying were close to the inside of the actual edges. Binomial curve was greatly affected by tilt angle. Polynomial curve was lack of geometrical properties and unstable. Conic section could calculate the tilted symmetry axis,eccentricity,circle center,etc. There were no significant differences between ＇e＇ values by corneal topography and conic section（t=0.9143,P=0.3760 〉0.05）.CONCLUSION：It is feasible to simulate the corneal surface with mathematical curve with Matlab software. Edge detection has better repeatability and higher efficiency. The manual identifying approach is an indispensable complement for detection. Polynomial and conic section are both the alternative methods for corneal curve fitting. Conic curve was the optimal choice based on the specific geometrical properties.

关键词： Matlab software edge detection curve fitting mathematic simulation optical coherence tomography corneal topography

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Intraocular pressure with rebound tonometry and effects of topical intraocular pressure reducing medications in guinea pigs

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International Journal of Ophthalmology(English edition) 2017年第2期10卷 186-190页

作者： yue di Xiu-Mei Luo Tong Qiao Na Lu Department of Ophthalmology Shanghai Children’s HospitalShanghai Jiao Tong University Department of Ophthalmology Jinshan HospitalFudan University Department of Radiology Huashan Hospital NorthFudan University

AIM： To investigate the intraocular pressure（IOP） of adult guinea pig eyes with rebound tonometry（RBT）,and assess the effects of four distinctive topical IOP reducing medications including Carteolol,Brimonidine,Brinzolamide and Latanoprost.METHODS： The IOPs of twenty-four 12-week-old guinea pigs（48 eyes） were measured every two hours in one day with RBT as baselines.All the animals were then divided into four groups（Carteolol,Brimonidine,Brinzolamide and Latanaprost groups,n=6）.The IOPs were measured and compared to the baseline 1,2,3,5,7,9,15 and 24 h after treatment.RESULTS： The mean baseline IOP of 24 guinea pigs（48 eyes） was 10.3±0.36 mm Hg（6-13 mm Hg） and no binocular significant differences of IOPs were observed（t=1.76,P〉0.05）.No significant difference of IOP in Carteolol group at each time point was observed before and after treatment（t=1.48,P〉0.05）.In Brimonidine group,IOP was 2.2±1.9 mm Hg lower than the baseline after one hour（t=3.856,P=0.003） and lasted for one hour.In Brinzolamide group,IOP was 1.4±1.1 mm Hg lower than the baseline after one hour（t=4.53,P=0.001） and lasted for 7h and the IOP declined most at 3h.In Latanaprost group,IOP was 2.1±1.3 mm Hg lower than the baseline after one hour（t=6.11,P=0.001） and lasted for one hour.CONCLUSION： The IOP of guinea pig eyes is relatively stable compared to human eyes.In four reducing IOP medications,no significant effect of Carteolol is observed.Brinzolamide has the longest duration,while the Brimonidine has the shortest duration and the maximum level of treatment.

关键词： guinea pig intraocular pressure Carteolol Brinzolamide Brimonidine Latanoprost

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清洁能源贸易格局演变及影响机制研究——以氢气为例

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价格月刊 2024年第6期 53-63页

作者：张永礼康跃迪天津科技大学经济与管理学院天津300457 河北地质大学管理学院河北石家庄050031

选取2011-2022年全球125个国家(地区)氢气贸易数据,基于时间指数随机图模型研究了氢气全球贸易依赖网络动态演化机制,并对发达国家和发展中国家两个群体进行异质性检验。结果表明:氢气全球贸易依赖网络具有“小世界”“中心-边缘”“多... 详细信息

选取2011-2022年全球125个国家(地区)氢气贸易数据,基于时间指数随机图模型研究了氢气全球贸易依赖网络动态演化机制,并对发达国家和发展中国家两个群体进行异质性检验。结果表明:氢气全球贸易依赖网络具有“小世界”“中心-边缘”“多核”结构特征,“富人俱乐部”现象明显;相较于2011年,2022年全球清洁能源贸易网络社群结构发生了较大变化,美国主导的集群大幅拓展,英国主导的集群日益收缩,英俄贸易中断;中美之间存在非对称性依赖,中国在网络中扮演跟随者角色;网络结构演化同时受到内外生效应影响,是一种高度自组织过程,存在较强的等级效应和分层级网络集聚现象,网络中部分国家间互有双向贸易行为,且倾向以群体结构运作;内外生效应对国家贸易依赖的影响因国家经济发展水平不同而具有异质性。

关键词：清洁能源贸易格局异质性检验全球氢气贸易依赖网络

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Myopia induced by flickering light in guinea pigs: a detailed assessment on susceptibility of different frequencies

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International Journal of Ophthalmology(English edition) 2013年第2期6卷 115-119页

作者： yue di Rui Liu Ren-Yuan Chu Xing-Tao Zhou Xiao-Dong Zhou Department of Ophthalmology Jinshan Hospital Fudan University Department of Ophthalmology Eye Ear Nose and Throat Hospital Fudan University

AIM: To investigate the effectiveness and feasibility of inducing myopia in guinea pigs by flickering light (FL) stimulation with different frequencies. METHODS: Seventy 2 -week-old guinea pigs were randomly assigned to six groups: five FL groups and a control group (n =12 for each). Animals in the five FL groups were raised under 500lx illumination with a duty diurnal cycle of 50% at a flash rate of 5, 1, 0.5, 0.25 and 0.1Hz respectively. Those in the control group were reared under steady 250lx illumination. Refraction, axial length, and radius of curvature were measured before and at 2, 4, 6, 8, 10 and 12 weeks after treatment. At week 12, the eyeballs were taken out and three ocular dimensions and dry weight of sclera were measured. RESULTS: A myopic shift and axial eye length increase developed in the five FL groups. Stimulation at 0.5Hz caused greater changes in myopic shift, axial elongation, eyeball dimension, and dry weight of sclera than stimulation at other frequencies. Compared with controls, eyes in 0.5Hz group were approximately -5.5 ±1.5D more myopic with increase in horizontal, vertical, axial dimensions by 0.89 ±0.3mm, 0.69 ±0.2mm, 1.12 ±0.2mm respectively and with increase in dry weight of sclera by 0.44mg. CONCLUSION: Chronic exposure to periodic illumination at temporal frequency is attended by development of excessive ocular enlargement and myopic refractive error. Emmetropization could bedisrupted differently by frequency alteration.

关键词： myopia flickering illumination stimulus guinea pig animal model eye development

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影响工业还原罐内铝热法炼镁过程还原效率的因素

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Transactions of Nonferrous Metals Society of China 2024年第4期34卷 1288-1299页

作者：傅大学王耀武狄跃忠彭建平冯乃祥东北大学多金属共生矿生态化冶金教育部重点实验室沈阳110819 东北大学冶金学院沈阳110819

在工业还原罐内进行铝热还原炼镁试验,分析影响还原效率的因素。结果表明:结晶镁的氧化和燃烧以及原料混合不均匀是导致还原效率降低的主要原因;原料混合不均匀导致贫铝区和MgO剩余,促进生成12CaO·7Al_(2)O_(3)和CaO·Al_(2)O_(3);对... 详细信息

在工业还原罐内进行铝热还原炼镁试验,分析影响还原效率的因素。结果表明:结晶镁的氧化和燃烧以及原料混合不均匀是导致还原效率降低的主要原因;原料混合不均匀导致贫铝区和MgO剩余,促进生成12CaO·7Al_(2)O_(3)和CaO·Al_(2)O_(3);对于富铝区域,MgO和CaO同时被还原,生成Mg_(2)Ca相。辐射传热和化学反应吸热是影响还原速率的关键因素;提高加热温度能够迅速提高球团层的温度,进而使球团获得足够的反应速度;此外,球团中含镁量越高,需要的反应时间越长。

关键词：镁冶金真空铝热还原皮江法传热

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PD-1单抗后线辅助治疗晚期结直肠癌患者对胃肠功能、肿瘤标志物的影响

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临床和实验医学杂志 2024年第9期23卷 941-945页

作者：吴翔岳春迪李春芸海口市人民医院监管医疗科海南海口570206

目的分析程序性死亡受体-1(PD-1)单抗后线辅助治疗晚期结直肠癌患者对胃肠功能、肿瘤标志物的影响。方法前瞻性选取2020年1月至2023年1月海口市人民医院收治的105例晚期结直肠癌患者为研究对象,按照随机数字表法将患者分为对照组(n=50)... 详细信息

目的分析程序性死亡受体-1(PD-1)单抗后线辅助治疗晚期结直肠癌患者对胃肠功能、肿瘤标志物的影响。方法前瞻性选取2020年1月至2023年1月海口市人民医院收治的105例晚期结直肠癌患者为研究对象,按照随机数字表法将患者分为对照组(n=50)、研究组(n=55)。对照组采用阿帕替尼治疗,研究组在对照组的基础上联合PD-1单抗后线治疗,3周为1个疗程,共治疗4个疗程。比较两组的临床疗效、胃肠功能改善时间,治疗前、治疗12周后的肿瘤标志物[癌胚抗原、糖类抗原(CA)72-4、CA199]、免疫功能(CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))指标以及不良反应发生情况。结果治疗12周后,研究组的客观缓解率(ORR)、病情控制率(DCR)分别为78.33%、90.91%,均高于对照组(58.00%、70.00%),差异均有统计学意义(P0.05)。结论通过PD-1单抗后线辅助治疗可有效改善晚期结直肠癌患者的临床疗效,效果明显,改善胃肠功能,降低肿瘤标志物指标水平,调节机体免疫功能,可为临床干预此病提供参考。

关键词：结直肠肿瘤晚期结直肠癌程序性死亡受体-1单抗胃肠功能肿瘤标志物

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