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Response mechanism of Chlamydomonas reinhardtii to nanoscale bismuth oxyiodide(nano-BiOI):Integrating analysis of mineral nutrient metabolism and metabolomics

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Journal of Environmental Sciences 2022年第11期34卷 13-24页

作者： Yan Huang Jinlong Lai Yang Huang Xuegang Luo Xu Yang Zewei Liu yue duan Chen Li School of Life Sciences Southwest University of Science and TechnologyMianyang 621010China College of Environment and Resources Southwest University of Science and TechnologyMianyang 621010China Laboratory of Solid Waste Treatment and Resource Recycle Ministry of EducationMianyang 621010China College of Chemical and Environment Science Shaanxi University of TechnologyHanzhong 723000China

Nanoscale bismuth oxyiodide(nano-BiOI) is widely studied and applied in environmental applications and biomedical fields, with the consequence that it may be deposited into aquatic environments. However, the impact of nano-Bi OI on aquatic ecosystems, especially freshwater microalga, remains limited. Herein, the nano-Bi OI was synthesized and its response mechanism towards microalga Chlamydomonas reinhardtii was evaluated. Results showed that a low concentration of nano-Bi OI(5 mg/L) could stimulate algal growth at the early stage of stress. With the increase in concentration, the growth rate of algal cells was inhibited and showed a dose effect. Intracellular reactive oxygen species(ROS) were significantly induced and accompanied by enhanced lipid peroxidation, decreased nonspecific esterase activity, and significantly upregulated glutathione S-transferase activity(GST) activity. Mineral nutrient metabolism analysis showed that nano-Bi OI significantly interfered with the mineral nutrients of the algae. Non-targeted metabolomics identified 35 different metabolites(DEMs, 22 upregulated, and 13 downregulated) under 100 mg/L Bi OI *** pathway analysis demonstrated that a high concentration of nano-Bi OI significantly induced metabolic pathways related to amino acid biosynthesis, lipid biosynthesis,and glutathione biosynthesis, and significantly inhibited the sterol biosynthesis *** finding will contribute to understanding the toxicological mechanisms of nano-Bi OI on C. reinhardtii.

关键词： Chlamydomonas reinhardtii Nano-BiOI Mineral nutrient Metabolomics

Polarization of the dielectronic recombination satellites including the generalized Breit interaction effects

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原子与分子物理学报 2006年第B4期23卷 21-25页

作者： WU Ze-qing LI yue-ming duan Bin ZHANG Hong Institute of Applied Physics and Computational Mathematics. Laboratory of Computational Physics P. O. Box 8009-57 Beijing 100088 P.R. China）

The polarizations of dielectronic recombination satellite lines for hydrogenlike F to U ions are calculated including the generalized Breit interaction(GBI). The calculated values of the asymmetry parameter are compared with other theoretical results and good agreements are obtained for all lines except for those from the level 2s2p3P1. The GBI effects on the polarization become much stronger as the atomic number increases. However, for different lines, the GBI effects on the polarization are different.

关键词：偏振 GBI 电子重组理论结构原子结构

Partition method for impact dynamics of flexible multibody systems based on contact constraint

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Applied Mathematics and Mechanics(English Edition) 2013年第11期34卷 1393-1404页

作者：段玥晨章定国洪嘉振 School of Mechanical Engineering Zhengzhou University School of Science Nanjing University of Science and Technology Department of Engineering Mechanics Shanghai Jiao Tong University

The impact dynamics of a flexible multibody system is investigated. By using a partition method, the system is divided into two parts, the local impact region and the region away from the impact. The two parts are connected by specific boundary conditions, and the system after partition is equivalent to the original system. According to the rigid-flexible coupling dynamic theory of multibody system, system＇s rigid-flexible coupling dynamic equations without impact are derived. A local impulse method for establishing the initial impact conditions is proposed. It satisfies the compatibility con- ditions for contact constraints and the actual physical situation of the impact process of flexible bodies. Based on the contact constraint method, system＇s impact dynamic equa- tions are derived in a differential-algebraic form. The contact/separation criterion and the algorithm are given. An impact dynamic simulation is given. The results show that system＇s dynamic behaviors including the energy, the deformations, the displacements, and the impact force during the impact process change dramatically. The impact makes great effects on the global dynamics of the system during and after impact.

关键词： flexible multibody system impact dynamics partition method impulse-momentum method contact constraint

Pharmacophenomics: the systematical paradigm for pharmacology of traditional Chinese medicine

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中国药理学与毒理学杂志 2018年第4期32卷 256-257页

作者： Ling-yu Linda YE Si-jin YANG Da-yue Darrel duan Center for Phenomics of Traditional Chinese Medicine and the Affiliated Hospital of Traditional Chinese MedicineSouthwest Medical University Department of Pharmacology University of Nevada Reno School of Medicine

In traditional Chinese medicine(TCM),abnormal and diseased conditions have been defined as Zheng Hou,a unique disease definition system in the context of *** over 3000 years the main clinical treatment method for TCM therapeutics has been so called Fang-ji,a TCM medicinal formula usually composed of several herbs and medical *** compositions of Fang-ji are based on the clinical practice under the guidelines of "bian-zheng-lun-zhi" and the principles of "Jun-chen-zuo-shi".Each Zheng is treated with a correspondingly-individualized *** modern approach to the study of Fang-ji pharmacology,however,has been focusing on the isolation and identification of individual active components for cellular and molecular *** this approach has led to the development of many new monomers purified from Fang-ji as new drugs widely used in clinical practice such as the *** artemsinin,which has earned a Nobel Prize,the pharmacological bases of these purified effective monomers or active components have lost the TCM characteristics and are far different from the *** theory and clinical applications of Fang-ji,in terms of the principles of "bian-zheng-lun-zhi" and "Jun-chen-zuo-shi".Here we introduce the emerging pharmacophenophenics as a systematical paradigm for the pharmacological study of *** studies the orchestrated multitarget pharmacology of combination *** well-defined molecular mechanisms of Zheng Hou at the level of multi-omics and a suite of new phenomics technologies and platforms,the *** may be used to characterize the drug-response phenome of Fang-ji and to identify the *** multiple therapeutic targets according to the TCM theory of *** study of Fang-ji will also lay a theoretical foundation for the new science of precision medicine.

关键词：中医病变治疗方法临床分析

The lymphatic system:a therapeutic target for central nervous system disorders

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Neural Regeneration Research 2023年第6期18卷 1249-1256页

作者： Jia-Qi Xu Qian-Qi Liu Sheng-Yuan Huang Chun-yue duan Hong-Bin Lu Yong Cao Jian-Zhong Hu Department of Spine Surgery and Orthopaedics Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangshaHunan ProvinceChina Mobile Health Ministry of Education-China Mobile Joint Laboratory ChangshaHunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Cardiovascular Surgery The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Sports Medicine Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

The lymphatic vasculature forms an organized network that covers the whole body and is involved in fluid homeostasis,metabolite clearance,and immune *** recent identification of functional lymphatic vessels in the meninges of the brain and the spinal cord has provided novel insights into *** emerge as major pathways for fluid *** abundance of immune cells in lymphatic vessels and meninges also suggests that lymphatic vessels are actively involved in *** lymphatic system,through its role in the clearance of neurotoxic proteins,autoimmune cell infiltration,and the transmission of pro-inflammatory signals,participates in the pathogenesis of a variety of neurological disorders,including neurodegenerative and neuroinflammatory diseases and traumatic *** endothelial growth factor C is the master regulator of lymphangiogenesis,a process that is critical for the maintenance of central nervous system *** this review,we summarize current knowledge and recent advances relating to the anatomical features and immunological functions of the lymphatic system of the central nervous system and highlight its potential as a therapeutic target for neurological disorders and central nervous system repair.

关键词： central nervous system central nervous system injury glymphatic system lymphatic vessels meninges neurodegenerative disorders neuroinflammatory diseases vascular endothelial growth factor C

Effects of heat treatment on magnetic properties of Co-Fe-plated hollow ceramic microspheres

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Progress in Natural Science:Materials International 2011年第5期21卷 392-400页

作者： Xiang LI,yue-xin duan,Yan ZHAO,Lei ZHU School of Materials Science and Engineering,Beijing University of Aeronautics and Astronautics, Beijing 100191,China School of Materials Science and Engineering Beijing University of Aeronautics and Astronautics Beijing 100191 China

Functional hollow ceramic microspheres plated with Co-Fe were obtained through electroless plating technique for the application of lightweight microwave *** were treated at different temperatures by vacuum annealing *** surface-coated hollow microspheres were characterized by scanning electron microscopy(SEM) and X-ray diffraction analysis (XRD).The microwave electromagnetic loss and absorbing properties of hollow microspheres plated with Co-Fe were tested by network vector *** magnetic properties were tested by vibrating sample magnetometer(VSM).The results show that the annealing treatment changed the crystal phase of Co from HCP to FCC,simultaneously increased the crystallinity and crystal size of Co and Fe in coating ***,after annealing at 800℃or 1 000℃,the microwave absorbing properties and soft magnetic properties of hollow microspheres plated with Co-Fe were further improved.

关键词： electroless plating hollow ceramic microspheres magnetic properties heat treatment Co-Fe

Ambiently fostering solid electrolyte interphase for low-temperature lithium metal batteries

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Journal of Energy Chemistry 2023年第12期87卷 473-478,I0012页

作者： Jia-yue duan Jin-Xiu Chen Fang-Fang Wang Jin-Hao Zhang Xiao-Zhong Fan Liping Wang Yingze Song Wei Xia Yusheng Zhao Long Kong Frontiers Science Center for Flexible Electronics and Xi’an Institute of Flexible Electronics(IFE) Northwestern Polytechnical UniversityXi’an 710129ShaanxiChina Department of Physics Academy for Advanced Interdisciplinary StudiesSouthern University of Science and TechnologyShenzhen 518055GuangdongChina State Key Laboratory of Environment-Friendly Energy Materials School of Materials Science and EngineeringGraphene Joint Innovation CentreSouthwest University of Science and TechnologyMianyang 621010SichuanChina Eastern Institute for Advanced Study Eastern Institute of TechnologyNingbo 315201ZhejiangChina

Despite being a leading candidate to meet stringent energy targets,lithium(Li) metal batteries(LMBs)face severe challenges at low temperatures such as dramatic increase in impedance,capacity loss and dendrite *** fingerprinting rate-limited factors of low-temperature LMBs would encourage targeted approaches to promote ***,the charge transfer impedance across solid electrolyte interphase(SEI) is identified to restrict battery operation under low temperature,and we propose a facile approach on the basis of ambiently fostering SEI(af-SEI) to facilitate charge *** concept of af-SEI stems from kinetic benefits and structural merits to construct SEI at ambient temperature over low temperature developed SEI that is temporally consuming to achieve steady state and that is structurally defective to incur dendrite *** af-SEI allows ionically conductive and morphologically uniform layer on the anode surface,which exhibits a lower resistance and induces an even deposition of Li in the subsequent low temperature battery *** with af-SEI,the LMBs deliver the improved rate performance and prolonged cycle life when subjected to low temperature *** work unveils the underlying causes that limit low temperature LMB performances,and enlightens the facile test protocols to build up favorable SEI,beyond scope of material and morphology design.

关键词： Li matel batteries Ambiently fostering SEI Charge transfer impedance Low temperature kinetics

Migration of Adipose-derived Mesenchymal Stem Cells Stably Expressing Chondroitinase ABC In vitro

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Chinese Medical Journal 2016年第13期129卷 1592-1599页

作者： Jian-Huang Wu Miao Li Yan Liang Tao Lu Chun-yue duan Department of Spine Surgery Xiangya Hospital Central South University Changsha Hunan 410008 China

Background： Several studies have revealed that adipose-derived mesenchymal stem cells （ADSCs） can be used as seed cells for the treatment of spinal cord injury （SCI）. Chondroitinase ABC （ChABC） decomposes chondroitin sulfate proteoglycans in the glial scar that forms following SCI, allowing stem cells to penetrate through the scar and promote recovery of nerve function. This study aimed to establish ADSCs that stably express ChABC （ChABC-ADSCs） and evaluate the migratory capability of ChABC-ADSCs in vitro. Methods： ADSCs were obtained from Sprague-Dawley rats using secondary collagenase digestion. Their phenotypes were characterized using flow cytometry detection of cell surface antigens and their stem cell properties were confirmed by induction of differentiation. After successful culture, ADSCs were transfected with lentiviral vectors and ChABC-ADSCs were obtained. Proliferation curves of ChABC-ADSCs were determined using the Cell Counting Kit-8 method, ChABC expression was verified using Western blotting, and the migration of ChABC-ADSCs was analyzed using the transwell assay. Results： Secondary collagenase digestion increased the isolation efficiency of primary ADSCs. Following transfection using lentivira[ vectors, the proliferation of ChABC-ADSCs was reduced in comparison with control ADSCs at 48 h （P 〈 0.05）. And the level of ChABC expression in the ChABC-ADSC group was significantly higher than that of the ADSC group （P 〈 0.05）, Moreover, ChABC-ADSC migration in matrigel was significantly enhanced in comparison with the control （P 〈 0.05）. Conclusions： Secondary collagenase digestion can be used to effectively isolate ADSCs. ChABC-ADSCs constructed using lentiviral vector transfection stably express ChABC, and ChABC expression significantly enhances the migratory capacity of ADSCs.

关键词： Adipose-derived Mesenchymal Stem Cells Chondroitinase ABC Spinal Cord Injury

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基于弹塑性接触的柔性多体系统碰撞动力学

南京理工大学学报 2012年第2期36卷 189-194页

作者：段玥晨章定国南京理工大学理学院江苏南京210094

为了研究作大范围回转运动的柔性梁与固定刚性质量发生正碰撞的动力学问题,该文以柔性多体系统刚柔耦合动力学理论为基础,考虑非线性耦合变形项和碰撞力势能概念,利用假设模态法和Lagrange方程建立了含碰撞力的系统刚柔耦合动力学方程... 详细信息

为了研究作大范围回转运动的柔性梁与固定刚性质量发生正碰撞的动力学问题,该文以柔性多体系统刚柔耦合动力学理论为基础,考虑非线性耦合变形项和碰撞力势能概念,利用假设模态法和Lagrange方程建立了含碰撞力的系统刚柔耦合动力学方程。该方程可以处理系统无碰撞和有碰撞的全局动力学问题。基于单轴压缩弹塑性接触模型将接触碰撞过程分为弹性加载、塑性加载和弹性卸载3个阶段,给出了描述碰撞过程的方法和接触判定条件。碰撞动力学仿真算例描述了碰撞过程中的碰撞力、变形、角位移等动力学特性。弹塑性接触模型与非线性弹簧阻尼模型的仿真结果对比发现,两种接触模型描述接触碰撞阶段和碰撞能量损失的方法不同,得到的碰撞力大小亦不同;弹塑性接触模型更接近实际情况,适用性较强。

关键词：柔性多体系统刚柔耦合碰撞弹塑性接触