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Effects of surface energy and substrate on modulus determination of biological films by conical indentation

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Science China(Technological Sciences) 2024年第6期67卷 1757-1764页

作者： ding yue LI Cheng-Ya NIU XinRui WANG Gang-Feng Department of Engineering Mechanics SVLXi’an Jiaotong UniversityXi’an710049China Department of Mechanical Engineering City University of Hong KongHong Kong SAR999077China

Micro-/nano-indentation has become prevalent in evaluating the mechanical characteristics of biological samples,such as cells and ***,the existing contact models describing conical indentation ignore the joint effects of surface energy and substrate,and consequently cannot accurately extract the Young's modulus of biological samples deposited on *** finite element methods,we examine the conical indentation of biological films on substrates while taking surface energy into *** on the dimensional analysis,the explicit relationship between load and indentation depth is achieved for films with their moduli varying from 0.001 to 100 times that of the *** the classical Sneddon's model was employed to analyze the load-depth data,the measured modulus could reach 18 times the real modulus for films on harder substrates,but only 4%of the real modulus for films on softer ***,in micro-/nano-indentations,neglecting the contribution of surface energy would result in an overestimation of the Young's modulus of films depending on the contact *** analytical expression provided here can be utilized to precisely deduce the mechanical characteristics of biological films deposited on substrate from the load and indentation depth data of a conical indentation.

关键词： biological film surface effect substrate effect indentation

Water–soluble and polarity–sensitive near–infrared fluorescent probe for long–time specific cancer cell membranes imaging and C. Elegans label

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Chinese Chemical Letters 2024年第4期35卷 321-323页

作者： Lixian Fu Yiyun Tan yue ding Weixia Qing Yong Wang Henan International Joint Laboratory of Medicinal Plants Utilization College of Chemistry and Molecular SciencesHenan UniversityKaifeng 475004China School of Basic Medical Science Henan UniversityKaifeng 475004China

A novel D–π –A structure and near–infrared fluorescent probe(DCITT) with high polarity sensitivity and membrane targeting was reported. The fluorescent spectra of DCITT were polarity dependent and Stokes shift was greater than 300 nm. Due to its high fluorescence quantum yield, low cytotoxicity and photostability, DCITT could be used as a labeling probe in multicellular organisms. In particular, DCITT effectively distinguished tumor cells from normal cells because it could specifically light up the cancer cells membrane based on strong red fluorescence for a long time. On this basis, a polar–sensitive cell membrane probe is developed to differentiate tumor cells from normal cells, which provides an idea and method for the early diagnosis of tumor at cellular level.

关键词： NIR–fluorescent probe Polarity–sensitive Bioimaging Targeting cell membrane Differentiate tumor and normal cells

CXCL13 shapes tumor immune microenvironment in ovarian cancer with homologous recombination deficiency

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Genes & Diseases 2024年第5期11卷 48-50页

作者： yue ding Zheng Ye Bo ding Songwei Feng Furong Du Xuejiao Ma Xiaoxuan Wang Yang Shen Department of Obstetrics and Gynaecology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu 210008China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjingJiangsu 210096China State Key Laboratory of Translational Medicine and Innovative Drug Development Jiangsu Simcere Diagnostics Co.Ltd.NanjingJiangsu 210042China

Recently,immune checkpoint inhibitors(ICIs)and poly(ADP-ribose)polymerase inhibitors(PARPi)have played a pivotal role in prolonging the recurrence-free survival of patients with ovarian cancer(OC).1,2 Although PARPi have revolutionized the treatment of OC,the absence of reliable predictive biomarkers limits the broad application of ICIs for patients with homologous recombination(HR)deficiency(HRD).3 CXC-chemokine ligand 13(CXCL13)is a cytokine constitutively secreted in the stromal cells of the B-cell region of secondary lymphoid tissue.4 It exclusively binds to the chemokine receptor CXCR5,which is abundantly expressed in subsets of mature circulating B lymphocytes,follicular helper T cells,and skin-derived dendritic cells,and governs the migration of these cells into secondary lymphoid organs in response to the CXCL13 gradient.5 In this study,we aimed to elucidate the role of CXCL13 in shaping the tumor immune microenvironment(TIME)in HR-deficient OC and to explore its relationship with the cGAS-STING signaling pathway.

关键词： CXCL13 cancer organs

Discovery and structure-activity relationship studies of novel tetrahydro-β-carboline derivatives as apoptosis initiators for treating bacterial infections

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Journal of Integrative Agriculture 2024年第4期23卷 1259-1273页

作者： Shanshan Su Hongwu Liu Junrong Zhang Puying Qi yue ding Ling Zhang Linli Yang Liwei Liu Xiang Zhou Song Yang National Key Laboratory of Green Pesticide/Key Laboratory of Green Pesticide and Agricultural Bioengineering Ministry of Education/Center for R&D of Fine ChemicalsGuizhou UniversityGuiyang 550025China

Developing and excavating new agrochemicals with highly active and safe is an important tactic for protecting crop health and food *** this paper,to discover the new bactericide candidates,we designed,prepared a new type of1,2,3,4-tetrahydro-β-carboline(THC)derivatives and evaluated the in vitro and in vivo bioactivities against the Xanthomonas oryzae ***(Xoo),Xanthomonas axonopodis ***(Xac),and Pseudomonas syringae ***(Psa).The in vitro bioassay results exhibited that most title molecules possessed good activity toward the three plant pathogenic bacteria,the compound A17 showed the most active against Xoo and Xac with EC50 values of 7.27 and 4.89 mg mL^(-1)respectively,and compound A8 exhibited the best inhibitory activity against Psa with EC50value of 4.87 mg mL^(-1).Pot experiments showed that compound A17 exhibited excellent in vivo antibacterial activities to manage rice bacterial leaf blight and citrus bacterial canker,with protective efficiencies of 52.67 and 79.79%at 200 mgmL^(-1),***,compound A8 showed good control efficiency(84.31%)against kiwifruit bacterial canker at 200 mg mL^(-1).Antibacterial mechanism suggested that these compounds could interfere with the balance of the redox system,damage the cell membrane,and induce the apoptosis of Xoo *** together,our study revealed that tetrahydro-β-carboline derivatives could be a promising candidate model for novel broadspectrum bactericides.

关键词： tetrahydro-β-carboline derivatives antibacterial activity ROS cell apoptosis

Dynamic intrauterine crosstalk promotes porcine embryo implantation during early pregnancy

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Science China(Life Sciences) 2024年第8期67卷 1676-1696页

作者： Xupeng Zang Shengchen Gu Wenjing Wang Junsong Shi Jianyu Gan Qun Hu Chen Zhou yue ding Yanjuan He Lei Jiang Ting Gu Zheng Xu Sixiu Huang Huaqiang Yang Fanming Meng Zicong Li Gengyuan Cai Linjun Hong Zhenfang Wu State Key Laboratory of Swine and Poultry Breeding Industry National Engineering Research Center for Breeding Swine IndustryCollege of Animal ScienceSouth China Agricultural UniversityGuangzhou 510642China Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding South China Agricultural UniversityGuangzhou 510642China Yunfu Subcenter of Guangdong Laboratory for Lingnan Modern Agriculture Yunfu 527300China Guangdong Key Laboratory of Animal Breeding and Nutrition Institute of Animal ScienceGuangdong Academy of Agricultural SciencesGuangzhou 510640China Key Laboratory of South China Modern Biological Seed Industry Ministry of Agriculture and Rural AffairsGuangzhou 510520China

Dynamic crosstalk between the embryo and mother is crucial during ***,we comprehensively profile the single-cell transcriptome of pig peri-implantation embryos and corresponding maternal endometrium,identifying 4 different lineages in embryos and 13 cell types in the ***-specific gene expression characterizes 4 distinct trophectoderm subpopulations,showing development from undifferentiated trophectoderm to polar and mural *** expression of genes in different types of endometrial cells illustrates their molecular response to embryos during ***,we developed a novel tool,ExtraCellTalk,generating an overall dynamic map of maternal-foetal crosstalk using uterine luminal proteins as *** cross-species comparisons,we identified a conserved RBP4/STRA6 pathway in which embryonic-derived RBP4 could target the STRA6 receptor on stromal cells to regulate the interaction with other endometrial *** results provide insight into the maternal-foetal crosstalk during embryo implantation and represent a valuable resource for further studies to improve embryo implantation.

关键词： endometrial remodeling ExtraCellTalk implantation maternal-foetal crosstalk trophoblast

A likely paleo-autotetraploidization event shaped the high conservation of Nyssaceae genome

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Horticultural Plant Journal 2024年第3期10卷 911-930页

作者： Yishan Feng Zhenyi Wang Qimeng Xiao Jia Teng Jianyu Wang Zijian Yu Jiaqi Wang Qiang Xu Yan Zhang Shaoqi Shen Shoutong Bao Yu Li Zimo Yan yue ding Zihan Liu Yuxian Li Tianyu Lei Min Yuan Xiu-Qing Li Jinpeng Wang Department of Bioinformatics School of Life SciencesNorth China University of Science and TechnologyTangshanHebei 063000China Fredericton Research and Development Centre Agriculture and Agri-Food CanadaFrederictonNew Brunswick E3B 4Z7Canada State Key Laboratory of Systematic and Evolutionary Botany Institute of BotanyChinese Academy of ScienceBeijing 100093China University of Chinese Academy of Sciences Beijing 100049China

Scientific knowledge about the ancestral genome of core eudicot plant kingdom can potentially have profound impacts on both basic and applied research,including evolution,genetics,genomics,ecology,agriculture,forestry,and global *** investigate which plant conserves best the core eudicots common ancestor genome,we compared Arcto-Tertiary relict Nyssaceae and 30 other eudicot plant *** genomes of Davidia involucrata(a known living fossil),Camptotheca acuminata and Nyssa sinensis,one per existent genus of Nyssaceae,were performed comparative genomic *** found that Nyssaceae originated from a single Nyssaceae common tetraploidization event(NCT)-autotetraploidization 28-31 Mya after the core eudicot common hexaploidization(ECH).We identified Nyssaceae orthologous and paralogous genes,determined its chromosomal evolutionary trajectory,and reconstructed the Nyssaceae most recent ancestor *** genome contained the entire seven paleochromosomes and 17 ECH-generated eudicot common ancestor chromosomes and was the slowest in mutation among the analyzed 42 species of 31 plant *** both its high retention of paleochromosomes and its low mutation rate,*** provides the best case in conservation of the core eudicot paleogenome.

关键词： Nyssaceae Polyploidization Multigenome alignment Evolutionary rate Autotetraploidization Karyotype evolution

内镜经鼻入路咽旁段颈内动脉临床解剖研究进展

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临床耳鼻咽喉头颈外科杂志 2024年第4期38卷 354-358页

作者：丁樾孟庆国深圳大学医学部广东深圳518000 深圳大学第一附属医院深圳市第二人民医院耳鼻咽喉头颈外科

位于颅内的颈内动脉节段走行于颅底骨性结构内或颅内,具有明确的解剖标志且解剖结构较为固定,而位于颅外的咽旁段颈内动脉被软组织包围,缺乏清晰可识别的解剖定位标志且常存在解剖变异,其与经鼻内镜手术关系密切,一旦在术中误伤会导致... 详细信息

位于颅内的颈内动脉节段走行于颅底骨性结构内或颅内,具有明确的解剖标志且解剖结构较为固定,而位于颅外的咽旁段颈内动脉被软组织包围,缺乏清晰可识别的解剖定位标志且常存在解剖变异,其与经鼻内镜手术关系密切,一旦在术中误伤会导致严重并发症甚至死亡。目前对于经鼻内镜下咽旁段颈内动脉相关的临床解剖学研究主要聚焦于其解剖变异与解剖标志。本文将从这两个方面进行综述,旨在为外科医师在经鼻内镜手术时提供解剖学参考从而降低手术风险。

关键词：鼻内镜手术颈内动脉解剖学咽旁间隙

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全球外汇市场的结构性新特点

中国金融 2024年第5期 75-77页

作者：丁志杰田园丁玥国家外汇管理局外汇研究中心中国投资有限责任公司博士后科研工作站

2023年,美联储加息见顶,地缘政治风险未减,高通胀问题有所缓解,全球外汇市场震荡分化。从中长期视角看,最长强势美元周期下的全球外汇市场正在显现一些结构性新特点,突出表现为新兴市场和发展中经济体货币韧性增强。展望未来,大国博弈... 详细信息

2023年,美联储加息见顶,地缘政治风险未减,高通胀问题有所缓解,全球外汇市场震荡分化。从中长期视角看,最长强势美元周期下的全球外汇市场正在显现一些结构性新特点,突出表现为新兴市场和发展中经济体货币韧性增强。展望未来,大国博弈下地缘政治风险仍然是最大的不确定性,全球经济似乎正在走向软着陆,但复苏进程缓慢且不平衡,货币政策分化程度或将收窄,外汇市场依然处在“风口浪尖”之中。

关键词：外汇市场美联储加息新兴市场地缘政治风险展望未来长期视角结构性不确定性

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基于网络关系的分类变量预测研究

统计研究 2024年第1期41卷 148-156页

作者：丁月方匡南兰伟徐顺西南交通大学经济管理学院西南交通大学服务科学与创新四川省重点实验室厦门大学经济学院西南财经大学统计学院和统计研究中心四川新网银行

传统的预测方法通常基于个体的协变量信息进行建模和预测,少有考虑个体间的网络结构信息。事实上,网络节点间的关联信息能够为节点的响应变量预测提供信息,为此本文提出网络标签传播算法。基于半监督学习框架,以邻接矩阵为节点相似性推... 详细信息

传统的预测方法通常基于个体的协变量信息进行建模和预测,少有考虑个体间的网络结构信息。事实上,网络节点间的关联信息能够为节点的响应变量预测提供信息,为此本文提出网络标签传播算法。基于半监督学习框架,以邻接矩阵为节点相似性推断依据,通过节点间的连接信息和已知节点的响应变量信息,来推断未知节点的响应变量信息。该算法适用于响应变量为分类变量的不完整网络数据。在网络服从随机分块模型的设定下,本文证明了该算法能够一致地预测未知节点的响应变量。数值模拟和实证数据分析结果显示,该算法预测效果较好。

关键词：不完整网络网络插补网络标签传播分类变量信用风险评估