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Fabrication of High-power White LEDs and White light Uniformity Testing

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Semiconductor Photonics and Technology 2007年第2期13卷 97-103页

作者： YU Xin-mei RAO Hai-bo HU yue li Jun-fei hou Bin School of Optoelectronic Information University of Electronic Science and Technology of China Chengdu 610054 CHN

As the blue and yellow lights are complementary colors, a blue InGaN LED chip is coated hy a yellow phosphor film to generate white light based on luminescence conversion mechanism. The emitted light of a blue LED is used as the primary source for exciting fluorescent material such as cerium doped yttrium aluminum garnet with the formula Y3Al2O12 ： Ce^3＋（in short： YAG ： Ce^3＋）. The matching of the spectrum of the blue LED chips and the YAG ： Ce^3＋ yellow phosphor is studied to improve the conversion efficiency. The packaging methods and manufacturing processes for high power single chip-white LEDs are introduced. The uniformity of the output white light is investigated. Based on the characteristics of the high power white LEDs, some approaches and processes are suggested to improve the light uniformity when they are fabricated. The effectiveness of those approaches on the improvement of LEDs is discussed in detail and some interesting conclusions are also presented.

关键词： solid state lighting high-power white LED packaging phosphor layer matching uniformity

Hypidone hydrochloride(YL-0919)ameliorates functional deficits after traumatic brain injury in mice by activating the sigma-1 receptor for antioxidation

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Neural Regeneration Research 2025年第8期20卷 2325-2336页

作者： Yafan Bai Hui Ma yue Zhang Jinfeng li Xiaojuan hou Yixin Yang Guyan Wang Yunfeng li Department of Anesthesiology Beijing Tongren HospitalCapital Medical UniversityBeijingChina Beijing Institute of Basic Medical Sciences BeijingChina Hebei North University ZhangjiakouHebei ProvinceChina Beijing Institute of Pharmacology and Toxicology State Key Laboratory of Toxicology and Medical CountermeasuresBeijing Key Laboratory of NeuropsychopharmacologyBeijingChina

Traumatic brain injury involves complex pathophysiological mechanisms,among which oxidative stress significantly contributes to the occurrence of secondary *** this study,we evaluated hypidone hydrochloride(YL-0919),a self-developed antidepressant with selective sigma-1 receptor agonist properties,and its associated mechanisms and targets in traumatic brain *** experiments to assess functional deficits were followed by assessment of neuronal damage through histological analyses and examination of blood-brain barrier permeability and brain ***,we investigated the antioxidative effects of YL-0919 by assessing the levels of traditional markers of oxidative stress in vivo in mice and in vitro in HT22 ***,the targeted action of YL-0919 was verified by employing a sigma-1 receptor antagonist(BD-1047).Our findings demonstrated that YL-0919 markedly improved deficits in motor function and spatial cognition on day 3 post traumatic brain injury,while also decreasing neuronal mortality and reversing blood-brain barrier disruption and brain ***,YL-0919 effectively combated oxidative stress both in vivo and in *** protective effects of YL-0919 were partially inhibited by *** results indicated that YL-0919 relieved impairments in motor and spatial cognition by restraining oxidative stress,a neuroprotective effect that was partially reversed by the sigma-1 receptor antagonist ***-0919 may have potential as a new treatment for traumatic brain injury.

关键词： antidepressant drug blood-brain barrier cognitive function hypidone hydrochloride(YL-0919) neurological function nuclear factor-erythroid 2 related factor 2 oxidative stress sigma-1 receptor superoxide dismutase traumatic brain injury

Inhibition of the cGAS–STING pathway:contributing to the treatment of cerebral ischemia-reperfusion injury

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Neural Regeneration Research 2025年第7期20卷 1900-1918页

作者： Hang Yang Yulei Xia yue Ma Mingtong Gao Shuai hou Shanshan Xu Yanqiang Wang School of Clinical Medicine Shandong Second Medical UniversityWeifangShandong ProvinceChina Department of Emergency The Affiliated Hospital of Weifang Medical UniversityWeifangShandong ProvinceChina Department of Neurology Ⅱ The Affiliated Hospital of Weifang Medical UniversityWeifangShandong ProvinceChina

The cGAS–STING pathway plays an important role in ischemia-reperfusion injury in the heart,liver,brain,and kidney,but its role and mechanisms in cerebral ischemia-reperfusion injury have not been systematically ***,we outline the components of the cGAS–STING pathway and then analyze its role in autophagy,ferroptosis,cellular pyroptosis,disequilibrium of calcium homeostasis,inflammatory responses,disruption of the blood–brain barrier,microglia transformation,and complement system activation following cerebral ischemia-reperfusion *** further analyze the value of cGAS–STING pathway inhibitors in the treatment of cerebral ischemia-reperfusion injury and conclude that the pathway can regulate cerebral ischemia-reperfusion injury through multiple *** of the cGAS–STING pathway may be helpful in the treatment of cerebral ischemia-reperfusion injury.

关键词： calcium homeostasis cellular autophagy cerebral ischemia-reperfusion injury cGAS–STING pathway ferroptosis gut–brain–microbiota axis inflammatory light chain 3 microglial cells Syntaxin-17 protein

Low-temperature chlorination roasting technology for the simultaneous recovery of valuable metals from spent liCoO_(2)cathode material

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 80-91页

作者： Junjie Shi Changle hou Jingjing Dong Dong Chen Jianzhong li Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China

With the continuous increase in the disposal volume of spent lithium-ion batteries(liBs),properly recycling spent liBs has become essential for the advancement of the circular *** study presents a systematic analysis of the chlorination roasting kinetics and proposes a new two-step chlorination roasting process that integrates thermodynamics for the recycling of liB cathode *** activation energy for the chloride reaction was 88.41 kJ/mol according to thermogravimetric analysis–derivative thermogravimetry data obtained by using model-free,model-fitting,and Z(α)function(αis conversion rate).Results indicated that the reaction was dominated by the first-order(F1)model when the conversion rate was less than or equal to 0.5 and shifted to the second-order(F2)model when the conversion rate exceeded *** conditions were determined by thoroughly investigating the effects of roasting temperature,roasting time,and the mass ratio of NH_(4)Cl to liCoO_(2).Under the optimal conditions,namely 400℃,20 min,and NH_(4)Cl/liCoO_(2)mass ratio of 3:1,the leaching efficiency of li and Co reached 99.43% and 99.05%,*** of the roasted products revealed that valuable metals in liCoO_(2)transformed into CoCl_(2) and ***,the reaction mechanism was elucidated,providing insights for the establishment of a novel low-temperature chlorination roasting technology based on a crystal structure *** technology can guide the development of liB recycling processes with low energy consumption,low secondary pollution,high recovery efficiency,and high added value.

关键词： spent lithium-ion battery thermodynamics chlorination roasting kinetics circular economy

长非编码RNA GAS5在卵巢癌患者中的低表达及其临床意义（英文）

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中山大学学报（医学科学版） 2017年第5期38卷 746-751页

作者：李婕李银广陈爱月李珠玉侯文汇游泽山中山大学附属第一医院东院妇产科广东广州510700 中山大学附属第一医院妇产科广东广州510080

【目的】探讨长链非编码RNA GAS5在卵巢癌中的表达水平及其临床意义。【方法】收集卵巢癌患者的瘤体组织标本,通过实时荧光定量PCR检测GAS5在卵巢癌组织中的表达水平。采用相关性分析,分析其表达水平与临床病理特征之间的关系、及其与... 详细信息

【目的】探讨长链非编码RNA GAS5在卵巢癌中的表达水平及其临床意义。【方法】收集卵巢癌患者的瘤体组织标本,通过实时荧光定量PCR检测GAS5在卵巢癌组织中的表达水平。采用相关性分析,分析其表达水平与临床病理特征之间的关系、及其与疾病预后之间的关系。【结果】在卵巢癌瘤体组织中GAS5表达显著下降(P=0.0004);GAS5的表达与瘤体体积呈负相关(d5 cm,P<0.000 1);GAS5的表达与肿瘤期别呈负相关(Ⅰ~Ⅱgrades vs.Ⅲ~Ⅳgrades,P=0.0086)。采用Kaplan-Meier分析表明,GAS5表达水平越低患者预后和生存越差。【结论】GAS5在卵巢癌中的表达情况与临床病理特征以及预后相关,可作为潜在的卵巢癌检测标记物。

关键词：长非编码RNA GAS5 卵巢癌临床意义

High‑Entropy Electrode Materials:Synthesis,Properties and Outlook

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Nano-Micro Letters 2025年第1期17卷 472-506页

作者： Dongxiao li Chang liu Shusheng Tao Jieming Cai Biao Zhong Jie li Wentao Deng Hongshuai hou Guoqiang Zou Xiaobo Ji College of Chemistry and Chemical Engineering Central South UniversityChangsha 410083People’s Republic of China School of Chemistry and Chemical Engineering Hunan Institute of EngineeringXiangtan 411104People’s Republic of China

High-entropy materials represent a new category of high-performance materials,first proposed in 2004 and extensively investigated by researchers over the past two *** definition of high-entropy materials has continuously *** the last ten years,the discovery of an increasing number of high-entropy materials has led to significant advancements in their utilization in energy storage,electrocatalysis,and related domains,accompanied by a rise in techniques for fabricating high-entropy electrode ***,the research emphasis has shifted from solely improving the performance of high-entropy materials toward exploring their reaction mechanisms and adopting cleaner preparation ***,the current definition of high-entropy materials remains relatively vague,and the preparation method of high-entropy materials is based on the preparation method of single metal/low-or medium-entropy *** should be noted that not all methods applicable to single metal/low-or medium-entropy materials can be directly applied to high-entropy *** this review,the definition and development of high-entropy materials are briefly ***,the classification of high-entropy electrode materials is presented,followed by a discussion of their applications in energy storage and catalysis from the perspective of synthesis ***,an evaluation of the advantages and disadvantages of various synthesis methods in the production process of different high-entropy materials is provided,along with a proposal for potential future development directions for high-entropy materials.

关键词： High-entropy Energy storage Electrode materials

Advances in Graphene‑Based Electrode for Triboelectric Nanogenerator

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Nano-Micro Letters 2025年第1期17卷 378-403页

作者： Bin Xie Yuanhui Guo Yun Chen Hao Zhang Jiawei Xiao Maoxiang hou Huilong liu li Ma Xin Chen Chingping Wong State Key Laboratory of Precision Electronic Manufacturing Technology and Equipment Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Electromechanical Engineering Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

With the continuous development of wearable electronics,wireless sensor networks and other micro-electronic devices,there is an increasingly urgent need for miniature,flexible and efficient nanopower generation *** nanogenerator(TENG)technology can convert small mechanical energy into electricity,which is expected to address this *** the core component of TENG,the choice of electrode materials significantly affects its *** metal electrode materials often suffer from problems such as durability,which limits the further application of ***,as a novel electrode material,shows excellent prospects for application in TENG owing to its unique structure and excellent electrical *** review systematically summarizes the recent research progress and application prospects of TENGs based on graphene *** precision processing methods of graphene electrodes are introduced,and the applications of graphene electrode-based TENGs in various scenarios as well as the enhancement of graphene electrodes for TENG performance are *** addition,the future development of graphene electrode-based TENGs is also prospectively discussed,aiming to promote the continuous advancement of graphene electrode-based TENGs.

关键词： Triboelectric nanogenerator Precision processing Graphene electrode Self-powered sensor

全柱成像毛细管等电聚焦电泳分析蛋白质药物电荷异质性

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分析测试学报 2017年第3期36卷 343-348页

作者：孟晓光甄里刘悦玫侯利平刘丹李斌欧阳伟民魏开华北京正旦国际科技有限责任公司北京102206 北京蛋白质组研究中心蛋白质组学国家重点实验室国家蛋白质科学中心(北京) 北京102206 江汉大学护理与医学技术学院湖北武汉430056 北京绿绵科技有限公司北京100080 军事医学科学院放射与辐射医学研究所北京100850

评价了cIEF-WCID检测多肽与蛋白质药物等电点的应用效果。测定标准多肽的等电点,验证了cIEF-WCID具有高的准确度和良好的重复性(相对标准偏差<0.50%)。人血红蛋白的4种主要异构体实现了基线分离;甘赖胰岛素的重复测试均只检出单一特征峰... 详细信息

评价了cIEF-WCID检测多肽与蛋白质药物等电点的应用效果。测定标准多肽的等电点,验证了cIEF-WCID具有高的准确度和良好的重复性(相对标准偏差<0.50%)。人血红蛋白的4种主要异构体实现了基线分离;甘赖胰岛素的重复测试均只检出单一特征峰(p I 5.95±0.01);比较重组人生长激素原液和成品,等电点特征峰比例差异明显,且成品有新特征峰出现;对比进口及国产贝伐单抗,发现厂家1、3与原研药基本一致,厂家1的主成分迁移规律与原研药高度一致,厂家2的重链C末端K缺失、N末端焦谷氨酸环化或脱酰胺修饰影响了电荷异质性;通过考察尿素浓度、电解质范围和聚焦时间,优化了检测重组人促卵泡素等电点条件:2 mol/L尿素,两性电解质pH 2.5~5.0与pH 3.0~10.0按1∶1混合,聚焦电压1 000 V(1 min)~1 800 V(4 min)~2 200 V(1 min)。cIEF-WCID可快速、准确测定具有电荷异质性的蛋白类药物等电点,分辨率和重复性好,尤其是可以跟踪聚焦过程中样本的迁移特征,特别适合蛋白类药物复杂电荷异质性的检测。

关键词：全柱成像毛细管等电聚焦电泳电荷异质性重组蛋白质药物抗体药学研究

LaneDraw: Cascaded lane and its bifurcation detection with nested fusion

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Science China(Technological Sciences) 2021年第6期64卷 1238-1249页

作者： REN KeYan hou HaoChen li SiYang yue TianYi Faculty of Information Technology Beijing University of TechnologyBeijing 100124China Beijing Engineering Research Center for IoT Software and Systems Beijing 100124China

Lane and its bifurcation detection is a vital and active research topic in low cost camera-based autonomous driving and advanced driver assistance system(ADAS). The common lane detection pipeline usually predicts lane segmentation mask firstly, and then makes line fitting by parabola or spline post-processing. However, if the speed of the lane and its bifurcation detection is fast and robust enough, we think curve fitting is not a necessary step. The goal of this work is to get accurate lane segmentation,identification of every lane, adaptability of lane numbers and the right combination of lane bifurcation. In this work, we relabeled lane and its bifurcation with solid line if the image of Tu Simple dataset has both of them. In the data training process, we apply a data balance strategy for the heavily biased lane and non-lane data. In such a way, we develop a competitive cascaded instance lane detection model and propose a novel bifurcation pixel embedding nested fusion method based on full binary segmentation pixel embedding with self-grouping cluster, called Lane Draw. Our method discards curve fitting process, therefore it reduces the complexity of post-processing and increases detection speed at 35 fps. Moreover, the proposed method yields better performance and high accuracy on the relabeled Tu Simple dataset. To the best of our knowledge, this is the first attempt in 2 D lane and bifurcation detection, which more often happens in actual situations.

关键词： lane detection bifurcation fusion instance segmentation autonomous driving