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Animal Models and Experimental Medicine 2024年第1期7卷 3-11页

作者： Hanwei yue Lin Bai NHC Key Laboratory of Human Disease Comparative Medicine Institute of Laboratory Animal SciencesCAMS and PUMCChao-yang DistrictBeijingChina

In recent years,humanized immune system(HIS)mice have been gradually used as models for preclinical research in pharmacotherapies and cell therapies with major breakthroughs in tumor and other fields,better mimicking the human immune system and the tumor immune microenvironment,compared to traditional immunodeficient *** better promote the application of HIS mice in preclinical research,we se-lectively summarize the current prevalent and breakthrough research and evaluation of chimeric antigen receptor(CAR)-T cells in various antiviral and antitumor *** exploring its application in preclinical research,we find that it can better reflect the actual clinical patient condition,with the advantages of providing high-efficiency detection indicators,even for progressive research and *** believe that it has better clinical patient simulation and promotion for the updated design of CAR-T cell therapy than directly transplanted immunodeficient *** characteristics of the main models are proposed to improve the use defects of the existing models by reducing the limitation of antihost reaction,combining multiple models,and unifying sources and organoid *** study of relapse and toxicity after CAR-T treatment also provides more possibilities for application and development.

关键词： antitumor antiviral CAR-T humanized immune system model humanized mice preclinical research

Coral records of Mid-Holocene sea-level highstands and climate responses in the northern South China Sea

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Acta Oceanologica Sinica 2024年第2期43卷 43-57页

作者： Yuanfu yue Lichao Tang Kefu Yu Rongyong Huang School of Marine Sciences Coral Reef Research Center of ChinaGuangxi UniversityNanning 530004China Guangxi Laboratory on the Study of Coral Reefs in the South China Sea Nanning 530004China

High-resolution sea-level data and high-precision dating of corals in the northern South China Sea(SCS)during the Holocene provide a reference and historical background for current and future sea-level changes and a basis for scientific assessment of the evolutionary trend of coral reefs in the *** sporadic studies have been performed around Hainan Island in the northern SCS,the reconstructed sea level presents different values or is controversial because the indicative meaning of the sea-level indicators were neither quantified nor uniform ***,we determined the quantitative relationship between modern living coral and sea level by measuring the top surfaces of 27 live Porites corals from the inner reef flat along the east coast of Hainan Island and assessed the accuracy of results obtained using coral as sea-level ***,three in situ fossil Porites corals were analyzed based on elevation measurements,digital X-ray radiography,and U-Th *** survey results showed that the indicative meanings for the modern live Porites corals is(146.09±8.35)cm below the mean tide level(MTL).It suggested that their upward growth limit is constrained by the sea level,and the lowest low water is the highest level of survival for the modern live Porites *** on the newly defined indicative meanings,6 new sea-level index points(SLIPs)were obtained and 19 published SLIPs were *** SLIPs indicated a relative sea level fluctuation between(227.7±9.8)cm to(154.88±9.8)cm MTL between(5393±25)cal a BP and(3390±12)cal a BP,providing evidences of the Mid-Holocene sea-level highstand in the northern *** that,our analysis demonstrated that different sea-level histories may be produced based on different indicative meanings or *** dataset of 276 coral U-Th ages indicates that coral reef development in the northern SCS comprised the initial development,boom growth,decline,and flourishing development again.A comparison wit

关键词： northern South China Sea Middle Holocene sea-level highstand Porites corals climate response

Design and Implementation of Nonlinear Precoding for MIMO-SDMA Toward 6G Wireless

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China Communications 2024年第1期21卷 69-87页

作者： Chaowu Wu yue Xiao Shu Fang Gang Wu National Key Laboratory of Wireless Communications University of Electronic Science and Technology of ChinaChengdu 611731China

In this paper,we present a novel and robust nonlinear precoding(NLP)design and detection structure specifically tailored for multiple-input multipleoutput space division multiple access(MIMO-SDMA)systems toward 6G *** approach aims to effectively mitigate the impact of imperfect channel estimation by leveraging the channel fluctuation mean square error(MSE)for reconstructing a highly accurate precoding matrix at the ***,we introduce a simplified receiver structure that eliminates the need for equalization,resulting in reduced interference and notable enhancements in overall system *** conduct both computer simulations and experimental tests to validate the efficacy of our proposed *** results reveals that the proposed NLP scheme offers significant performance improvements,making it particularly well-suited for the forthcoming 6G wireless.

关键词： MIMO-SDMA nonlinear precoding Tomlinson-Harashima precoding(THP) vector perturbation(VP)

Paleosalinity reconstruction in offshore lacustrine basins based on elemental geochemistry:a case study of Middle Upper Eocene Shahejie Formation,Zhanhua Sag,Bohai Bay Basin

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Journal of Oceanology and Limnology 2024年第4期42卷 1087-1105页

作者： Long SUN Shenghe WU Dali yue Wenfu CUI National Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing 102249China College of Geosciences China University of Petroleum(Beijing)Beijing 102249China Shengli Oil Production Plant Shengli Oilfield CompanySINOPECDongying 257400China

Salinity is a crucial property of water body and is essential for the restoration of paleoecology and ***,the theoretical method of application of elemental geochemical proxies to paleosalinity reconstruction is still ***,accurate determination and reconstruction of paleosalinity and its variation in an offshore lacustrine basin have been extremely challenging thus *** study presents detailed elemental geochemical investigations from the Zhanhua Sag in the southern Bohai Bay Basin to reconstruct the salinity variation in the Paleogene Eocene Shahejie Formation(50.8-33.9 Ma).Based on the variation of strontium barium ratio(Sr/Ba)and boron gallium ratio(B/Ga),we determined three typical salinity types of water body:salty water(Sr/Ba>0.5,B/Ga>6),brackish water(0.2

关键词： paleosalinity paleoclimate Zhanhua Sag Middle-Upper Eocene Shahejie Formation

Natural products inspired[3+2]cycloaddition enables efficient construction of hydroxylated tetrahydrofuran acetals and concise syntheses of lignans

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Science China Chemistry 2024年第7期67卷 2306-2313页

作者： Dong-yue Cai Weiming Shi Zhao-Hui Jin Zhi-Xiang Yu Jin-Xin Zhao Jian-Min yue State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Beijing National Laboratory for Molecular Sciences(BNLMS) Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationCollege of ChemistryPeking UniversityBeijing 100871China

Mimicking biosynthetic pathways of hongkonoids led to the development of a new Cu(Ⅰ)-catalyzed[3+2]cycloaddition ofα-hydroxyketone andβ-keto enol ethers,affording tetrahydrofuran acetals in a highly diastereoselective manner and 100%atom *** studies on the mechanism disclosed a concerted but asynchronous Michael addition/aldol *** the same importance,this methodology provides a practical biomimetic approach for one-step construction of the dibenzylbutyrolactol lignan backbone starting from two phenyl propane derivatives,opening up a powerful new approach for lignan synthesis,which is showcased by succinct total syntheses of two biologically important aryltetralin-type lignans,β-apopicropodophyllin and *** the mild and operationally simple conditions,the developed chemistry might have a promising prospect in potential industrial applications.

关键词： [3+2]cycloaddition transition-metal catalysis tetrahydrofuran lignans natural products

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The age of vanadium-based nanozymes: Synthesis, catalytic mechanisms, regulation and biomedical applications

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Chinese Chemical Letters 2024年第4期35卷 52-60页

作者： Shuaiwen Li Zihui Chen Feng Yang Wanqing yue Department of Chemistry Key Laboratory of Biomedical Functional MaterialsSchool of ScienceChina Pharmaceutical UniversityNanjing 211198China Key Laboratory of Drug Quality Control and Pharmacovigilance(China Pharmaceutical University) Ministry of EducationNanjing 211198China

Nanomaterials with enzyme-mimic(nanozyme) activity have garnered considerable attention as a potential alternative to natural enzymes, thanks to their low preparation cost, high activity, ease of preservation, and unique physicochemical properties. Vanadium(V) is a transition metal that integrates the benefits of valence-richness, low cost, and non-toxicity, making it a desirable candidate for developing a range of emerging nanozymes. In this review, we provide the first systematic summary of recent research progress on V-based nanozymes. First, we summarize the preparation of V-based nanozymes using both top-down and bottom-up synthesis methods. Next, we review the mechanism of V-based nanozymes that mimic the activity of various enzymes. We then discuss methods for regulating V-based nanozyme activity, including morphology, size, valence engineering, defect engineering, external triggering, and surface engineering. Afterward, we outline various biomedical applications, including therapeutic, anti-inflammatory, antibacterial, and biosensing. Finally, we prospect the challenges and countermeasures for V-based nanozymes based on their development. By summarizing recent research progress on V-based nanozymes, we hope to provide useful insights for researchers to further explore their potential applications and overcome their existing challenges.

关键词： Vanadium Nanozymes Catalytic mechanisms Biomedical applications Regulation

Online identification and extraction method of regional large-scale adjustable load-aggregation characteristics

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Global Energy Interconnection 2024年第3期7卷 313-323页

作者： Siwei Li Liang yue Xiangyu Kong Chengshan Wang Key Laboratory of Smart Grid of Ministry of Education Tianjin UniversityTianjin 300072P.R.China Beijing Fibrlink Communications Co. Ltd.Beijing 100071P.R.China

This article introduces the concept of load aggregation,which involves a comprehensive analysis of loads to acquire their external characteristics for the purpose of modeling and analyzing power *** online identification method is a computer-involved approach for data collection,processing,and system identification,commonly used for adaptive control and *** paper proposes a method for dynamically aggregating large-scale adjustable loads to support high proportions of new energy integration,aiming to study the aggregation characteristics of regional large-scale adjustable loads using online identification techniques and feature extraction *** experiment selected 300 central air conditioners as the research subject and analyzed their regulation characteristics,economic efficiency,and *** experimental results show that as the adjustment time of the air conditioner increases from 5 minutes to 35 minutes,the stable adjustment quantity during the adjustment period decreases from 28.46 to 3.57,indicating that air conditioning loads can be controlled over a long period and have better adjustment effects in the short ***,the experimental results of this paper demonstrate that analyzing the aggregation characteristics of regional large-scale adjustable loads using online identification techniques and feature extraction algorithms is effective.

关键词： Load aggregation Regional large-scale Online recognition Feature extraction method

Implications of the Stellar Mass Density of High-z Massive Galaxies from JWST on Warm Dark Matter

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Research in Astronomy and Astrophysics 2024年第1期24卷 128-134页

作者： Hengjie Lin Yan Gong Bin yue Xuelei Chen National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Science Center for China Space Station Telescope National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Department of Physics College of SciencesNortheastern UniversityShenyang 110819China Center for High Energy Physics Peking UniversityBeijing 100871China

A significant excess of the stellar mass density at high redshift has been discovered from the early data release of James Webb Space Telescope(JWST),and it may require a high star formation ***,this will lead to large number density of ionizing photons in the epoch of reionization(EoR),so that the reionization history will be changed,which can arise tension with the current EoR *** dark matter(WDM),via the free streaming effect,can suppress the formation of small-scale structure as well as low-mass *** provides an effective way to decrease the ionizing photons when considering a large star formation efficiency in high-z massive galaxies without altering the cosmic reionization *** the other hand,the constraints on the properties of WDM can be derived from the JWST *** this work,we study WDM as a possible solution to reconcile the JWST stellar mass density of high-z massive galaxies and reionization *** find that,the JWST high-z comoving cumulative stellar mass density alone has no significant preference for either CDM or WDM *** using the observational data of other stellar mass density measurements and reionization history,we obtain that the WDM particle mass with mw=0.51_(-0.12)^(+0.22) keV and star formation efficiency parameter f_(*)^(0)> 0.39 in 2σ confidence level can match both the JWST high-z comoving cumulative stellar mass density and the reionization history.

关键词： Cosmology (cosmology:)dark matter (cosmology:)large-scale structure of universe

Natural marmatite photocatalyst for treatment of mineral processing wastewater to help zero wastewater discharge

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Journal of Environmental Sciences 2024年第8期142卷 83-91页

作者： Meirong Wu Wei Sun Xiangsong Meng Jianhua Kang yue Yang School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China Key Laboratory of Hunan Province for Clean and Efficient Utilization of Strategic Calcium-containing Mineral Resources Central South UniversityChangsha 410083China

Mineral processing wastewater(MPW)with large discharge and high toxicity affects environmental safety,and the realizing zero discharge of MPW is of great significance for reducing environmental pollution,saving water resources,and promoting the sustainable development of the mining *** this study,we reported natural marmatite(NM)as a low-cost and efficient photocatalyst for the treatment of MPW to help zero wastewater *** photocatalytic activity of NM was evaluated by the removal of total organic carbon(TOC)from MPW under visible-light illumination,and the optimal degradation conditions were *** showed that superoxide free radicals(^(·)O_(2)^(-))were the dominant active species responsible for organic pollutants degradation,and 74.25%TOC removal was obtained after 120 min reaction under the optimum treatment ***,the wastewater treated by NM photocatalysis can be reused in the flotation system without adverse impact on the product *** on these findings,a model of zero wastewater discharge for flotation with the help of photocatalytic treatment was established,it indicated that the water of the whole system can be balanced without affecting the ore dressing index,which showed that visible light-driven photocatalyst has a promising application prospect in the treatment and recycling of industrial wastewater.

关键词： Natural mineral Photocatalysis Industrial wastewater Wastewater recycling Water balance

A hybrid memory architecture supporting fine-grained data migration

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Frontiers of Computer Science 2024年第2期18卷 31-41页

作者： Ye CHI Jianhui yue Xiaofei LIAO Haikun LIU Hai JIN National Engineering Research Center for Big Data Technology and System Services Computing Technology and System LabCluster and Grid Computing LabSchool of Computer Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China Department of Computer Science Michigan Technological UniversityMichigan 49931USA

Hybrid memory systems composed of dynamic random access memory(DRAM)and Non-volatile memory(NVM)often exploit page migration technologies to fully take the advantages of different memory *** previous proposals usually migrate data at a granularity of 4 KB pages,and thus waste memory bandwidth and DRAM *** this paper,we propose Mocha,a non-hierarchical architecture that organizes DRAM and NVM in a flat address space physically,but manages them in a cache/memory *** the commercial NVM device-Intel Optane DC Persistent Memory Modules(DCPMM)actually access the physical media at a granularity of 256 bytes(an Optane block),we manage the DRAM cache at the 256-byte size to adapt to this feature of *** design not only enables fine-grained data migration and management for the DRAM cache,but also avoids write amplification for Intel Optane *** also create an Indirect Address Cache(IAC)in Hybrid Memory Controller(HMC)and propose a reverse address mapping table in the DRAM to speed up address translation and cache ***,we exploit a utility-based caching mechanism to filter cold blocks in the NVM,and further improve the efficiency of the DRAM *** implement Mocha in an architectural *** results show that Mocha can improve application performance by 8.2%on average(up to 24.6%),reduce 6.9%energy consumption and 25.9%data migration traffic on average,compared with a typical hybrid memory architecture-HSCC.

关键词： non-volatile memory hybrid memory system data migration fine-grained caching