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Interactions between myoblasts and macrophages under high glucose milieus result in inflammatory response and impaired insulin sensitivity

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World Journal of Diabetes 2024年第7期15卷 1589-1602页

作者： Wei Luo yue zhou Li-Ying Wang Lei Ai Department of Sports and Health Sciences Nanjing Sport InstituteNanjing 210014Jiangsu ProvinceChina Department of Exercise Physiology Beijing Sport UniversityBeijing 100084China Department of Sports Physiology Research Jiangsu Research Institute of Sports ScienceNanjing 210033Jiangsu ProvinceChina

BACKGROUND Skeletal muscle handles about 80% of insulin-stimulated glucose uptake and become the major organ occurring insulin resistance(IR).Many studies have confirmed the interactions between macrophages and skeletal muscle regulated the inflammation and regeneration of skeletal ***,despite of the decades of research,whether macrophages infiltration and polarization in skeletal muscle under high glucose(HG)milieus results in the development of IR is yet to be elucidated.C2C12 myoblasts are well-established and excellent model to study myogenic regulation and its responses to *** exploration of macrophages'role in myoblasts IR and the dynamics of their infiltration and polarization is *** To evaluate interactions between myoblasts and macrophages under HG,and its effects on inflammation and IR in skeletal *** We detected the polarization status of macrophages infiltrated to skeletal muscles of IR mice by hematoxylin and eosin and immunohistochemical ***,we developed an in vitro co-culture system to study the interactions between myoblasts and macrophages under HG *** effects of myoblasts on macrophages were explored through morphological observation,CCK-8 assay,Flow Cytometry,and enzyme-linked immunosorbent *** mediation of macrophages to myogenesis and insulin sensitivity were detected by morphological observation,CCK-8 assay,Immunofluorescence,and 2-NBDG *** The F4/80 and co-localization of F4/80 and CD86 increased,and the myofiber size decreased in IR group(P0.8).In McM+HG group,F4/80+CD86+CD206-cells,monocyte chemoattractant protein 1,TNFα,IL-1βand IL-6 were increased,and F4/80+CD206+CD86-cells and IL-10 were decreased compared with Mc+HG group and McM group(P0.8).Compered to M group,myotube area,myotube n

关键词： Macrophages phenotype Myoblasts Cross-talk Glucose toxicity Chronic inflammation Insulin sensitivity

Complementary memtransistors for neuromorphic computing: How, what and why

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Journal of Semiconductors 2024年第6期45卷 64-80页

作者： Qi Chen yue zhou Weiwei Xiong Zirui Chen Yasai Wang Xiangshui Miao Yuhui He School of Integrated Circuits Huazhong University of Science and TechnologyWuhan 430074China Department of Electrical and Computer Engineering University of CaliforniaSan DiegoUSA Dipartimento di Elettronica e Informazione and *** Politecnico di MilanoMilanoItaly Department of Applied Physics Hong Kong Polytechnic UniversityHong KongChina

Memtransistors in which the source-drain channel conductance can be nonvolatilely manipulated through the gate signals have emerged as promising components for implementing neuromorphic *** the other side,it is known that the complementary metal-oxide-semiconductor(CMOS)field effect transistors have played the fundamental role in the modern integrated circuit ***,will complementary memtransistors(CMT)also play such a role in the future neuromorphic circuits and chips?In this review,various types of materials and physical mechanisms for constructing CMT(how)are inspected with their merits and need-to-address challenges *** the unique properties(what)and poten-tial applications of CMT in different learning algorithms/scenarios of spiking neural networks(why)are reviewed,including super-vised rule,reinforcement one,dynamic vision with in-sensor computing,*** exploiting the complementary structure-related novel functions,significant reduction of hardware consuming,enhancement of energy/efficiency ratio and other advan-tages have been gained,illustrating the alluring prospect of design technology co-optimization(DTCO)of CMT towards neuro-morphic computing.

关键词： complementary memtransistor neuromorphic computing reward-modulated spike timing-dependent plasticity remote supervise method in-sensor computing

Bimetallic NiCoP catalysts anchored on phosphorus-doped lignin-based carbon for robust oxygen evolution performance

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Rare Metals 2024年第7期43卷 3084-3095页

作者： Ling-Ying-Zi Xiong Bo-Wen Liu Lei Du yue-Kuan zhou Xu-Liang Lin Huan Wang Guangdong Engineering Technology Research Center for Sensing Materials & Devices Guangzhou Key Laboratory of Sensing Materials & DevicesSchool of Chemistry and Chemical EngineeringGuangzhou University School of Chemical Engineering and Light Industry Guangdong University of Technology Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center Sustainable Energy and Environment Thrust Function HubThe Hong Kong University of Science and Technology (Guangzhou) Division of Emerging Interdisciplinary Areas Department of Mechanical and Aerospace EngineeringThe Hong Kong University of Science and Technology State Key Lab of Pulp and Paper Engineering South China University of Technology

Oxygen evolution reaction（OER） catalysts are the key core materials that determine the performance of fuel cells,metal-air batteries,electrolytic water decomposition,and other *** this work,a green lignin-based non-precious metal OER catalyst was prepared by a simple ***,c arboxylated lignin was used to complex Ni and Co in situ,and then they were placed with sodium hypophosphite in the same tube furnace for upstream and downstream high-temperature calcination to construct a lignin carbon-based Ni-Co bimetallic OER catalyst（NiCoP@C）.The synthesized catalyst is a porous bimetallic phosphide with a three-dimensional network structure and high-density electrochemical active ***@C exhibited favorable catalytic activity for the oxygen evolution reaction（OER） with overpotential of 280 mV at 10 mA·cm-2and a Tafel slope of 77 mV·***,it exhibited remarkable durability during *** functional theory（DFT） calculations revealed that by leveraging the distinctive structure of transition metal phosphide nanoparticles incorporated into a reticulated substrate,the NiCoP@C catalyst offered an increased number of active sites for OER catalysis,significantly enhancing its stability during practical *** present study broadens the utilization pathways of biomass to "turn waste into treasure," aligning the development concept of green sustainable development.

关键词： Oxygen evolution reaction Lignin Carbon-based catalyst Nickel–cobalt bimetal Metal phosphide

Single thiolate replacement of metal nanoclusters

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Science China Chemistry 2024年第2期67卷 523-528页

作者： Ambreen Ambreen yue zhou Wanmiao Gu Qing You Liang Fang Guoqing Bian Nan Yan Nan Xia Zhikun Wu Key Laboratory of Materials Physics Anhui Key Laboratory of Nanomaterials and NanotechnologyInstitute of Solid State PhysicsHefei Institutes of Physical Science(HFIPS)Chinese Academy of SciencesHefei230031China University of Science and Technology of China Hefei230601China Institute of Physical Science and Information Technology Anhui UniversityHefei230601China

Surface thiolates play important roles in evincing the structures and properties of thiolated metal nanoclusters—one type of recently emerging inorganic-organic hybrids,and thus the thiolate substitution,especially single thiolate substitution,is highly desirable for subtly tailoring the structures and properties of metal ***,such a single-thiolate substituting is challenging,and its influence on the metal-metal and metal-sulfur bonds remains mysterious due to the absence of the singlethiolate-substituted ***,we developed a combined method,concurrently synthesized the single-thiolate-substituted nanocluster and its parent nanocluster,and successfully resolved their structures by single crystal X-ray crystallography,which reveals that the single thiolate substitute has an obvious influence on the metal-metal and metal-sulfur bond lengths although it has no effect on the absorption ***,the metal-metal and metal-sulfur bonds show various thermal extensibility and even the negative thermal expansion phenomena of the Au–S bond were observed in the single-thiolate-substituted *** bond length-related stability was also ***,this study highlights a novel synthesis method and offers novel structural insights and an in-depth structure-property correlation of thiolated metal nanoclusters.

关键词： metal nanoclusters single thiolate replacement thermal expansion stability intercluster interaction

植物PEAT复合体介导组蛋白H2A去泛素化

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科学通报 2024年第2期69卷 140-142页

作者：周岳北京大学蛋白质与植物基因研究国家重点实验室现代农学院北京大学-清华大学生命科学联合中心北京100871

组蛋白翻译后修饰是重要的表观遗传调控方式,包括组蛋白甲基化、乙酰化、磷酸化和泛素化等,在真核生物的基因组DNA复制、损伤修复、基因转录等生物学过程中发挥着重要的作用.组蛋白H2A单泛素化修饰(H2Aub)在动植物中高度保守,通常与基... 详细信息

组蛋白翻译后修饰是重要的表观遗传调控方式,包括组蛋白甲基化、乙酰化、磷酸化和泛素化等,在真核生物的基因组DNA复制、损伤修复、基因转录等生物学过程中发挥着重要的作用.组蛋白H2A单泛素化修饰(H2Aub)在动植物中高度保守,通常与基因的转录抑制相关[1,2].组蛋白泛素化是可逆的,维持生物体内组蛋白泛素化的正常水平对正常生长发育至关重要.以往的研究表明,动植物中具有保守RING结构域的E3连接酶形成PRC1复合体,负责催化H2A的单泛素修饰[1,3].组蛋白H2A去泛素化需要去泛素蛋白酶催化,对调控染色质上的H2A泛素修饰水平具有重要作用.以往的研究已经在动物中弄清了H2A去泛素化的分子机制,然而对植物中组蛋白H2A去泛素化的分子机制知之甚少.

关键词：去泛素化表观遗传调控组蛋白甲基化复合体转录抑制泛素化修饰损伤修复基因转录

Tumor biomarkers for diagnosis,prognosis and targeted therapy

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2391-2476页

作者： yue zhou Lei Tao Jiahao Qiu Jing Xu Xinyu Yang Yu Zhang Xinyu Tian Xinqi Guan Xiaobo Cen Yinglan Zhao Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China West China School of Pharmacy Sichuan UniversityChengdu 610041China School of Medicine Tibet UniversityLhasa 850000China National Chengdu Center for Safety Evaluation of Drugs State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China

Tumor biomarkers,the substances which are produced by tumors or the body’s responses to tumors during tumorigenesis and progression,have been demonstrated to possess critical and encouraging value in screening and early diagnosis,prognosis prediction,recurrence detection,and therapeutic efficacy monitoring of *** the past decades,continuous progress has been made in exploring and discovering novel,sensitive,specific,and accurate tumor biomarkers,which has significantly promoted personalized medicine and improved the outcomes of cancer patients,especially advances in molecular biology technologies developed for the detection of tumor ***,we summarize the discovery and development of tumor biomarkers,including the history of tumor biomarkers,the conventional and innovative technologies used for biomarker discovery and detection,the classification of tumor biomarkers based on tissue origins,and the application of tumor biomarkers in clinical cancer *** particular,we highlight the recent advancements in biomarker-based anticancer-targeted therapies which are emerging as breakthroughs and promising cancer therapeutic *** also discuss limitations and challenges that need to be addressed and provide insights and perspectives to turn challenges into opportunities in this ***,the discovery and application of multiple tumor biomarkers emphasized in this review may provide guidance on improved precision medicine,broaden horizons in future research directions,and expedite the clinical classification of cancer patients according to their molecular biomarkers rather than organs of origin.

关键词： diagnosis breakthrough biomarkers

Identification and effective regulation of scarb1 gene involved in pigmentation change in autotetraploid Carassius auratus

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Zoological Research 2024年第2期45卷 381-397页

作者： Xi-Dan Xu yue zhou Chong-Qing Wang Xu Huang Kun Zhang Xiao-Wei Xu Li-Wen He Xin-yue Zhang Xin-Zhu Fu Ming Ma Qin-Bo Qin Shao-Jun Liu State Key Laboratory of Developmental Biology of Freshwater Fish Engineering Research Center of Polyploid Fish Reproduction and Breeding of the State Education MinistryCollege of Life SciencesHunan Normal UniversityChangshaHunan 410081China Nansha-South China Agricultural University Fishery Research Institute GuangzhouGuangdong 511458China Hunan yuelu Mountain Science and Technology Co.Ltd.for Aquatic Breeding ChangshaHunan 410081China College of Chemistry and Chemical Engineering Hunan Normal UniversityChangshaHunan 410081China

The autotetraploid Carassius auratus(4nRR,4n=200,RRRR)is derived from whole-genome duplication of Carassius auratus red var.(RCC,2n=100,RR).In the current study,we demonstrated that chromatophores and pigment changes directly caused the coloration and variation of 4nRR skin(red in RCC,brownish-yellow in4nRR).To further explore the molecular mechanisms underlying coloration formation and variation in 4nRR,we performed transcriptome profiling and molecular functional verification in RCC and *** revealed that scarb1,associated with carotenoid metabolism,underwent significant down-regulation in *** editing of this candidate pigment gene provided clear evidence of its significant role in RCC ***,we identified four divergent scarb1 homeologs in 4nRR:two original scarb1 homeologs from RCC and two duplicated ***,three of these homeologs possessed two highly conserved alleles,exhibiting biased and allelespecific expression in the ***,after precise editing of both the original and duplicated scarb1homeologs and/or alleles,4nRR individuals,whether singly or multiply mutated,displayed a transition from brownishyellow skin to a cyan-gray ***,the proportional areas of the cyan-gray regions displayed a gene-dose *** findings illustrate the subfunctionalization of duplicated scarb1,with all scarb1genes synergistically and equally contributing to the pigmentation of *** is the first report concerning the functional differentiation of duplicated homeologs in an autopolyploidfish,substantiallyenrichingour understanding of coloration formation and change within this group of organisms.

关键词： Autopolyploidization Coloration change scarb1 Functional differentiation Genetic changes

Torque effect on vibration behavior of high-speed train gearbox under internal and external excitations

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Railway Engineering Science 2024年第2期32卷 229-243页

作者： yue zhou Xi Wang Hongbo Que Rubing Guo Xinhai Lin Siqin Jin Chengpan Wu Yu Hou School of Mechanical Electronic and Control EngineeringBeijing Jiaotong UniversityBeijing 100044China CRRC Qishuyan Institute Co. Ltd.No.258Wuyi RoadQishuyanChangzhou 213011China Frontiers Science Center for Smart High-Speed Railway System Beijing Jiaotong UniversityBeijing 100044China

The high-speed train transmission system,experiencing both the internal excitation originating from gear meshing and the external excitation originating from the wheel-rail interaction,exhibits complex dynamic behavior in the actual service *** paper focuses on the gearbox in the high-speed train to carry out the bench test,in which various operat-ing conditions(torques and rotation speeds)were set up and the excitation condition covering both internal and external was *** responses on multiple positions of the gearbox were acquired in the test and the vibration behavior of the gearbox was ***,a stochastic excitation modal test was also carried out on the test bench under different torques,and the modal parameter of the gearbox was ***,the sweep frequency response of the gearbox under gear meshing excitation was analyzed through dynamic *** results showed that the torque has an attenuating effect on the amplitude of gear meshing frequency on the gearbox,and the effect of external excitation on the gearbox vibration cannot be ignored,especially under the rated operating *** was also found that the torque affects the modal param-eter of the gearbox *** torque has a great effect on both the gear meshing stiffness and the bearing stiffness in the transmission system,which is the inherent reason for the changed modal characteristics observed in the modal test and affects the vibration behavior of the gearbox consequently.

关键词： High-speed train Gearbox Bench test Vibration behavior Modal identification

中国心画理论与川端康成的文学理念——从写心、适意到求品

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重庆大学学报（社会科学版） 2024年第1期30卷 156-165页

作者：周阅北京语言大学文学院北京100083

中国自宋以降,在苏轼等精英知识分子的自觉引领下,形成了心画(文人画)传统。这也正是川端康成热爱中国宋元美术的重要原因。在“达吾心”“适吾意”以及诗画结合的精神品格等方面,川端康成的文学理念与中国文人画家的艺术追求十分契合... 详细信息

中国自宋以降,在苏轼等精英知识分子的自觉引领下,形成了心画(文人画)传统。这也正是川端康成热爱中国宋元美术的重要原因。在“达吾心”“适吾意”以及诗画结合的精神品格等方面,川端康成的文学理念与中国文人画家的艺术追求十分契合。首先,心画理论强调人情味和抒情性,这是宋代文人画家们在清楚地意识到自己作为士大夫群体的艺术担当之后,着力倡导并身体力行的。而川端康成也认为绘画不仅可以写形状物,更可以表达人的潜在的精神世界,这一艺术观念在其《梦》《阵雨》等小说中均有明显体现。川端康成在大量作品中所描写的绘画都是一种“心画”,它们并不是静止的物体,而是精神的流动。其次,中国宋元时代文人向绘画领域的主动渗透和理论引领,带来了绘画“适吾意”的思潮,使得绘画得以抒“胸中盘郁”。在这一点上,川端的文学创作理念与中国文人画家的主张完全相通,因此也使得其小说中的绘画作品具有了内涵的无限性和解读的丰富性。第三,宋代带有精英阶层之精神自觉的文人对绘画提出指导性的艺术理论,在诗画结合的基础上进一步追求品格。这种绘画理论也伴随中国绘画传入日本的第二次浪潮而东传,这恰值川端康成人生的前三十年,对他的文学道路产生了潜在而深远的影响。中国的心画理论不仅对日本文人画的形成,而且对日本近现代文学都产生了跨文化、跨学科的影响。从川端康成文学的个案可以看到,渗透于域外的中国画论,作为艺术理论的一个侧面,展现了中外文化交流的样态。这一越境的文化传播现象,还有很多极具学术价值的课题值得挖掘和探究。

关键词：心画苏轼川端康成写心适意求品

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