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Dynamic resistance exercise increases skeletal muscle-derived FSTL1 inducing cardiac angiogenesis via DIP2A-Smad2/3 in rats following myocardial infarction

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Journal of Sport and Health Science 2021年第5期10卷 594-603页

作者： yue xi Meili Hao Qiaoqin Liang Yongxia Li Da-Wei Gong Zhenjun Tian Institute of Sports and Exercise Biology Shaanxi Normal UniversityXi’an 710119China School of Physical Education Luoyang Normal UniversityLuoyang 471934China School of Life Science Shaanxi Normal UniversityXi’an 710119China Division of Endocrinology Diabetes and NutritionDepartment of MedicineUniversity of Maryland School of MedicineBaltimoreMD 21201USA

Purpose:The aim of this study was to investigate the potential of dynamic resistance exercise to generate skeletal muscle-derived follistatin like-1(FSTL1),which may induce cardioprotection in rats following myocardial infarction(MI)by inducing ***:Male,adult Sprague-Dawley rats were randomly divided into 5 groups(n=12 in each group):sham group(S),sedentary MI group(MI),MI+resistance exercise group(MR),MI+adeno-associated virus(AAV)-FSTL1 injection group(MA),and MI+AAV-FSTL1 injection+resistance exercise group(MAR).The AAV-FSTL1 vector was prepared by molecular biology methods and injected into the anterior tibialis *** MI model was established by ligation of the left anterior descending coronary *** in the MR and MAR groups underwent 4 weeks of dynamic resistance exercise training using a weighted climbing-up *** function was evaluated by hemodynamic *** volume fraction of myocardium was observed and analyzed by Masson’s *** umbilical vein vessel endothelial cells culture and recombinant human FSTL1 protein or transforming growth factor-b receptor 1(TGFbR1)inhibitor treatment were used to elucidate the molecular signaling mechanism of ***,cell proliferation,and disco interacting protein 2 homolog A(DIP2A)location were observed by immunofluorescence *** expression of FSTL1,DIP2A,and the activation of signaling pathways were detected by Western *** of endothelial cells was observed by tubule ***-way analysis of variance and Student’s t test were used for statistical ***:Resistance exercise stimulated the secretion of skeletal muscle FSTL1,which promoted myocardial angiogenesis,inhibited pathological remodeling,and protected cardiac function in MI *** facilitated skeletal muscle FSTL1 to play a role in protecting the *** FSTL1 promoted the human umbilical vein vessel endothelial cells proliferation and up-regulated t

关键词： Angiogenesis Follistatin like-1 Myocardial infarction Resistance exercise Signaling mechanism

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Using Homology Modeling, Molecular Dynamics and Molecular Docking Techniques to Identify Inhibitor Binding Regions of Somatostatin Receptor 1

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Chemical Research in Chinese Universities 2013年第1期29卷 139-143页

作者： LAN Hai-nan WANG yue-xi ZHENG Ming-zhu HAN Wei-wei ZHENG xin College of Animal Science and Technology Jilin Agricultural University Changchun 130118 P. R. China Key Laboratory for Molecular Enzymology and Engineering Ministry of Education Jilin University Changchun 130012 P. R. China

The G protein coupled receptor（GPCR）, one of the members in the superfamily, which consists of thousands of integral membrane proteins, exerts a wide variety of physiological functions and responses to a large portion of the drug targets. The 3D structure of somatostatin receptor I（SSTR1） was modeled and refined by means of homology modeling and molecular dynamics simulation. This model was assessed by Verify-3D and Vadar, which confirmed the reliability of the refined model. The interaction between the inhibitor cysteamine, somatostatin（SST） and SSTR1 was investigated by a molecular docking program, Affinity. The binding module not only showed the crucial residues involved in the interaction, but also provided important information about the interaction between SSTR1 on the one hand and ligands on the other, which might be the significant evidence for the structure-based design.

关键词： Somatostatin receptor 1 Homology modeling Docking

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Vibration attenuation of meta-mortar with spring-mass resonators

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Defence Technology（防务技术） 2023年第2期20卷 11-23页

作者： San-feng Liu Hai-long Chen Yang Liu Hu-guang He xi-yue An Feng-nian Jin Hua-lin Fan State Key Laboratory for Disaster Prevention&Mitigation of Explosion&Impact Army Engineering University of PLANanjing210007China Research Center of Lightweight Structures and Intelligent Manufacturing State Key Laboratory of Mechanics and Control of Mechanical StructuresNanjing University of Aeronautics and AstronauticsNanjing210016China

Metamaterial based on local resonance has excellent vibration attenuation ability in low *** this research,an attempt was performed to make meta-mortar with spring-mass resonators to attenuate vibration and shock ***-spring-mass resonators and dual-spring-mass resonators were designed and made using lead or aluminum blocks and SWPB springs encased by PMMA(polymethyl methacrylate)or aluminum *** resonators were placed into mortar blocks to make metamortar *** attenuation effect was investigated by sweeping vibration with frequency from 50 Hz to 2000 *** these meta-mortar blocks exhibit excellent vibration attenuation ability in the designed band *** dual-spring-mass resonators,meta-mortar blocks have two distinct vibration attenuation bands.

关键词： Meta-mortar Vibration attenuation Spring-mass resonators

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Current Situation of International Organization for Standardization/Technical Committee 249 International Standards of Traditional Chinese Medicine

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Chinese Journal of Integrative Medicine 2017年第5期23卷 376-380页

作者： Liu Yu-qi WANG yue-xi SHI Nan-nan HAN Xue-jie LU Ai-ping Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences School of Chinese medicine Hong Kong Baptist University

Objective： To review the current situation and progress of traditional Chinese medicine（TCM） international standards, standard projects and proposals in International Organization for Standardization（ISO）/technical committee（TC） 249. Methods： ISO/TC 249 standards and standard projects on the ISO website were searched and new standard proposals information were collected from ISO/TC 249 National Mirror Committee in China. Then all the available data were summarized in 5 closely related items, including proposed time, proposed country, assigned working group（WG）, current stage and classification. Results： In ISO/TC 249, there were 2 international standards, 18 standard projects and 24 new standard proposals proposed in 2014. These 44 standard subjects increased year by year since 2011. Twenty-nine of them were proposed by China, 15 were assigned to WG 4, 36 were in preliminary and preparatory stage and 8 were categorized into 4 fields, 7 groups and sub-groups based on International Classification Standards. Conclusion： A rapid and steady development of international standardization in TCM can be observed in ISO/TC 249.

关键词： International Organization for Standardization/Technical Committee 249 international standards traditional Chinese medicine

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Effect of Shoutai Pills on Th1/Th2 Cytokines in Serum and Endometrium of Rats with Stimulated Ovulation

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Current Medical Science 2019年第2期39卷 285-290页

作者： Juan ZHANG Li CHEN Cui-hong ZHENG Jing WANG Di xiE yue-xi ZHOU Department of Obstetrics and Gynecology Central Theater General Hospital of Chinese People's Liberation ArmyWuhan 430070China Hubei University of Chinese Medicine Wuhan 430065China Institute of Integrated Traditional Chinese and Western Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

In our previous study,we found that Shoutai pills could improve the embryo implantation rate as well as the levels of estrogen,progesterone and estrogen receptor in rats with stimulated ***,the mechanism is not *** study was designed to investigate the effect of Shoutai pills on the levels of Th1 and Th2 cytokines in rats with stimulated ovulation and the *** rat model of stimulated ovulation was established by combined injection of pregnant mare serum gonadotropin(PMSG)and human chorionic gonadotropin(HCG).Then the rats were randomly divided into model group(M),Shoutai pills group(S),progesterone group(P)and normal group(N).All the pregnant rats were treated from the first *** S and P groups were administrated with gavage of Shoutai pills and injection of progesterone respectively,and N and M groups were given the same volume of normal saline and distilled water *** treatment for 7 days,the animals were executed for serum and uterine *** ELISA method was adopted to detect the contents of Thl cytokines[interferon-γ(INF-γ),interleukin-2(IL-2)]and Th2 cytokines(IL-4,IL-6,IL-10).The expression of leukemia inhibitory factor(L1F)and leukemia inhibitory factor receptor(LIFR)was detected by Western blotting and real-time *** compared with N group,the expression levels of IFN-y and IL-2 in M group were significantly increased,and those of IL-4,IL-6,*** and LIFR were significantly decreased(P<0.05).As compared with M group,the levels of IL-4,IL-6,IL-10,LIF and LIFR in S group were significantly increased(P<0.05),and those of IFN-γand IL-2 were significantly decreased(P<0.05).It was suggested that Shoutai pills can increase the levels of IL-4.1L-6,IL-10,LIF and LIFR as well as reduce the levels of INF-γand IL-2 in rats with stimulated *** Shoutai pills may improve endometrial receptivity and promote embryo implantation by maintaining the balanee of Th1/Th2 cytokines.

关键词： Shoutai pills Th1/Th2 cytokines rats

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Atom Response Theory of Nonlinear Optical Responses and Its Applications

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Chinese Journal of Structural Chemistry 2020年第12期39卷 2172-2181,2056页

作者： CHENG xi-yue WHANGBO Myung-Hwan HONG Mao-Chun DENG Shui-Quan State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China Fujian Provincial Key Laboratory of Theoretical and Computational Chemistry Xiamen 361005China Department of Chemistry North Carolina State UniversityRaleighNC 27695-8204USA Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108China

Second-order nonlinear optical(NLO)crystalline materials are fundamentally and technologically important for their ability to double or triple the frequency of *** article provides a brief review of the atom response theory(ART)of NLO responses recently developed on the basis of the partial response functional *** ART analysis enables one to quantitatively evaluate the contributions of individual constituent atoms to the second harmonic generation(SHG)response of a NLO crystal material on the basis of first principles DFT *** general partitioning principles developed in our recent work provide the conceptual foundation for determining the functional motifs of SHG *** this mini review we will focus on the concepts and principles as well as on applications with *** practically important empirical rules resulting from the ART studies will also be reviewed.

关键词： atom response theory nonlinear optical materials functional motif first-principles calculation

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Evaluation of Stabilization Performances of Antioxidants in Poly(ether ether ketone)

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Chemical Research in Chinese Universities 2012年第5期28卷 907-911页

作者： ZHOU Zheng ZHOU Fu-gui ZHANG Shu-ling MU Jian-xin yue xi-gui WANG Gui-bin High Performance Plastics Engineering Research Center Ministry of EducationCollege of ChemistryJilin UniversityChangehun 130012P.R.China

Two types of antioxidants（a primary antioxidant and a secondary antioxidant） were used to improve the stability of poly（ether ether ketone）（PEEK）. The effects of the antioxidants on the properties of PEEK and the stabilization mechanism were investigated by some characterization methods, such as rheometer, thermogravimetric ana- lysis（TGA）, universal tester and electron spin resonance（ESR）. The results indicate that the efficiency of the phosphorous antioxidant（DS） in improving the stability of PEEK was better than that of the phenolic antioxidant（DN） in both melting stability and thermal stability, and the thermal stability of PEEK sample containing 0.07%（mass fraction） DS was the best among all the samples due to the decrease of the free radicals density, as proven by ESR measurement. Additionally, no obvious changes could be observed in mechanical properties of PEEK containing antioxidants compared to those of virgin PEEK.

关键词： Poly(ether ether ketone) Antioxidant Stability Mechanical property Radical

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Elevation and Land Use Types Have Significant Impacts on Spatial Variability of Soil Organic Matter Content in Hani Terraced Field of Yuanyang County,China

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Rice science 2015年第1期22卷 27-34页

作者： LI Feng-bo LU Guang-de ZHOU xi-yue NI Hui-xiang XU Chun-chun yue Chao YANG xiu-mei FENG Jin-fei FANG Fu-ping Rice Science & Technology Information Center China National Rice Research Institute Agro-Tech Extension Center of Yuanyang

Soil organic matter （SOM） content is one of the most important indicators of the sustainability of soil. To maintain sustainable soil utilization and management in fragile Hani terraced field, it is meaningful to investigate the effects of topography and land use type on SOM content. Descriptive statistics and geostatistics were used to analyze the data and the kriging method was applied to map the spatial patterns of SOM content. The results showed that the mean SOM content was 32.76 g/kg, with a variation coefficient of 40%. The SOM content was affected by elevation and land use type. As the increase of elevation, the SOM content in Hani terraced field also increased obviously. The SOM content in tea garden, which is almost at high elevation, was the highest in all six land use types, and the SOM content decreased in a following sequence： tea garden 〉 paddy field 〉 corn field 〉 banana garden 〉 cassava field 〉 sugarcane field. In addition, at the same elevation, the paddy field had the highest SOM content compared with other land use types. All these results demonstrate that paddy field is the most efficient and suitable land use type for SOM conservation at high, middle or low elevations in the fragile Hani terraced field. In order to protect soil quality and maintain the sustainable agricultural development, it is necessary to maintain or even to enlarge the area of paddy field in Yuanyang county, Yunnan Province, China.

关键词： Hani terraced field elevation land use type geostatistics soil organic matter content

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The Kite Produced in Tianjin

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China's Foreign Trade 1997年第5期 62-63页

作者： yue xi

The kite-making in China has a long history of more than 2,000 years. It is said that Gong Shuban of Lu State of the Spring and Autumn and Warring Period made a wood magpie. Also at that time, Mu Zhai made a wood eagle to fly in the sky. These were the prototype of kites in China. During the end of Qin Dynasty and the beginning of Han Dynasty, a man named Hah xin made a paper kite using bomboo sticks as its framework, which was covered with paper and drawn by a string of thread to fly in the sky. During the period of the Five Dynasties, Li

关键词： The Kite Produced in Tianjin time

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Sulfation of chondroitin and bile acids converges to antagonize Wnt/β-catenin signaling and inhibit APC deficiency-induced gut tumorigenesis

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1241-1256页

作者： Pengfei Xu yue xi Jong-Won Kim Junjie Zhu Min Zhang Meishu Xu Songrong Ren Da Yang xiaochao Ma Wen xie Center for Pharmacogenetics and Department of Pharmaceutical Sciences University of PittsburghPittsburghPA 15261USA Department of Hepatobiliary and Pancreatic Surgery Zhongnan Hospital of Wuhan UniversitySchool of Pharmaceutical SciencesWuhan UniversityWuhan 430071China Department of Pharmacology&Chemical Biology University of PittsburghPittsburghPA 15261USA

Sulfation is a crucial and prevalent conjugation reaction involved in cellular processes and mammalian physiology.3’-Phosphoadenosine 5’-phosphosulfate(PAPS)synthase 2(PAPSS2)is the primary enzyme to generate the universal sulfonate donor *** involvement of PAPSS2-mediated sulfation in adenomatous polyposis coli(APC)mutation-promoted colonic carcinogenesis has not been ***,we showed that the expression of PAPSS2 was decreased in human colon tumors along with cancer stages,and the lower expression of PAPSS2 was correlated with poor prognosis in advanced colon *** epithelial-specific heterozygous Apc deficient and Papss2-knockout(Apc^(Δgut-Het)Papss2^(Δgut))mice were created,and the phenotypes were compared to the spontaneous intestinal tumorigenesis of Apc^(Δgut-Het)***^(Δgut-Het)Papss2^(Δgutmice) were more sensitive to gut tumorigenesis,which was mechanistically accounted for by the activation of Wnt/β-catenin signaling pathway due to the suppression of chondroitin sulfation and inhibition of the farnesoid X receptor(FXR)-transducin-like enhancer of split 3(TLE3)gene regulatory *** sulfate supplementation in Apc^(Δgut-Het)Papss2^(Δgutmice) alleviated intestinal *** summary,we have uncovered the protective role of PAPSS2-mediated chondroitin sulfation and bile acids-FXR-TLE3 activation in the prevention of gut carcinogenesis via the antagonization of Wnt/β-catenin *** sulfate may be explored as a therapeutic agent for Papss2 deficiency-associated colonic carcinogenesis.

关键词： Colon cancer APC Wnt/b-catenin PAPSS2 Chondroitin sulfate Sulfation Bile acids FXR

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