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Homogenous coating of Li+ conductive Li5AlO4 on single-crystalline nonstoichiometric Li1.04Ni0.92Al0.04O2 for rechargeable lithium-ion batteries

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Journal of Energy Chemistry 2024年第8期95卷 651-659页

作者： Guoyu Ding Shizhou Wang Jinhan Li Ziyan wu Jiayu Chen Jiayong Du Xinhui Huang Kuiming Liu yudong Zhang Zhonghan wu Yiyang Peng Qiancheng Zhao Meng Yu Fangyi Cheng Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Engineering Research Center of High-efficiency Energy Storage(Ministry of Education) College of Chemistry Nankai University State Key Laboratory of Advanced Chemical Power Sources Nankai University Haihe Laboratory of Sustainable Chemical Transformations

Cobalt-free,nickel-rich LiNi1-xAlxO2（x ≤ 0.1） is an attractive cathode material because of high energy density and low cost but suffers from severe structural degradation and poor rate performance.In this study,we propose a molten salt-assisted synthesis in combination with a Li-refeeding induced aluminum segregation strategy to prepare Li5AlO4-coated single-crystalline slightly Li-rich Li1.04Ni0.92Al0.04O2.The symbiotic formation of Li5AlO4from reaction between molten lithium hydroxide and doped aluminum in the bulk ensures a high lattice matching between the Ni-rich oxide and the homogenous conductive Li5AlO4that permits high Li+conductivity.Benefiting from mitigated undesirable side reactions and phase evolution,the Li5AlO4-coated single-crystalline Li1.04Ni0.92Al0.04O2delivers a high specific capacity of220.2 mA h g-1at 0.1 C and considerable rate capability(182.5 mA h g-1at 10 C).Besides,superior capacity retention of 90.8% is obtained at 1/3 C after 100 cycles in a 498.1 mA h pouch full cell.Furthermore,the particulate morphology of Li1.04Ni0.92Al0.04O2remains intact after cycling at a cutoff voltage of 4.3 V,whereas slightly Li-deficient Li0.98Ni0.97Al0.05O2features intragranular cracks and irreversible lattice distortion.The results highlight the value of molten salt-assisted synthesis and Li-refeeding induced elemental segregation strategy to upgrade Ni-based layered oxide cathode materials for advanced Li-ion batteries.

关键词： Aluminum segregation Cathode materials Molten synthesis Nonstoichiometric oxides Surface coating

Sequential neoadjuvant chemotherapy using pegylated liposomal doxorubicin and cyclophosphamide followed by taxanes with complete trastuzumab and pertuzumab treatment for HER2-positive breast cancer: A phase Ⅱ single-arm study

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Chinese Journal of Cancer Research 2024年第1期36卷 55-65页

作者： Yaping Yang Liang Jin yudong Li Nanyan Rao Chang Gong Shunrong Li Jiannan wu Jinghua Zhao Linxiaoxiao Ding Fengxia Gan Jun Zhang Ruifa Feng Zhenzhen Liu Qiang Liu Breast Tumor Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene RegulationGuangzhou 510120China Department of Thyroid and Breast Surgery Shenzhen Qianhai Shekou Free Trade Zone HospitalShenzhen 518000China Breast and Thyroid Surgery Guilin Medical College Second Affiliated HospitalGuilin 541199China Department of Breast Disease Henan Breast Cancer Centerthe Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalZhengzhou 450008China

Objective: Despite cardiotoxicity overlap, the trastuzumab/pertuzumab and anthracycline combination remains crucial due to significant benefits. Pegylated liposomal doxorubicin(PLD), a less cardiotoxic anthracycline, was evaluated for efficacy and cardiac safety when combined with cyclophosphamide and followed by taxanes with trastuzumab/pertuzumab in human epidermal growth factor receptor-2(HER2)-positive early breast cancer(BC).Methods: In this multicenter, phase II study, patients with confirmed HER2-positive early BC received four cycles of PLD(30-35 mg/m^(2)) and cyclophosphamide(600 mg/m^(2)), followed by four cycles of taxanes(docetaxel,90-100 mg/m^(2) or nab-paclitaxel, 260 mg/m^(2)), concomitant with eight cycles of trastuzumab(8 mg/kg loading dose,then 6 mg/kg) and pertuzumab(840 mg loading dose, then 420 mg) every 3 weeks. The primary endpoint was total pathological complete response(tp CR, yp T0/is yp N0). Secondary endpoints included breast p CR(bp CR),objective response rate(ORR), disease control rate, rate of breast-conserving surgery(BCS), and safety(with a focus on cardiotoxicity).Results: Between May 27, 2020 and May 11, 2022, 78 patients were treated with surgery, 42(53.8%) of whom had BCS. After neoadjuvant therapy, 47 [60.3%, 95% confidence interval(95% CI), 48.5%-71.2%] patients achieved tp CR, and 49(62.8%) achieved bp CR. ORRs were 76.9%(95% CI, 66.0%-85.7%) and 93.6%(95% CI,85.7%-97.9%) after 4-cycle and 8-cycle neoadjuvant therapy, respectively. Nine(11.5%) patients experienced asymptomatic left ventricular ejection fraction(LVEF) reductions of ≥10% from baseline, all with a minimum value of >55%. No treatment-related abnormal cardiac function changes were observed in mean N-terminal pro-BNP(NT-pro BNP), troponin I, or high-sensitivity troponin.Conclusions: This dual HER2-blockade with sequential polychemotherapy showed promising activity with rapid tumor regression in HER2-positive BC. Importantly, this regimen showed an acceptable safety profile,especially a low risk of cardiac events,

关键词： Breast cancer HER2-positive breast cancer dual HER2 blockade neoadjuvant therapy sequential therapy

Surface terminals reconstruction:The way to widen the output voltage of MXene-based aqueous symmetrical microsupercapacitors

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Nano Research 2023年第5期16卷 6780-6788页

作者： yudong wu Jimin Fu Ningning He Jun Liu Tao Hua Chengbing Qin Haibo Hu School of Physics and Materials Science Key Laboratory of Structure and Functional Regulation of Hybrid MaterialsAnhui UniversityHefei 230601China Nanotechnology Centre Institute of Textiles&ClothingThe Hong Kong Polytechnic UniversityHung HomKowloon 999077Hong KongChina Institute of Solid State Physics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China State Key Laboratory of Quantum Optics and Quantum Optics Devices Institute of Laser SpectroscopyCollaborative Innovation Center of Extreme OpticsShanxi UniversityTaiyuanShanxi 030006China

The low anodic oxidation potential severely suppresses the output voltage(≤0.6 V)of MXene-based symmetrical aqueous microsupercapacitors(MSA-MSCs)employing acidic electrolytes.Herein,a surface terminals reconstruction mechanism on cathode of MSA-MSCs adopting aqueous neutral electrolyte(1 M Na_(2)SO_(4))is first revealed by systematical electrochemical experiments and in/ex-situ spectral analysis,which indicates that:the-O terminals on Ti3C2Tx flakes of cathode can combine with intercalated Na+cations during charging process to reconstruct into-ONa units to(i)inhibit the splitting reaction of adjacent water molecules,decreasing cathodic hydrogen evolution potential,more significantly,(ii)lower the potential of zero voltage(P0V)between the symmetrical electrodes to avoid anode oxidation,enabling full use of the unexploited potential range of cathode.Thus,the output voltage of the MSA-MSCs tremendously expanded from 0.6 V in acidic polyacrylamide(PAM)/1 M H_(2)SO_(4)hydrogel electrolyte to 1.5 V in neutral polyacrylamide/1 M Na2SO4 hydrogel electrolyte,boosting the corresponding areal energy density from 9.9 to 34.6μW·h·cm^(-2).The demonstrated deep insight on the surface terminals reconstruction mechanism for synchronously modulating the P0V between symmetrical electrodes and hydrogen evolution potential on cathode provides critical guidance for widening the cell voltage of MSA-MSCs with safer and more inexpensive neutral electrolytes.

关键词： terminals reconstruction MXene potential of zero voltage symmetrical micro-supercapacitor aqueous electrolyte

A causal multiomics study discriminates the early immune features of Ad5-vectored Ebola vaccine recipients

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The Innovation 2024年第3期5卷 77-87页

作者： Zhe Zhang Wenjing Yang Zhengshan Chen Haoang Chi Shipo wu Wanru Zheng Ruochun Jin Busen Wang yudong Wang Nan Huo Jinlong Zhang Xiaohong Song Liyang Xu Jun Zhang Lihua Hou Wei Chen Institute of Biotechnology Academy of Military Medical SciencesBeijing 100071China Department of Intelligent Data Science College of Computer Science and TechnologyNational University of Defense TechnologyChangsha 410073China Intelligent Game and Decision Lab Academy of Military ScienceBeijing 100091China

The vaccine-induced innate immune response is essential for the generation of an antibody response.To date,how Ad5-vectored vaccines are influenced by preexisting anti-Ad5 antibodies during activation of the early immune response remains unclear.Here,we investigated the specific alterations in GP1,2-specific IgG-related elements of the early immune response at the genetic,molecular,and cellular levels on days 0,1,3,and 7 after Ad5-EBOV vaccination.In a causal multiomics analysis,distinct early immune responses associated with GP1,2-specific IgG were observed in Ad5-EBOV recipients with a low level of preexisting anti-Ad5 antibodies.This study revealed the correlates of the Ad5-EBOV-induced IgG response and provided mechanistic evidence for overcoming preexisting Ad5 immunity during the administration of Ad5-vectored vaccines.

关键词： vaccine immunity alterations

Adaptive Multi-Feature Fusion for Vehicle Micro-Motor Noise Recognition Considering Auditory Perception

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Sound & Vibration 2023年第1期57卷 133-153页

作者： Ting Zhao Weiping Ding Haibo Huang yudong wu School of Mechanical Engineering Southwest Jiaotong UniversityChengdu610031China National Laboratory for Rail Transportation Southwest Jiaotong UniversityChengdu610031China

The deployment of vehicle micro-motors has witnessed an expansion owing to the progression in electrification and intelligent technologies.However,some micro-motors may exhibit design deficiencies,component wear,assembly errors,and other imperfections that may arise during the design or manufacturing phases.Conse-quently,these micro-motors might generate anomalous noises during their operation,consequently exerting a substantial adverse influence on the overall comfort of drivers and passengers.Automobile micro-motors exhibit a diverse array of structural variations,consequently leading to the manifestation of a multitude of distinctive auditory irregularities.To address the identification of diverse forms of abnormal noise,this research presents a novel approach rooted in the utilization of vibro-acoustic fusion-convolutional neural network(VAF-CNN).This method entails the deployment of distinct network branches,each serving to capture disparate features from the multi-sensor data,all the while considering the auditory perception traits inherent in the human auditory sys-tem.The intermediary layer integrates the concept of adaptive weighting of multi-sensor features,thus affording a calibration mechanism for the features hailing from multiple sensors,thereby enabling a further refinement of features within the branch network.For optimal model efficacy,a feature fusion mechanism is implemented in the concluding layer.To substantiate the efficacy of the proposed approach,this paper initially employs an augmented data methodology inspired by modified SpecAugment,applied to the dataset of abnormal noise sam-ples,encompassing scenarios both with and without in-vehicle interior noise.This serves to mitigate the issue of limited sample availability.Subsequent comparative evaluations are executed,contrasting the performance of the model founded upon single-sensor data against other feature fusion models reliant on multi-sensor data.The experimental results substantiate that the suggested methodology yields heightened re

关键词： Auditory perception multi-sensor feature adaptive fusion abnormal noise recognition vehicle interior noise

Multi-Objective Prediction and Optimization of Vehicle Acoustic Package Based on ResNet Neural Network

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Sound & Vibration 2023年第1期57卷 73-95页

作者： Yunru wu Xiangbo Liu Haibo Huang yudong wu Weiping Ding Mingliang Yang School of Mechanical Engineering Southwest Jiaotong UniversityChengdu610031China Engineering Research Center of Advanced Driving Energy-Saving Technology Ministry of EducationChengdu610031China

Vehicle interior noise has emerged as a crucial assessment criterion for automotive NVH(Noise,Vibration,and Harshness).When analyzing the NVH performance of the vehicle body,the traditional SEA(Statistical Energy Analysis)simulation technology is usually limited by the accuracy of the material parameters obtained during the acoustic package modeling and the limitations of the application conditions.In order to effectively solve these shortcomings,based on the analysis of the vehicle noise transmission path,a multi-level objective decomposition architecture of the interior noise at the driver’s right ear is established.Combined with the data-driven method,the ResNet neural network model is introduced.The stacked residual blocks avoid the problem of gradient dis-appearance caused by the increasing network level of the traditional CNN network,thus establishing a higher-precision prediction model.This method alleviates the inherent limitations of traditional SEA simulation design,and enhances the prediction performance of the ResNet model by dynamically adjusting the learning rate.Finally,the proposed method is applied to a specific vehicle model and verified.The results show that the proposed meth-od has significant advantages in prediction accuracy and robustness.

关键词： NVH acoustic package performance prediction ResNet data-driven

Genome-Wide Identification of Tomato (Solanum lycopersicum L.) CKX Gene Family and Expression Analysis in the Callus Tissue under Zeatin Treatment

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Phyton-International Journal of Experimental Botany 2024年第6期93卷 1143-1158页

作者： Zhengfeng Lai Dongmei Lian Shaoping Zhang yudong Ju Bizhen Lin Yunfa Yao Songhai wu Jianji Hong Zhou Li Subtropical Agriculture Research Institute Fujian Academy of Agricultural SciencesZhangzhou363005China

The cytokinin oxidase/dehydrogenase(CKX)enzyme is essential for controlling theﬂuctuating levels of endogen-ous cytokinin(CK)and has a signiﬁcant impact on different aspects of plant growth and development.Nonethe-less,there is limited knowledge about CKX genes in tomato(Solanum lycopersicum L.).Here we performed genome-wide identiﬁcation and analysis of nine SlCKX family members in tomatoes using bioinformatics tools.The results revealed that nine SlCKX genes were unevenly distributed onﬁve chromosomes(Chr.1,Chr.4,Chr.8,Chr.10,and Chr.12).The amino acid length,isoelectric points,and molecular weight of the nine SlCKX proteins ranged from 453 to 553,5.77 to 8.59,and 51.661 to 62.494 kD,respectively.Subcellular localization analysis indi-cated that SlCKX2 proteins were located in both the vacuole and cytoplasmic matrix;SlCKX3 and SlCKX5 pro-teins were located in the vacuole;and SlCKX1,4,6,7,8,and 9 proteins were located in the cytoplasmic matrix.Furthermore,we observed differences in the gene structures and phylogenetic relationships of SlCKX proteins among different members.SlCKX1-9 were positioned on two out of the three branches of the CKX phylogenetic tree in the multispecies phylogenetic tree construction,revealing their strong conservation within phylogenetic subgroups.Unique patterns of expression of CKX genes were noticed in callus cultures exposed to varying con-centrations of exogenous ZT,suggesting their roles in speciﬁc developmental and physiological functions in the regeneration system.These results may facilitate subsequent functional analysis of SlCKX genes and provide valu-able insights for establishing an efﬁcient regeneration system for tomatoes.

关键词： Tomato SlCKX gene family phylogenetic relationships trans-zeatin expression pattern

基于EWT-KLD的机械密封金刚石涂层磨损声发射降噪

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西南交通大学学报 2024年第1期59卷 177-184页

作者：林志斌高宏力吴昱东谭咏文西南交通大学机械工程学院四川成都610031

为了准确获得机械密封金刚石涂层在磨损过程的声发射信号,在分析机械密封设备的噪声特性基础上,提出了基于经验小波变换(EWT)和相对熵(KLD)的声发射降噪方法;通过对磨损声发射信号进行经验小波变换得到划分其频带的滤波器组,对磨损声发... 详细信息

为了准确获得机械密封金刚石涂层在磨损过程的声发射信号,在分析机械密封设备的噪声特性基础上,提出了基于经验小波变换(EWT)和相对熵(KLD)的声发射降噪方法;通过对磨损声发射信号进行经验小波变换得到划分其频带的滤波器组,对磨损声发射信号和背景噪声发射信号用相同的滤波器组划分频带;计算相应频带2种信号的相对熵,用累计和算法在升序排列的相对熵中找到首个大于3σ的值作为阈值,保留相对熵值大于阈值的频带重构信号,完成降噪.研究结果表明:本文所提的EWT-KLD方法可以有效抑制不同工况、不同磨损状态的声发射信号的噪声,有效改善了磨损声发射信号的信噪比,尤其是微弱磨损信号的信噪比,提高了密封端面磨损声发射检测的精度和灵敏度;通过与传统降噪方法的对比发现,本文方法能够对不同工况下的密封磨损声发射信号降噪表现出更强的适应性和稳定性,对于及时检测早期密封磨损和准确监测磨损累积变化过程具有重要意义.

关键词：机械密封声发射降噪经验小波分解金刚石涂层

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复合海藻酸钠益生菌微胶囊研究进展

食品工业科技 2024年第3期45卷 372-377页

作者：常诗晗武俊瑞李紫晶史玉东乌日娜沈阳农业大学食品学院辽宁沈阳110866 辽宁省食品发酵技术工程研究中心辽宁沈阳110161 沈阳市微生物发酵技术创新重点实验室辽宁沈阳110866 内蒙古蒙牛乳业(集团)股份有限公司研发中心内蒙古呼和浩特011500

海藻酸钠微胶囊制备的研究一直是微胶囊技术的重要组成部分。由海藻酸钠制成的益生菌胶囊有孔隙和裂缝,通过利用不同壁材与海藻酸钠组合形成复合海藻酸钠微胶囊,可对益生菌起到更有效的保护作用。本文概述了三类材料对海藻酸钠微胶囊复... 详细信息

海藻酸钠微胶囊制备的研究一直是微胶囊技术的重要组成部分。由海藻酸钠制成的益生菌胶囊有孔隙和裂缝,通过利用不同壁材与海藻酸钠组合形成复合海藻酸钠微胶囊,可对益生菌起到更有效的保护作用。本文概述了三类材料对海藻酸钠微胶囊复合的研究进展,包括添加益生元刺激益生菌增长,共混纳米材料来提升机械性能,利用涂层成膜材料减少外部物质进入或内部芯材渗透。总结不同包埋结构的优缺点,并对益生菌微胶囊包埋的发展趋势进行了展望,以期为复合海藻酸钠益生菌微胶囊的科学研究提供参考。

关键词：复合海藻酸钠益生菌微胶囊化益生元纳米材料涂层成膜