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SARS coronavirus papain-like protease inhibits the type I interferon signaling pathway through interaction with the STING-TRAF3- TBK1 complex

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Protein & Cell 2014年第5期5卷 369-381页

作者： Xiaojuan Chen Xingxing yang yang Zheng yudong yang Yaling Xing Zhongbin Chen Division of Infection and Immunity Department of Electromagnetic and Laser Biology Beijing Institute of Radiation Medicine_ Beijing 100850 China Anhui Medical University Hefei 230032 China

SARS coronavirus （SARS-CoV） develops an antagonis- tic mechanism by which to evade the antiviral activities of interferon （IFN）. Previous studies suggested that SARS-CoV papain-like protease （PLpro） inhibits activa- tion of the IRF3 pathway, which would normally elicit a robust IFN response, but the mechanism（s） used by SARS PLpro to inhibit activation of the IRF3 pathway is not fully known. In this study, we uncovered a novel mechanism that may explain how SARS PLpro effi- ciently inhibits activation of the IRF3 pathway. We found that expression of the membrane-anchored PLpro domain （PLpro-TM） from SARS-CoV inhibits STING/ TBKl/IKKE-mediated activation of type I IFNs and dis- rupts the phosphorylation and dimerization of IRF3, which are activated by STING and TBKI. Meanwhile, we showed that PLpro-TM physically interacts with TRAF3, TBK1, IKK~, STING, and IRF3, the key components that assemble the STING-TRAF3-TBK1 complex for activa- tion of IFN expression. However, the interaction between the components in STING-TRAF3-TBK1 complex is dis- rupted by PLpro-TM. Furthermore, SARS PLpro-TM reduces the levels of ubiquitinated forms of RIG-I, STING, TRAF3, TBK1, and IRF3 in the STING-TRAF3- TBK1 complex. These results collectively point to a new mechanism used by SARS-CoV through which PLpro negatively regulates IRF3 activation by interaction withSTING-TRAF3-TBK1 complex, yielding a SARS-CoV countermeasure against host innate immunity.

关键词： SARS coronavirus papain-like protease,interferon deubiquitinase STING-TRAF3-TBK1 complex

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Catalytic oxidation effect of MnSO_(4) on As(Ⅲ) by air in alkaline solution

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Journal of Environmental Sciences 2023年第4期126卷 644-655页

作者： Yuhu Li yudong yang Ruixiang Wang Zhifeng Xu Guizhong Jin Chengyong Jin Faculty of materials Metallurgy and Chemistry Jiangxi University of Science and TechnologyGanzhou 341000China Hsikwang Shan Twinkling Star Co.Ltd. Lengshui Jiang 417500China

The catalytic oxidation effect of MnSO_(4)on As(Ⅲ) by air in an alkaline solution was *** to the X-ray diffraction (XRD),scanning electron microscope-energy dispersive spectrometer (SEM-EDS) and X-ray photoelectron spectroscopy (XPS) analysis results of the product,it was shown that the introduction of MnSO_(4)in the form of solution would generate Na_(0.55)Mn_(2)O_(4)·1.5H_(2)O with strong catalytic oxidation ability in the aerobic alkaline solution,whereas the catalytic effect of the other product MnOOH is not *** the optimal reaction conditions of temperature 90℃,As/Mn molar ratio 12.74:1,air flow rate1.0 L/min,and stirring speed 300 r/min,As(Ⅲ) can be completely oxidized after 2 hr *** excellent catalytic oxidation ability of MnSO_(4)on As(Ⅲ) was mainly attributed to the indirect oxidation of As(Ⅲ) by the product Na_(0.55)Mn_(2)O_(4)·1.5H_(2)*** study shows a convenient and efficient process for the oxidation of As(Ⅲ) in alkali solutions,which has potential application value for the pre-oxidation of arsenic-containing solution or the detoxification of As(Ⅲ).

关键词： Arsenic Air oxidation Catalytic oxidation Manganese sulfate

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Ambient photolysis frequency of NO2 determined using chemical actinometer and spectroradiometer at an urban site in Beijing

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Frontiers of Environmental Science & Engineering 2016年第6期10卷 73-81页

作者： Qi Zou Keding Lu Yusheng Wu yudong yang Zhuofei Du Min Hu State Key Joint Laboratory of Environmental Simulation and Pollution Control College of Environmental Sciences and Engineering Peking University Beijing 100871 China

The photolysis frequency of NO2, j（NO2）, is an important analytical parameter in the study of tropospheric chemistry. A chemical actinometer （CA） was built to measure the ambient j（NQ） based on a high precision NOx instrument with 1 min time resolution. Parallel measurements of the ambient j（NO2） by using the CA and a commercial spectroradiometer （SR） were conducted at a typical urban site （Peking University Urban Environmental Monitoring Station） in Beijing. In general, good agreement was achieved between the CA and SR data with a high linear correlation coefficient （R2 = 0.977） and a regression slope of 1.12. The regression offset was negligible compared to the measured signal level. Thej（NO2） data were calculated using the tropospheric ultraviolet visible radiation （TUV） model, which was constrained to observe aerosol optical properties. The calculated j（NO2） was intermediate between the results obtained with CA and SR, demonstrating the consistency of all the parameters observed at this site. The good agreement between the CA and SR data, and the consistency with the TUV model results, demonstrate the good performance of the installed SR instrument. Since a drift of the SR sensitivity is expected by the manufacturer, we propose a regular check of the data acquired via SR against those obtained by CA for long-term delivery of a high quality series ofj（NO2） data. Establishing such a time series will be invaluable for analyzing the long-term atmospheric oxidation capacity trends as well as O3 pollution for urban Beijing.

关键词： Photolysis frequency of nitrogen dioxide Chemical actinometer Spectroradiometer Tropospheric ultraviolet visible radiationmodel

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How different types of financial service providers support small- and mediumenterprises under the impact of COVID-19 pandemic: From the perspective of expectancy theory

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Frontiers of Business Research in China 2020年第4期14卷 448-474页

作者： Hua Song yudong yang Zheng Tao Business School Renmin University of ChinaBeijing 100872China

The 2019 novel coronavirus disease(COVID-19)pandemic has significantly impacted several aspects of the society and the economy.A problem that needs prompt attention in this situation is the increasing difficulties faced by small-and mediumsized enterprises(SMEs)in raising capital,which has aroused great concern from multiple stakeholders such as public administrations and *** the major supply of capital,financial service providers(FSPs)play a critical role in financing ***,how FSPs deal with SME financing during shocks has not yet been fully ***,in this study,a theoretical framework based on expectancy theory is proposed to explore the expected strategic adjustments of FSPs in financing ***,this study investigates 272 FSPs in China on their expectancy and attitude on financing to SMEs during the COVID-19 ***,this study has divided FSPs into three categories:commercial banks,non-bank financial institutions,and credit-enhanced *** among these categories are compared and analyzed.

关键词： 2019 novel coronavirus disease(COVID-19)pandemic Financial service providers(FSPs) Expectancy theory Financing to small-and medium-sized enterprises(SMEs)

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Crustal structure along the Zhenkang-Luxi deep seismic sounding profile in Yunnan derived from receiver functions

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Geodesy and Geodynamics 2018年第4期9卷 334-341页

作者： Zhanyong Gao Yanna Zhao Xiaoguo Deng yudong yang Geophysical Exploration Center China Earthquake Administration

The crustal thicknesses and the Poisson’s ratios under the seismic stations can be calculated by receiver function method with H-κ stacking effectively. But the stacking results are affected to some extent by the average crustal P-wave velocity. To eliminate this effect and get more accurate crustal structure along the Zhenkang-Luxi deep seismic sounding profile which lies in Yunnan Province, we calculate the receiver functions from the teleseismic events recorded by 11 temporary stations as well as 5 permanent ones along the profile and carry out the stacking with Vp obtained from the profile in this study. Our study shows that the crustal thicknesses along the Zhenkang-Luxi profile range from 34.8 km to 41.8 km with an average of 39 km. The crust is thicker in the middle part of the profile and thinner in both sides in general. Dramatic changes of crustal thickness about 3 km are detected across both the Lancangjiang fault and the Xiaojiang fault, which implies that these faults cut through the Moho. The lowest Poisson’s ratio under the stations is 0.22 and the highest is 0.27 with the mean of 0.25, which is lower than the global average value 0.27 in the continental crust. It suggests that most of the crust along the profile lacks mafic component, but contains more felsic substance. The low Poisson’s ratio also indicates that there is no satisfying condition for partial melting. We deduce that the material flow in the middle-lower crust in the southeastern margin of the Tibetan plateau may occur only in the north region of 24°N.

关键词： Receiver function Crustal structure Lancangjiang fault Xiaojiang fault Mid-lower crust flow

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Crustal P-wave velocity structure in the northeastern margin of the Qinghai-Tibetan Plateau and insights into crustal deformation

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Science China Earth Sciences 2018年第9期61卷 1221-1237页

作者： Shuaijun WANG Baojin LIU Xiaofeng TIAN Baofeng LIU Xianghui SONG Xiaoguo DENG Yinan SUN Cejun MA yudong yang Geophysical Exploration Center of China Earthquake Administration Zhengzhou 450002 China

The transitional area between the northeastern margin of the Qinghai-Tibetan Plateau, Ordos Block and Alxa Block, also being the northern segment of the North-South Seismic Belt, is characterized by considerably high seismicity level and high risk of strong earthquakes. In view of the special tectonic environment and deep tectonic setting in this area, this study used two seismic wide-angle reflection/refraction cross profiles for double constraining, so as to more reliably obtain the fine-scale velocity structure characteristics in both the shallow and deep crust of individual blocks and their boundaries in the study area, and further discuss the seismogenic environment in seismic zones with strong historical earthquakes. In this paper, the P-wave data from the two profiles are processed and interpreted, and two-dimensional crustal velocity structure models along the two profiles are constructed by travel time forward modeling. The results show that there are great differences in velocity structure, shape of intra-crustal interfaces and crustal thickness among different blocks sampled by the two seismic profiles. The crustal thickness along the Lanzhou-Huianbu-Yulin seismic sounding profile （L1） increases from -43 km in the western margin of Ordos Block to -56 km in the Qilian Block to the west. In the Ordos Block, the velocity contours vary gently, and the average velocity of the crust is about 6.30 km s^-1; On the other hand, the velocity structures in the crust of the Qilian Block and the arc-like tectonic zone vary dramatically, and the average crustal velocities in these areas are about 0.10 km s^-1 lower than that of the Ordos Block. In addition, discontinuous low-velocity bodies （LVZ1 and LVZ2） are identified in the crust of the Qilian Block and the arc-like tectonic zone, the velocity of which is 0.10-0.20 krn s^-1 lower than that of the surroundings. The average crustal thickness of the Ordos Block is consistently estimated to be around 43 km along both Pr

关键词： Northeastern margin of the Qinghai-Tibetan Plateau The Ordos Block Crustal velocity structure Deep seismicsounding

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Potential of secondary aerosol formation from Chinese gasoline engine exhaust

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Journal of Environmental Sciences 2018年第4期30卷 348-357页

作者： Zhuofei Du Min Hu Jianfei Peng Song Guo Rong Zheng Jing Zheng Dongjie Shang Yanhong Qin He Niu Mengren Li yudong yang Sihua Lu Yusheng Wu Min Shao Shijin Shuai State Key Joint Laboratory of Environmental Simulation and Pollution Control College of Environmental Sciences and EngineeringPeking University State key Laboratory of Automotive Safety and Energy Department of Automotive Engineering Tsinghua University

Light-duty gasoline vehicles have drawn public attention in China due to their significant primary emissions of particulate matter and volatile organic compounds（VOCs）. However,little information on secondary aerosol formation from exhaust for Chinese vehicles and fuel conditions is available. In this study, chamber experiments were conducted to quantify the potential of secondary aerosol formation from the exhaust of a port fuel injection gasoline engine. The engine and fuel used are common in the Chinese market, and the fuel satisfies the China V gasoline fuel standard. Substantial secondary aerosol formation was observed during a 4–5 hr simulation, which was estimated to represent more than 10 days of equivalent atmospheric photo-oxidation in Beijing. As a consequence, the extreme case secondary organic aerosol（SOA） production was 426 ± 85 mg/kg-fuel, with high levels of precursors and OH exposure. The low hygroscopicity of the aerosols formed inside the chamber suggests that SOA was the dominant chemical composition. Fourteen percent of SOA measured in the chamber experiments could be explained through the oxidation of speciated single-ring aromatics. Unspeciated precursors, such as intermediate-volatility organic compounds and semi-volatile organic compounds, might be significant for SOA formation from gasoline VOCs. We concluded that reductions of emissions of aerosol precursor gases from vehicles are essential to mediate pollution in China.

关键词： Port fuel injection Gasoline engine exhaust Secondary aerosol formation Chamber simulation Secondary organic aerosol

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亚周期激光脉冲光场整形研究(特邀)

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光子学报 2022年第1期51卷 153-163页

作者：杨煜东魏志义松山湖材料实验室广东东莞523808 中国科学院物理研究所北京100190

超快激光脉冲整形技术是基础研究和应用研究中广泛使用的重要实验手段,将其升级为亚周期激光脉冲光场整形技术是当今超快激光研究最前沿的重要课题之一。亚周期光场整形技术意味着对激光脉冲的完全控制,也标志着通过任意波形光场直接操... 详细信息

超快激光脉冲整形技术是基础研究和应用研究中广泛使用的重要实验手段,将其升级为亚周期激光脉冲光场整形技术是当今超快激光研究最前沿的重要课题之一。亚周期光场整形技术意味着对激光脉冲的完全控制,也标志着通过任意波形光场直接操控强场物理过程成为可能。亚周期光场整形技术的实现与亚周期光脉冲的产生建立在同样的技术基础之上,即超宽带光谱的产生与精确控制。实验上,用于产生亚周期光脉冲的光场相干合成技术同时也是亚周期激光脉冲光场整形有效且几乎唯一的实现手段。本文将综述介绍亚周期激光脉冲光场整形的研究进展,主要描述亚周期光场整形的技术基础、光场相干合成光源的实验结果及其在强场物理实验中的应用。

关键词：超快光学光场调控亚周期脉冲光场相干合成高次谐波产生

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基于螯合导向C—H/C—H氧化交叉偶联/环化反应策略构筑稠杂芳烃化合物

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化学进展 2020年第11期32卷 1824-1834页

作者：杨宇东游劲松四川大学化学学院绿色化学与技术教育部重点实验室

稠杂芳烃的合成是有机化学的重要研究内容之一,对有机光电功能材料和器件研究具有重要意义。C—H键是有机化合物中最广泛存在的化学键。利用C—H键的断裂与重组成键直接构筑稠杂芳烃具有简洁、高效的优势,能够解决传统合成方法在底物制... 详细信息

稠杂芳烃的合成是有机化学的重要研究内容之一,对有机光电功能材料和器件研究具有重要意义。C—H键是有机化合物中最广泛存在的化学键。利用C—H键的断裂与重组成键直接构筑稠杂芳烃具有简洁、高效的优势,能够解决传统合成方法在底物制备和产物结构类型方面的局限。本文对近六年来,本课题组在基于导向过渡金属催化(杂)芳环与(杂)芳环之间的C—H/C—H氧化交叉偶联/分子内环化反应策略构筑稠(杂)芳环方面所做的系列工作进行了评述,重点讨论了有关反应的特点、优势和催化机理,并对该策略在新型有机光电材料开发中的应用进行了阐述。最后,对该策略目前存在的问题进行了总结,并展望了其发展前景。

关键词： C—H活化氧化交叉偶联环化反应稠杂芳烃串联反应有机光电材料

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从中式课例研究看上海数学教师的专业学习

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中国教育学刊 2019年第11期 6-11页

作者：杨玉东上海市教育科学研究院普通教育研究所

国际和国内对上海基础教育均高度关注,上海数学教育基本经验之一是"强而有力的教研与教师队伍"。从国际比较视角,揭示上海数学教师经历的与国内其他地区教师类似的中式课例研究的根本特征,并进一步从上海对中式课例研究的发展和贡献角度... 详细信息

国际和国内对上海基础教育均高度关注,上海数学教育基本经验之一是"强而有力的教研与教师队伍"。从国际比较视角,揭示上海数学教师经历的与国内其他地区教师类似的中式课例研究的根本特征,并进一步从上海对中式课例研究的发展和贡献角度,概括出上海数学教师正是通过课例研究聚焦数学教改中的问题、发展数学学科教学知识、下移专业发展重心,从而获得了专业成长,在此基础上明确了中式课例研究对于教师专业学习在精致化传统教研活动、提升方法论自觉、践行中华优秀传统文化和思想的意义。

关键词：课例研究国际比较教师学习教研磨课

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