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聚苯胺纳米纤维阵列涂层的原位构筑和图案化

中国塑料 2020年第1期34卷 64-68页

作者：蔡玉东高海南中国石油天然气股份有限公司石油化工研究院北京102200 北京工商大学理学院北京100048

报道了一种基于原位聚合和光刻技术相结合的方法,在聚对苯二甲酸乙二醇酯表面构筑聚苯胺(PANI)纳米纤维阵列微观图案。结果表明,该方法所制备的PANI涂层具有大面积、均一的纳米纤维阵列结构;与滴涂成膜相比,原位聚合方法获得的微米级图... 详细信息

报道了一种基于原位聚合和光刻技术相结合的方法,在聚对苯二甲酸乙二醇酯表面构筑聚苯胺(PANI)纳米纤维阵列微观图案。结果表明,该方法所制备的PANI涂层具有大面积、均一的纳米纤维阵列结构;与滴涂成膜相比,原位聚合方法获得的微米级图案结构具有更高的精度和基底结合能力;同时,基于原位聚合的PANI全塑料湿度传感器件,在湿度传感方面具有更好的重复性和稳定性。

关键词：聚苯胺纳米纤维湿度传感原位聚合图案化

An atlas of CNV maps in cattle, goat and sheep

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Science China(Life Sciences) 2021年第10期64卷 1747-1764页

作者： Yongzhen Huang Yunjia Li Xihong Wang Jiantao Yu yudong cai Zhuqing Zheng Ran Li Shunjin Zhang Ningbo Chen Hojjat Asadollahpour Nanaei Quratulain Hanif Qiuming Chen Weiwei Fu Chao Li Xiukai Cao Guangxian Zhou Shudong Liu Sangang He Wenrong Li Yulin Chen Hong Chen Chuzhao Lei Mingjun Liu Yu Jiang College of Animal Science and Technology Northwest A&F UniversityYangling 712100China College of Information Engineering Northwest A&F UniversityYangling 712100China Key Laboratory of Genetics Breeding and Reproduction of Grass feeding Livestock Ministry of AgricultureBiotechnology Research InstituteXinjiang Academy of Animal SciencesUrumqi 830026China National Institute for Biotechnology and Genetic Engineering(NIBGE) Faisalabad 577PunjabPakistan Pakistan Institute of Engineering&Applied Sciences(PIEAS) Nilore 45650IslamabadPakistan

Copy number variation(CNV)is the most prevalent type of genetic structural variation that has been recognized as an important source of phenotypic variation in humans,animals and ***,the mechanisms underlying the evolution of CNVs and their function in natural or artificial selection remain ***,we generated CNV region(CNVR)datasets which were diverged or shared among cattle,goat,and sheep,including 886 individuals from 171 diverse *** 9 environmental factors for genome-wide association study(GWAS),we identified a series of candidate CNVRs,including genes relating to immunity,tick resistance,multi-drug resistance,and muscle *** number of CNVRs shared between species is significantly higher than expected(P<0.00001),and these CNVRs may be more persist than the single nucleotide polymorphisms(SNPs)shared between *** also identified genomic regions under long-term balancing selection and uncovered the potential diversity of the selected CNVRs close to the important functional *** study provides the evidence that balancing selection might be more common in mammals than previously considered,and might play an important role in the daily activities of these ruminant species.

关键词： copy number variation species-shared balancing selection ruminant livestock

Gene finding by integrating gene finders

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Journal of Biomedical Science and Engineering 2010年第11期3卷 1061-1068页

作者： yudong cai Zhisong He Lele Hu Bin Li Yi Zhou Han Xiao Zhiwen Wang Kairui Feng Lin Lu Kaiyan Feng Haipeng Li 不详

Gene finding, the accurate annotation of genomic DNA, has become one of the central topics in biological research. Although various computational methods (gene finders) have been proposed and developed, they all have their own limitations in gene findings. In this paper, we introduce an integrating gene finder, which combines the results of several existing gene finders together, to improve the accuracy of gene finding. Four integration schemes, based on majority voting, are developed for the analysis of two datasets – the basic dataset and the testing dataset. The basic dataset consists of 1500 DNA sequences and the testing dataset consists of 103 DNA sequences. It is demonstrated that a simple integration (a simple voting for each nucleotide) can significantly improve the finding performance, and removing confusing gene finders, caused by poor performance or redundant results, is important for a further improvement of the integration. The best prediction results are obtained using weighted majority voting, aided by the mRMR (Minimum Redundancy Maximum Relevance) (Peng, 2005) method for the gene finder selection. The prediction accuracies are 84.16% and 90.06% for the basic dataset and testing dataset respectively, which are better than any individual gene finding software in our research.

关键词： Gene Finding Intergration mRMR

地中海膳食对冠心病介入术后糖脂代谢指标的影响研究

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基层医学论坛 2021年第17期25卷 2379-2381页

作者：蔡愉东丰顺县人民医院广东丰顺514300

目的分析冠心病介入术后患者采用地中海膳食对糖脂代谢指标的影响。方法选取丰顺县人民医院2019年1月—2020年1月收治的冠心病介入术患者100例作为研究对象,按照随机数字表分为2组,每组各50例。一组术后予以常规膳食,一组术后予以地中... 详细信息

目的分析冠心病介入术后患者采用地中海膳食对糖脂代谢指标的影响。方法选取丰顺县人民医院2019年1月—2020年1月收治的冠心病介入术患者100例作为研究对象,按照随机数字表分为2组,每组各50例。一组术后予以常规膳食,一组术后予以地中海膳食,比较干预前后2组患者甘油三酯(TG)、总胆固醇(TC)、空腹血糖(FPG)、餐后2 h血糖(2 h PG)、胰岛素抵抗指数(HOMA-IR)、糖化血红蛋白(Hb A1c)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)水平变化。结果膳食干预前,2组TG、TC、FPG、2 h PG、HOMA-IR、Hb A1c、LDL-C、HDL-C比较无显著差异(P>0.05);膳食干预3个月、6个月后,地中海膳食组HDL-C水平高于常规膳食组,TG、TC、FPG、2 h PG、HOMA-IR、Hb A1c、LDL-C水平低于常规膳食组,差异均有统计学意义(P<0.05)。结论冠心病介入治疗术后患者采用地中海膳食有利于改善糖脂代谢水平,适宜推广应用。

关键词：冠心病介入术地中海膳食糖脂代谢影响

药物联合溶栓治疗急性ST段抬高型心肌梗死的疗效观察

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黑龙江医药 2020年第4期33卷 818-820页

作者：蔡愉东丰顺县人民医院心血管内科广东梅州514300

目的:探讨对急性ST段抬高型心肌梗死(STEMI)的患者,采用药物联合溶栓治疗方案治疗疾病的疗效。方法:将本院2017年10月至2019年1月收治的70例STEMI患者随机分成观察组(35例)与对照组(35例),针对对照组的患者,采用常规阿司匹林联合尿激酶... 详细信息

目的:探讨对急性ST段抬高型心肌梗死(STEMI)的患者,采用药物联合溶栓治疗方案治疗疾病的疗效。方法:将本院2017年10月至2019年1月收治的70例STEMI患者随机分成观察组(35例)与对照组(35例),针对对照组的患者,采用常规阿司匹林联合尿激酶的溶栓治疗方案,而观察组则在对照组用药基础上,加用大剂量的氯吡格雷进行联合溶栓治疗,观察两组患者的治疗效果。结果:观察组患者治疗总有效率为94.29%,明显高于对照组74.28%的总有效率(P<0.05);治疗2周后,两组患者CK、CK-MB两项指标水平均呈现治疗后较治疗前下降,但是治疗后的各项指标上则是观察组要远比对照组治疗后的指标水平更低(P<0.05)。结论:在STEMI的临床治疗中,采用大剂量氯吡格雷联合阿司匹林、尿激酶溶栓治疗的方法,可取得显著的治疗效果,降低患者血清CK、CK-MB水平,值得推广。

关键词：氯吡格雷阿司匹林尿激酶溶栓治疗急性ST段抬高型心肌梗死

一种基于图论的计算蛋白质数据库代表序列的算法

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计算机与应用化学 2008年第5期25卷 607-610页

作者：刘鹏飞曾振柄蔡煜东华东师范大学软件学院上海市200062 中国科学院上海生命科学研究院计算生物学研究所(中国科学院-马普学会计算生物学伙伴研究所) 上海市200031

许多生物序列数据库中都含有大量的冗余序列,这些冗余序列通常不利于对数据库的统计分析和处理,而且它们要占用更多的计算机存储和处理资源。针对这个问题,本文中我们设计了一种去除蛋白质冗余序列的算法。该算法基于图论最大独立集的... 详细信息

许多生物序列数据库中都含有大量的冗余序列,这些冗余序列通常不利于对数据库的统计分析和处理,而且它们要占用更多的计算机存储和处理资源。针对这个问题,本文中我们设计了一种去除蛋白质冗余序列的算法。该算法基于图论最大独立集的概念来生成非冗余序列集合,对目前存在的不少蛋白质去冗余程序所采用的由Hobohm和Sander最早设计的一种首先将序列分成若干簇然后取出代表序列的算法进行了改进,使得生成了更多的非冗余代表序列集合,避免了一些非冗余的序列也被去除。我们开发出了实现该算法的程序FastCluster,可以用来去除蛋白质数据库中的冗余序列。

关键词：生物信息学最大独立集代表序列去冗余

基于中心组合设计的主动进气格栅多开度控制模型的建立

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汽车工程 2015年第11期37卷 1240-1245页

作者：王文玺吴存学干能强王显李旭蔡渝东中国长安汽车工程研究院重庆401120 重庆大学机械工程学院重庆400044

本文中对一种基于冷却需求预测进行AGS多开度控制的新方法的研究。首先通过建立发动机舱热管理模型,对发动机散热和冷却需求进行理论分析,提出能满足冷却系统对进风量的实时需求的格栅多开角度控制算法。接着,引入中心组合设计法设计标... 详细信息

本文中对一种基于冷却需求预测进行AGS多开度控制的新方法的研究。首先通过建立发动机舱热管理模型,对发动机散热和冷却需求进行理论分析,提出能满足冷却系统对进风量的实时需求的格栅多开角度控制算法。接着,引入中心组合设计法设计标定方案并采用二次多项式回归方程建立车速-格栅开度-风扇状态的3因素风量预测模型。最后进行实车试验。结果表明,该方法能实时满足整车冷却需求,优化标定方案,有效降低汽车行驶阻力,提升燃油经济性。

关键词：主动进气格栅中心组合设计控制模型燃油经济性

用多种地震信息预测油气的自组织人工神经网络模型

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石油物探 1994年第2期33卷 80-84页

作者：蔡煜东许伟杰中国科学院上海冶金研究所上海200050

本文提出了油气预测的自组织人工神经网络模型，并选取一组标样作为研究对象，预测成功率达100％。结果表明，本方法性能良好，可望成为利用地震信息预测油气的一种有效辅助手段。

关键词：预测神经网络油气勘探地震勘探

Modes of genetic adaptations underlying functional innovations in the rumen

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Science China(Life Sciences) 2021年第1期64卷 1-21页

作者： Xiangyu Pan yudong cai Zongjun Li Xianqing Chen Rasmus Heller Nini Wang Yu Wang Chen Zhao Yong Wang Han Xu Songhai Li Ming Li Cunyuan Li Shengwei Hu Hui Li Kun Wang Lei Chen Bin Wei Zhuqing Zheng Weiwei Fu Yue Yang Tingting Zhang Zhuoting Hou Yueyang Yan Xiaoyang Lv Wei Sun Xinyu Li Shisheng Huang Lixiang Liu Shengyong Mao Wenqing Liu Jinlian Hua Zhipeng Li Guojie Zhang Yulin Chen Xihong Wang Qiang Qiu Brian PDalrymple Wen Wang Yu Jiang Key Laboratory of Animal Genetics Breeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYangling712100China School of Ecology and Environment Northwestern Polytechnical UniversityXi’an710072China Section for Computational and RNA Biology Department of BiologyUniversity of CopenhagenCopenhagenDK-2100Denmark University of Chinese Academy of Sciences Beijing100049China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunming650223China CEMS NCMISMDISAcademy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing100080China Marine Mammal and Marine Bioacoustics Laboratory Institute of Deep-sea Science and EngineeringChinese Academy of SciencesSanya572000China College of Life Sciences Shihezi UniversityShihezi832003China State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources College of Animal Science and TechnologyGuangxi UniversityNanning530005China College of Animal Science and Technology Yangzhou UniversityYangzhou225009China Joint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China Yangzhou UniversityYangzhou225009China Key Laboratory for Major Obstetric Diseases of Guangdong Province The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510150China School of Life Science and Technology Shanghai Tech UniversityShanghai201210China College of Animal Science and Technology Nanjing Agricultural UniversityNanjing210095China College of Veterinary Medicine Shaanxi Centre of Stem Cells Engineering&TechnologyNorthwest A&F UniversityYangling712100China Department of Special Economic Animal Nutrition and Feed Science Institute of Special Animal and Plant SciencesChinese Academy of Agricultural SciencesChangchun130112China Section for Ecology and Evolution Department of BiologyUniversity of CopenhagenCopenhagenDK-2100Denmark China National GeneBank BGI-ShenzhenShen

The rumen is the hallmark organ of ruminants and hosts a diverse ecosystem of microorganisms that facilitates efficient digestion of plant *** analyzed 897 transcriptomes from three Cetartiodactyla lineages:ruminants,camels and cetaceans,as well as data from ruminant comparative genomics and functional assays to explore the genetic basis of rumen functional *** identified genes with relatively high expression in the rumen,of which many appeared to be recruited from other *** genes show functional enrichment in ketone body metabolism,regulation of microbial community,and epithelium absorption,which are the most prominent biological processes involved in rumen *** modes of genetic change underlying rumen functional innovations were uncovered,including coding mutations,genes newly evolved,and changes of regulatory *** validated that the key ketogenesis rate-limiting gene(HMGCS2)with five ruminant-specific mutations was under positive selection and exhibits higher synthesis activity than those of other *** newly evolved genes(LYZ1 and DEFB1)are resistant to Gram-positive bacteria and thereby may regulate microbial community ***,we confirmed that the changes of regulatory elements accounted for the majority of rumen gene *** results greatly improve our understanding of rumen evolution and organ evo-devo in general.

关键词： rumen innovations comparative transcriptomics comparative genomics evo-devo evolution of organs