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抗原改造联合纳米肿瘤疫苗用以克服肿瘤新抗原短缺及在多种肿瘤类型上激起强效抗肿瘤免疫反应

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Science Bulletin 2024年第7期69卷 922-932页

作者：陈宏宇黄子超李佳玄董思徐玉笛马胜赵佳雨刘丽萍孙天盟宋万通陈学思 School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China Key laboratory of Polymer Ecomaterials Changchun Institue of Applied ChemistryChinese Academy of SciencesChangchun 130022China Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education Institute of ImmunologyThe First HospitalJilin UniversityChangchun 130021China Jilin Biomedical Polymers Engineering Laboratory Changchun 130022China

Neoantigen cancer vaccines have been envisioned as one of the most promising means for cancer ***,identifying neoantigens for tumor types with low tumor mutation burdens continues to limit the effectiveness of neoantigen ***,we proposed a "hit-and-run" vaccine strategy which primes T cells to attack tumor cells decorated with exogenous "neo-antigens".This vaccine strategy utilizes a peptide nanovaccine to elicit antigen-specific T cell responses after tumor-specific decoration with a nanocarrier containing the same peptide *** demonstrated that a poly(2-oxazoline)s(POx) conjugated with OVA_(257-264) peptide through a matrix metalloprotease 2(MMP-2) sensitive linker could efficiently and selectively decorate tumor cells with OVA peptides in ***,a POx-based nanovaccine containing OVA_(257-264) peptides to elicit OVA-specific T cell responses was *** combination with this hit-and-run vaccine system,an effective vaccine therapy was demonstrated across tumor types even without OVA antigen *** approach provides a promising and uniform vaccine strategy against tumors with a low tumor mutation burden.

关键词： Cancer immunotherapy Cancer vaccine Neoantigen Nanocarrier Poly(2-oxazoline)s

广东省佛山市南海区适龄儿童水痘抗体水平变化与免疫策略分析

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医学动物防制 2018年第11期34卷 1024-1027页

作者：黄宇迪吕海韵邱宗耀钱树星李俊勇林畅琪佛山市南海区疾病预防控制中心广东528200 广东药科大学

目的了解佛山市南海区3~10岁儿童接种水痘疫苗后抗体水平变化情况,为推行两剂次水痘疫苗免疫策略的调整提供参考依据。方法随机抽取佛山市南海区接种水痘疫苗1、3、5、7年后的儿童491人,无疫苗接种史儿童142人,均检测水痘Ig G抗体,率的... 详细信息

目的了解佛山市南海区3~10岁儿童接种水痘疫苗后抗体水平变化情况,为推行两剂次水痘疫苗免疫策略的调整提供参考依据。方法随机抽取佛山市南海区接种水痘疫苗1、3、5、7年后的儿童491人,无疫苗接种史儿童142人,均检测水痘Ig G抗体,率的比较采用卡方检验,抗体水平比较使用t检验。结果不同性别儿童中,有接种史儿童的抗体阳性率及抗体浓度差异无统计学意义(χ~2=0.99,P>0.05),无接种史儿童的抗体阳性率差异无统计学意义(χ~2=1.75,P>0.05),但抗体浓度间差异有统计学意义(t=2.26,P0.05);5~6岁不同接种史的儿童水痘抗体阳性率、水痘抗体浓度间差异均有统计学意义(χ~2=12.46,t=5.13,P<0.05);比较接种后1年组与5年组(χ~2=11.0 061,P<0.05)、接种后1年组与7年组(χ~2=13.6 184,P<0.05)、接种后3年组与5年组(χ~2=9.1 115,P<0.05)、接种后3年组与7年组(χ~2=11.6 307,P<0.05)抗体阳性率间差异均有统计学意义;比较不同接种年限后抗体浓度间的差异,发现接种后1年组与5年组(χ~2=3.587,P<0.05)、接种后1年组与7年组(χ~2=4.925,P<0.05)、接种后3年组与5年组(χ~2=3.483,P<0.05)、接种后3年组与7年组(χ~2=4.866,P<0.05)抗体浓度间差异均有统计学意义。结论佛山市南海区儿童在接种第1剂次水痘疫苗后,4年内建议加强1剂次疫苗,以维持体内抗体水平。

关键词：水痘抗体水平现况调查免疫策略

Trinity immune enhancing nanoparticles for boosting antitumor immune responses of immunogenic chemotherapy

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Nano Research 2022年第2期15卷 1183-1192页

作者： yudi Xu Sheng Ma Jiayu Zhao Xinghui Si Zichao huang Yu Zhang Wantong Song Zhaohui Tang Xuesi Chen Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China University of Chinese Academy of Sciences Beijing 100039China University of Science and Technology of China Hefei 230026China Jilin Biomedical Polymers Engineering Laboratory Changchun 130022China

Certain chemo drugs have been reported to potentially induce tumor-specific immune recognition by triggering immunogenic cell death(ICD),which provides a promising alternative way for cancer ***,the immunogenic effects of such treatments are still weak and robust systemic antitumor immune responses are rarely seen when these agents were used ***,we proposed a trinity immune enhancing nanoparticles(TIENs)for boosting antitumor immune responses of chemo *** TIENs was constructed with Food and Drug Administration(FDA)approved polylactic acid(PLA),canonical proton-sponging cationic polymer polyethyleneimine(PEI),and Toll-like receptor 9(TLR9)agonist cytosine phosphate guanine oligodeoxynucleotide(CpG-ODN).In in vitro studies,the TIENs was proved to(1)promote antigen capturing,(2)antigen-presenting cells(APCs)activation,and(3)antigen *** in vivo studies,intratumorally injected TIENs greatly enhanced antitumor effect and robust immune responses of oxaliplatin and doxorubicin in murine CT26 and 4T1 tumor models,***,after decoration with a detachable shielding,the TIENs was proved to be effective in promoting the antitumor effects of chemo agents after intravenous *** combination of TIENs with clinically widely used chemo agents should be meaningful in boosting effective antitumor immune responses and cancer therapy.

关键词： nanoparticles immunotherapy antigen capturing cross-presentation immune activation

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电动汽车电池全生命周期碳足迹

华南师范大学学报（自然科学版） 2024年第4期56卷 1-9页

作者：唐昕雅蔡军黄鲲张思瑶王文涛林磊庄宇迪才华陈军工业产品环境适应性全国重点实验室广州514000 中南大学化学化工学院长沙410083 嘉兴威凯检测技术有限公司嘉兴314000

围绕《欧盟新电池法规(EU)2023/1542》中动力电池碳足迹的计算规则,对其进行全生命周期系统性的研究。回顾了电池在原材料获取与预加工阶段、生产制造阶段、分销阶段及废弃物处理与回收阶段的碳排放情况,突出了生命周期分析的必要性,并... 详细信息

围绕《欧盟新电池法规(EU)2023/1542》中动力电池碳足迹的计算规则,对其进行全生命周期系统性的研究。回顾了电池在原材料获取与预加工阶段、生产制造阶段、分销阶段及废弃物处理与回收阶段的碳排放情况,突出了生命周期分析的必要性,并对不同类型电池碳足迹进行了对比。结合研究结果进行情景预测,提出电动汽车电池碳减排策略。文章有助于深化对电动汽车可持续发展的理解,为政策制定和产业发展提供科学依据。

关键词：生命周期评价锂离子电池碳足迹电动汽车

压力性尿失禁女性患者尿动力学的影响因素分析

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中国医刊 2024年第5期59卷 517-519页

作者：张立芳王静璇黄亮张宇迪卢丹首都医科大学附属北京妇产医院/北京妇幼保健院妇科北京100026

目的探讨影响压力性尿失禁女性患者尿动力学检查结果的相关因素。方法选取2017年10月至2019年10月首都医科大学附属北京妇产医院妇科门诊收治的压力性尿失禁女性患者141例为研究对象,尿动力学检查采用重量-时间法(承重法)和导尿管导... 详细信息

目的探讨影响压力性尿失禁女性患者尿动力学检查结果的相关因素。方法选取2017年10月至2019年10月首都医科大学附属北京妇产医院妇科门诊收治的压力性尿失禁女性患者141例为研究对象,尿动力学检查采用重量-时间法(承重法)和导尿管导尿法测量尿流率参数,包括最大尿流率、平均尿流率、排尿时间、尿流时间、最大尿流率达峰时间、残余尿量。尿动力学检查过程中若有尿液自尿道口不自主流出视为阳性。在141例压力性尿失禁患者中,将尿动力学检查结果阳性的93例患者作为阳性组,检查结果阴性的48例患者作为阴性组。比较两组患者的年龄、尿流率参数、尿流率曲线是否起伏,探讨其与尿动力学检查结果阳性的关系。结果单因素分析结果显示,与阴性组患者相比,阳性组患者的年龄更大,最大尿流率、平均尿流率和尿流率曲线不起伏比例更高,尿流时间更短,差异均有统计学意义(P0.05)。多因素logistic回归分析结果显示,年龄和尿流率曲线是影响检测结果阳性的独立危险因素(P<0.05),年龄大、尿流率曲线不起伏的患者检测结果阳性的风险较高。结论压力性尿失禁患者年龄和排尿方式为主要影响尿动力学检查结果的因素。

关键词：压力性尿失禁尿动力学检查尿流率

An ultra-fast charging strategy for lithium-ion battery at low temperature without lithium plating

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Journal of Energy Chemistry 2022年第9期31卷 442-452,I0013页

作者： yudi Qin Pengyu Zuo Xiaoru Chen Wenjing Yuan Rong huang Xiaokan Yang Jiuyu Du Languang Lu Xuebing Han Minggao Ouyang State Key Laboratory of Automotive Safety and Energy School of Vehicle and MobilityTsinghua UniversityBeijing 100084China Beijing LianYu Technology Co. Ltd.Beijing 100084China Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China Beijing Electric Vehicle Co. Ltd.Beijing 100176China

Conventional charging methods for lithium-ion battery(LIB)are challenged with vital problems at low temperatures:risk of lithium(Li)plating and low charging *** study proposes a fast-charging strategy without Li plating to achieve high-rate charging at low temperatures with bidirectional *** strategy combines the pulsed-heating method and the optimal charging method via precise control of the battery states.A thermo-electric coupled model is developed based on the pseudo-twodimensional(P2D)electrochemical model to derive charging *** current maps of pulsed heating and charging are generated to realize real-time ***,our proposed strategy achieves a 3 C equivalent rate at 0℃ and 1.5 C at-10℃ without Li plating,which is 10–30 times faster than the traditional *** entropy method is employed to balance the charging speed and the energy efficiency,and the charging performance is further *** practical application,the power limitation of the charger is considered,and a 2.4 C equivalent rate is achieved at 0℃ with a 250 kW maximum power *** novel strategy significantly expands LIB usage boundary,and increases charging speed and battery safety.

关键词： Lithium-ion battery Pulsed heating Fast charging Low temperature Lithium deposition

慢性阻塞性肺疾病患者疲劳管理的最佳证据总结

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护理与康复 2024年第3期23卷 33-40页

作者：王净骆晓琳黄浠婷王智乾俞玉娣蔡莎莎黄丽华浙江大学医学院附属第一医院浙江杭州310003 浙江省医疗服务管理评价中心浙江杭州310003

目的总结慢性阻塞性肺疾病患者疲劳管理的最佳证据,为临床护理工作提供参考。方法系统检索UpToDate、BMJ Best Practice、国内外相关指南网站、相关专业协会网站、Cochrane Library、澳大利亚JBI循证卫生保健中心数据库、PubMed、Web of... 详细信息

目的总结慢性阻塞性肺疾病患者疲劳管理的最佳证据,为临床护理工作提供参考。方法系统检索UpToDate、BMJ Best Practice、国内外相关指南网站、相关专业协会网站、Cochrane Library、澳大利亚JBI循证卫生保健中心数据库、PubMed、Web of Science、Embase、中国知网、万方数据知识服务平台、维普资讯中文期刊服务平台、中国生物医学文献数据库中有关慢性阻塞性肺疾病疲劳管理的证据。检索时限为建库至2023年3月5日。2名研究者独立对文献进行质量评价和资料提取。结果共纳入19篇文献,其中指南4篇、系统评价11篇、随机对照试验4篇,从症状评估、运动管理、氧疗、心理干预、自我管理、中医管理、姑息治疗7个方面总结了21条最佳证据。结论本研究总结的慢性阻塞性肺疾病患者疲劳管理最佳证据方法科学严谨,临床医护人员可遵循最佳证据,并结合具体临床情景和患者意愿制定个性化的疲劳管理方案,有效、规范缓解慢性阻塞性肺疾病患者疲劳。

关键词：慢性阻塞性肺疾病疲劳证据总结循证护理

Myc inhibition tips the immune balance to promote antitumor immunity

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Cellular & Molecular Immunology 2022年第9期19卷 1030-1041页

作者： Chao Yang Yun Liu yudi Hu Liang Fang Zhe huang Huanhuan Cui Jun Xie Yazhen Hong Wei Chen Nengming Xiao Qiyuan Li Wen-Hsien Liu Changchun Xiao State Key Laboratory of Cellular Stress Biology School of Life SciencesFaculty of Medicine and Life SciencesXiamen UniversityXiamen361102FujianChina Institute of Hematology School of MedicineXiamen UniversityXiamen361102FujianChina Shenzhen Key Laboratory of Gene Regulation and Systems Biology School of Life Sciences and Academy for Advanced Interdisciplinary StudiesSouthern University of Science and TechnologyShenzhen518005GuangdongChina Sanofi Institute for Biomedical Research Suzhou215123JiangsuChina Department of Immunology and Microbiology The Scripps Research InstituteLa JollaCA92037USA

Aberrant expression of Myc is one of the most common oncogenic events in human *** of Myc inhibitors are currently under development for treating Myc-driven *** addition to directly targeting tumor cells,Myc inhibition has been shown to modulate the tumor microenvironment to promote tumor ***,the effect of Myc inhibition on immune cells in the tumor microenvironment remains poorly ***,we show that the adaptive immune system plays a vital role in the antitumor effect of pharmacologic inhibition of *** genetic and pharmacologic approaches,we found that Myc inhibition enhanced CD8 T cell function by suppressing the homeostasis of regulatory T(Treg)cells and the differentiation of resting Treg(rTreg)cells to activated Treg(aTreg)cells in ***,we demonstrated that different Myc expression levels confer differential sensitivity of T cell subsets to pharmacologic inhibition of *** ablation of the Myc gene has been shown to suppress CD8 T cell function,Treg cells,which express much less Myc protein than CD8 T cells,are more sensitive to Myc *** differential sensitivity of CD8 T and Treg cells to Myc inhibitors resulted in enhanced CD8 T cell function upon Myc *** findings revealed that Myc inhibitors can induce an antitumor immune response during tumor progression.

关键词： Myc inhibition Regulatory T cells Differential sensitivity Antitumor immunity Cancer immunotherapy

Clinical factors associated with composition of lung microbiota and important taxa predicting clinical prognosis in patients with severe community-acquired pneumonia

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Frontiers of Medicine 2022年第3期16卷 389-402页

作者： Sisi Du Xiaojing Wu Binbin Li Yimin Wang Lianhan Shang Xu huang yudi Xia Donghao Yu Naicong Lu Zhibo Liu Chunlei Wang Xinmeng Liu Zhujia Xiong Xiaohui Zou Binghuai Lu Yingmei Liu Qingyuan Zhan Bin Cao China-Japan Friendship Hospital National Clinical Research Center for Respiratory DiseasesNational Center for Respiratory MedicineClinical Center for Pulmonary InfectionsCapital Medical UniversityBeijing 100029China Institute of Respiratory Medicine Chinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100029China Department of Pulmonary and Critical Care Medicine Center for Respiratory DiseasesChina-Japan Friendship HospitalBeijing 100029China Beijing University of Chinese Medicine Beijing 100029China Beijing Luhe Hospital Beijing 101100China Tsinghua University–Peking University Joint Center for Life Sciences Beijing 100084China

Few studies have described the key features and prognostic roles of lung microbiota in patients with severe community-acquired pneumonia(SCAP).We prospectively enrolled consecutive SCAP patients admitted to *** was performed at bedside within 48 h of ICU admission,and 16S rRNA gene sequencing was applied to the collected bronchoalveolar lavage *** primary outcome was clinical improvements defined as a decrease of 2 categories and above on a 7-category ordinal scale within 14 days following ***-seven patients were *** permutational multivariate analysis of variance found that positive bacteria lab test results had the strongest independent association with lung microbiota(R2=0.033;P=0.018),followed by acute kidney injury(AKI;R2=0.032;P=0.011)and plasma MIP-1βlevel(R2=0.027;P=0.044).Random forest identified that the families Prevotellaceae,Moraxellaceae,and Staphylococcaceae were the biomarkers related to the positive bacteria lab test *** Cox regression showed that the increase inα-diversity and the abundance of the families Prevotellaceae and Actinomycetaceae were associated with clinical *** positive bacteria lab test results,AKI,and plasma MIP-1βlevel were associated with patients’lung microbiota composition on ICU *** families Prevotellaceae and Actinomycetaceae on admission predicted clinical improvements.

关键词： severe community-acquired pneumonia lung microbiota clinical improvements 7-category ordinal scale Prevotellaceae