检索结果-南通市图书馆

同方期刊数据库

Using MsfNet to Predict the ISUP Grade of Renal Clear Cell Carcinoma in Digital Pathology Images

在线全文

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2024年第1期78卷 393-410页

作者： Kun Yang Shilong Chang yucheng Wang Minghui Wang Jiahui Yang Shuang Liu Kun Liu Linyan xue College of Quality and Technical Supervision Hebei UniversityBaoding071002China National and Local Joint Engineering Research Center of Metrology Instrument and System Hebei UniversityBaoding071002China Hebei Technology Innovation Center for Lightweight of New Energy Vehicle Power System Hebei UniversityBaoding071002China

Clear cell renal cell carcinoma(ccRCC)represents the most frequent form of renal cell carcinoma(RCC),and accurate International Society of Urological Pathology(ISUP)grading is crucial for prognosis and treatment *** study presents a new deep network called Multi-scale Fusion Network(MsfNet),which aims to enhance the automatic ISUP grade of ccRCC with digital histopathology pathology *** MsfNet overcomes the limitations of traditional ResNet50 by multi-scale information fusion and dynamic allocation of channel *** model was trained and tested using 90 Hematoxylin and Eosin(H&E)stained whole slide images(WSIs),which were all cropped into 320×320-pixel patches at 40×*** achieved a micro-averaged area under the curve(AUC)of 0.9807,a macro-averaged AUC of 0.9778 on the test *** Gradient-weighted Class Activation Mapping(Grad-CAM)visually demonstrated MsfNet’s ability to distinguish and highlight abnormal areas more effectively than *** t-Distributed Stochastic Neighbor Embedding(t-SNE)plot indicates our model can efficiently extract critical features from images,reducing the impact of noise and redundant *** results suggest that MsfNet offers an accurate ISUP grade of ccRCC in digital images,emphasizing the potential of AI-assisted histopathological systems in clinical practice.

关键词： Renal cell carcinoma computer-aided diagnosis pathology image deep learning machine learning

Enhancement of T cell infiltration via tumor-targeted Th9 cell delivery improves the efficacy of antitumor immunotherapy of solid tumors

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bioactive Materials 2023年第5期23卷 508-523页

作者： Tao Chen yucheng xue Shengdong Wang Jinwei Lu Hao Zhou Wenkan Zhang Zhiyi Zhou Binghao Li Yong Li Zenan Wang Changwei Li Yinwang Eloy Hangxiang Sun Yihang Shen Mohamed Diaty Diarra Chang Ge Xupeng Chai Haochen Mou Peng Lin Xiaohua Yu Zhaoming Ye Orthopaedic Oncology Services Department of OrthopaedicsThe Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou310009China Orthopaedic Research Institute Zhejiang UniversityHangzhou310009China Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province Hangzhou310009China The Second Clinical Medical College of Zhejiang Chinese Medical University Hangzhou310009China Qingtian People’s Hospital Department of OrthopedicsLishui323900China Department of Orthopedics Shanghai Key Laboratory for the Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopedicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai20025China Department of Radiology The Second Affiliated HospitalZhejiang University School of MedicineHangzhou310009China

Insufficient infiltration of T cells severely compromises the antitumor efficacy of adoptive cell therapy(ACT)against solid ***,we present a facile immune cell surface engineering strategy aiming to substantially enhance the anti-tumor efficacy of Th9-mediated ACT by rapidly identifying tumor-specific binding ligands and improving the infiltration of infused cells into solid ***-genetic decoration of Th9 cells with tumor-targeting peptide screened from phage display not only allowed precise targeted ACT against highly heterogeneous solid tumors but also substantially enhanced infiltration of CD8+T cells,which led to improved antitumor ***,infusion of Th9 cells modified with tumor-specific binding ligands facilitated the enhanced distribution of tumor-killing cells and remodeled the immunosuppressive microenvironment of solid tumors via IL-9 mediated ***,we presented a simple,cost-effective,and cell-friendly strategy to enhance the efficacy of ACT against solid tumors with the potential to complement the current ACT.

关键词： Adoptive cell therapy(ACT) Phage display Cell surface engineering Th9 cell Solid tumor

Character Sheaves for Classical Graded Lie Algebras

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2024年第3期40卷 870-884页

作者： Ting xue School of Mathematics and Statistics University of MelbourneVIC 3010Australia Department of Mathematics and Statistics University of HelsinkiHelsinki 00014Finland

In this note we study character sheaves for graded Lie algebras arising from inner automorphisms of special linear groups and Vinberg’s type Ⅱ classical graded Lie algebras.

关键词： Graded Lie algebras character sheaves Fourier transform nilpotent orbits

Mechanical property of cylindrical sandwich shell with gradient core of entangled wire mesh

在线全文

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2024年第1期31卷 510-522页

作者： Xin xue Chao Zheng Fu-qiang Lai xue-qian Wu Institute of Metal-rubber&Vibration Noise School of Mechanical Engineering and AutomationFuzhou UniversityFuzhou350116China Fujian Metallurgical Industry Design Institute Fuzhou350116China

To explore the wide-frequency damping and vibration-attenuation performances in the application of aerospace components,the cylindrical sandwich shell structure with a gradient core of entangled wire mesh was proposed in this ***,the gradient cores of entangled wire mesh in the axial and radial directions were prepared by using an in-house Numerical Control weaving machine,and the metallurgical connection between skin sheets and the gradient core was performed using vacuum ***,to investigate the mechanical properties of cylindrical sandwich shells with axial or radial gradient cores,quasi-static and dynamic mechanical experiments were carried *** primary evaluations of mechanical properties include secant stiffness,natural frequency,Specific Energy Absorption(SEA),vibration acceleration level,and so *** results suggest that the vibration-attenuation performance of the sandwich shell is remarkable when the high-density core layer is at the end of the shell or abuts the inner *** axial gradient material has almost no influence on the vibration frequencies of the shell,whereas the vibration frequencies increase dramatically when the high-density core layer approaches the ***,compared to the conventional sandwich shells,the proposed functional grading cylindrical sandwich shell exhibits more potential in mass reduction,stiffness designing,and energy dissipation.

关键词： Entangled wire mesh Gradient cylindrical sandwich shell Vacuum brazing Secant stiffness Damping

Linear Quadratic Optimal Control for Systems Governed by First-Order Hyperbolic Partial Differential Equations

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Science & Complexity 2024年第1期37卷 230-252页

作者： xue Xiaomin XU Juanjuan ZHANG Huanshui School of Control Science and Engineering Shandong UniversityJinan 250061China College of Electrical Engineering and Automation Shandong University of Science and TechnologyQingdao 266000China

This paper focuses on linear-quadratic(LQ)optimal control for a class of systems governed by first-order hyperbolic partial differential equations(PDEs).Different from most of the previous works,an approach of discretization-then-continuousization is proposed in this paper to cope with the infinite-dimensional nature of PDE *** contributions of this paper consist of the following aspects:(1)The differential Riccati equations and the solvability condition of the LQ optimal control problems are obtained via the discretization-then-continuousization method.(2)A numerical calculation way of the differential Riccati equations and a practical design way of the optimal controller are ***,the relationship between the optimal costate and the optimal state is established by solving a set of forward and backward partial difference equations(FBPDEs).(3)The correctness of the method used in this paper is verified by a complementary continuous method and the comparative analysis with the existing operator results is *** is shown that the proposed results not only contain the classic results of the standard LQ control problem of systems governed by ordinary differential equations as a special case,but also support the existing operator results and give a more convenient form of computation.

关键词： Discretization-then-continuousization method first-order hyperbolic partial differential equations forward and backward partial difference equations linear quadratic optimal control.

Thermodynamic property of sandwich cylindrical shell structure with metallic wire mesh:Numerical modeling and experimental analysis

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2024年第1期37卷 138-152页

作者： Xin xue Guojian SHEN Juan LIAO Institute of Metal Rubber&Vibration Noise School of Mechanical Engineering and AutomationFuzhou UniversityFuzhou 350116China Fujian Shuikou Power Generation Group Co. LTDFuzhou 350000China

As a new addition to lightweight composite structures,the sandwich cylindrical shell with a metallic wire mesh core has emerged as a promising solution for thermodynamic performance analysis at elevated *** intricate interwoven cellular formations within the metallic wire mesh pose difficulties for thermo-mechanical modeling and property ***,the constitutive models employed to characterize hysteresis phenomena were presented,comprising isotropic elasticity,Bergstrom-Boyce model,Ogden hyper-elasticity,and parameter identification through mechanical examinations at varying ***,the finite element modeling of cylindrical shell structures was determined for modal and steady-state dynamic ***,the experimental procedures were carried out,including the preparation of the sandwich cylindrical shell and the dynamic testing *** first-order natural frequency of the cylindrical shell structure is close to the resonance frequency of the dynamic test results,with a maximum error of 6.5%,demonstrating the accuracy of the simulation *** compared to the solid-core cylindrical shell,the average insertion loss of the sandwich cylindrical shell structure within the frequency range of 10–1000 Hz at room temperature is up to 11.09 ***,at elevated temperatures,the average insertion loss of the sandwich cylindrical shell decreases but fluctuates as the temperature changes.

关键词： Energy dissipation Metallic matrix composites Numerical analysis Sandwich structure Thermodynamic properties

Interface property of dissimilar Ti-6Al-4V/AA1050 composite laminate made by non-equal channel lateral co-extrusion and heat treatment

在线全文

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2024年第3期33卷 197-208页

作者： Juan Liao Mengmeng Tian Xin xue School of Mechanical Engineering and Automation Fuzhou UniversityFuzhou 350116China

The purpose of this paper is to examine the effect of processing parameters and subsequent heat treatments on the microstructures and bonding strengths of Ti-6Al-4V/AA1050 laminations formed via a non-equal channel lateral co-extrusion *** microstructural evolution and growth mechanism in the diffusion layer were discussed further to optimize the bonding quality by appropriately adjusting process *** electron microscopes(SEM),energy dispersive spectrometer(EDS),and X-ray diffraction(XRD)were used to characterize interfacial diffusion *** shear test was used to determine the mechanical properties of the interfacial diffusion *** experimental results indicate that it is possible to co-extrusion Ti-6Al-4V/AA1050 compound profiles using non-equal channel lateral *** heat treatment processes affect the thickness of the diffusion *** the temperature and time of heat treatment increase,the thickness of the reaction layers increases ***,the shear strength of the Ti-6Al-4V/AA1050 composite interface is proportional to the diffusion layer *** is observed that a medium interface thickness results in superior mechanical performance when compared to neither a greater nor a lesser interface *** characterization of all heat treatments reveals that the only intermetallic compound observed in the diffusion layers is TiAl_(3).Due to the inter-diffusion of Ti and Al atoms,the TiAl_(3) layer grows primarily at AA1050/TiAl_(3) interfaces.

关键词： Shear strength Co-extrusion Heat treatment Microstructure Intermetallic compounds

Experimental Study on Wire Melting Control Ability of Twin-Body Plasma Arc

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Mechanical Engineering 2024年第2期37卷 184-194页

作者： Ruiying Zhang Fan Jiang Long xue School of Mechanical Engineering Beijing Institute of Petrochemical TechnologyBeijing 102617China Beijing Academy of Safety Engineering and Technology Beijing 102617China College of Mechanical and Energy Engineering Beijing University of TechnologyBeijing 100124China

The twin-body plasma arc has the decoupling control ability of heat transfer and mass transfer,which is beneficial to shape and property control in wire arc additive *** this paper,with the wire feeding speed as a characteristic quantity,the wire melting control ability of twin-body plasma arc was studied by adjusting the current separation ratio(under the condition of a constant total current),the wire current/main current and the position of the wire in the arc axial *** results showed that under the premise that the total current remains unchanged(100 A),as the current separation ratio increased,the middle and minimum melting amounts increased approximately synchronously under the effect of anode effect power,the first melting mass range remained constant;the maximum melting amount increased twice as fast as the middle melting amount under the effect of the wire feeding speed,and the second melting mass range was *** the wire current increased,the anode effect power and the plasma arc power were both factors causing the increase in the wire melting amount;however,when the main current increased,the plasma arc power was the only factor causing the increase in the wire melting *** average wire melting increment caused by the anode effect power was approximately 2.7 times that caused by the plasma arc *** minimum melting amount was not affected by the wire-torch distance under any current separation ratio *** the current separation ratio increased and reached a threshold,the middle melting amount remained constant with increasing wire-torch *** the current separation ratio continued to increase and reached the next threshold,the maximum melting amount remained constant with the increasing wire-torch *** effect of the wire-torch distance on the wire melting amount reduced with the increase in the current separation *** this study,the decoupling mechanism and ability of this innovative

关键词： Twin-body plasma arc Melting control ability Melting amount Current separation ratio

Very long wave infrared quantum dot photodetector up to 18μm

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applications) 2024年第4期13卷 772-782页

作者： Xiaomeng xue Qun Hao Menglu Chen School of Optics and Photonics Beijing Institute of TechnologyBeijing 100081China. Westlake Institute for Optoelectronics FuyangHangzhou 311421China. Physics Department Changchun University of Science and TechnologyChangchun 130022China

Colloidal quantum dots(CQDs)are of interest for optoelectronic devices because of the possibility of high-throughput solution processing and the wide energy gap tunability from ultraviolet to infrared *** may question about the upper limit on the CQD wavelength *** date,although the CQD absorption already reaches terahertz,the practical photodetection wavelength is limited within mid-wave *** figure out challenges on CQD photoresponse in longer wavelength,would reveal the ultimate property on these ***’s more,it motivates interest in bottom-up infrared photodetection with less than 10%cost compared with epitaxial growth semiconductor *** this work,developing a re-growth method and ionic doping modification,we demonstrate photodetection up to 18μm wavelength on HgTe *** liquid nitrogen temperature,the responsivity reaches 0.3 A/W and 0.13 A/W,with specific detectivity 6.6×108 Jones and 2.3×109 Jones for 18μm and 10μm CQD photoconductors,*** work is a step toward answering the general question on the CQD photodetection wavelength limitation.

关键词： quantum wave ultraviolet