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Lipid droplets in the nervous system:involvement in cell metabolic homeostasis

Neural Regeneration Research 2025年第3期20卷 740-750页

作者： yuchen zhang.yiqing.chen cheng Zhuang Jingxuan Qi Robert Chunhua Zhao Jiao Wang School of Life Sciences Shanghai UniversityShanghaiChina School of Medicine Shanghai UniversityShanghaiChina Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic MedicinePeking Union Medical CollegeBeijingChina Center of Excellence in Tissue Engineering Chinese Academy of Medical SciencesBeijingChina Beijing Key Laboratory of New Drug Development and Clinical Trial of Stem Cell Therapy BeijingChina

Lipid droplets serve as primary storage organelles for neutral lipids in neurons,glial cells,and other cells in the nervous *** droplet formation begins with the synthesis of neutral lipids in the endoplasmic ***,lipid droplets were recognized for their role in maintaining lipid metabolism and energy homeostasis;however,recent research has shown that lipid droplets are highly adaptive organelles with diverse functions in the nervous *** addition to their role in regulating cell metabolism,lipid droplets play a protective role in various cellular stress ***,lipid droplets exhibit specific functions in neurons and glial *** of lipid droplet formation leads to cellular dysfunction,metabolic abnormalities,and nervous system *** review aims to provide an overview of the role of lipid droplets in the nervous system,covering topics such as biogenesis,cellular specificity,and ***,it will explore the association between lipid droplets and neurodegenerative *** the involvement of lipid droplets in cell metabolic homeostasis related to the nervous system is crucial to determine the underlying causes and in exploring potential therapeutic approaches for these diseases.

关键词： Alzheimer's disease lipid droplet biogenesis lipid droplets lipid metabolism nervous system neurodegenerative disorders oxidative stress Parkinson's disease

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Characteristic changes in astrocyte properties during astrocyte-to-neuron conversion induced by NeuroD1/Ascl1/Dlx2

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Neural Regeneration Research 2025年第6期20卷 1801-1815页

作者： Qing He Zhen Wang yuchen Wang Mengjie Zhu Zhile Liang Kanghong zhang Yuge Xu Gong chen GHM Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina

Direct in vivo conversion of astrocytes into functional new neurons induced by neural transcription factors has been recognized as a potential new therapeutic intervention for neural injury and degenerative disorders. However, a few recent studies have claimed that neural transcription factors cannot convert astrocytes into neurons, attributing the converted neurons to pre-existing neurons mis-expressing transgenes. In this study, we overexpressed three distinct neural transcription factors––NeuroD1, Ascl1, and Dlx2––in reactive astrocytes in mouse cortices subjected to stab injury, resulting in a series of significant changes in astrocyte properties. Initially, the three neural transcription factors were exclusively expressed in the nuclei of astrocytes. Over time, however, these astrocytes gradually adopted neuronal morphology, and the neural transcription factors was gradually observed in the nuclei of neuron-like cells instead of astrocytes. Furthermore,we noted that transcription factor-infected astrocytes showed a progressive decrease in the expression of astrocytic markers AQP4(astrocyte endfeet signal), CX43(gap junction signal), and S100β. Importantly, none of these changes could be attributed to transgene leakage into preexisting neurons. Therefore, our findings suggest that neural transcription factors such as NeuroD1, Ascl1, and Dlx2 can effectively convert reactive astrocytes into neurons in the adult mammalian brain.

关键词： aquaporin-4 Ascl1 astrocyte cortex Dlx2 gap junction glia-to-neuron conversion neural regeneration NeuroD1 reprogramming

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A fast streptomycin sulfate sensing based on Nb2CTX functionalized titled fiber Bragg grating

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Optoelectronics Letters 2025年

作者： BI Mingpan LIU Jie zhang yuchen LI Xiaolan MIAO Yinping Tianjin Key Laboratory of Film Electronic & Communicate Devices，School of Integrated Circuit Science and Engineering，Tianjin University of Technology Key Laboratory of Quantum Optics and Intelligent Photonics， School of Science， Tianjin University of Technology

We proposed a fast and temperature self-compensation method to detect streptomycin sulfate aqueous solution concentration based on a 2D Nb2CTXMXene nanosheets functionalized tilted Bragg grating（N-TFBG）. The introduction of 2D Nb2CTXMXene nanosheets brought more than 100% increase in sensitivity and exhibited a high sensitivity of 253.8 pm/mg/mL and detection limit 80 μg/mL in range of 0.2-0.8 mg/mL. Due to high sensitivity and compact structure， N-TFBG sensor has a faster measure time than previous method; additionally， the sensor has simultaneous temperature measurement by detecting the cladding mode and the core mode resonance peak simultaneously. Our research will hopefully open a new research platform for online detection of streptomycin sulfate concentration.

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Highly efficient degradation of acid orangeⅡon a defect-enriched Fe-based nanoporous electrode by the pulsed square-wave method

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Journal of Materials Science & Technology 2021年第33期92卷 40-50页

作者： yuchen Chi Feng chen Hangning Wang Fengxiang Qin Haifeng zhang School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China Institute of Metal Research Chinese Academy of SciencesShenyang 110016China

The degradation of acid orange II(AO II)by a nanoporous Fe-Si-B(NP-Fe Si B)electrode under the pulsed square-wave potential has been investigated in this ***-enriched NP-Fe Si B electrode was fabricated through dealloying of annealed Fe_(76)Si_(9)B_(15)amorphous *** results of UV-vis spectra and FTIR indicated that AO II solution was degraded efficiently into unharmful molecules H_(2)O and CO_(2)on NPFe Si B electrode within 5 mins under the square-wave potential of±1.5 *** degradation efficiency of the NP-Fe Si B electrode remains 98.9%even after 5-time *** large amount of active surface area of the nanoporous Fe Si B electrode with lattice disorders and stacking faults,and alternate electrochemical redox reactions were mainly responsible for the excellent degradation performance of the NP-Fe Si B *** electrochemical pulsed square-wave process accelerated the redox of Fe element in Fe-based nanoporous electrode and promoted the generation of hydroxyl radicals(·OH)with strong oxidizability as predominant oxidants for the degradation of azo dye molecules,which was not only beneficial to improving the catalytic degradation activity,but also beneficial to enhancing the reusability of the nanoporous *** work provides a highly possibility to efficiently degrade azo dyes and broadens the application fields of nanoporous metals.

关键词： Amorphous alloy Nanoporous electrode Defects,Azo dye Electrochemical degradation Pulsed square-wave potential

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苏北不同林龄杨树人工林碳储量时空分配格局

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水土保持研究 2025年第1期32卷 243-248页

作者：顾宇晨张茜安宇超王国兵南京林业大学生态与环境学院南方现代林业协同创新中心南京210037

[目的]探讨不同林龄对苏北杨树人工林生产力形成及林分碳储量地上、地下空间分配格局的影响及机理,为提高杨树人工林生态系统碳汇功能以及为杨树人工林经营和管理等提供科学依据。[方法]基于江苏省宿迁市泗洪林场,选取10个不同林龄分别... 详细信息

[目的]探讨不同林龄对苏北杨树人工林生产力形成及林分碳储量地上、地下空间分配格局的影响及机理,为提高杨树人工林生态系统碳汇功能以及为杨树人工林经营和管理等提供科学依据。[方法]基于江苏省宿迁市泗洪林场,选取10个不同林龄分别为2,5,6,7,8,10,14,16,17,26 a生,林分密度为6 m×6 m的杨树人工林作为试验调查样地。分析了杨树人工林乔木层、草本层及土壤层碳储量净积累随林龄的变化规律及杨树人工林不同层次碳储量变化与土壤理化性质的相关关系。[结果](1)乔木层碳储量在林分发展过程中呈现快速净积累特征,拟合其年平均积累速率、连年积累速率两条曲线,表明杨树人工林最佳轮伐期为15~20 a;(2)土壤有机碳在林分发展过程中呈现出缓慢的净积累,林下草本层碳储量随林分发展呈降低趋势;(3)杨树人工林土壤层和乔木层碳储量与土壤中SOC,TN,NO_(3)^(-)-N,N/P呈显著正相关,与AP,C/N,pH呈负相关。[结论]在杨树人工林生长过程中施N肥以及在土壤固碳水平最佳时期15~20 a进行轮作,有助于林分碳储量增加。

关键词：碳储量杨树人工林不同林龄苏北地区

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Preload-responsive adhesion of microfibre arrays to rough surfaces

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Applied Mathematics and Mechanics(English Edition) 2017年第2期38卷 155-160页

作者： yuchen zhang Linghui HE Chinese Academy of Science (CAS) Key Laboratory of Mechanical Behavior and Design of Materials University of Science and Technology of China Hefei 230026 China

Adhesion of bio-inspired microfibre arrays to a rough surface is studied theoretically. The array consists of vertical elastic rods fixed on a rigid backing layer, and the surface is modeled by rigid steps with a normally distributed height. Analytical expressions are obtained for the adhesion forces in both the approach and retraction processes. It is shown that, with the increasing preload, the pull-off force increases at first and then attains a plateau value. The results agree with the previous experiments and are expected helpful in adhesion control of the array in practical applications.

关键词： fibrillar adhesion rough surface preload pull-off force

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Temperature-sensing array using the metal-to-insulator transition of Nd_(x)Sm_(1-x)NiO_(3)

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International Journal of Minerals,Metallurgy and Materials 2024年第7期31卷 1694-1700页

作者： Fengbo Yan Ziang Li Hao zhang yuchen Cui Kaiqi Nie Nuofu chen Jikun chen School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China School of Renewable Energy North China Electric Power UniversityBeijing 102206China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China

Rare-earth nickelates(RENiO_(3))show widely tunable metal-to-insulator transition(MIT)properties with ignorable variations in lattice constants and small latent heat across the critical temperature(TMIT).Particularly,it is worth noting that compared with the more commonly investigated vanadium oxides,the MIT of RENiO_(3)is less abrupt but usually across a wider range of *** sheds light on their alternative applications as negative temperature coefficient resistance(NTCR)thermistors with high sensitivity compared with the current NTCR thermistors,other than their expected use as critical temperature resistance *** this work,we demonstrate the NTCR thermistor functionality for using the adjustable MIT of Nd_(x)Sm_(1-x)NiO_(3)within 200–400 K,which displays larger magnitudes of NTCR(e.g.,more than 7%/K)that is unattainable in traditional NTCR thermistor *** temperature dependence of resistance(R–T)shows sharp variation during the MIT of Nd_(x)Sm_(1-x)NiO_(3)with no hysteresis via decreasing the Nd content(e.g.,x≤0.8),and such a R–T tendency can be linearized by introducing an optimum parallel *** sensitive range of temperature can be further extended to 210–360 K by combining a series of Nd_(x)Sm_(1-x)NiO_(3)with eight rare-earth co-occupation ratios as an array,with a high magnitude of NTCR(e.g.,7%–14%/K)covering the entire range of temperatures.

关键词： rare-earth nickelates metal-to-insulator transition correlated oxides perovskites

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Antibiotics along an alpine river and in the receiving lake with a catchment dominated by grazing husbandry

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Journal of Environmental Sciences 2022年第5期34卷 374-382页

作者： Jianwei Dong Dandan Yan Kangle Mo Qiuwen chen Jianyun zhang yuchen chen Zhiyuan Wang State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Nanjing Hydraulic Research InstituteNanjing 210029China Center for Eco-Environmental Research Nanjing Hydraulic Research InstituteNanjing 210029China Yangtze Institute for Conservation and Green Development Nanjing 210029China School of Marine Science and Engineering Nanjing Normal UniversityNanjing 210023China

The livestock breeding industries face overuse of antibiotics,which has been intensively studied in recent ***,the occurrence and fate of antibiotics as well as their potential threats to the aquatic environments in alpine and arid regions remain *** study investigated the relationship of the occurrence and concentrations of antibi-otics between the Kaidu River and Bosten Lake in a typical alpine basin in *** spots with antibiotic pollution source were *** antibiotic concentrations in river water and suspended sediment(SPS)were 2.20-99.4 ng/L and 1.03-176 ng/*** dominant antibi-otics were tetracyclines,sulphacetamide,and ofloxacin in river water and sulfonamides,clarithromycin,roxithromycin,and ofloxacin in *** apparent differences in pollution sources and landscapes in different reaches led to the obvious spatial patterns of antibiotics in the Kaidu *** partition coefficient of antibiotic between SPS and water phases for sulfonamides than tetracyclines was because that tetracyclines strongly responded to clay contents while sulfonamides significantly responded to organic carbon contents in *** were significant differences in detected antibiotic categories between the river and the ***(especially ciprofloxacin and enrofloxacin)were detected in the lake while sulphacetamide was only detected in the ***,the surrounding husbandry and aquaculture around the Bosten Lake was an important antibiotic pollution source in addition to inputs from the Kaidu *** research suggested that alpine lakes could be an important sink of antibiotics in alpine dry regions,and thus impose greater threats to the aquatic ecosystem.

关键词： Antibiotics Lotic-lentic contamination Suspended sediment Partition

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Catalytic urea hydrolysis by composite metal oxide catalyst towards efficient urea-based SCR process:performance evaluation and mechanism investigation

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Frontiers of Environmental Science & Engineering 2023年第5期17卷 67-80页

作者： yuchen Li Zhen chen Xiangyu zhang Kun Yang Lidong Wang Junhua Li MOE Key Laboratory of Resources and Environmental Systems Optimization Department of Environmental Science and EngineeringNorth China Electric Power UniversityBeijing 102206China State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China Xi’an Thermal Power Research Institute Co. Xi’an 710032China

As a promising option to provide gaseous NH_(3) for SCR system,catalytic urea hydrolysis has aroused great attention,and improving surface area and activity of catalysis are the crucial issues to be solved for efficient urea ***,a composite metal oxide(TiO_(2)@Al_(2)O_(3))catalyst was prepared by a simple hydrothermal method,with mesoporous alumina(γ-Al_(2)O_(3))as *** results verify the mesoporous structure and submicron cluster of TiO_(2)@Al_(2)O_(3),with exposed crystal faces of(101)and(400)for TiO_(2)andγ-Al_(2)O_(3),*** electronegativity difference of Ti4+and Al3+changes the charge distribution scheme around the interface,which provides abundant acid/base sites to boost the urea ***,for an optimal proportioning with nano TiO_(2)content at 10 wt.%,the hydrolysis efficiency can reach up to 35.2%at 100℃ in 2 h,increasing by~7.1%than that of the blank experiment.^(13)C NMR spectrum measurements provide the impossible intermediate species during urea *** calculations are performed to clarify the efficient H_(2)O decomposition at the interface of TiO_(2)@Al_(2)O_(3).The result offers a favorable technology for energy-efficiency urea hydrolysis.

关键词： SCR Urea hydrolysis Catalytic Water dissociation Electronegativity

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Green fabrication of nickel-iron layered double hydroxides nanosheets efficient for the enhanced capacitive performance

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Green Energy & Environment 2022年第5期7卷 1053-1061页

作者： yuchen Wang Zuo chen Man zhang Yaoyu Liu Huixia Luo Kai Yan School of Environmental Science and Engineering Sun Yat-sen UniversityGuangzhou510275China Key Lab of Polymer Composite&Functional Materials School of Materials Science and EngineeringSun Yat-sen UniversityGuangzhou510275China Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology Guangzhou510275China

Rational synthesis of robust layered double hydroxides(LDHs) nanosheets for high-energy supercapacitors is full of ***,we reported an ultrasonication-assisted strategy to eco-friendly fabricate NiFe-LDHs nanosheets for the enhanced capacitive *** experimental results combined with different advanced characterization tools document that the utilization of ultrasonication has a profound effect on the morphology and thickness of the as-obtained NiFe-LDHs,alternatively affecting the capacitive *** shows that NiFe-LDHs nanosheets prepared with 2-h ultrasonic treatments display the exceptional capacitive performance because of the synergetic effect of ultrathin thickness,large specific surface area,and high mesoporous *** maximum specific capacitance of Ni_(3) Fe_(1)-LDHs nanosheets with the thickness of 7.39 nm and the specific surface area of 77.16 m~2 g^(-1) reached 1923 F g^(-1),which is competitive with most previously reported *** addition,the maximum specific energy of the assembled NiFe-LDHs//AC asymmetric supercapacitor achieved 49.13 Wh kg^(-1) at400 W kg^(-1).This work provides a green technology to fabricate LDHs nanosheets,and offers deep insights for understanding the relationship between the morphology/structure and capacitive behavior of LDHs nanosheets,which is helpful for achieving high-performance LDHs-based electrode materials.

关键词： performance double sheets

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