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Supersaturation-driven self-assembly formation of ceftriaxone sodium spherulites:From amorphous form to spherulites

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Particuology 2024年第7期90卷 10-19页

作者： Shankun Liang yuchao Niu Xueyan Hu Wu Xiao Xuehua Ruan Gaohong he Xiaobin Jiang State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart MaterialsSchool of Chemical EngineeringDalian University of TechnologyDalian116024China School of Chemical Engineering at Panjin Dalian University of TechnologyPanjin124221China

Drug particles with spherical morphology possess amazing advantages in terms of particle flowability,mechanical properties,drug solubility,and *** growth mechanism of drug spherulite is of great importance for the preparation and regulation of ***,ceftriaxone sodium spherulites were fabricated by the antisolvent crystallization method using dropwise addition of ceftriaxone sodium solution to *** observation of the whole crystallization process combined with electron microscopy technique revealed the spherical growth process from amorphous form to *** the supersaturation of the crystallization system was adjusted,the ceftriaxone sodium crystals transformed from amorphous form to *** the process of antisolvent crystallization with acetone as antisolvent,when the theoretical supersaturation degree S was higher than 2.62,the crystallization system tended to appear amorphous form;when S was between 2.57 and 2.62,the amorphous form transformed into clustered spherulites;when S was less than 2.57,the surface of spherulites will be covered with flaky crystal,which transformed into urchin-like *** the understanding of the spherical growth mechanism,the ceftriaxone sodium spherulites prepared in this research with modified supersaturation control had a low residue of antisolvent acetone,and the flowability was significantly improved.

关键词： Spherulite Ceftriaxone sodium Antisolvent crystallization Supersaturation Online observation

Restoring cellular calcium homeostasis to rescue ER stress by 1,2-bis(2-aminophenoxy)ethane-N,N,N’,N’-tetraacetic acid acetoxymethyl ester-loaded lipid-mPLGA hybrid-nanoparticles for acute kidney injury therapy

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Chinese Chemical Letters 2024年第3期35卷 337-345页

作者： Jingwen Zhang Jiahui Yan Yanan Wang Hong Liu Xueping Sun yuchao Gu Liangmin Yu Changcheng Li Jun Wu Zhiyu he Frontiers Science Center for Deep Ocean Multispheres and Earth System and Key Laboratory of Marine Chemistry Theory and TechnologyMinistry of EducationOcean University of ChinaQingdao 266100China College of Chemistry and Chemical Engineering Ocean University of ChinaQingdao 266100China School of Medicine and Pharmacy Ocean University of ChinaQingdao 266003China Sanya Oceanographic Institution Ocean University of ChinaQingdao 572024China Bioscience and Biomedical Engineering Thrust The Hong Kong University of Science and Technology(Guangzhou)NanshaGuangzhou 511400China Division of Life Science The Hong Kong University of Science and TechnologyHong Kong 999077China

Early pathogenesis of ischemia-reperfusion(I/R)-induced acute kidney injury(AKI)is dominated by intracellular calcium overload,which induces oxidative stress,intracellular energy metabolism disorder,inflammatory activation,and a series of pathologic cascaded reactions that are closely intertwined with self-amplifying and interactive feedback loops,ultimately resulting in cell damage and kidney ***,most nanomedicines originate from the perspective of antioxidant stress,which can only quench existing reactive oxide species(ROS)but cannot prevent the continuous production of ROS,resulting in insufficient *** a safe and promising drug,BAPTA-AM is hydrolyzed into BAPTA by intracellular esterase upon entering cells,which can rapidly chelate with overloaded Ca^(2+),restoring intracellular calcium homeostasis,thus inhibiting ROS regeneration at the ***,we designed a KTP-targeting peptide-modified yolk-shell structure of liposome–poly(ethylene glycol)methyl ether-block-poly(L-lactide-co-glycolic)(mPLGA)hybrid nanoparticles(he characteristics of high encapsulation rate,high colloid stability,facile modification,and prolonged blood circulation *** the BA/mPLGA@Lipo-KTP was targeted to the site of kidney injury,the cholesteryl hemisuccinate(CheMS)in the phospholipid bilayer,as an acidic cholesterol ester,was protonated in the simulated inflammatory slightly acidic environment(pH 6.5),causing the liposomes to rupture and release the BA/mPLGA nanoparticles,which were then depolymerized by intracellular *** BAPTA-AM was diffused and hydrolyzed to produce BAPTA,which can rapidly cut off the malignant loop of calcium overload/ROS generation at its source,blocking the endoplasmic reticulum(ER)apoptosis pathway(ATF4–CHOP–Bax/Bcl-2,Casp-12–Casp-3)and the inflammatory pathway(TNF-α–NF-κB–IL-6 axes),thus alleviating pathological changes in kidney tissue,thereby inhibiting the expression of renal tubular marker kidney injury mole

关键词： BAPTA-AM Calcium overload Acid-responsive AKI ER stress

Cytosolic phospholipase A2α modulates cell-matrix adhesion via the FAK/paxillin pathway in hepatocellular carcinoma

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Cancer Biology & Medicine 2019年第2期16卷 377-390页

作者： Piao Guo yuchao he Lu Chen Lisha Qi Dongming Liu Ziye Chen Manyu Xiao Liwei Chen Yi Luo Ning Zhang Hua Guo Department of Tumor Cell Biology Department of hepatobiliary Cancer Department of Pathology Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer/ Key Laboratory of Cancer Prevention and Therapy Tianjin Tianjin's Clinical Research Center for Cancer Tianjin 300060 China

Objective: To explore the effect of cytosolic phospholipase A2α(cPLA2α) on hepatocellular carcinoma(HCC) cell adhesion and the underlying ***: Cell adhesion, detachment, and hanging-drop assays were utilized to examine the effect of cPLA2α on the cell-matrix and cell-cell adhesion. Downstream substrates and effectors of cPLA2α were screened via a phospho-antibody *** signaling pathways were identified by the functional annotation tool DAVID. Candidate proteins were verified using Western blot and colocalization was investigated via immunofluorescence. Western blot and immunohistochemistry were used to detect protein expression in HCC tissues. Prognosis evaluation was conducted using Kaplan-Meier and Cox-proportional hazards regression ***: Our findings showed that cPLA2α knockdown decreases cell-matrix adhesion but increases cell-cell adhesion in hepG2 cells. Microarray analysis revealed that phosphorylation of multiple proteins at specific sites were regulated by cPLA2α. These phosphorylated proteins were involved in various biological processes. In addition, our results indicated that the focal adhesion pathway was highly enriched in the cPLA2α-relevant signaling pathway. Furthermore, cPLA2α was found to elevate phosphorylation levels of FAK and paxillin, two crucial components of focal adhesion. Moreover, localization of p-FAK to focal adhesions in the plasma membrane was significantly reduced with the downregulation of cPLA2α. Clinically, cPLA2α expression was positively correlated with p-FAK levels. Additionally, high expression of both cPLA2α and p-FAK predicted the worst prognoses for HCC ***: Our study indicated that cPLA2α may promote cell-matrix adhesion via the FAK/paxillin pathway, which partly explains the malignant cPLA2α phenotype seen in HCC.

关键词： hepatocellular carcinoma cytosolic phospholipase A2α cell-matrix adhesion FAK paxillin

Genomic Surveillance for SARS-CoV-2 Variants: Dominance of XBB Replacement — China, January–June 2023

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China CDC weekly 2024年第15期6卷 324-331页

作者： Yenan Feng Qiudong Su Lili Li Xiaozhou he Peihua Niu Xiaojuan Guo Xiang Zhao Jing Tang Zhiyuan Jia Ji Wang Changcheng Wu Baicheng Xia Zhixiao Chen yuchao Wu Jing Yang Songqi Chen Cao Chen Shiwen Wang Xiaoping Dong National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina NHC Key Laboratory of Medical Virology and Viral Diseases National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina

Introduction:In the first half of 2023,a global shift was observed towards the predominance of XBB *** faced a significant epidemic between late 2022 and early 2023 due to Omicron subvariants BA.5.2 and *** study aims to depict the evolving variant distribution among provincial-level administrative divisions(PLADs)in China and explore the factors driving the predominance of XBB ***:Sequences from local and imported coronavirus disease 2019(COVID-19)cases recorded between January 1 and June 30,2023,were *** study analyzed the changing distribution of viral variants and assessed how the prior dominance of specific variants,XBB subvariants,and imported cases influenced the prevalence of the XBB replacement ***:A total of 56,486 sequences were obtained from local cases,and 8,669 sequences were from imported *** in April,there was a shift in the prevalence of XBB from imported to local cases,with varying dominance among *** PLADs previously high in BF.7,the rise of XBB was delayed.A positive correlation was found between XBB proportions in imported cases from January to March and local cases in *** distribution pattern of XBB subvariants differed between local and imported cases within the same *** significant differences were noted in the replacement rates of XBB ***:The timing of XBB dominance differed among various PLADs in China in the first half of 2023,correlating closely with the prevalence of XBB variants among imported cases.

关键词： dominance imported distribution

Periostin mediates epithelial-mesenchymal transition through the MAPK/ERK pathway in hepatoblastoma

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Cancer Biology & Medicine 2019年第1期16卷 89-99页

作者： Lu Chen Xiangdong Tian Wenchen Gong Bo Sun Guangtao Li Dongming Liu Piao Guo yuchao he Ziye Chen Yuren Xia Tianqiang Song Hua Guo Department of Tumor Cell Biology Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and TherapyTianjin Tianjin's Clinical Research Center for Cancer

Objective: The aim of the present study was to analyze the prognostic factors in patients with hepatoblastoma(HB) in our single center and to evaluate periostin(POSTN) expression in HB and its association with clinicopathological variables. In addition, the underlying mechanism of how POSTN promotes HB progression was ***: POSTN expression was investigated in HB tumors by immunohistochemistry(IHC), immunofluorescence(IF) and Western blot(WB). The association among POSTN expression, clinicopathological features and overall survival(OS) was also evaluated. The migration and adhesion ability of HB cells were measured using chemotaxis and cell-matrix adhesion assays,respectively. Epithelial-mesenchymal transition(EMT)-associated markers and activation of the ERK pathway were detected by ***: HB patients had poor prognosis which displayed lymph node metastasis, vascular invasion, POSTN and vimentin expression. POSTN expression was also associated with lymph node metastasis. Furthermore, overexpressed POSTN promoted migration and the adhesive ability of HB cells in vitro. In addition, we demonstrated that POSTN activated the MAPK/ERK pathway, upregulated the expression of Snail and decreased the expression of OVOL2. Finally, POSTN promoted the expression of EMT-associated ***: POSTN might modulate EMT via the ERK signaling pathway, thereby promoting cellular migration and *** study also suggests that POSTN may serve as a therapeutic biomarker in HB patients.

关键词： Periostin hepatoblastoma EMT MAPK/ERK

Pt/Ni-Co/CNTs催化剂的制备及其电化学性能研究

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广东石油化工学院学报 2023年第1期33卷 33-37页

作者：罗兰萍何宇超李翔广东石油化工学院分析测试中心广东茂名525000 广东石油化工学院化学工程学院广东茂名525000

采用Ni与Co离子共掺杂改性Pt/CNTs催化剂。首先采用液相浸渍法制备Ni-Co/CNTs,通过X射线衍射与能谱结果判断是否成功制备Ni-Co/CNTs,通过电催化甲醇氧化反应活性优化掺杂量,并比较了掺杂的Pt/Ni-Co/CNTs与未掺杂的Pt/CNTs的电化学活性... 详细信息

采用Ni与Co离子共掺杂改性Pt/CNTs催化剂。首先采用液相浸渍法制备Ni-Co/CNTs,通过X射线衍射与能谱结果判断是否成功制备Ni-Co/CNTs,通过电催化甲醇氧化反应活性优化掺杂量,并比较了掺杂的Pt/Ni-Co/CNTs与未掺杂的Pt/CNTs的电化学活性和稳定性。实验结果显示:Ni-Co最优掺杂量为30%,改性的Pt/Ni-Co/CNTs具有更高的电催化活性和更好的稳定性。文章对Pt/CNTs催化剂改性、降低甲醇燃料电池阳极催化剂的成本、改善催化剂中毒等问题有一定的指导作用。

关键词：直接甲醇燃料电池(DMFC) 甲醇氧化反应电化学催化剂共掺杂

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考虑透平背压影响的燃气轮机动态特性研究

中国电机工程学报 2024年第8期44卷 3155-3164,I0018页

作者：何怡冲李永毅林育超张国强杨泽雨张磊华北电力大学能源动力与机械工程学院北京市昌平区102206 华北电力大学动力工程系河北省保定市071003

燃气透平的背压是决定燃气轮机性能的重要参数之一,对燃气轮机运行效率以及安全性都具有不可忽略的影响。该文采用模块化建模方法,结合燃气轮机的控制策略,基于仿真平台建立某重型燃气轮机的动态仿真模型,研究透平背压调控过程及负荷波... 详细信息

燃气透平的背压是决定燃气轮机性能的重要参数之一,对燃气轮机运行效率以及安全性都具有不可忽略的影响。该文采用模块化建模方法,结合燃气轮机的控制策略,基于仿真平台建立某重型燃气轮机的动态仿真模型,研究透平背压调控过程及负荷波动过程机组的动态特性。结果表明,建立的动态模型可以较为准确地模拟重型燃气轮机的动态特性。对不同输入信号的仿真结果进行对比分析,探究透平背压的不同变化趋势对燃气轮机动态特性的影响,包括背压降低时不同控制策略下燃气轮机透平进出口温度变化对机组的影响及不同控制策略面对扰动时各参数动态响应的差异。验证了透平背压调控对燃气轮机动态响应特性和变几何性能的优化作用,包括低背压下燃气轮机具有更快的响应速度及更高的级效率,透平背压调控能够确保机组在更大的负荷范围内透平进出口温度维持在目标值附近,可保证机组高效、稳定运行。

关键词：燃气轮机模块化建模动态模型透平背压响应特性

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云南拉沙山黑白仰鼻猴对种子传播潜力的评估

生态学报 2023年第10期43卷 4066-4073页

作者：邓云丹牛鑫和育超胡善斌李延鹏黄志旁崔亮伟肖文大理大学东喜玛拉雅研究院大理671003 西南林业大学云南省高校极小种群野生动物保育重点实验室昆明650224 兰坪云岭省级自然保护区管护局兰坪671400 云岭滇金丝猴云南省野外科学观测研究站大理671003 国际生物多样性与灵长类保护中心大理671003 大理大学三江并流区域生物多样性保护与利用云南省创新团队大理671003

灵长类是森林生态系统中植物种子的主要传播者,有助于森林植被的更新,然而受研究方法的限制,灵长类种子传播潜力常被低估。为全面评估温带灵长类动物的种子传播潜力,采用直接观察法和粪便分析法评估珍稀濒危灵长类动物黑白仰鼻猴的种子... 详细信息

灵长类是森林生态系统中植物种子的主要传播者,有助于森林植被的更新,然而受研究方法的限制,灵长类种子传播潜力常被低估。为全面评估温带灵长类动物的种子传播潜力,采用直接观察法和粪便分析法评估珍稀濒危灵长类动物黑白仰鼻猴的种子传播潜力。于2018年11月—2019年10月采用直接观察法(瞬时扫描取样法)收集云岭省级自然保护区拉沙山黑白仰鼻猴的活动时间分配数据,获取每月取食果实的比例;同时每月收集黑白仰鼻猴的粪便,采用粪便分析法分拣猴粪中残留的植物种子,统计有完整种子残留的月份和粪便比例,应用这两种方法评估黑白仰鼻猴种子传播潜力及其差异。结果表明:直接观察法收集到黑白仰鼻猴取食果实的月份数为6个月(7—12月),月均取食果实的比例为(15.31±20.15)%,共取食13种果实;而粪便分析法发现黑白仰鼻猴粪粒内全年都有完整种子残留,粪便中月均完整种子残留比例(35.19±35.43)%,其中9月至第二年1月粪便中种子残留比例都大于50%,共取食18种果实;综合两种方法发现云南拉沙山黑白仰鼻猴共取食20种植物果实,具有较高的种子传播潜力。直接观察法可确定黑白仰鼻猴取食果实的物种数,而粪便分析法能反映其可传播的物种和数量,并发现黑白仰鼻猴全年都取食果实,增加了对黑白仰鼻猴果实性比例和种子传播月份的认识。因此,建议结合两种方法全面评估黑白仰鼻猴及其它灵长类物种的种子传播潜力,从而更好地评估其对植物种子传播的有效性及对森林生态系统更新的贡献,为认识灵长类通过种子传播提升森林生态系统更新能力提供新的视角。

关键词：黑白仰鼻猴种子传播潜力粪便分析法直接观察法拉沙山

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Rolling Shutter Camera:Modeling,Optimization and Learning

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Machine Intelligence Research 2023年第6期20卷 783-798页

作者： Bin Fan yuchao Dai Mingyi he School of Electronics and Information Northwestern Polytechnical UniversityXi’an710129China

Most modern consumer-grade cameras are often equipped with a rolling shutter mechanism,which is becoming increasingly important in computer vision,robotics and autonomous driving ***,its temporal-dynamic imaging nature leads to the rolling shutter effect that manifests as geometric *** the years,researchers have made significant progress in developing tractable rolling shutter models,optimization methods,and learning approaches,aiming to remove geometry distortion and improve visual *** this survey,we review the recent advances in rolling shutter cameras from two aspects of motion modeling and deep *** the best of our knowledge,this is the first comprehensive survey of rolling shutter *** the part of rolling shutter motion modeling and optimization,the principles of various rolling shutter motion models are elaborated and their typical applications are ***,the applications of deep learning in rolling shutter based image processing are ***,we conclude this survey with discussions on future research directions.

关键词： Rolling shutter motion modeling image correction temporal super-resolution deep learning