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EFFECTS OF PARATHYROID HORMONE AND ESTRADIOL ON PROLIFERATION AND FUNCTION OF HUMAN OSTEOBLASTS FROM FETAL LONG BONE-AN IN VITRO STUDY

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EFFECTS OF PARATHYROID HORMONE AND ESTRADIOL ON PROLIFERATIO...

THE EFFECT OF INTERMITTENT CYCLICAL AND CONTINOUS TREATMENT OF ETIDRONATE DISODIUM ON EXPERIMENTAL OSTEOPOROSIS IN OVARIECTOMIZED RATS

第一届国际骨质疏松和代谢性骨病研讨会

作者： Zang Xiaoyi Zhao Jie Zhang Wenzhi Pang Zhiling tan yubin Tianjin Institute of Endocrinology

Parathyroid hormone(PTH) and estradiol(E?) arc two critical hormones related to controlling bone metabolism and the pathogenesis of osteoporosis and other metabolic bone *** effect of these hormones singly or in coordination on[H]-thymidinc incorporation,alkaline phosphatase(ALP) and adenylate cyclase activities wore investigated in human fetal osteoblasts in scrum-free monolayer primary *** results showed that PTH inhibited cell proliferation,as evidenced by dosc-dependent decreases in[H]-thymidine incorporation(e.g.,76%of control after 22 h exposure at lOnM,P<0.05),while Ej increased H]-thymidinc incorporation to 47%above control value(after 46 h exposure at 1nM,P<0.001).The E effects were specific for 17β-E,since they wore not observed with the biologically less active stereoisomer 17α-*** continuously exposed to the cell for 72 h,PTH showed biphasic action on *** low concentration(0.1 nM),PTH increased the enzyme activity, but inhibited higher concentration(1nM).Both were about 20%of that in the control(P<0.001 for each).E inhibited it slightly after 72 h at InM and lOnM(P<0.001 for each).Actions of PTH and Et in coordination were *** high-dose,effects of PTH(10nM) were antagonized by E,as reduced lOnM PTH-stimulatcd adenylate cyclase activity by 43%(P<0.001) after treatment with InM E for 24 h,and enhanced PTH-inhibited[H]-thymidinc incorporation by 77-107%after treatment with different doses of E(l-10nM).Tn low dose,effects of E on actions of PTH(<1nM) were different according to the doses of *** above results indicated that both PTH and E effect directly on the proliferation and function of human osteoblasts prepared from fetal long *** in some cases,the effects of PTH on bone cells can be modulated by E through the production of cAMP.

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THE EFFECT OF INTERMITTENT CYCLICAL AND CONTINOUS TREATMENT ...

第二届国际骨质疏松研讨会

作者： Zhang Mingfang Zhang Naixin tan yubin Wang xiaoyan Zhao Xiulan Department of Pathology Tianjin University

＜正＞To compare the effect of intermittent cyclical with continous administration of etidronate disodium（HEBP）,57 female Wistar rats weighing an average of 265g were divided into five groups（GP）.GP A was sham-ovariectomized;GP B was bilateral ovariectomized（OVX）;GP C was OVX and then the intermittent cyclical HEBP was given orally;GP D was OVX and then the continous HEBP was given orally;GP E was OVX and then the intermittent cyclical HEBP was given by intraperitoneal *** was given during fasting for 5 days followed by a rest of 25 days and the intermittent cycles were for 3 and up to 90th day after OVX, *** proximal tibiae were processed undecalcified for quatitive bone histomorphometry and histological *** results are as *** C presented more trabecular bone volume than that of GP B,and the elevated bone turnover induced by OVX was reduced properly indicaing the scheme of GP C could retard the degree of *** D presented more trabecular bone volume but its bone turnover was more lower than that of not only GP B and C but also GP A, and the appearance and arrangement of trabeculae were irregular meaning the disturbance of bone *** E exhibited the accumulation of cartilage matrix resulting in abnormally thickened epiphyseal plate and the increase of osteoid at metaphyses indicating the highly inhibition of mineralization of bone.

关键词： Osteoporosis Etidronate disodium Bone histomorphometry rats

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地方性甲状腺肿结节的形成和演变

天津医药 1982年第5期 259-263页

作者：谭郁彬天津医学院病理解剖学教研室

结节形成是地方性甲状腺肿发展过程中的一个关键性阶段,说明病变已从弥漫型发展为结节型,在预后和治疗上与弥漫型甲状腺肿都有明显的不同。但是,对结节是怎样

关键词：结节胶质癌变腺瘤胶性甲状腺癌地方性甲状腺肿地方病纤维组织金相组织

Co-production of hydrogen, oxygen, and electricity via an integrated solar-driven system with decoupled water electrolyzer and Na-Zn ion battery

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Journal of Energy Chemistry 2025年第1期100卷 621-627页

作者： Fei Lv Longjie Liu Jiazhe Wu Pengfei Wang Lixia Pan Dengwei Jing yubin Chen International Research Center for Renewable Energy State Key Laboratory of Multiphase Flow in Power Engineering Xi'an Jiaotong University

Combining water electrolysis and rechargeable battery technologies into a single system holds great promise for the co-production of hydrogen （H2） and ***,the design and development of such systems is still in its ***,an integrated hydrogen-oxygen （O2）-electricity co-production system featuring a bipolar membrane-assisted decoupled electrolyzer and a Na-Zn ion battery was established with sodium nickelhexacyanoferrate （NaNiHCF） and Zn2+/Zn as dual redox *** decoupled electrolyzer enables to produce H2and O2in different time and space with almost 100%Faradaic efficiency at 100 mA ***,the charged NaNiHCF and Zn electrodes after the electrolysis processes formed a Na-Zn ion battery,which can generate electricity with an average cell voltage of 1.75 V at 10 m A *** connecting Si photovoltaics with the modular electrochemical device,a well-matched solar driven system was built to convert the intermittent solar energy into hydrogen and electric energy with a solar to hydrogen-electricity efficiency of 16.7%,demonstrating the flexible storage and conversion of renewables.

关键词： Hydrogen Electricity Decoupled water electrolyzer Na-Zn ion battery Solar energy

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甲状腺组织培养条件对移植存活的影响

中华器官移植杂志 1997年第2期18卷 93-95页

作者：刘文革庞智玲谭郁彬中国医学科学院生物医学工程研究所天津300192 天津市内分泌研究所

本文采用两个大气压氧与低pH值（5．5及6．9）相结合培养大鼠甲状腺组织48小时，将甲状腺组织块移植入受体的肾包膜下，从T3、T4均值、平均体重增长及移植组织观察四个方面评价移植物存活及排斥反应情况。结果发现，此方法可减弱排斥反... 详细信息

本文采用两个大气压氧与低pH值（5．5及6．9）相结合培养大鼠甲状腺组织48小时，将甲状腺组织块移植入受体的肾包膜下，从T3、T4均值、平均体重增长及移植组织观察四个方面评价移植物存活及排斥反应情况。结果发现，此方法可减弱排斥反应，延长移植物存活时间，培养后滤泡间过客白细胞并未完全去除，提示此方法以改变主要组织相容性抗原为主。

关键词：甲状腺组织培养同种移植甲状腺移植

鼻腔鼻窦恶性淋巴瘤——一个独立的临床病理学范畴

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耳鼻咽喉（头颈外科） 2001年第1期8卷 61-64页

作者：曹海光谭郁彬天津第一中心医院耳鼻咽喉科 300912 天津医科大学

鼻腔鼻窦出现阻塞性肿块首先会被考虑为癌或炎性包块。而鼻 T/NK细胞淋巴瘤代表头颈区淋巴结外淋巴瘤的一个独立的临床病理亚型 ,多见于亚洲 ,少见于西方。本文就近年来对鼻腔鼻窦淋巴瘤的认识过程、免疫类型、临床病理学特征以及特殊... 详细信息

鼻腔鼻窦出现阻塞性肿块首先会被考虑为癌或炎性包块。而鼻 T/NK细胞淋巴瘤代表头颈区淋巴结外淋巴瘤的一个独立的临床病理亚型 ,多见于亚洲 ,少见于西方。本文就近年来对鼻腔鼻窦淋巴瘤的认识过程、免疫类型、临床病理学特征以及特殊的活检方法予以介绍。

关键词：淋巴瘤鼻窦肿瘤恶性肿瘤病理

支气管扩张症中神经内分泌免疫网络及肥大细胞的变化

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天津医药 2005年第10期33卷 639-641页

作者：仇晓菲孙保存谭郁彬赵凤云天津医科大学病理教研室 300070

目的:探讨支气管扩张症中神经内分泌免疫网络的异常和肥大细胞(MC)在该病发病中的作用及关系。方法:应用组织化学、免疫组化、组织化学与免疫组化结合的方法和形态计量学方法进行观测。结果:支气管扩张症中,支气管上皮蛙皮素(Bombesin)... 详细信息

目的:探讨支气管扩张症中神经内分泌免疫网络的异常和肥大细胞(MC)在该病发病中的作用及关系。方法:应用组织化学、免疫组化、组织化学与免疫组化结合的方法和形态计量学方法进行观测。结果:支气管扩张症中,支气管上皮蛙皮素(Bombesin)阳性细胞、固有膜S-100蛋白和神经特异性烯醇化酶(NSE)阳性神经纤维、IgE阳性细胞、MC和IgE阳性MC均显著增多,且在支气管相关淋巴组织(BALT)增生的区域上述肺内分泌细胞、神经纤维和IgE阳性细胞增多尤为显著,S-100蛋白和NSE阳性神经纤维分布于弥散淋巴组织和BALT中,MC与S-100蛋白阳性神经纤维紧密接触,MC表面有IgE阳性环状带,MC和IgE阳性细胞出现在支气管上皮间和肺泡壁。结论:支气管扩张症的发病与局部神经内分泌免疫网络异常有关;MC可能作为感受器、分泌细胞或靶细胞参与神经内分泌免疫网络,在支气管扩张症的发病中起重要作用。

关键词：支气管扩张症神经分泌系统肥大细胞神经内分泌免疫网络 S-100蛋白阳性神经纤维神经特异性烯醇化酶相关淋巴组织阳性细胞支气管上皮

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亚急性甲状腺炎的免疫发病机理研究

天津医药 1995年第5期23卷 285-287页

作者：江昌新谭郁彬天津医科大学病理学教研室 300070

用组织化学、免疫组织化学方法观察亚急性甲状腺炎的甲状腺实质和间质的变化。结果提示:单纯的亚急性甲状腺炎不影响甲状腺功能。Ig阳性细胞及Ig重链、轻链各亚型细胞和T细胞的数量和比例与桥本氏甲状腺炎相近。结果说明亚急性甲状腺炎... 详细信息

用组织化学、免疫组织化学方法观察亚急性甲状腺炎的甲状腺实质和间质的变化。结果提示:单纯的亚急性甲状腺炎不影响甲状腺功能。Ig阳性细胞及Ig重链、轻链各亚型细胞和T细胞的数量和比例与桥本氏甲状腺炎相近。结果说明亚急性甲状腺炎的发病除由病毒感染所致外,自身免疫反应在其发生、发展过程中也起到一定的作用。溶菌酶染色结果进一步支持亚急性甲状腺炎中的巨细胞来源于巨噬细胞的观点。

关键词：组织化学免疫组织化学亚急性甲状腺炎病理

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颌骨骨肉瘤临床病理学观察及文献复习

临床口腔医学杂志 2000年第1期16卷 15-17页

作者：曹海光谭郁彬赵志环天津市第一中心医院耳鼻咽喉科病理室天津300192 天津医科大学病理解剖教研室

本文复习两例颌骨骨肉瘤临床、病理组织学及免疫组织化学表现,并讨论这一少见病变的组织学诊断要点。认为应仔细寻找最有力的诊断依据即异形性骨母细胞直接产生杂乱无章、不成熟交织骨及骨样组织,即肿瘤性骨。肿瘤性骨母细胞可呈碱性磷... 详细信息

本文复习两例颌骨骨肉瘤临床、病理组织学及免疫组织化学表现,并讨论这一少见病变的组织学诊断要点。认为应仔细寻找最有力的诊断依据即异形性骨母细胞直接产生杂乱无章、不成熟交织骨及骨样组织,即肿瘤性骨。肿瘤性骨母细胞可呈碱性磷酸酶阳性反应。此外,进行性面部肿胀、肿瘤局部侵犯。

关键词：颌骨骨肉瘤颌骨肿瘤组织学诊断鉴别诊断