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Chinese Medical Journal 2023年第17期136卷 2107-2109页

作者： Cong Zhou Xing Wei yuanyuan xiao Shanling Liu Jing Wang Department of Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengduSichuan 610041China Key Laboratory of Birth Defects and Related Diseases of Women and Children Ministry of EducationSichuan UniversityChengduSichuan 610041China

To the Editor:Autosomal recessive mental retardation-52(MRT52,OMIM:616887)was first reported in 2016 and is characterized by global developmental delay,[1]severe intellectual disability(ID),speech disorder,and seizures,but no dysmorphic features.[1,2]MRT52 is caused by a homozygous mutation in the vesicular integral membrane protein 36 kDa(VIP36)-like protein,which is also named lectin mannose-binding 2-like(LMAN2L)gene(OMIM:609552).[3]Nufer et al[4]mapped the LMAN2L gene to chromosome 2q11.2.Although the exact LMAN2L function is not clear,evidence suggests that the LMAN2L gene encodes a transmembrane protein(TM)located in the endoplasmic reticulum(ER).

关键词： expansion exact delay

Coupling between the Cenozoic west Pacific subduction initiation and decreases of atmospheric carbon dioxides

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Acta Geochimica 2023年第3期42卷 387-392页

作者： Guozhi Xie Fanfan Tian Kun Wang yuanyuan xiao Tianyu Chen Weidong Sun Center of Deep Sea Research Institute of OceanologyChinese Academy of SciencesQingdao 266071China Deep-Sea Multidisciplinary Research Center Laoshan LaboratoryQingdao 266237China University of Chinese Academy of Sciences Beijing 100049China CAS Key Laboratory of Marine Geology and Environment Ocean Mega-Science CenterInstitute of OceanologyChinese Academy of SciencesQingdao 266071China State Key Lab Mineral Deposits Research School of Earth Science and EngineerNanjing UniversityNanjing 210023China

At the beginning of the Cenozoic,the atmospheric CO_(2)concentration increased rapidly from~2000 ppmv at 60 Ma to~4600 ppmv at 51 Ma,which is 5–10 times higher than the present value,and then continuous declined from~51 to 34 Ma.The cause of this phenomenon is still not well understood.In this study,we demonstrate that the initiation of Cenozoic west Pacific plate subduction,triggered by the hard collision in the Tibetan Plateau,occurred at approximately 51 Ma,coinciding with the tipping point.The water depths of the Pacific subduction zones are mostly below the carbonate compensation depths,while those of the Neo-Tethys were much shallower before the collision and caused far more carbonate subducting.Additionally,more volcanic ashes erupted from the west Pacific subduction zones,which consume CO_(2).The average annual west Pacific volvano eruption is 1.11 km~3,which is higher than previous estimations.The amount of annual CO_(2)absorbed by chemical weathering of additional west Pacific volcanic ashes could be comparable to the silicate weathering by the global river.We propose that the initiation of the western Pacific subduction controlled the long-term reduction of atmospheric CO_(2)concentration.

关键词： Subduction initiation in the west Pacific Collision of the Neo-Tethys Volcano eruption rates Cenozoic CO_(2)declining Carbonate compensation depths Chemical weathering

Compositional characteristics of sediment from Jiaozhou Bay in North China and the implication to the provenance

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Journal of Oceanology and Limnology 2023年第5期41卷 1729-1741页

作者： Ziwei SUN Jin LIU Yue ZHANG Jinming SONG yuanyuan xiao Huamao YUAN Ning LI Xuegang LI College of Chemistry and Molecular Engineering College of Marine Science and Biological EngineeringQingdao University of Science and TechnologyQingdao 266042China Public Technology Service Center Institute of OceanologyChinese Academy of SciencesQingdao 266071China Key Laboratory of Marine Ecology&Environmental Sciences Institute of OceanologyChinese Academy of SciencesQingdao 266071China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China Qingdao National Laboratory for Marine Science and Technology Qingdao 266061China Key Laboratory of Marine Geology and Environment Institute of OceanologyChinese Academy of SciencesQingdao 266071China

Rare earth elements(REEs)can be used to trace source materials and identify their provenances,because of significant conservation and immobility during chemical alteration processes after erosion of materials from the provenance.This study focused on the temporal variation of REEs for columnar sediments from the mouth of Jiaozhou Bay in North China to understand the potential controls for the geochemical variations of sediments.Through extraction experiments,we identified that the residual fraction is the main host for REEs compared with other fractions(i.e.,exchangeable and carbonate fraction,easily reducible oxides fraction,reducible oxides fraction,magnetite fraction).REE ratios(e.g.,La_(N)/Sm_(N)and La_(N)/Yb_(N);N:normalized by chondrite)lack correlations with grain size or the chemical index of alteration(CIA),which is correlated with major elements.All these indicate that these REE variations reflect the varying contribution of source materials from different provenances instead of grain size or chemical weathering effects.REE ratios(e.g.,La_(N)/Sm_(N)and La_(N)/Yb_(N))remain relatively constant until the depth of roughly 40 cm(equivalent to the year 1995),and show obvious changes beyond this depth.Compared REE characteristics of Jiaozhou Bay with those of neighboring rivers and bedrocks,the relative contributions of Dagu River-Jiaolai River,and Licun River may have been increased during the sedimentary processes,which could be caused by the construction of reservoir and related change of aquaculture(e.g.,rapid accumulation of organic materials).

关键词： Jiaozhou Bay sediments rare earth elements(REEs) sequential extraction provenance

Progress in Age Estimation Based on DNA Methylation

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Journal of Forensic Science and Medicine 2023年第4期9卷 360-366页

作者： Yihang Huang Shengqiu Qu yuanyuan xiao Hui Jian Weibo Liang Department of Forensic Genetics West China School of Basic Medical Sciences and Forensic MedicineSichuan UniversityChengduSichuanChina Department of Laboratory Medicine West China Second University HospitalSichuan UniversityChengduSichuanChina

In forensic practice,the age of suspects or victims is crucial information that aids in the resolution of cases.In recent years,age estimation based on DNA methylation has gained significant attention in forensic science.DNA methylation,an epigenetic marker,undergoes specific changes with age,making it a valuable tool for inferring the age of samples left at crime scenes.Therefore,the identification of age-related DNA methylation markers and the development of novel age estimation models are of great importance in forensic medicine.Numerous studies in the past decade have successfully established age estimation models based on DNA methylation,demonstrating excellent sensitivity and accuracy.To provide a comprehensive review,the authors of this paper conducted a systematic review of relevant articles published from 2012 to the present.We used keywords such as“forensic,”“DNA methylation,”and“age estimation”to retrieve pertinent articles from the Web of Science database.The review covers various aspects,including the sources of sample tissues used for age estimation,DNA methylation conversion methods,and different techniques for DNA methylation detection.In addition,the paper reviews the modeling methods for age estimation based on DNA methylation and factors that can influence DNA methylation.Overall,this review serves as a valuable reference for forensic genetics,offering insights into the latest advancements in age estimation using DNA methylation.As the field of forensic science continues to evolve,the integration of DNA methylation-based age estimation into practice is expected to enhance the accuracy and reliability of age determination in criminal investigations.

关键词： Age estimation DNA methylation forensic genetics

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儿童皮肤浅部真菌感染诊疗进展

中华实用儿科临床杂志 2024年第1期39卷 35-39页

作者：肖媛媛马琳国家儿童医学中心首都医科大学附属北京儿童医院皮肤科北京100045

皮肤浅部真菌感染由只侵犯完全角化组织, 例如角质层、毛发和甲的真菌引起。临床上, 儿童皮肤浅部真菌感染最常见的为头癣, 而体/股癣、手/足癣、甲真菌病及花斑糠疹的发病率相对较低, 现就儿童皮肤浅部真菌感染的临床表现、诊断及治疗... 详细信息

皮肤浅部真菌感染由只侵犯完全角化组织, 例如角质层、毛发和甲的真菌引起。临床上, 儿童皮肤浅部真菌感染最常见的为头癣, 而体/股癣、手/足癣、甲真菌病及花斑糠疹的发病率相对较低, 现就儿童皮肤浅部真菌感染的临床表现、诊断及治疗进展进行阐述。

关键词：儿童皮肤癣菌头癣体/股癣手/足癣甲真菌病花斑糠疹诊断治疗

Neoproterozoic Diamictite of the Luoquan Formation from the North China Block and Their Implications

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Journal of Earth Science 2023年第4期34卷 1128-1139页

作者： Peishan Sui Weidong Sun Nan Han Lei Wang Shiwen Xie Zihang Huang xiaohong Wang Hongmei Gong Jin Liu Jinyan Lin yuanyuan xiao CAS Key Laboratory of Marine Geology and Environment Institute of OceanologyChinese Academy of SciencesQingdao 266071China Laboratory for Marine Geology Qingdao National Laboratory for Marine Science and TechnologyQingdao 266061China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China Center of Deep-Sea Research Institute of OceanologyChinese Academy of SciencesQingdao 266071China Changqing Oilfield Exploration and Development Research Institute Xi'an 710018China Yanchang Oilfield Exploration and Development Technology Research Center Xi'an 716001China Beijing SHRIMP Center Institute of GeologyChinese Academy of Geological SciencesBeijing 100037China Public Technology Service Center Institute of OceanologyChinese Academy of SciencesQingdao 266071China Department of Geology Northwest UniversityXi'an 710069China

Glacial diamictite may provide important information on paleoenvironment and average composition of the upper continental crust(UCC).In this study,we report sedimentary facies,petrological and geochemical characteristics of Neoproterozoic diamictite from a profile of the Luoquan Formation on the southern margin of the North China Block(NCB).Upwards the sampling profile,lithostratigraphic strata vary from massive diamictite with poorly sorted carbonate gravels to laminated diamictite with small gravels of terrestrial detrital materials.Along the profile,CaO-MgO-LOI-Sr values decrease with the increase of SiO_(2)-Al2O_(3)-K2O contents.All these petrological and geochemical variations indicate a change from lodgement till deposition in the proximal of ice sheet to ice-rafting deposition in glacial-marine environment with less dolomite to supply their source.Together with previous studies on diamictite from other outcrops on the NCB,the deposition of Luoquan diamictite reflects that the glaciation on the NCB vanished and the ice-rafting effect weakened with glacial transgression process.In addition,significant co-variations of various elements with La and Al2O_(3)confirm the significant conservation of most analyzed elements during the sedimentary processes to produce diamictite.

关键词： diamictite North China Craton paleoenvironment the Luoquan Formation Neopro-terozoic sedimentation.

Simple and cost-effective methods for precise analysis of trace element abundances in geological materials with ICP-MS

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Science Bulletin 2017年第4期62卷 277-289页

作者： Shuo Chen xiaohong Wang Yaoling Niu Pu Sun Meng Duan yuanyuan xiao Pengyuan Guo Hongmei Gong Guodong Wang Qiqi Xue Institute of Oceanology Chinese Academy of SciencesQingdao 266071China Laboratory for Marine Geology Qingdao National Laboratory for Marine Science and TechnologyQingdao 266061China University of Chinese Academy of Sciences Beijing 100049China Department of Earth Sciences Durham UniversityDurham DH1 3LEUK School of Earth Science and Mineral Resources China University of GeosciencesBeijing 100083China

Inductively coupled plasma mass spectrometry(ICP-MS) is the most commonly used technique to determine the abundances of trace elements in a wide range of geological materials. However, incomplete sample digestion, isobaric interferences and instrumental drift remain obvious problems that must be overcome in order to obtain precise and accurate results. For this reason, we have done many experiments and developed a set of simple, cost-effective and practical methods widely applicable for precise and rapid determination of trace element abundances in geological materials using ICP-MS. Commonly used high-pressure digestion technique is indeed effective in decomposing refractory phases, but this inevitably produces fluoride complexes that create new problems. We demonstrate that the fluoride complexes formed during high-pressure digestion can be readily re-dissolved using high-pressure vessel at 190 °C for only 2 h for 50 mg sample. In the case of isobaric interferences, although oxide(e.g., MO+/M+) and hydroxide(e.g., MOH+/M+) productivity is variable between runs, the(MO+/M+)/(Ce O+/Ce+)and(MOH+/M+)/(Ce O+/Ce+) ratios remain constant, making isobaric interference correction for all other elements of interest straightforward, for which we provide an easy-to-use off-line procedure. We also show that mass-time-intensity drift curve is smooth as recognized previously, for which the correction can be readily done by analyzing a quality-control(QC) solution and using off-line Excel VBA procedure without internal standards. With these methods, we can produce data in reasonable agreement with recommended values of international rock reference standards with a relative error of 60% of time(e.g., 60 h).

关键词： ICP-MS 元素丰度地质材料精确分析经济电感耦合等离子体质谱 VBA程序干扰校正

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硬脆材料孔加工损伤及抑制措施研究现状综述

农业装备与车辆工程 2024年第4期62卷 128-131页

作者：刘红文肖渊渊新乡工程学院机电工程学院河南新乡453700

硬脆材料自身的硬脆特性,导致在传统孔加工过程中容易出现孔口损伤、内孔表面缺陷和内孔亚表面损伤等缺陷。为针对性解决缺陷,对研究现状进行剖析。首先,从硬脆材料孔加工的材料去除机理和孔加工的工艺特性等方面进行梳理,分析当前孔加... 详细信息

硬脆材料自身的硬脆特性,导致在传统孔加工过程中容易出现孔口损伤、内孔表面缺陷和内孔亚表面损伤等缺陷。为针对性解决缺陷,对研究现状进行剖析。首先,从硬脆材料孔加工的材料去除机理和孔加工的工艺特性等方面进行梳理,分析当前孔加工产生缺陷的原因;其次提出抑制孔加工损伤的措施研究主要集中在孔口处增加辅助支撑、改进刀具结构以及优化工艺参数等方面;最后提出通过优化工艺参数和增加辅助支撑共同作用来提高硬脆材料孔加工质量。为提高硬脆材料的孔加工质量提供参考。

关键词：硬脆材料孔加工损伤抑制措施加工质量

胶州湾沉积物的不同相态主量元素含量及铁同位素组成初探

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青岛科技大学学报（自然科学版） 2024年第2期45卷 38-46页

作者：孙子威肖媛媛张跃刘瑾青岛科技大学化学与分子工程学院海洋科学与生物工程学院山东青岛266042 青岛海洋科学技术国家重点实验室山东青岛266061 中国科学院海洋研究所地质与环境重点实验室海洋大科学研究中心海洋研究所公共技术服务中心山东青岛266071

沉积物是物源、沉积环境、生源过程等多因素影响下的产物,不同元素进入沉积物的方式不同导致其赋存在不同的相态中,通过研究不同相态沉积物的元素丰度及同位素组成,可以揭示由于多种过程混合所掩盖的生物、物理及化学信息。本研究通过... 详细信息

沉积物是物源、沉积环境、生源过程等多因素影响下的产物,不同元素进入沉积物的方式不同导致其赋存在不同的相态中,通过研究不同相态沉积物的元素丰度及同位素组成,可以揭示由于多种过程混合所掩盖的生物、物理及化学信息。本研究通过选择性化学提取法,对胶州湾沉积物进行了分级提取,包括碳酸盐结合态、易还原的氧化物态、可还原的氧化物态、磁铁矿态和残留态。测试结果表明:主量元素主要赋存在残留态中,但在非残留态中不同程度保留有Ca、Fe、Mg、Mn和P。结合胶州湾沉积物中的常见矿物成分,除了之前研究已介绍的不同相态的目标矿物组成,推测易还原的氧化物态的潜在矿物还有独居石和磷灰石;可还原的氧化物态的潜在矿物还有褐铁矿;磁铁矿态的潜在矿物还有钛铁矿;部分硅酸盐矿物也存在于易还原的氧化物态和可还原的氧化物态中。残留态富集了重铁同位素,继承了物源区的特征,并且全组分的铁同位素主要受控于残留态;活性铁组分的铁同位素由于受到了非陆源组分的影响,导致同位素变化。

关键词：胶州湾沉积物连续提取铁同位素

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中药六味地黄丸辅助二甲双胍治疗对2型糖尿病患者血糖指标的影响研究

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糖尿病新世界 2024年第5期27卷 103-106页

作者：吴晓芬王秀艳肖圆圆广东省东源县中医院中药房广东河源517500

目的探究2型糖尿病患者接受六味地黄丸辅助二甲双胍的治疗价值。方法选取2023年4—9月广东省东源县中医院收治的90例2型糖尿病患者为研究对象,以随机数表法分为对照组(45例,二甲双胍治疗)和观察组(45例,六味地黄丸辅助二甲双胍治疗),对... 详细信息

目的探究2型糖尿病患者接受六味地黄丸辅助二甲双胍的治疗价值。方法选取2023年4—9月广东省东源县中医院收治的90例2型糖尿病患者为研究对象,以随机数表法分为对照组(45例,二甲双胍治疗)和观察组(45例,六味地黄丸辅助二甲双胍治疗),对比两组血糖水平、中医证候积分、治疗效果与不良反应发生情况。结果治疗后,两组血糖水平与中医证候积分均下降,且观察组低于对照组,差异有统计学意义(P均0.05)。结论中药六味地黄丸辅助二甲双胍可提升2型糖尿病患者治疗总有效率,改善血糖水平与中医证候,安全可靠。

关键词： 2型糖尿病二甲双胍血糖指标六味地黄丸

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