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MicrornA (let-7b-5p)-targeted DArS2 regulates lung adenocarcinoma growth by PI3K/AKT signaling pathway

Oncology research 2024年第3期32卷 517-528页

作者： yuanyuan XU XIAOKE CHEn Department of Oncology Surgery Shanghai Lung Cancer CenterShanghai Chest HospitalShanghai Jiao Tong UniversityShanghaiChina

Background:The aberr.nt intraellular expression of a mitochondrial aspartyl trnA synthetase 2(DArS2)has been reported in human *** its critical role and detailed mechanism in lung adenocarcinoma(LUAD)remain ***:Initially,The Cancer Genome Atlas(TCGA)based Gene Expression Profiling Interactive Analysis(GEPIA)database (http:/***/)was used to analyze the prognostic relevance of DArS2 expression in ***,cell counting kit(CCK)8,immunostaining,and tr.nswell invasion assays in LUAD cell lines in vitro,as well as DArS2 silence on LUAD by tumorigenicity experiments in wivo in nude mice,were ***,we analyzed the expression levels of p-PI3K(phosphorylated Phosphotylinosital3 kinase),PI3K,AKT(Protein Kinase B),p-AKT(phosphorylated Protein Kinase B),PCnA(proliferating cell nudear antigen),cleaved-caspase 3,E cadher.n,and n-cadher.n proteins using the Westem blot ***:LUAD tissues showed higher DArS2 expression compared to normal *** of DArS2 could be related to Tumor.node-Metastasis(TnM)stage,high lymph node metastasis,and inferior ***2 silence decreased the proliferation,migration,and invasion abilities of LUAD *** addition,the DArS2 downregulation decreased the PCnA and n-cadher.n expression and increased cleaved:caspase 3 and E cadher.n expressions in LUAD cells,coupled with the inactivation of the PI3K/AKT signaling ***,DArS2 silence impaired the tumonigenicity of LUAD in ***,let:7b-5p could recognize DArS2 through a complementary ***,the increased let 7b 5p expression attenuated the promo oncogenic action of DArS2 dur.ng LUAD progression,which were inversely correlated to each other in the LUAD tssues Conclusion:In summary,let 7b-5p,downregulated DArS2 expression,regulating the progression of LUAD cells by the PI3K/AKT signaling pathway.

关键词： Lung adenocarcinoma Prognosis PI3K/AKT pathway Mitochondrial asparty-trnA synthetase MicrornAs

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Effect of nourishing Yin and purging fire Chinese herbal mixture on delaying light-induced premature puberty in rats

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Journal of Traditional Chinese Medicine 2024年第1期44卷 95-102页

作者： SUn Yanyan XUE yuanyuan SUn Wen WAnG Yonghong YU Jian Department of Traditional Chinese Medicine Children's Hospital of Fudan UniversityShanghai 201102China Department of Pediatrics Zibo Central HospitalZibo 255000China

OBJECTIVE:To elucidate the mechanism of the nourishing Yin and purging fire Chinese herbal mixture(nYPF)in delaying light-induced premature puberty in ***:Twenty-one days old female SpragueDawley rats were r.ndomly assigned to normal group(n),long light exposure group(L),nYPF and normal saline group(nS).rats in the L,nYPF and nS groups were exposed to 16 h:350 lux light/8 h:dark,while rats in the n group were exposed to 12 h:50 lux light/12 h:*** and normal saline was administered to the rats in the nYPF group or.nS group,respectively,from day *** rats in every group were sacrificed at 9 *** day 28(P28),on the day when rat's vulva opened in the L group(L-VO),on the day when the first estrous interphase occurred in rats of L group(L-E1),and on the day when the second estrous interphase occurred in rats of L group(L-E2),***:On day 34,all rats in the L group,80%of rats in the nS group,40%of rats in the n group,and 20%of rats in the nYPF group showed complete opening of the *** P28,m rnA level of hypothalamic kisspeptin(Kiss-1)in the L group was significantly higher than that in the n group(Prats in the L and nS groups had significantly lower hypothalamic argininephenylalanine-amide(rFamide)-related peptide 3(rFrP-3)m rnA levels than those in the n group(Preas rFrP-3 m rnA level was significantly higher in the nYPF group than that in the L group(Prian index of the L and nS groups was significantly higher than that of the n group(Pnd estradiol(E2)level of the nYPF group was significantly lower than that of the n and nS groups(PrnA level in the L and nS groups was significantly higher than that in the n and nYPF groups(Preas hypothalamic rFrP-3 m rnA level in the L,nYPF,and nS groups was significantly lower than that in the n group(Pnd nS groups was significantly higher than that of the n group(Pr

关键词： light puberty precocious kisspeptins rFrP-3 melatonin nourishing Yin and Purging Fire

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Secondary metabolites of mulberry leaves exert anti-lung cancer activity through regulating the PD-L1/PD-1 signaling pathway

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Journal of Pharmaceutical Analysis 2024年第6期14卷 914-925页

作者： Guiqin Ye Xin Sun Jiuzhou Li yuanyuan Mai ruilan Gao Jianbin Zhang Cancer Center Department of Medical OncologyKey Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang ProvinceZhejiang Provincial People's HospitalAffiliated People's HospitalHangzhou Medical CollegeHangzhou310014China Clinical Laboratory Yuhuan City HospitalTaizhouZhejiang317600China Hangzhou Medical College Hangzhou311300China Department of neurosurgery Binzhou People's HospitalBinzhouShandong256600China Institute of Hematology research The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou310060China

Lung cancer r.nks the top of malignancies that cause cancer-related deaths *** leaves of Morus alba L are traditional Chinese medicine widely applied in respiratory *** previous work has demonstrated the anti-lung cancer effect of secondary metabolites of mulberry leaf,but their mechanism of action has still not fully *** synthesized Moracin n(MAn)-Probe conjugated with alkyne to label lung cancer cells and identified protein targets by chemical proteomic *** and its probe exerted similar growth-inhibitory effect on human lung cancer *** proteomic results showed that MAn targeted the programmed death ligand 1(PD-L1)checkpoint pathway and T cell receptor(TCr)signaling pathway,indicating its immune-regulatory ***-free surface plasmon resonance(SPr)results showed the direct interaction of MAn with PD-L1 *** docking analysis demonstrated that MAn bound to E158 residue of PD-L1 *** downregulated the expression levels of PD-L1 in a time-and dose-dependent manner and disrupted the PD-L1/programmed death 1(PD-1)binding,including other secondary metabolites of mulberry leaves Guangsangon E(GSE)and Chalcomoracin(CMr).Human peripheral blood mononuclear cells(PBMCs)co-cultured with MAn-treated A549 cells,resulting in the increase of CD8^(+)GZMB^(+)T cells and the decrease of CD8^(+)PD-1^(+)T *** suggested that MAn exerts anti-cancer effect through blocking the PD-L1/PD-1 *** vivo,MAn combined with anti-PD-1 antibody significantly inhibited lung cancer development and metastasis,indicating their synergistic *** together,secondary metabolites of mulberry leaves target the PD-L1/PD-1 signaling,enhance T cell-mediated immunity and inhibit the tumorigenesis of lung *** modulatory effect on tumor microenvir.nment makes them able to enhance the therapeutic efficacy of immune checkpoint inhibitors in lung cancer.

关键词： Moracin n Click chemistry PD-L1 T cell Lung cancer

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Synthesis of naY zeolite from a submolten depolymerized perlite:Alkalinity effect and crystallization kinetics

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Chinese Journal of Chemical Engineer.ng 2024年第6期70卷 130-138页

作者： Yanli Qu Peng Dong Li Yang yuanyuan Yue Haoliang Wang Jingcai Cheng Chao Yang CAS Key Laboratory of Green Process and Engineer.ng State Key Laboratory of Petroleum Molecular&Process EngineeringInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineer.ng University of Chinese Academy of SciencesBeijing 100190China Qingyuan Innovation Laboratory Quanzhou 362801China national Engineer.ng research Center of Chemical Fertilizer Catalyst College of Chemical EngineeringFuzhou UniversityFuzhou 350108China

naY zeolites are synthesized using submolten salt depolymerized natural perlite mineral as the main silica and alumina sources in a 0.94 L stirred *** of alkalinity r.nging from 0.38 to 0.55(n(na_(2)O)/n(SiO_(2)))on the relative crystallinity,textural properties and crystallization kinetics were *** results show that alkalinity exerts a nonmonotonic influence on the relative crystallinity and textural properties,which exhibit a maximum at the alkalinity of *** nucleation kinetics are studied by fitting the experimental data of relative crystallinity with the Gualtieri *** is shown that the nucleation rate constant increases with increasing alkalinity,while the duration period of nucleation decreases with increasing *** n(na_(2)O)/n(SiO_(2))ratios r.nging from 0.38 to 0.55,the as-synthesized naY zeolites exhibit narrower crystal size distributions with the increase in *** growth rates determined from the variations of average crystal size with time are 51.09,157.50,46.17 and 24.75 nm·h^(-1),*** is found that the larger average crystal sizes at the alkalinity of 0.38 and 0.43 are attributed to the dominant role of crystal growth over ***,the combined action of prominent crystal growth and the longer duration periods of nucleation at the alkalinity of 0.38 and 0.43 results in broader crystal size *** findings demonstrate that control of the properties of naY zeolite and the crystallization kinetics can be achieved by conducting the crystallization process in an appropriate r.nge of alkalinity of the reaction mixture.

关键词： naY zeolite Submolten salt depolymerized perlite Alkalinity Crystallization kinetics

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OSDA-free synthesis of FeZSM-22 zeolite from natural minerals for.n-octane hydroisomerization

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Chinese Journal of Chemical Engineer.ng 2024年第2期66卷 51-59页

作者： Tiesen Li Ting Chen Yinghui Ye Peng Dong TinghaiWang Qingyan Cui Chan Wang yuanyuan Yue national Engineer.ng research Center of Chemical Fertilizer Catalyst College of Chemical EngineeringFuzhou UniversityFuzhou 350002China Qingyuan Innovation Laboratory Quanzhou 362801China

A seed-directed approach to synthesizing Fe ZSM-22 zeolite without organic structure directing agent(OSDA)was developed by using Fe-rich diatomite as all aluminum and ir.n *** Fe ZSM-22zeolite with optimal crystallinity and purity can be obtained by systematically adjusting feed composition and synthesis *** show that Fe ZSM-22 zeolite synthesized with OSDA-free owns high crystallinity,obvious thin needle-shaped morphology and high Br.nsted/Lewis acid ***,when used for.n-octane hydroisomerization reaction,its derived catalyst exhibits the best catalytic performance reflected by the highest selectivity to C_(8)isomers compared to the two refer.nce catalysts prepared based on a Fe-containing and a Fe-free ZSM-22 synthesized through an OSDA-directed route from natural diatomite and conventional chemicals,*** work provides an alternative route to sustainably synthesizing heteroatomic zeolites with high performance.

关键词： FeZSM-22 zeolite OSDA-free synthesis natural minerals n-octane hydroisomerization

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Covalent organic frameworks doped with manganese-metal organic framework for peroxymonosulfate activation

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Chinese Chemical Letters 2024年第4期35卷 199-203页

作者： Yinyin Xu yuanyuan Li Jingbo Feng Chen Wang Yan Zhang Yukun Wang Xiuwen Cheng Key Laboratory for Envir.nmental Pollution Prediction and Control College of Earth and Environmental SciencesLanzhou UniversityLanzhou 730000China Key Laboratory of Pollutant Chemistry and Envir.nmental Treatment College of Chemistry and Environmental ScienceYili Normal UniversityYining 835000China

A novel n, O modified Mn_(3)O_(4)@porous carbon catalyst(nOC-Mn_(3)O_(4)) was prepared by direct carbonization using the manganese-metal organic framework(Mn-MOF) and covalent organic framework(COF) as precursors to activate peroxymonosulfate(PMS) for the degradation of bisphenol A(BPA) and rhodamine B(rh B). Benefiting from the n and O co-doping of COF, larger specific surface area, faster electr.n tr.nsfer and Mn cycling, the optimum 1nOC-Mn_(3)O_(4)could significantly improve the degradation performance of BPA and rh B(92.1% and 96.9% within 30 min) as compared to C-Mn_(3)O_(4)without COF doping. In addition, 1nOC-Mn_(3)O_(4) showed good reusability and str.ng anti-interfer.nce ability. radical quenching experiments, X-ray photoelectr.n spectroscopy(XPS), Electr.n paramagnetic resonance spectrometer(EPr) and electrochemical tests showed that the 1nOC-Mn_(3)O_(4)/PMS system degraded BPA and rh B by both radical and non-radical pathways. Moreover, the possible degradation pathways of BPA and rh B were proposed by liquid chromatography-mass spectrometry(LC-MS). Except for that, the toxicity of BPA, rh B and their intermediates were evaluated. This study opens up a new prospect for the design of COF-doped PMS catalysts.

关键词： Peroxymonosulfate Covalent organic framework Mn-metal organic framework Organic pollutant Degradation

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rapid Phase Ambiguity Elimination Methods for DOA Estimator via Hybrid Massive MIMO receive Array

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Chinese Journal of Electr.nics 2024年第1期33卷 175-184页

作者： Xichao ZHAn Zhongwen SUn Feng SHU Yiwen CHEn Xin CHEnG yuanyuan WU Qi ZHAnG Yifan LI Peng ZHAnG School of Information and Communication Engineer.ng Hainan University School of Electr.nic and Optical Engineer.ng Nanjing University of Science and Technology

For a sub-connected hybrid multiple-input multiple-output(MIMO) receiver with K subarrays and n antennas, there exists a challenging problem of how to rapidly remove phase ambiguity in only single time-slot. A direction of arrival(DOA) estimator of maximizing received power(Max-rP) is proposed to find the maximum value of K-subarray output powers, where each subarray is in charge of one sector, and the center angle of the sector corresponding to the maximum output is the estimated true DOA. To make an enhancement on precision, Max-rP plus quadratic interpolation(Max-rP-QI) method is designed. In the proposed Max-rP-QI, a quadratic interpolation scheme is adopted to interpolate the three DOA values corresponding to the largest three receive powers of *** achieve the Cramer rao lower bound, a root-MUSIC plus Max-rP-QI scheme is developed. Simulation results show that the proposed three methods eliminate the phase ambiguity dur.ng one time-slot and also show low computational complexities. The proposed root-MUSIC plus Max-rP-QI scheme can reach the Cramer rao lower bound,and the proposed Max-rP and Max-rP-QI are still some performance losses 2–4 d B compared to the Cramer rao lower bound.

关键词： Phased arrays Interpolation Wireless sensor.networks Direction-of-arrival estimation Simulation receiving antennas Massive MIMO

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Elaborate Design of Two novel Fluorescent Zinc-based Metal-Organic Frameworks for Highly Efficient Tetracycline Antibiotics Detection

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Chemical research in Chinese Universities 2024年第3期40卷 499-507页

作者： TAO He JI Chengshan ZHAnG Jian YIn yuanyuan JIA Wenwen JIAnG Xin XU Jie YAnG Yulin MIT Key Laboratory of Critical Materials Technology for.new Energy Conversion and Storage School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001P.R.China

The abuse of tetracycline antibiotics has caused great harm to human health and *** inexpensive,convenient and sensitive methods for the detection of tetracycline antibiotics is highly ***,based on the H_(4)ddp ligand[H_(4)ddp=3-(3,5-dicarboxyphenyl)pyridine-2,6-dicarboxylic acid],two novel zinc-based metal-organic frameworks(MOFs){[Zn_(3)(ddp)_(2)(H_(2)O)_(4)]·3H_(2)O}n(Zn1-ddp)and{[Zn_(3)(ddp)_(2)(H_(2)O)_(4)]·3H_(2)O}n(Zn2-ddp)were successfully designed by delicate structural *** Zn1-ddp and Zn2-ddp exhibited excellent water and chemical stability and showed excellent fluorescence quenching performance for tetracycline ***,the more advanced framework structure and better fluorescent performance make Zn1-ddp more sensitive than Zn2-ddp in fluorescent detection with a detection limit of 0.29µmol/L for tetracycline(TC),0.09µmol/L for doxycycline(DOX),0.10µmol/L for minocycline(MIn)and metacycline(MEL),0.19µmol/L for chlortetracycline(CTC),and 0.67µmol/L for oxytetracycline(OTC)among tetracycline *** fluorescence quenching mechanism of Zn1-ddp and Zn2-ddp for tetracycline antibiotics detection was deeply *** reasons for the superior detection performance of Zn1-ddp over Zn2-ddp were also analyzed in depth through Fourier tr.nsform infrared spectrophotometry(FTIr),X-ray photoelectr.n spectroscopy(XPS)analysis and framework structure *** developed method opens up a new perspective for antibiotics detection based on zinc-based MOFs.

关键词： Water system Metal-organic framework Fluorescent detection Tetracycline antibiotic

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Autotomy and regeneration of Appendages in Crustaceans:A review

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Journal of Ocean University of China 2024年第3期23卷 731-742页

作者： LIU Lei TAO Dandan WAnG Chunlin FU yuanyuan WAnG Sixiang HUAnG Xinlian ZHAI Wei SOnG Weiwei School of Mar.ne Sciences Ningbo UniversityNingbo 315832China ningbo Institute of Oceanography Ningbo 315832China

Autotomy of appendages is a self-protection mechanism in crustaceans,which is defined as the reflexive loss of a limb in response to predation,competition,or other envir.nmental ***-limb injuries were the most common among the species surveyed in the present study,and the chelicerae were the most frequently lost *** autotomy,hormones and signaling pathways are *** of limbs can affect foraging efficiency,although cheliped loss may be compensated by shifting to alternative prey or using both motor and oral *** heterogeneous species,the loss of the major chelae may affect the selectivity of *** can affect crustacean growth by reducing size increases at molting and alter.ng the timing of *** commercial production,removing chelicerae is an effective strategy to reduce cannibalism,and production of soft-shell crabs can be increased via *** autotomy,a new limb will regrow through regeneration and *** process involves the regulation of hormones,regrowth of nerves,and a number of signaling pathways that include the Wnt/β-catenin signaling pathway and tr.nsforming growth factorβsignaling *** are somewhat differ.nt from vertebrates in terms of *** review provides theoretical guidance about autotomy and regeneration applied in artificial aquaculture,and we offer several suggestions for future research on autotomy and regeneration in crustaceans.

关键词： autotomy regeneration appendages crustaceans

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Chemoselective Tr.nsfer Hydrogenation of nitroar.nes with Ammonia Bor.ne Catalyzed by Copper.n-Heterocyclic Carbene Complexes

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Chinese Journal of Chemistry 2024年第15期42卷 1721-1726页

作者： Hui Zhou Hongmei Jiao Xing Lu yuanyuan Gao Zhiqiang r.n Haojie Ma Yuqi Zhang Bo Han Laboratory of new Energy&new Function Materials Shaanxi Key Laboratory of Chemical Reaction EngineeringCollege of Chemistry and Chemical EngineeringYan'an UniversityYan'anShaanxi 716000China

Herein,we present a method for the homogeneous hydrogenation of nitroar.nes to produce anilines using low catalyst loading(1 mo%)of copper.n-heterocyclic carbene complexes as the catalyst and ammonia bor.ne as the source of hydrogen.A wide r.nge of nitroar.nes,featur.ng diverse functional groups,were selectively tr.nsformed into their corresponding primary aromatic amines with high *** process can be readily scaled up and exhibits compatibility with various sensitive functional groups,including halogen,trifluoromethyl,aminomethyl,alkenyl,cyano,ester,amide,and ***,this catalytic methodology finds application in the synthesis of essential drug *** investigations suggest that the in-situ-generated Cu-H species may serve as active intermediates,with reduction pathways involving species such as azobenzene,1,2-diphenylhydrazine,nitrosobenzene,and n-phenylhydroxylamine.

关键词： Homogeneous catalysis Hydrogenation n-Heterocyclic carbene complexes nitroar.nes Ammonia bor.ne

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