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How to reach the orbital configuration of the inner three planets in HD 40307 planet system?

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Science China(Physics,Mechanics & Astronomy) 2015年第3期58卷 102-108页

作者： chen yuanyuan ZHOU JiLin MA YueHua Department of Astronomy & Key Laboratory of Modern Astronomy and Astrophysics in Ministry of Education Nanjing University Purple Mountain Observatory Chinese Academy of Sciences Key Laboratory of Planetary Sciences Chinese Academy of Sciences

The formation of the present configuration of three hot super-Earths in the planet system HD 40307 is a challenge to dynamical *** the two successive period ratios both near and slightly larger than 2,the system may have evolved from pairwise2:1 mean motion resonances(MMRs).In this paper,we investigate the evolutions of the period ratios of the three planets after the primordial gas disk was *** routines are found to probably result in the current configuration under tidal dissipation with the center star,they are:(i)through apsidal alignment only;(ii)out of pairwise 2:1 MMRs,then through apsidal alignment;(iii)out of the 4:2:1 Laplace Resonance(LR),then through apsidal *** the three scenarios require the initial eccentricities of planets～0.15,which implies a planetary scattering history during and after the gas disk was *** the three routines will go through the apsidal alignment phase,and enter a state with near-zero eccentricities *** also find some special characteristics for each *** the system went through pairwise 2:1 MMRs at the beginning,the MMR of the outer two planets would be broken first to reach the current *** for routine(iii),the planets would be out of the LR at the place where some high-order resonances are *** the high-order resonances 17:8 or 32:15 of the planets c and d,the system will possibly enter the current state as the final equilibrium.

关键词： planets and satellites: formation planets and satellites: HD40307

Analysis of Incomplete Data of Accelerated Life Testing with Competing Failure Modes

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Chinese Journal of Mechanical Engineering 2009年第6期22卷 883-889页

作者： TAN yuanyuan ZHANG Chunhua chen Xun College of Mechatronics Engineering and Automation National University of Defense Technology Changsha 410073 China

Data obtained from accelerated life testing （ALT） when there are two or more failure modes, which is commonly referred to as competing failure modes, are often incomplete. The incompleteness is mainly due to censoring, as well as masking which might be the case that the failure time is observed, but its corresponding failure mode is not identified. Because the identification of the failure mode may be expensive, or very difficult to investigate due to lack of appropriate diagnostics. A method is proposed for analyzing incomplete data of constant stress ALT with competing failure modes. It is assumed that failure modes have s-independent latent lifetimes and the log lifetime of each failure mode can be written as a linear function of stress. The parameters of the model are estimated by using the expectation maximum （EM） algorithm with incomplete data. Simulation studies are performed to check＇model validity and investigate the properties of estimates. For further validation, the method is also illustrated by an example, which shows the process of analyze incomplete data from ALT of some insulation system. Because of considering the incompleteness of data in modeling and making use of the EM algorithm in estimating, the method becomes more flexible in ALT analysis.

关键词： accelerated life testing competing failure modes expectation maximum algorithm incomplete data Monte Carlo simulation

Long non-coding RNAs: From disease code to drug role

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Acta Pharmaceutica Sinica B 2021年第2期11卷 340-354页

作者： yuanyuan chen Zhaojun Li Xiaoguang chen Sen Zhang State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia MedicaChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100050China

Enormous studies have corroborated that long non-codig RNAs(LncRNAs)extensively participate in crucial physiological processes such as metabolism and immunity,and are closely related to the occurrence and development of tumors,cardiovascular diseases,nervous system disorders,nephropathy,and other *** application of lncRNAs as biomarkers or intervention targets can provide new insights into the diagnosis and treatment of *** paper has focused on the emerging research into lncRNAs as pharmacological targets and has reviewed the transition of IncRNAs from the role of disease coding to acting as drug candidates,including the current status and progress in preclinical ***-edge strategies for lncRNA modulation have been summarized,including the sources of LncRNA-related drugs,such as genetic technology and small-molecule compounds,and related delivery *** current progress of clinical trials of lncRNA-targeting drugs is also *** information will form a latest updated reference for research and development of lncRNA-based drugs.

关键词： LncRNAs Targeted drug Gene therapy Small molecules Delivery ASncmtRNA Translational medicine Clinical trials

Surface analysis and electrochemical behaviour of the self-assembled polydopamine/dodecanethiol complex films in protecting 304 stainless steel

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Science China(Technological Sciences) 2012年第6期55卷 1527-1534页

作者： chen yuanyuan chen ShouGang chen Yan SONG XianWang XU FengZhen Institute of Material Science and Engineering Ocean University of ChinaQingdao 266100China

A self-assembled 1-dodecanethiol film assisted with the preferential adhesion of polydopamine was prepared on the non-etching 304 stainless steel surfaces by a simple dip-coating *** formation and surface structure of the film were characterized by water contact angle measurement,atomic force microscopy(AFM),and X-ray photoelectron spectroscopy(XPS).The corrosion behavior of the complex films was evaluated by Tafel polarization curve and electrochemical impedance spectroscopy(EIS).The excellent corrosion resistance property could be attributed to the compact hybrid film structure and superior seawater stability for modified 304 stainless steel surface.

关键词： stainless steel polymer coatings EIS XPS AFM

Facile Synthesis of Mesoporous Cuprous Oxide Nanoparticles for Enhanced Visible-light-driven Photodegradation

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Journal of Wuhan University of Technology(Materials Science) 2018年第1期33卷 91-96页

作者：肖涵雷利文 WANG Zhiqiang chen yuanyuan School of Materials Science and Engineering Wuhan University of Technology

The visible-light-active mesoporous cuprous oxide nanoparticles were successfully synthesized via a facile precipitation process with the presence of gelatin, which was demonstrated to play an important role in the formation of mesoporous structure and the grain size control. The nanoscale grain size and mesoporous structure lead to lager specific surface area with the addition of gelatin. Furthermore, the photodegradation of as-prepared catalysts in the presence of gelatin toward the negatively charged methyl orange（MO） was investigated. The cuprous oxide displayed an excellent visible light photocatalytic activity of MO, owing to its exposed active（111） face and large specific surface area. The adsorption of positively charged methyl blue（MB） revealed that the mesoporous cuprous oxide displayed better adsorption of anionic dye MB due to the residual gelatin on the surface of the grains, compared to that in the absence of gelatin.

关键词： cuprous oxide mesoporous materials photocatalyst

Deciphering suppressive effects of Lianhua Qingwen Capsule on COVID-19 and synergistic effects of its major botanical drug pairs

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Chinese Journal of Natural Medicines 2023年第5期21卷 383-400页

作者： chen yuanyuan ZHANG cheng WANG Ning FENG Yibin School of Chinese Medicine Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong 999077China

The COVID-19 pandemic has resulted in excess deaths *** antiviral medicines have been used to relieve the symptoms,with limited therapeutic *** contrast,Lianhua Qingwen Capsule is reported to exert remarkable anti-COVID-19 *** current review aims to:1)uncover the main pharmacological actions of Lianhua Qingwen Capsule for managing COVID-19;2)verify the bioactive ingredients and pharmacological actions of Lianhua Qingwen Capsule by network analysis;3)investigate the compatibility effect of major botanical drug pairs in Lianhua Qingwen Capsule;and 4)clarify the clinical evidence and safety of the combined therapy of Lianhua Qingwen Capsule and conventional *** bioactive ingredients in Lianhu Qingwen,such as quercetin,naringenin,β-sitosterol,luteolin,and stigmasterol,were identified to target host cytokines,and to regulate the immune defence in response to *** including androgen receptor(AR),myeloperoxidase(MPO),epidermal growth factor receptor(EGFR),insulin(INS),and aryl hydrocarbon receptor(AHR)were found to be significantly involved in the pharmacological actions of Lianhua Qingwen Capsule against *** botanical drug pairs in Lianhua Qingwen Capsule were shown to have synergistic effect for the treatment of *** studies demonstrated the medicinal effect of the combined use of Lianhua Qingwen Capsule and conventional drugs against *** conclusion,the four main pharmacological mechanisms of Lianhua Qingwen Capsule for managing COVID-19 are *** effect has been noted against COVID-19 in Lianhua Qingwen Capsule.

关键词： COVID-19 Traditional Chinese medicine Herbal medicine Lianhua Qingwen Capsule Botanical drug pairs Network pharmacology

Social Media Based Transportation Research: the State of the Work and the Networking

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IEEE/CAA Journal of Automatica Sinica 2017年第1期4卷 19-26页

作者： Yisheng Lv yuanyuan chen Xiqiao Zhang Yanjie Duan Naiqiang Li State Key Laboratory of Management and Control for Complex Systems Institute of Automation Chinese Academy of Sciences Qingdao Academy of Intelligent Industries Department of Transportation Engineering School of Transportation Science and Technology Harbin Institute of Technology

Recently, there has been an increased interest in the use of social media data as important traffic information sources. In this paper, we review social media based transportation research with social network analysis *** summarize main research topics in this field, and report collaboration patterns at levels of researchers, institutions, and countries, respectively. Finally, some future research directions are identified. © 2014 Chinese Association of Automation.

关键词： Traffic control Transportation

Dynamically Securing the Data by^(1)O_(2)Sensitization of Fluorescent Composites with a High Latency and Uncrackable Features

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Chinese Journal of Chemistry 2024年第14期42卷 1651-1658页

作者： yuanyuan chen Jiamao chen Huacan Wu Yifan Liu Donghui Wang Weiguo Huang College of Chemistry and Materials Science Fujian Normal UniversityFuzhouFujian350002 China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of Sciences155 Yangqiao West RoadFuzhouFujian350002 China University of Chinese Academy of Sciences 19A Yuquan RoadBeijing100049 China

Dynamic fluorescent materials play a crucial role in secure inks for data encryption;however,they are still plagued by issues such as photodegradation,poor latency,and susceptibility to unauthorized ***,we propose a photochemically modulated dynamic fluorescent encryption system based on^(1)O_(2)sensitization of fluorescent composites,comprising a^(1)O_(2)-sensitive fluorophore(F2)and non-emissive *** UV irradiation,in-situ generated^(1)O_(2)from the polymer effectively binds with F2 to form endoperoxides(F2EPO),resulting in a significant redshift in emission,up to 150 ***^(1)O_(2)concentration is closely related to the irradiation time,rendering different fluorescent colors in a time-gated ***,the emission of F2EPO can be regulated by polymer chemical structure,molecular weight,and crosslinking *** on these merits,we develop a dynamic data encryption method with various non-emissive polymers as the data storage media,UV light irradiation as the data encoder,and F2 as the data *** light irradiation of diverse polymer solutions generates^(1)O_(2)at different concentrations,effectively encoding the data,which remains invisible under both UV and natural *** addition of F2 to these irradiated polymer solutions produces different redshifted fluorescence,enabling secure data *** to the non-emissive nature of the polymers,time-gated readout fashion,excellent latency of^(1)O_(2),and subtle interactions between^(1)O_(2)and F2,this data encryption is nearly *** work offers an advantage data encryption approach beyond the reach of conventional fluorophores.

关键词： Dynamic fluorescent materials Photochemically modulation ^(1)O_(2)-sensitive fluorophore High latency Data encryption Fluorescence Photochemistry Singlet oxygen

Co-regulator NCOA5 and cancer

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BIOCELL 2022年第7期46卷 1643-1650页

作者： yuanyuan chen SHUAISHUAI CUI YUNFEI GUO DAHU chen School of Life Sciences Shandong University of TechnologyZibo225000China

NCOA5 encodes a co-regulator for estrogen receptors(ERαand ERβ),orphan nuclear receptors(REV-ERBαand REV-ERBβ)and liver X *** can influence many cellular processes by either promoting or inhibiting gene expression through its two important functional motifs:LxxLL(co-activator)andΦxxΦΦ(co-repressor).Many reports have revealed the important roles of NCOA5 in diseases,such as diabetes,reproductive defects and autoimmune *** this review,we focus on its function in cancers and summary the current research progresses regarding its different roles in various cancers.

关键词： NCOA5 Co-regulator Structure and function Nuclear receptors Cancer