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Copper homeostasis and neurodegenerative diseases

Neural Regeneration Research 2025年第11期20卷 3124-3143页

作者： yuanyuan wang Daidi Li Kaifei Xu Guoqing wang Feng Zhang International Research Laboratory of Ethnomedicine of Ministry of Education Key Laboratory of Basic Pharmacology of Ministry of EducationLaboratory Animal Center and Key Laboratory of Basic Pharmacology of Guizhou ProvinceZunyi Medical UniversityZunyiGuizhou ProvinceChina

Copper,one of the most prolific transition metals in the body,is required for normal brain physiological activity and allows various functions to work normally through its range of *** homeostasis is meticulously maintained through a complex network of copper-dependent proteins,including copper transporters(CTR1 and CTR2),the two copper ion transporters the Cu-transporting ATPase 1(ATP7A)and Cu-transporting beta(ATP7B),and the three copper chaperones ATOX1,CCS,and *** in copper homeostasis can lead to either the deficiency or accumulation of copper in brain *** evidence suggests that abnormal copper metabolism or copper binding to various proteins,including ceruloplasmin and metallothionein,is involved in the pathogenesis of neurodegenerative ***,the exact mechanisms underlying these processes are not *** is a potent oxidant that increases reactive oxygen species production and promotes oxidative *** reactive oxygen species levels may further compromise mitochondrial integrity and cause mitochondrial *** oxygen species serve as key signaling molecules in copper-induced neuroinflammation,with elevated levels activating several critical inflammatory ***,copper can bind aberrantly to several neuronal proteins,including alphasynuclein,tau,superoxide dismutase 1,and huntingtin,thereby inducing neurotoxicity and ultimately cell *** study focuses on the latest literature evaluating the role of copper in neurodegenerative diseases,with a particular focus on copper-containing metalloenzymes and copper-binding proteins in the regulation of copper homeostasis and their involvement in neurodegenerative disease *** synthesizing the current findings on the functions of copper in oxidative stress,neuroinflammation,mitochondrial dysfunction,and protein misfolding,we aim to elucidate the mechanisms by which copper contributes to a wide range of heredit

关键词： Alzheimer's disease amyotrophic lateral sclerosis disease copper homeostasis copper toxicity Huntington's disease Menkes'disease multiple sclerosis neurodegenerative disease Parkinson's disease Wilson's disease

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Single particles in a reflection-asymmetric potential

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Science China(Physics,Mechanics & Astronomy) 2018年第8期61卷 61-68页

作者： yuanyuan wang ZhengXue Ren School of Physics and Nuclear Energy Engineering and International Research Center for Nuclei and Particles in the Cosmos Beihang University State Key Laboratory of Nuclear Physics and Technology School of Physics Peking University

Single particles moving in a reflection-asymmetric potential are investigated by solving the Schr6dinger equation of the reflectionasymmetric Nilsson Hamiltonian with the imaginary time method in 3D lattice space and the harmonic oscillator basis expansion method. In the 3D lattice calculation, the l2 divergence problem is avoided by introducing a damping function, and the（l2）N term in the non-spherical case is calculated by introducing an equivalent N-independent operator. The efficiency of these numerical techniques is demonstrated by solving the spherical Nilsson Hamiltonian in 3D lattice space. The evolution of the single-particle levels in a reflection-asvmmetric ootential is obtained and discussed bv the above two numerical methods, and their consistencv is shown in the obtained single-particle energies with the differences smaller than 10-4[hω0]

关键词： single particles reflection-asymmetric potential imaginary time method harmonic oscillator basis expansion method

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Decomposition and phosphorus release from four different size fractions of Microcystis *** from Lake Taihu,China

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Journal of Environmental Sciences 2008年第7期20卷 891-896页

作者： yuanyuan, wang Feizhou, Chen Chinese Acad Sci Nanjing Inst Geog & Limnol State Key Lab Lake Sci & Environm Nanjing 210008 Peoples R China Nanjing Univ Informat Sci & Technol Coll Environm Sci & Engn Nanjing 210044 Peoples R China

Decomposition of Microcystis is accompanied by the release of phosphorus,during bacteria play an important role.A series of experiments were undertaken to evaluate the effect of bacteria on the decomposition of Microcystis taken from Lake Taihu,China,a lake that is suffering from dense Microcystis *** 16 experiments involved four size fractions of colonial Microcystis with or without the addition of lake sediment and Gram-negative bacterial inhibitor NAN_*** highest decomposition rates were recorde...

关键词： Microcystis decomposition phosphorus sediment bacteria

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Biogenic Sedimentary Structures of the Yellow River Delta in China and Their Composition and Distribution Characters

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Acta Geologica Sinica(English Edition) 2014年第5期88卷 1488-1498页

作者： wang yuanyuan HU Bin Institute of Resource and Environment Henan Polytechnic University Henan Key Laboratory of Biogenic Traces & Sedimentary Minerals of Henan Province

The biogenic sedimentary structures （i.e., the morphology and trace makers of burrows, tracks, trails and traces made by extant organisms） and their composition and distribution characters in different micro environments and sub environments of the Yellow River delta in China are described. Three ichnocoenosis can be recognized：（1） Steinichnus-like ichnocoenosis, includes F, Y-shaped traces, birds＇ footprints on bedding plane, and Y, U-shaped burrows in intrastratal bedding, produced by Coleoptera （Heteroceridae）, Orthoptera （Gryllotalpidae） and birds. It is majorly found at the delta plain point bar deposits, denoting the fresh water-related terrestrial environments. （2） Steinichnus-Psilonichnus-like ichnocoenosis, consitsis of Steinichnus-like traces on the bedding plane and Psilonichnus-like burrow which a vertical, irregularly J-, Y-, or U-shaped burrows, some of them with bulbous basal cells burrows in the intrastratal bedding, created by Coleoptera （Heteroceridae）, Orthoptera （Gryllotalpidae） and crabs. It is observed in the delta plain abandoned distributary channels, and the delta front tidal creek and subaquous distributary channels, indicating the brackish water environment. （3） Palaeophycus-like ichnocoenosis, includes the round entrance burrows or with craters-shaped loop-protrusionsand and the parallel forked trails on the bedding plane, and the U, J or vertical shaped feeding burrows are in the intrastratal bedding, majorly produced by the clam （bivalve molluscs）, gastropods and Nereis. It is present in the subaqueous interdistributary bay, reflecting the intertidal related environment.

关键词： Biogenic sedimentary structures modern ichnocoenosis Yellow River delta China

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Real-domain GMUSIC algorithm based on unitary-transform for low-angle estimation

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Journal of Systems Engineering and Electronics 2014年第5期25卷 794-799页

作者： Zheng Liu yuanyuan wang Yunhe Cao National Laboratory of Radar Signal Processing Xidian University

In order to realize the elevation angle estimation for low-altitude targets at a low computational cost, a generalized multiple signal classification （GMUSIC） algorithm based on unitary transform is proposed, i.e., the DU-GMUSlC algorithm. Firstly, the covariance matrix of received data is used to construct the Centro- Hermitian matrix. Then, the real-domain GMUSIC algorithm is used to implement the initial angle estimation, and the multipath attenuation coefficient is calculated in succession. Finally, the attenuation coefficient is taken into account in the GMUSIC method to carry out the secondary angle estimation which is beneficial to further improvement of the angle estimation accuracy. This method can meet requirements of low-angle accuracy as well as lower computational burden. Simulation results prove the correctness and effectiveness of the proposed algorithm. Moreover, field experiment data are used to further validate the effectiveness of this method.

关键词： multipath effect low-angle estimation unitary transform. attenuation coefficient.

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Feature fusion method for edge detection of color images

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Journal of Systems Engineering and Electronics 2009年第2期20卷 394-399页

作者： Ma Yu Gu Xiaodong wang yuanyuan Dept. of Electronic Engineering Fudan Univ. Shanghai 200433 P. R. China

A novel feature fusion method is proposed for the edge detection of color images. Except for the typical features used in edge detection, the color contrast similarity and the orientation consistency are also selected as the features. The four features are combined together as a parameter to detect the edges of color images. Experimental results show that the method can inhibit noisy edges and facilitate the detection for weak edges. It has a better performance than conventional methods in noisy environments.

关键词： color image processing edge detection feature extraction feature fusion

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Impacts of hydraulic redistribution on eco-hydrological cycles： A case study over the Amazon basin

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Science China Earth Sciences 2018年第9期61卷 1330-1340页

作者： yuanyuan wang Binghao JIA Zhenghui XIE Beijing Meteorological Observatory Beijing 100089 China State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 China

Hydraulic redistribution(HR)refers to the process of soil water transport through the low-resistance pathway provided by plant *** has been observed in field studies and proposed to be one of the processes that enable plants to resist water ***,most land-surface models(LSMs)currently do not include this underground root *** this study,a HR scheme was incorporated into the Community Land Model version 4.5(CLM4.5)to investigate the effect of HR on the eco-hydrological *** paired numerical simulations(with and without the new HR scheme)were conducted for the Tapajos National Forest km83(BRSa3)site and the *** for the BRSa3 site in the Amazon showed that HR during the wet season was small,<0.1 mm day^(–1),transferring water from shallow wet layers to deep dry layers at night;however,HR in the dry season was more obvious,up to 0.3 mm day^(–1),transferring water from deep wet layers to shallow dry layers at *** incorporating HR into CLM4.5,the new model increased gross primary production(GPP)and evapotranspiration(ET)by 10%and 15%,respectively,at the BRSa3 site,partly overcoming the *** the Amazon,regional analysis also revealed that vegetation responses(including GPP and ET)to seasonal drought and the severe drought of 2005 were better captured with the HR scheme incorporated.

关键词： Land-surface model CLM4.5 Hydraulic redistribution Gross primary production Evapotranspiration

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Simultaneously measuring ocular aberration and anterior segment biometry during accommodation

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Journal of Innovative Optical Health Sciences 2015年第2期8卷 37-42页

作者： yuanyuan wang Yilei Shao Yimin Yuan School of Optometry and Ophthalmology and Eye Hospital Wenzhou Medical University Wenzhou 325027 Zhejiang ProvinceP.R.China

In the human eye,accommodation is essential for functional ***,the mechanisms regulating accommodation and the ocular parameters afcting aberrations remain to be *** order to measure the alterations of ocular aberration and crystalline lens biometry during dynamic acoommodative stimuli,we designed an optical coberence tomography with ultra-long penetration depth(UL-OCT)combined with a Shack-Hartmann wavefront sensor(SHWFS).This integrated set up measures human eye's anterior segment as well as mono-chromatie high-order aberrations(HOAs)with 6 um resolution and(1/20)λaccuracy.A total of 10 healthy volunteers without ocular diseases were *** exposure to accommodative stimuli,the wavefront aberrations became *** the anterior segment biometry,the anterior crystalline lens demonstrated significant curvature during accommodation and was the major cause of high-order *** findings suggest that the front surface of the crys-talline lens can siguificantly affect variation among aberrations,which is a key factor underlying the quality of human vision.

关键词： Optical coberence tomography wavefront sensor accommodlation

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Deviation matrix and asymptotic variance for GI/M/1-type Markov chains

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Frontiers of Mathematics in China 2014年第4期9卷 863-880页

作者： yuanyuan LIU Pengfei wang Yanmin XIE School of Mathematics New Campus Central South University Changsha 410083 China

We investigate deviation matrix for discrete-time GI/M/1-type Markov chains in terms of the matrix-analytic method, and revisit the link between deviation matrix and the asymptotic variance. Parallel results are obtained for continuous-time GI/M/1-type Markov chains based on the technique of uniformization. We conclude with A. B. Clarke＇s tandem queue as an illustrative example, and compute the asymptotic variance for the queue length for this model.

关键词： GI/M/1-type Markov chains deviation matrix asymptoticvariance matrix-analytic method

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Homogenization of Stationary Navier-Stokes Equations in Domains with 3 Kinds of Typical Holes

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Journal of Partial Differential Equations 2021年第3期34卷 284-296页

作者： wang yuanyuan YANG Yongfu College of Science Hohai UniversityNanjing 211100China

The aim of this paper is to investigate homogenization of stationary Navier-Stokes equations with a Dirichlet boundary condition in domains with 3 kinds of typical *** space dimension N=2 and 3,we utilize a unified approach for 3 kinds of tiny holes to accomplish the homogenization of stationary Navier-Stokes *** unified approach due to Lu[1]is mainly based on the uniform estimates with respect to εefor the generalized cell problem inspired by Tartar.

关键词： Homogenization Navier-Stokes equations perforated domain cell problem

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