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基于临床疗效评价的中医药论文多标签分类研究

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中国数字医学 2025年第2期20卷 14-20页

作者：高曼童元元刘扬孙美玲张雨琪赵芳华李彦文李海燕中国中医科学院中医药信息研究所北京100700

目的:利用深度学习和多标签分类技术,对论文题录信息实施多学科分类,促进实现中医药领域文献自动分类。方法:选取《2022年度中医医院学科(专科)学术影响力评价研究报告》21万余条中文论文题录信息作为样本,采用BERT、CNN、BiLSTM、CNN-B... 详细信息

目的:利用深度学习和多标签分类技术,对论文题录信息实施多学科分类,促进实现中医药领域文献自动分类。方法:选取《2022年度中医医院学科(专科)学术影响力评价研究报告》21万余条中文论文题录信息作为样本,采用BERT、CNN、BiLSTM、CNN-BiLSTM等深度学习方法,构建多标签分类模型进行实验,并对比不同模型和特征组合的实验效果。结果:中医药学术论文的多学科自动分类效果最好的模型为BiLSTM和CNN,最佳特征组合为题名+关键词+摘要,两个模型Macro-F1值分别达95.81%和95.06%。结论:当前深度学习模型多样,受到训练数据、任务特性等方面影响,不同模型在相同任务中表现效果会有所差异,因此实施文本分类时可采用多种不同类型的深度学习模型进行训练对比结果,从而筛选最佳模型与特征组合。

关键词：中医药临床疗效评价多标签分类文本分类深度学习

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Content analysis of systematic reviews on effectiveness ofTraditional Chinese Medicine

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Journal of Traditional Chinese Medicine 2013年第2期33卷 156-163页

作者： Junwen Wang Meng Cui Hongguan Jiao yuanyuan tong Jun Xu Yingkai Zhao Mei Han Jianping Liu Institute of Information onTraditional Chinese Medicine China Academy of Chinese Medical SciencesCACMS Center for Evidence Based Chinese Medicine Beijing University of Chinese Medicine

OBJECTIVE:To evaluate evidence for the efficacy of Traditional Chinese Medicine(TCM) in systematic ***:Chinese(TCM Periodical Literature Database,Chinese Biological Medicine database,Chinese Medical Current Contents,China Hospital Knowledge Database journal fulltext database,Virtual Machining and Inspection System,and Wanfang) and English(Cochrane Database of Systematic Reviews,PubMed and Embase) databases were ***:Three thousand,nine hundred and fifty-five articles were initially identified,606 of which met the inclusion criteria,including 251 in English(83 from the Cochrane Database) and 355 in *** number of articles published each year increased between 1989 and *** disease was the most studied target *** measures included TCM preparations(177 articles),acupuncture(133 articles) and combinations of TCM and Western Medicine(38 articles).Control measures included positive medical(177 articles),basic treatment(100 articles),placebo(219 articles),and blank and mutual(107 articles).All articles included at least one reference;the greatest number was *** of 10 articles with high quality references demonstrated curative effectsagainst target diseases including upper respiratory tract infection,dementia and *** that were not recommended were tripterygium for rheumatoid arthritis and TCM syndrome differentiation for pediatric *** 10.4% of the studies,the authors concluded that the intervention had a curative *** assessors agreed with the authors' conclusions in 88.32% of cases,but rejected 8.94%(54 articles).CONCLUSION:1) Training in systematic review methods,including topic selection,study design,methods and technology,should be improved.2) Upper respiratory tract infection,dementia and depression may become the predominant diseases treated by TCM,and the corresponding interventions could be developed into practical applications.3) Use of non-recommended inter

关键词： Evidence-based medicine Systematicreview Traditional Chinese Medicine Curative ef-fect Content analysis

Review of controlled clinical trials on acupuncture versus sham acupuncture in Germany

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Journal of Traditional Chinese Medicine 2013年第3期33卷 403-407页

作者： Wei He yuanyuan tong Yingkai Zhao Li Zhang Hui Ben Qingguang Qin Feng Huang Peijing Rong Institute of Medical Informatics China Academy of Chinese Medical Sciences Institute of Acupuncture and Moxibustion China Academy of Chinese Medical Sciences

OBJECTIVE: To examine German controlled clinical trials on the therapeutic effects of acupuncture vs sham acupuncture, and to find whether there are problems with the conclusion that sham acupuncture has no significant deviation from acupuncture. METHODS: We focused on literature from the last ten years (2002-2011) included in PubMed about controlled clinical trials on acupuncture vs sham acupuncture carried out in Germany. The methods applied in sham acupuncture are summarized, and the difference between the acupuncture and sham groups were analyzed. We measured effects based on the following criteria: acupuncture is effective and superior to sham, acupuncture is effective but similar to sham, both of them have uncertainty regarding treatment effect, or no significant effect. Finally, we reviewed the hypotheses of different scholars on sham acupuncture and analyzed their ***: Four types of controlled clinical trials including sham acupuncture on non-Traditional Chinese Medicine acupoints, minimal acupuncture on non-acupoints, placebo needle and sham laser acupuncture had varying results in the 57 articles analyzed. Some showed that acupuncture had a better effect than sham, while some suggest acupuncture and sham had similar effects. In all studies using sham acupuncture on non-therapeutic points, sham electrodes, and sham electro-acupuncture, the therapeutic effect was better than sham. Of the trials, 37 demonstrated that acupuncture had a better effect than sham acupuncture. Only nine trials found no significant difference between acupuncture and sham. Two controlled trials for the same condition (neck pain) conducted by two different German research institutes used the same control method, but reached contradictory conclusions. CONCLUSION: We found problems in conclusions based on results of controlled clinical trials of sham acupuncture in Germany. Therefore, there is still not enough evidence to support the statements that "acupuncture and sham acu

关键词： Acupuncture therapy Placebos Con- trolled clinical trials Germany

Perioperative outcomes of different temperature management in pediatric aortic arch surgery:a single center 8-year experience

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中国循环杂志 2018年第S1期33卷 171-171页

作者： yuanyuan tong Jinping Liu Ruoning Lv Yu Jin Department of Cardiopulmonary Bypass National Center for Cardiovascular DiseasesFuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Objective With the widespread application of regional low flow perfusion, deep hypothermia is non-essential for organ protection;therefore, there is a growing tendency to increase systemic temperature.

关键词： different temperature low flow perfusion increase systemic temperature

Application of cerebral-myocardial perfusion combined with lower body circulatory arrest in pediatric complex aortic arch surgery

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中国循环杂志 2018年第S1期33卷 171-171页

Background Adjunct RCP to DHCA ensures some extent uninterrupted cerebral perfusion and that promotes one-stage repair of complex aortic arch ***-stage repair may induce longer myocardial ischemic *** there evolved cerebral-myocardial perfusion to reduce myocardial ischemic *** We reviewed 78 patients from January 2010 to July 2017 in our center.

关键词： lower body circulatory arrest pediatric complex aortic arch surgery DHCA

Reconstruction characteristics of gut microbiota from patients with type 1 diabetes affect the phenotypic reproducibility of glucose metabolism in mice

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Science China(Life Sciences) 2025年第1期68卷 176-188页

作者： Zhiyi Wang Mengxue Gong yuanyuan Fang Huijuan Yuan Chenhong Zhang State Key Laboratory of Microbial Metabolism School of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China Department of Endocrinology Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityZhengzhou 450003China

The human microbiota-associated(HMA)mice model,especially the germ-free(GF)-humanized mice,has been widely used to probe the causal relationships between gut microbiota and human diseases such as type 1 diabetes(T1D).However,most studies have not clarified the extent to which the reconstruction of the human donor microbiota in recipient mice correlates with corresponding phenotypic *** this study,we transplanted fecal microbiota from five patients with T1D and four healthy people into GF mice,and microbiota from each donor were transplanted into 10 *** with similar microbiota structure to the donor exhibited better phenotypic *** characteristics of the microbial community assembly of donors also influenced the phenotypic reproducibility in mice,and individuals with a higher proportion of stochastic processes showed more severe *** enriched in patients with T1D had a stronger colonization potential in mice with impaired glucose metabolism,and microbiota functional features related to T1D were better reproduced in these *** indicates that assembly traits and colonization efficacy of microbiota influence phenotypic reproducibility in GF-humanized *** findings provide important insights for using HMA mice models to explore links between gut microbiota and human diseases.

关键词： gut microbiome human microbiota-associated animal model type 1 diabetes

LaCl_3掺杂聚丙烯酰胺/硅灰基阻燃材料的制备及其阻燃机理

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材料研究学报 2017年第5期31卷 387-393页

作者：王亚超赵江平童媛媛丁建雄西安建筑科技大学材料与矿资学院西安710055

在Na_2SiO_3·9H_2O-KOH改性硅灰(溶胶-凝胶法)制备阻燃材料的基础上,基于正交试验L_9(3~4)研究了焦磷酸钠、聚丙烯酰胺(PAM)和LaCl_3对其阻燃性能的影响(包括它们的主次顺序和显著水平),合成了稀土元素掺杂的有机-无机杂化阻燃材料LaCl... 详细信息

在Na_2SiO_3·9H_2O-KOH改性硅灰(溶胶-凝胶法)制备阻燃材料的基础上,基于正交试验L_9(3~4)研究了焦磷酸钠、聚丙烯酰胺(PAM)和LaCl_3对其阻燃性能的影响(包括它们的主次顺序和显著水平),合成了稀土元素掺杂的有机-无机杂化阻燃材料LaCl_3/PAM/SiO_2·nH_2O。用热重/差示扫描量热(TG/DSC),扫描电镜(SEM),X-射线衍射(XRD)和红外光谱(FT-IR)等手段进行表征,提出并阐明了其阻燃机理。LaCl_3/PAM/SiO_2·nH_2O可使帆布的LOI达到39.2%;极差分析表明其主次顺序依次为PAM>LaCl_3·7H_2O>Na_4P_2O_7·10H_2O,方差分析表明PAM与其阻燃性能成高度显著影响,LaCl_3·7H_2O为显著影响;XRD和SEM结果表明PAM和LaCl_3有助于形成片层状的无定型膨胀硅质层,FT-IR和TG/DSC结果证实其具有优良的高温稳定性,进而产生隔热阻燃效应。

关键词：复合材料阻燃方差分析微结构机理

消核片相关肝损害回顾性研究及风险控制措施探讨

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中国中药杂志 2010年第16期35卷 2199-2203页

作者：张力杨晓晖郭朋童元元国家食品药品监督管理局药品评价中心北京100045 中国中医科学院西苑医院北京100091 北京中医药大学东方医院北京100078 中国中医科学院中医药信息研究所北京100700

调查与消核片相关肝损害病例的临床特征和影响因素以提出风险控制措施。检索1978—2009年国内公开发表的与消核片相关肝损害个案及群案病例报告信息,进行调查登记、数据整理、统计分析。结果消核片相关肝损害病例共194例,其中个案病例9... 详细信息

调查与消核片相关肝损害病例的临床特征和影响因素以提出风险控制措施。检索1978—2009年国内公开发表的与消核片相关肝损害个案及群案病例报告信息,进行调查登记、数据整理、统计分析。结果消核片相关肝损害病例共194例,其中个案病例9例,群案病例185例,与消核片相关肝损害临床主要表现为消化道症状;皮肤、巩膜黄染以及肝功能异常,并有肝衰竭病例发生。相关肝损害病例多为可逆性,停药后经过积极治疗临床痊愈。消核片与肝损害之间存在一定相关性。在医师指导下严格按照说明书推荐剂量和适应症用药、临床用药过程中密切监测肝功能,同时加强安全性相关基础研究是控制消核片用药风险的有效措施。

关键词：消核片安全性评价肝损害回顾性研究风险控制

对比沙格列汀、达格列净在血糖控制不佳肥胖2型糖尿病治疗中的应用效果

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糖尿病新世界 2021年第17期24卷 85-88页

作者：佟媛媛新疆生产建设兵团第四师医院内分泌科新疆伊宁835000

目的对比沙格列汀、达格列净在血糖控制不佳肥胖2型糖尿病(T2DM)治疗中的应用效果。方法血糖控制不佳肥胖T2DM患者100例为该院2019年9月—2021年2月收治,随机分为对照组、观察组。前组应用沙格列汀治疗,后组应用达格列净治疗,比较两组... 详细信息

目的对比沙格列汀、达格列净在血糖控制不佳肥胖2型糖尿病(T2DM)治疗中的应用效果。方法血糖控制不佳肥胖T2DM患者100例为该院2019年9月—2021年2月收治,随机分为对照组、观察组。前组应用沙格列汀治疗,后组应用达格列净治疗,比较两组患者治疗前后的血糖水平、血脂水平、脂肪细胞功能、氧化应激因子水平、血清补体水平以及血液流变学指标。结果两组治疗前比较血糖水平、血脂水平、脂肪细胞功能、氧化应激因子水平、血清补体水平、血液流变学指标差异无统计学意义(P>0.05);观察组治疗后上述指标改善均优于对照组,差异有统计学意义(P<0.05)。结论为血糖控制不佳肥胖T2DM患者应用达格列净治疗可取得明显的效果,建议在临床广泛应用并推广。

关键词：沙格列汀达格列净血糖控制肥胖 T2DM