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Association between p53 Pro72Arg polymorphism and prostate cancer risk:a meta-analysis

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The Journal of Biomedical Research 2011年第1期25卷 25-32页

作者： Lifeng Zhang Ning Shao Qianqian Yu Lixin Hua yuanyuan mi Ninghan Feng Department of Urology the First Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu 210029 China Department of Ophthalmology Wuxi People ’ s Hospital Affiliated with Nanjing Medical University Wuxi Jiangsu 214023 China

The tumor suppressor gene p53 appears to be important in the development of many human cancers, such as prostate cancer. The association of p53 codon72 polymorphism with prostate cancer has been widely reported; however, the results are inconsistent. To derive a more precise estimation of this relationship, we performed an updated meta-analysis from 10 case-control studies. We conducted a search in the PubMed database without a language limitation, covering all papers published until July 2010. Risk ratios （RR） with 95% confidence intervals （CIs） were used to assess the strength of the association. Ten studies including 1,196 cases and 1,704 controls were selected. Overall, no significant differences of total prostate cancer risk and p53 codon polymorphism was found （Pro/Pro vs Arg/Arg, RR = 1.12, 95%CI=0.74-1.70, P heterogeneity = 0.016, I 2 = 55.8%; Pro/Pro＋Pro/Arg vs Arg/ Arg, RR = 1.05, 95%CI=1.00-1.11, P heterogeneity = 0.077, I 2 = 51.1%）. In the stratified analysis by ethnicity, the same results were found. However, in the control subgroup, there was a modest decreased association between prostate cancer risk and population-based control subjects under the recessive genetic model （RR = 0.31, 95%CI=0.10- 0.91, P heterogeneity = 0.110, I 2 =60.8%）. This meta-analysis suggested that p53 codon Pro72Arg polymorphism could be weakly associated with prostate cancer risk.

关键词： p53 prostate cancer polymorphism meta-analysis risk

Robust and conductive hydrogel based on mussel adhesive chemistry for remote monitoring of body signals

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Friction 2022年第1期10卷 80-93页

作者： Weijun LI Hao LIU yuanyuan mi miaoran ZHANG Jinmiao SHI ming ZHAO Melvin A.RAMOS Travis Shihao HU Jianxiong LI Meng XU Quan XU State Key Laboratory of Heavy Oil Processing.Beijing Key Laboratory of Biogas Upgrading Utilization Harvard SEAS-C UPB Joint L aboratory on Petroleum ScienceChina University of PetroleumBeijing 102249China Department of Mechanical Engineering.California State University Los AngelesCA 90032USA Department of Orthopedics General Hospital of Chinese People's Liberat ion Army Beijing 100853China

There is a high demand for hydrogels with multifunctional performance(a combination of adhesive,mechanical,and electrical properties)in biological,tissue engineering,robotics,and smart device ***,a majority of existing hydrogels are relatively rigid and brittle,with limited stretchability;this hinders their application in the emerging field of flexible *** this study,cheap and abundant potato residues were used with polyacrylamide(PAM)to fabricate a multifunctional hydrogel,and chitosan was used for the design of a three-dimentional(3D)network-structured *** as-prepared hydrogels exhibited excellent stretchability,with an extension exceeding 900%and a recovery degree of over 99%.Due to the combination of physical and chemical cross-linking properties and the introduction of dopamine,the designed hydrogel exhibits a remarkable self-healing ability(80%mechanical recovery in 2 h),high tensile strength(0.75 MPa),and ultra-stretchability(900%).The resultant products offer superior properties compared to those of previously reported tough and self-healing hydrogels for wound *** and potato residues were used as scaffold materials for the hydrogels with excellent mechanical *** addition,in vitro experiments show that these hydrogels feature excellent antibacterial properties,effectively hindering the reproduction of ***,the ternary hydrogel can act as a strain sensor with high sensitivity and a gauge factor of *** proposed strategy is expected to serve as a reference for the development of green and recyclable conductive polymers to fabricate *** proposed hydrogel can also act as a suitable strain sensor for bio-friendly devices such as smart wearable electronic devices and/or for health monitoring.

关键词： properties hydrogel conductive

Conductive photo-thermal responsive bifunctional hydrogel system with self-actuating and self-monitoring abilities

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Nano Research 2022年第8期15卷 7703-7712页

作者： Neng Chen Yang Zhou Yinping Liu yuanyuan mi Sisi Zhao Wang Yang Sai Che Hongchen liu FengJiang Chen Chong Xu Guang Ma Xue Peng Yongfeng Li State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing 102249China

Despite enormous efforts in actuators,most researches are only limited to various actuation behaviors and demonstrations of soft *** has not yet been reported to capture and monitor its movement status in an invisible ***,it is of great significance to develop a self-sensing and self-actuating dual-function hydrogel actuator system to realize real-time ***,we report a bifunctional hydrogel system with self-actuating and self-monitoring abilities,which combines the functions of photothermal actuation and electrical resistance sensing into a single *** bilayer tough conductive hydrogel synthesized by unconventional complementary concentration recombination and cryogenic freezing technique presents a dense conductive network and high-porosity structure,achieving high toughness at 190.3 kPa of tensile strength,high stretchability(164.3%strain),and the toughness dramatically(1,471.4 kJ·m^(−3)).The working mechanism of the monitoring and self-sensing system is accomplished through the integrated monitoring device of surface temperature–bending angle–electron current,to solve the problem of not apperceiving actuator motion state when encountering obstacles in an invisible *** demonstrated for the first time a photothermal actuator’s motion of a football player and goalkeeper to finish the penalty and a soft actuator hand,which can achieve the action of sticking to grab and release under photo-thermal *** connected to the control closed circuit,the actuator realized closed-loop monitoring and sensing *** development of bifunctional hydrogel systems may bring new opportunities and ideas in the fields of material science,circuit technology,sensors,and mechanical engineering.

关键词： photo-thermal hydrogel actuator graphene nanosheets self-monitoring self-actuating surface temperature-bending angle-electron current

Arg462Gln and Asp541Glu polymorphisms in ribonuclease L and prostate cancer risk:a meta-analysis

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The Journal of Biomedical Research 2010年第5期24卷 365-373页

作者： yuanyuan mi Qianqian Yu Zhichao min Bin Xu Lifeng Zhang Wei Zhang Ninghan Feng L ixin Hua Department of Urology the First Affiliated HospitalNanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina Department of Ophthalmology Wuxi People's Hospital Affiliated with Nanjing Medical UniversityWuxi 214023Jiangsu ProvinceChina

Objective：The association between ribonuclease L（RNASEL）gene polymorphisms and prostate cancer risk has been widely reported,but the results of these studies remained controversial and *** performed a meta-analysis of 28 studies to evaluate the association between Arg462Gln and Asp541Glu polymorphisms in the RNASEL gene and prostate cancer ***：Odds ratios（ORs）with 95%confidence intervals（CIs） were estimated to assess the association between RNASEL polymorphisms and prostate cancer ***：A significantly increased prostate cancer risk was found for the Arg462Gln polymorphism in Africans（Gln/Gln vs Arg/Arg：OR=2.50,95%CI=1.28-4.87;Gln/Gln vs Gln/Arg＋Arg/Arg：OR=2.54,95%CI=1.30-4.95）,but not in Europeans and ***,the Asp541Glu polymorphism was associated with increased total prostate cancer risk（Glu-allele vs Asp-allele：OR=1.04,95%CI=1.01-1.07;Glu/Glu vs Asp/Asp：OR=1.22,95%CI= 1.03-1.46;Glu/Glu vs Glu/Asp＋Asp/Asp：OR=1.09,95%CI=1.02-1.16）.In the stratified analysis for the Asp541Glu polymorphism,there was a significantly increased prostate cancer risk in Africans and Europeans,and in hospital-based prostate cancer ***：The meta-analysis results showed evidence that RNASEL Arg462Gln and Asp541Glu polymorphisms are associated with prostate cancer risk and could be low-penetrance prostate cancer susceptibility biomarkers.

关键词： ribonuclease L polymorphism prostate cancer risk meta-analysis

危重症患者肠内营养中断预防及管理的最佳证据总结

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护理学杂志 2024年第16期39卷 99-104页

作者：米元元刘猛吴白女蔡喆燚向成林朱丽群包磊田飞黄培培张艳红徐芸杨婷婷孙亮黄海燕华中科技大学同济医学院附属协和医院重症医学科湖北武汉430022 郑州大学附属肿瘤医院/河南省肿瘤医院重症医学科浙江中医药大学附属第一医院肿瘤科湖南中医药大学第一附属医院重症医学科江苏大学附属医院护理部江苏大学附属医院手术室宜昌市中心人民医院护理部浙江省人民医院/杭州医学院附属人民医院静脉治疗护理江苏大学附属医院神经内科安徽医科大学第一附属医院日间病房安徽医科大学第一附属医院肿瘤科江汉大学附属医院重症医学科

目的总结危重症患者肠内营养喂养中断预防及管理最佳证据,为防范肠内营养喂养中断提供指引。方法以循证护理方法学构建护理问题,按照“6S”证据模型检索BMJ Best Practice、UpToDate、JBI循证卫生保健中心数据库、欧洲临床营养与代谢学... 详细信息

目的总结危重症患者肠内营养喂养中断预防及管理最佳证据,为防范肠内营养喂养中断提供指引。方法以循证护理方法学构建护理问题,按照“6S”证据模型检索BMJ Best Practice、UpToDate、JBI循证卫生保健中心数据库、欧洲临床营养与代谢学会、美国肠外肠内营养学会、医脉通(指南版)、PubMed、Web of Science、中国知网、万方数据、中国生物医学文献等数据库中关于危重症患者肠内营养喂养中断预防及管理相关主题的文献,检索时限为建库至2023年6月10日。由2名研究者独立对纳入的文献进行评价和证据提取。结果共纳入34篇研究,总结了23条最佳证据,包括肠内营养中断定义、肠内营养启动时机、肠内营养评估与监测、肠内营养中断原因、肠内营养中断时机、预防和管理肠内营养中断策略、培训与教育7个方面。结论本研究总结的危重症患者肠内营养中断预防及管理的最佳证据,可为临床医护人员分析肠内营养中断原因、制定临床肠内营养中断干预方案提供循证依据。

关键词：危重症患者重症监护肠内营养营养中断证据总结循证护理

护士对吞咽障碍患者服药管理知信行问卷的编制及信效度检验

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重庆医学 2024年第5期53卷 738-744页

作者：刘艺朱丽群眭升庄若倪益益米元元包磊厉丽郑兰平陈梦梦江苏大学附属医院神经科江苏镇江212002 江苏大学附属医院护理部江苏镇江212002 华中科技大学同济医学院附属协和医院重症医学科武汉430022 江苏大学附属医院手术室江苏镇江212002 江苏大学医学院江苏镇江212013 复旦大学附属肿瘤医院胰腺外科上海200032

目的编制护士对吞咽障碍患者服药管理知信行问卷并检验其信效度。方法基于循证总结吞咽障碍患者服药管理最佳证据,以知信行理论为指导,通过小组讨论、德尔菲专家函询、预调查后确定问卷基本维度和条目池,便利选取江苏省10所三级医院437... 详细信息

目的编制护士对吞咽障碍患者服药管理知信行问卷并检验其信效度。方法基于循证总结吞咽障碍患者服药管理最佳证据,以知信行理论为指导,通过小组讨论、德尔菲专家函询、预调查后确定问卷基本维度和条目池,便利选取江苏省10所三级医院437名护士进行调查以修订问卷,根据调查结果检验问卷信效度。结果护士对吞咽障碍患者服药管理知信行问卷包括3个维度共43个条目。分别将3个维度按探索性因子分析,共提取特征根>1的6个公因子,其中知识维度提取出2个因子,累积方差贡献率为74.958%;信念维度提取出1个因子,累积方差贡献率为77.655%;行为维度提取出3个因子,累积方差贡献率为72.274%。各条目因子载荷为0.618~0.902,总问卷Cronbach’sα系数为0.949,重测信度为0.909。问卷整体水平内容效度为0.922,条目水平内容效度为0.800~1.000。结论本研究编制的护士对吞咽障碍患者服药管理知信行问卷具有良好的信效度,可作为评估护士对吞咽障碍患者服药管理现状的有效工具。

关键词：吞咽障碍服药管理护士知信行调查和问卷信效度

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An Experimental Analysis of Gas-Liquid Flow Breakdown in a T-Junction

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Fluid Dynamics & Materials Processing 2024年第6期20卷 1381-1392页

作者： Lihui Ma Zhuo Han Wei Li Guangfeng Qi Ran Cheng yuanyuan Wang Xiangran mi Xiaohan Zhang Yunfei Li Technical Inspection Center Sinopec Shengli Oilfield CompanyDongying257000China New Energy Development Center Sinopec Shengli Oilfield CompanyDongying257000China China National Oil and Gas Exploration and Development Company Ltd.Beijing100034China

When a gas-liquid two-phase flow(GLTPF)enters a parallel separator through a T-junction,it generally splits *** phenomenon can seriously affect the operation efficiency and safety of the equipment located *** order to investigate these aspects and,more specifically,the so-called bias phenomenon(all gas and liquid flowing to one pipe,while the other pipe is a liquid column that fluctuates up and down),laboratory experiments were carried out by using a T-junction connected to two parallel vertical ***,a GLTPF prediction model based on the principle of minimum potential energy was *** research results indicate that this model can accurately predict the GLTPF state in parallel *** boundary of the slug flow and the churn flow in the opposite pipe can be ***,according to the results,the pressure drop curves of the two-phase flow in the parallel risers are basically the same when there is no bias phenomenon,but the pressure drop in the parallel riser displays a large deviation when there is a slug flow-churn *** when the parallel riser is in a state of asymmetric flow and one of the risers produces churn flow,the two-phase flow is prone to produce the bias phenomenon.

关键词： Two-phase flow T-junction split model entrance effect mechanism model improved model

急性胰腺炎患者早期液体复苏管理的最佳证据总结

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重庆医学 2024年第1期53卷 114-120页

作者：厉丽朱丽群张文华周英凤包磊孙国付米元元杨丽萍仲蕾媛张炜江苏大学附属医院消化科江苏镇江212001 江苏大学附属医院护理部江苏镇江212001 复旦大学护理学院上海200433 江苏大学附属医院手术室江苏镇江212001 江苏大学附属医院急诊科江苏镇江212001 华中科技大学同济医学院附属协和医院重症医学科武汉430022

目的系统检索、评价并整合国内外关于急性胰腺炎(AP)患者早期液体复苏管理的最佳证据,为临床决策提供参考。方法计算机检索BMJ Best Practice、Up To Date、JBI循证卫生保健中心、英国国家卫生与临床优化研究所、加拿大安大略注册护士... 详细信息

目的系统检索、评价并整合国内外关于急性胰腺炎(AP)患者早期液体复苏管理的最佳证据,为临床决策提供参考。方法计算机检索BMJ Best Practice、Up To Date、JBI循证卫生保健中心、英国国家卫生与临床优化研究所、加拿大安大略注册护士协会、国际指南协作组、苏格兰学院间指南网、国际胰腺学会、美国胰腺学会、美国胃肠病学会、医脉通、Cochrane Library、PubMed、Embass、CINAHL、The Web of Science、中国知网、万方数据库中关于AP早期液体复苏管理的相关证据,检索时限为建库至2022年3月20日。文献类型包括专题证据汇总、指南、证据总结、系统评价、专家共识,由研究员对文献进行质量评价,并对符合标准的文献进行证据提取。结果共纳入13篇文献,包括专题证据汇总3篇、指南4篇、证据总结2篇、系统评价2篇、专家共识2篇,整合了16条最佳证据,涉及组织管理、评估与监测、补液策略、健康教育4个方面。结论建议应用目标导向疗法进行早期液体复苏管理,在确诊后即刻进行液体复苏,并根据患者基础疾病、病情变化及监测指标,精准实施早期液体复苏,以利于逆转胰腺微循环障碍,增加组织灌注,改善患者预后。

关键词：急性胰腺炎液体复苏证据总结循证护理

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国内肾移植术后患者心理体验的质性Meta整合

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护理学杂志 2019年第4期34卷 79-82页

作者：刘静米元元华中科技大学同济医学院附属协和医院肾移植科湖北武汉430022 华中科技大学同济医学院附属协和医院重症医学科湖北武汉430022

目的系统评价肾移植患者术后心理体验。方法计算机检索数据库中国知网、万方数据库、维普数据库、中国生物医学文献数据库,搜索关于肾移植患者术后真实体验的质性研究,检索时限从建库至2018年5月。进行文献质量评价后,采用Meta整合方法... 详细信息

目的系统评价肾移植患者术后心理体验。方法计算机检索数据库中国知网、万方数据库、维普数据库、中国生物医学文献数据库,搜索关于肾移植患者术后真实体验的质性研究,检索时限从建库至2018年5月。进行文献质量评价后,采用Meta整合方法对研究结果进行归纳、诠释。结果共纳入8篇文献,提炼出52个结果、6个类别和3个整合结果,分别为肾移植术后患者消极心理、肾移植术后患者对未来与生命的心理感受、肾移植术后患者的自身健康需求与期望。结论医护人员应充分了解肾移植术后患者心理体验,做好针对性心理干预,引导患者调整认知和行为方式,提高患者的术后生活质量,并且增强患者对未来生活的心理资本。

关键词：肾移植术后患者质性研究心理体验 Meta整合