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Jixuecao(Herba Centellae Asiaticae) alleviates mesangial cell proliferation in IgA nephropathy by inducing mitofusin 2 expression

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Journal of Traditional Chinese Medicine 2019年第3期39卷 346-355页

作者： Chen Hongyu du yuanyuan Li Yayu Zeng Jiali Miao Jianxia Jiang Xue Department of Nephrology Hangzhou Hospital of Traditional Chinese Medicine

OBJECTIVE:To investigate the effect of mitofusin 2 (Mfn2) and its downstream signaling pathway on glomerular mesangial cells (GMCs) proliferation in IgA nephropathy (IgAN),as well as the mechanism of action of Jixuecao (Herba Centellae Asiaticae,HCA) in the treatment of ***:Adenovirus-mediated Mfn2 gene transfection and Mfn2 expression were analyzed by real-time polymerase chain reaction (PCR) and Western ***1 induced the proliferation of GMCs,which were then treated with *** proliferation was detected with cell counting kit-8 (CCK-8),and Mfn2 expression was analyzed by real-time PCR and western *** IgAN animal model was also established and treated with *** proliferation was detected by hematoxylin-eosin staining,mitochondrial structure was analyzed by electron microscopy,mitochondrial function was determined by the Clark oxygen electrode method,and the expression of Mfn2,Phospho-extracellular regulated protein kinases1/2 (P-ERK1/2),Cyclin-dependent kinase 2 (CDK2),Phospho-p27 (p-p27),and cyclin A was analyzed by Western ***:In vitro,HCA inhibited GMCs in a concentration-dependent manner in association with the upregulation of Mfn2 *** overexpression of Mfn2 inhibited IgA1-induced GMCs proliferation and elevated the effect of *** vivo,treatment with HCA could alleviate albuminuria and creatinine and GMCs *** effects were related to the upregulation of Mfn2,p-p27 and inhibition of p-ERK1/2,CDK2,and *** swelling,vacuolar degeneration,and reduction of respiratory control rate were identified in IgAN,but HCA could improve the mitochondrial structure and ***:HCA inhibited GMCs proliferation via the upregulation Mfn2 and the inhibition of Ras-Raf-ERK/*** revealed that changes of mitochondrial structure and function are associated with IgAN,but that HCA can improve these mitochondrial features.

关键词： Centella Glomerulonephritis,IGA Mesangial cells Mitofusin 2

Accurate Application of the Levator Palpebrae Superioris Anterior Migration and Shortening Technique in Blepharoptosis Correction Surgery

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Chinese Journal of Plastic and Reconstructive Surgery 2020年第1期2卷 1-7,34页

作者： Peng XU Huizhen HUANG Jun YANG yuanyuan du Department of Plastic Surgery Mylike Medical Cosmetic HospitalShanghaiChina Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

Background Accurate preoperative evaluation of the levator palpebrae superioris(LPS)strength is required for specific calculation of anterior migration or *** information serves as a surgical reference for more accurate correction of *** Between June 2017 and June 2019,155 eyes of 97 patients were *** were divided into the following 3 groups based on the ptosis degree:mild(28 cases),moderate(53 cases),and severe(16 cases).The LPS strength was evaluated preoperatively and used to calculate LPS anterior migration and *** LPS aponeurosis and Müller’s muscle(L-M)complex was separated from the upper margin of the tarsal plate to the calculated height according to the levator muscle suspension system retention *** complex was subsequently fixed to the planned tarsal plate *** upper eyelid margin(UEM)height,eyelid morphology,eyelid closure,eye symmetry,exposure keratitis status,and patient satisfaction were evaluated at 1 week and at 1 and 6 months *** In all cases,the UEM positions were normal,and only patients with severe ptosis exhibited lagophthalmos in the early posterative *** months postoperatively,13%of eyes in the severe group had residual ptosis;all mild and moderate cases exhibited good surgical *** eyelids closed well with no exposure *** patients were satisfied with the eyelid *** Accurate LPS anterior migration and aponeurosis shortening can eliminate various factors affecting surgical blepharoptosis *** procedures not only reduce operation time but also enhance the stability of postoperative correction.

关键词： Ptosis Suspensory system of the levator palpebrae superioris(LPS) LPS shortening LPS anterior migration Levator-Müller(L-M)complex

The Legal Regulation of the Information Exchange for Trade Association in China

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International English Education Research 2014年第3期 171-173页

作者： du yuanyuan HengShui University HengShui Ctiy HeBei Province China 053000

In the modem society where information is efficient, information exchange is an important affair and function of trade association. However, information exchange behaviors of industry association will have double and legal effect on market and competition, which can not only promote the communication among members of the industry to find a solution to the industry benefit maximization, but also can produce inhibition and barriers to competition in the market. So in this paper, the industry association analysis will be made on the pros and cons of the information exchange, and the legislative defects and the insufficiency of information exchange industry association in our country. According to the practice in our country, the author puts forward the system design of our country industry association information exchange behavior.

关键词： Industry association Restrict competition Information exchange Law regulation

Consensus on the diagnosis and treatment of blepharoptosis

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Chinese Journal of Plastic and Reconstructive Surgery 2021年第3期3卷 167-172页

作者： Xianyu Zhou Fei Liu yuanyuan du Dongmei Li Tianxiang Ouyang Jun Yang Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 20001China Shanghai Beaucare Clinics Shanghai 200052China Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing 100005China Department of Plastic and Reconstructive Surgery Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghai 200092China

Blepharoptosis is a symptom that is commonly observed in *** presents with drooping of the upper eyelid and an asymmetric appearance of the *** can occur because of various *** left untreated,severe congenital blepharoptosis may impair visual *** surgical approach largely depends on the severity of blepharoptosis,Bell’s phenomenon,and surgical ***,it is intricate and difficult to achieve satisfactory symmetry and avoid *** to the complexity involved and discrepancies in treatment,we planned to arrive at a consensus on the diagnosis and correction of blepharoptosis among Chinese plastic surgeons and ophthalmologists,aiming to establish more standardized treatments and cause less harm to patients.

关键词： Blepharoptosis Correction Complication Consensus Diagnosis Treatment

Clinical and prognostic values of TP53 mutation in patients with B-lineage acute lymphoblastic leukemia

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China Medical Abstracts(Internal Medicine) 2021年第4期38卷 229-230页

作者： du yuanyuan Blood&Marrow Transplant Hematol Collabora Innovat Center Soochow UnivSuzhou 215006

Objective To investigate the survival and prognosis of B-lineage acute lymphoblastic leukemia (B-ALL) patients with TP53 *** The clinical data of 479 newly diagnosed B-ALL patients treated in the First Affiliated Hosp... 详细信息

关键词： TP53 patients lymphoblastic

A new technique for correction of iatrogenic upper eyelid retraction by using a composite flap of the orbicularis muscle and fascia on the anterior surface of the tarsal plate

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Chinese Journal of Plastic and Reconstructive Surgery 2024年第3期6卷 116-123页

作者： Kaichong Nie Lidan Chen Xinzhu Qi Shiruo Zhang Xuanyu Yin Miaomiao Zhao yuanyuan du Shanghai EyesShine BeauCare Medical Aesthetic Clinic Shanghai201107China

Background:Upper eyelid retraction is a challenging complication of cosmetic upper eyelid *** avoid extra trauma,we developed a new technique for correcting iatrogenic upper eyelid retraction by postmigrating a compound flap of the orbicularis muscle and fascia(OFC)on the anterior surface of the tarsal *** method extends the aponeurosis of the levator palpebrae superioris muscle(LPS),which can achieve a good correction for post-blepharoplasty ***:We collected data from 15 patients with mild to moderate iatrogenic upper eyelid retraction who were treated at our hospital between February 2017 and December *** OFC was used to replace the missing part of the LPS,and post-migration of the LPS and fixation of the OFC to the tarsal margin were *** outcome measurements included postoperative binocular symmetry,double eyelid smoothness,eyelid fullness,margin reflex distance(MRD1),degree of eyelid closure,and exposure *** patients were followed-up at seven days,one month,and six months ***:One patient with moderate eyelid retraction showed undercorrection 6 months postoperatively,with the upper eyelid margin located at the upper edge of the *** remaining patients had the upper eyelid margin stabilized at 1.0–2.0 mm below the upper corneal *** observational indicators were satisfactory,including binocular symmetry,double eyelid fluency,and eyelid *** the follow-up,no exposure keratitis was *** MRD1 indexes after the operation were significantly different(P<0.001)from those before the ***:Extension and post-migration of the LPS using the orbicularis muscle and OFC structure can effectively correct mild iatrogenic eyelid retraction after ptosis with less damage and good postoperative eyelid morphology and closure function.

关键词： Upper eyelid retraction Levator palpebrae superioris Orbicularis muscle and fascia Migration

Rapid growth of industrial nitrogen fluxes in China: Driving forces and consequences

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Science China Earth Sciences 2013年第3期56卷 662-670页

作者： GU BaoJing YANG GuoFu LUO WeiDong du yuanyuan GE Ying CHANG Jie College of Economics Zhejiang University College of Life Sciences Zhejiang University Research Center for Sustainable Development Zhejiang University

Human activities are strongly modifying the global nitrogen (N) cycle through increasing input, N species diversity, and pool size of industrial reactive N (Nr). However, the fluxes, fates and environmental consequences of industrial Nr (excluding synthesized N fertilizer) remain poorly understood and quantified. We report here that industrial Nr flux has increased 13.4-fold over the past 30 years in China, reaching 3.7Tg N (1 Tg=10 12g) in 2008, accounting for over 50% of China's food Nr flux. Socioeconomic development (per capita GDP, urbanization and household size) significantly drives the growth of industrial Nr fluxes. This leads to "hotspots" of industrial Nr, mainly in relatively developed Eastern China. Industrial Nr loss rate during production is only 5%, much lower than that of cropland (50%) and livestock (80%). However, industrial Nr loss is point source pollution, and Nr release in concentrated doses produces serious risk in small regions. The contribution of structural N to total industrial Nr with a lifespan longer than one year (e.g., synthetic fiber, plastic) increased from 20% in 1980 to 70% in 2008. There was about 2.6 Tg N structural industrial Nr accumulated in human settlements in 2008, which could be one ex- planation of an unknown Nr sink of anthropogenic Nr input (mainly Haber-Bosch N fixation). Legacy effects caused by structural N accumulation have long-term consequences for environmental and human health, although structural N delays Nr release and reduces short-term Nr pollution. Industrial Nr use generates new features of modern global N biogeochemistry, such as increasing Nr species diversity, reducing Nr turnover rate. Future dynamics simulation of the earth system should involve industrial Nr. Explicit consideration and accounting of the fluxes and environmental consequences of industrial Nr would provide decision-makers a novel view of regional sustainable development.

关键词： legacy effect garbage siege food nitrogen structural nitrogen point source pollution

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Promotion and Renewal of the Outdoor Environment of the Collective Housing That Promotes Health <br/>—Based on the Post-Epidemic Perspective

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Journal of Environmental Protection 2021年第12期12卷 1218-1233页

作者： Jing Li yuanyuan du Yajing Lei School of Architecture and Art North China University of Technology Beijing China

The COVID-19 is a major global health event that has changed people’s lives and behaviors. As a fragile and sensitive area with high population density and poor living conditions in the city, collective housing is also an important construction area for future urban renewal. In the process of the spread of the new crown epidemic, the collective housing has exposed a series of weaknesses such as difficult community management, inconvenience of life, and insufficient outdoor space. Therefore, the update and transformation of the outdoor environment of the collective housing combined with the concept of public health is a problem that must be considered at present. This article combines the practice of renewal and transformation of the X community in Chaoyang District, Beijing, combined with survey methods such as questionnaires, interviews, and observations, combined with the needs of residents and the practical experience of the grassroots management unit, and carried out an overall renewal design of the external space environment of the collective housing. The epidemic is combined with the division of functional layout, refined design of outdoor activity space to ensure safe distance, and increased shared smart facilities to improve the quality of the outdoor environment of collective residences and strengthen community resilience;to achieve communication and sharing, epidemic prevention and control on the basis of ensuring safe social distance outdoor sports and other functions. In this way, the ability of collective housing to prevent, identify, and dispose of urban risks will be improved, and will provide residents with a better and livable community life.

关键词： Health Collective Housing Outdoor Environment Renewal Post-Epidemic

Studies of the linearity of the readout module assembling using the eXTP-GPD chips

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Radiation Detection Technology and Methods 2023年第2期7卷 255-262页

作者： Jiechen Jiang Liang Sun Yang Jiao Weichun Jiang Yupeng Xu Huilin He Xiaohua Liu yuanyuan du Sheng Yang Zefang Dong Xiaojing Liu Boyu Dai Institute of High Energy Physics Chinese Academy of SciencesBeijing100049China Key Laboratory of Particle Astrophysics Chinese Academy of SciencesBeijing100049China University of Chinese Academy of Sciences Beijing100049China

Background The Gas Pixel Detector(GPD)is a key part of the Polarimetry Focusing Array(PFA)sub-system onboard the enhance X-ray Timing and Polarimetry mission(eXTP).The GPD can accurately provide the polarized angle and degree for incoming soft X-rays(requirements of minimum detectable polarizationdures for the GPD assembly,and the parallelism between the top surface of an ASIC chip and the bottom surface of a Gas Electron Multiplier(GEM)foil can have impact on the distribution of electric field within transfer region and reconstruction of photoelectric trajectories,resulting in deterioration of the GPD *** study quantifies the influence and gives a reasonable expectation of the *** A simulation framework of the GPD is constructed to quantify the influence on the GPD performance and values of the parallelism are measured by a gauge with a position resolution of o.1μ***:The difference of degree of modulation is less than 1% comparing the parallelism with a value of 20μm to a value of 0μm in response to both polarized and unpolarized ***,the value of parallelism can reach 6.9±3.4μm(0.0176°±0.0087°)by testing and *** The impact on the GPD performance can be less than 1%as the parallelism with an order of 20μm,and we also give a reasonable measuring method and verify the controllability and feasibility of the parallelism with an order of 20μm for pasting the ASIC chip on the surface of a ceramic package.

关键词： Parallelism Gas pixel detectors Gaseous detector simulation Measurements