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Food Science and Human Wellness 2024年

作者： Zhen Cheng Rendong Li Tie Ma Aihua Xu yuanyuan bian Bin Li College of Food Science Shenyang Agricultural University Physical Education Department Shenyang University of Chemical Technology Shenyang Economic and Technological Development Zone The College of Kinesiology Shenyang Sport University Department of Rehabilitation Medicine The First Hospital of China Medical University

The prevalence of high blood pressure is on the rise among younger individuals， and recent findings have linked exercise to changes in the diversity and configuration of gut microbiota. However， specific modifications to one's diet， such as incorporating blueberries while engaging in physical activity， can also influence this association. To explore the effects of exercise and blueberry consumption on gut bacteria， we conducted an eight-week study involving healthy and hypertensive college students. Our microbiome analysis revealed slight shifts in gut bacteria composition in response to increased physical activity， with significant changes in the diversity of the g＿[Eubacterium]＿eligens＿group observed in hypertensive college students who regularly consumed blueberries. Although exercise and blueberry supplementation had a negligible impact on the gut microbiota diversity of healthy college students， it significantly boosted the production of butyric acid bacteria in hypertensive young adults. These results suggest that the changes in gut bacteria variety and abundance brought about by blueberries may be tied to alterations in the body composition of patients with hypertension. This study aims to reveal the impact of blueberry on the hypertensive students from a unique perspective， suggesting the impact of taking blueberry while taking exercises.

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Potato protease inhibitors,a functional food material with antioxidant and anticancer potential

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Food Science and Human Wellness 2023年第5期12卷 1762-1771页

作者： Yaotong Liu yuanyuan bian Yan Bai Siqi Yu Yuxuan Tian Jie Li Suhong Li Tuoping Li College of Food Science Shenyang Agricultural UniversityShenyang 110866China College of Grain Science and Technology Shenyang Normal UniversityShenyang 110034China College of Pharmaceutical Science Liaoning UniversityShenyang 110036China

Potato protease inhibitors(PPIs),as the main component of potato protein isolate,have good safety,nutrition and great market potential.The antioxidant and anticancer properties of PPIs were evaluated with cellbased biological assays.The results showed that when the concentration of PPIs was 5 mg/mL,the peroxyl radical scavenging value was(2119±204)mg VCE/100 g,and the cellular antioxidant activity values were(45.83±3.5)(no PBS wash)and(33.25±4.4)μmol QE/100 g(PBS wash).Cells pretreated with PPIs could significantly prevent the oxidative damage induced by H_(2)O_(2),inhibit the morphological changes of cells and maintain the integrity.Furthermore,PPIs had selective anti-proliferative effects on GIST882 cells(IC50=(10.53±3.87)mg/mL)and demonstrated potent inhibition of the growth,migration and invasion of cancer cells.These findings provide a scientific basis for PPIs as promising candidates for functional foods to aid in the prevention of oxidative damage and cancer.

关键词： Potato protease inhibitors Antioxidant activity Cytoprotection Anticancer activity

Pterostilbene antagonizes homocysteine-induced oxidative stress,apoptosis and lipid deposition in vascular endothelial cells

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Food Science and Human Wellness 2023年第5期12卷 1683-1692页

作者： Qiao Jiang Li Wang Xu Si yuanyuan bian Weijia Zhang Huijun Cui Hailong Gui Ye Zhang Bin Li Dehong Tan College of Food Science Shenyang Agricultural UniversityShenyang 110866China State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China

Hyperhomocysteinemia(HHcy)causes oxidative stress, induces apoptosis, and leads to damage to the vascular endothelium is the starting point of atherosclerosis. Pterostilbene(Pte)has been reported to have antioxidant and anti-apoptotic effects under various pathological conditions. The purpose of this study was to explore whether Pte can inhibit the oxidative stress and apoptosis of vascular endothelium induced by homocysteine(Hcy)and to explain the possible mechanism by which it occurs. The results showed that 20 μmol/L Pte significantly reduced the accumulation of reactive oxygen species, malondialdehyde, and lipids in cells induced by Hcy and promoted the activities of superoxide dismutase and catalase. The Hoechst 33342/PI staining assay showed that Pte antagonized Hcy-induced apoptosis. Pte inhibited Hcy-induced Akt dephosphorylation, increased p53, and decreased the Bcl-2/Bax ratio and caspase-9/caspase-3 activation in a dose-dependent manner. LY294002 pretreatment partially reversed the protective effect of Pte by blocking the PI3K/Akt pathway. Moreover, Pte reduced lipid deposition in human umbilical vein endothelial cells(HUVECs). This study proposes that Pte can inhibit Hcy-induced oxidative stress and apoptosis of HUVECs, and the PI3K/Akt/p53 signaling pathway of apoptosis was revealed. These results suggest that Pte exhibits significant potential for dealing with HHcy-induced vascular endothelial injury, such as atherosclerosis.

关键词： Pterostilbene Hyperhomocysteinemia Methionine Polyphenols Atherosclerosis

Sexual spores in edible mushroom: bioactive components, discharge mechanisms and effects on fruiting bodies quality

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Food Science and Human Wellness 2023年第6期12卷 2111-2123页

作者： Yunting Li Yao Feng Yuling Shang Heran Xu Rongrong Xia Zhenshan Hou Song Pan Li Li yuanyuan bian Jiayi Zhu Zijian Wang Guang Xin College of Food Science Shenyang Agricultural UniversityShenyang 110866China Shenyang Agricultural University Library Shenyang 110866China

Edible mushroom sexual spores have been gaining more interest due to their bioactive components and functions.Spore discharge(SD)is an important factor affecting the quality of edible mushrooms.In this review,the bioactive nutrients of sexual spores of edible mushrooms were summarized,the SD mechanism was described,and the relationship between postharvest SD and the quality of edible mushrooms was analyzed.Spores contain various bioactive nutrients that are benefi cial to the human body.Mature mushrooms can actively discharge spores in a process affected by light,relative humidity,and temperature.During storage,the physiological metabolism of spore-bearing gill tissue is vigorous,promoting the release of postharvest spores and changing the nutritional value of fruiting bodies.The flavor of the fruiting bodies also varied signifi cantly during SD.Edible mushroom sexual spores have the potential to become new raw materials for functional food and medical resources.Research on the effect of the mechanism of SD on the quality of edible mushrooms and the development of SD regulation technology may be a new trend in the quality control of edible mushrooms,which will promote the development of the edible mushroom industry.

关键词： Edible mushroom Sexual spores Bioactive component Discharge mechanism Postharvest quality

考虑降雨条件陕北Q_(2)黄土斜坡稳定性的非线性劣化研究

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地质科技通报 2024年第3期43卷 218-226页

作者：周少伟边小卫李卫波马园园李菲陕西省地质调查院陕西省地质科技中心西安710004

降雨致灾是陕北黄土斜坡最常见的灾害之一,揭示降雨对黄土斜坡稳定性影响特征有利于预防滑坡灾害的发生。通过一系列室内试验研究了降雨条件下陕北Q_(2)黄土的力学特性变化特征,并结合数值模拟分析了其对陕北黄土斜坡稳定性的影响。首... 详细信息

降雨致灾是陕北黄土斜坡最常见的灾害之一,揭示降雨对黄土斜坡稳定性影响特征有利于预防滑坡灾害的发生。通过一系列室内试验研究了降雨条件下陕北Q_(2)黄土的力学特性变化特征,并结合数值模拟分析了其对陕北黄土斜坡稳定性的影响。首先设计干湿循环试验(循环路径和次数)以模拟降雨条件(如强度、频次等);其次通过三轴剪切试验获取陕北Q_(2)黄土的力学性质的变化规律;最后以陕北地区某黄土斜坡为例,利用有限元计算并分析不同降雨条件下斜坡安全系数和塑性区的变化特征。结果表明:(1)干湿循环作用后Q_(2)黄土的抗剪强度存在非线性劣化特征。当干湿循环次数超过一定范围后,黄土物理力学性质参数劣化的边际效应减弱,并趋于稳定。(2)降雨作用下黄土斜坡的稳定性呈现出随着降雨频次或降雨强度的增加而降低的趋势。(3)Q_(2)黄土斜坡的塑性区范围随着Q_(2)黄土力学性能的不断劣化而增大,体现了降雨条件对黄土斜坡稳定性影响的非线性特征。研究结果为降雨型滑坡预防提供参考。

关键词：降雨条件 Q_(2)黄土干湿循环作用抗剪强度安全系数黄土斜坡非线性劣化陕北地区

Potato protease inhibitors(PPIs)， a functional food material with antioxidant and anticancer potential

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Food Science and Human Wellness 2022年

作者： Yaotong Liu yuanyuan bian Yan Bai Siqi Yu Yuxuan Tian Jie Li Suhong Li Tuoping Li College of Food Science， Shenyang Agricultural University College of Pharmaceutical Science， Liaoning University College of Grain Science and technology Shenyang Normal Universuty

Potato protease inhibitors (PPIs)， as the main component of potato protein isolate， have good safety， nutrition and great market potential. The antioxidant and anticancer properties of PPIs were evaluated with cell-based biological assays. The results showed that when the concentration of PPIs was 5 mg/mL， the peroxyl radical scavenging (PSC) value was (2119 ± 204) mg VCE/100 g， and the cellular antioxidant activity (CAA) values were (45.83 ± 3.5) (no PBS wash) and (33.25 ± 4.4) μmol QE/100 g (PBS wash). Cells pretreated with PPIs could significantly prevent the oxidative damage induced by HO， inhibit the morphological changes of cells and maintain the integrity. Furthermore， PPIs had selective anti-proliferative effects on GIST882 cells (IC=(10.53 ± 3.87) mg/mL) and demonstrated potent inhibition of the growth， migration and invasion of cancer cells. These findings provide a scientific basis for PPIs as promising candidates for functional foods to aid in the prevention of oxidative damage and cancer.

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花青素类化合物影响淀粉理化性质研究进展

食品工业科技 2024年第1期45卷 343-351页

作者：李斌王琳岳健苏娟杨曙方杨一鋆牛文博边媛媛沈阳农业大学食品学院辽宁沈阳110866 云南山里红生物科技有限公司云南昆明650299 浙江蓝美技术股份有限公司浙江诸暨311800 锦州海关综合技术服务中心辽宁锦州121001

花青素类化合物包括原花青素、花青素、花色苷等。其中,原花青素是一种聚多酚类化合物,花青素和花色苷均属黄酮类化合物。当在酸性介质中加热时,原花青素可产生花青素,花青素可通过糖苷键与糖相结合可产生花色苷。在深色谷物、浆果及蔬... 详细信息

花青素类化合物包括原花青素、花青素、花色苷等。其中,原花青素是一种聚多酚类化合物,花青素和花色苷均属黄酮类化合物。当在酸性介质中加热时,原花青素可产生花青素,花青素可通过糖苷键与糖相结合可产生花色苷。在深色谷物、浆果及蔬菜中,原花青素、花青素、花色苷广泛分布,均具有多种功效。淀粉价格低廉、来源丰富,具有多种功能特性,淀粉基食品的感官品质及营养价值主要由淀粉糊化性质、热力学性质、流变学性质、老化性质及消化性质等变化所决定。对于淀粉与其他化合物共存能够改善淀粉原本性质已有很多研究,但关于花青素类化合物对淀粉性质影响的概述较少。因此,本文综述了花青素类化合物提高淀粉的糊化温度,降低淀粉的糊化焓值,进而影响淀粉的热力学性质,同时降低淀粉的老化焓以及老化率,降低淀粉的消化速率等对淀粉糊化特性、热力学特性、流变学特性、老化特性和消化性质影响的最新研究进展,为利用花青素类化合物等改善淀粉基食品的加工性能、感官和营养品质提供指导。

关键词：花青素类化合物原花青素花青素花色苷淀粉

基于零信任安全模型的电力敏感数据访问控制方法

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信息安全研究 2024年第1期10卷 88-93页

作者：林奕夫陈雪许媛媛汤晓冬唐仁杰边珊国网福建省电力有限公司经济技术研究院福州350013 中国电力科学研究院有限公司北京100192 上海物盾信息科技有限公司上海201100

针对大数据环境下数据访问控制难度大、数据窃取行为增多造成的电力敏感数据的大量泄露问题,为保护电力敏感数据安全,提出了以零信任安全模型为基础的电力敏感数据访问控制方法.以零信任安全模型为基础,采集用户访问行为信任因素,构建... 详细信息

针对大数据环境下数据访问控制难度大、数据窃取行为增多造成的电力敏感数据的大量泄露问题,为保护电力敏感数据安全,提出了以零信任安全模型为基础的电力敏感数据访问控制方法.以零信任安全模型为基础,采集用户访问行为信任因素,构建零信任安全模型,采用层次分解模型分解信任属性,基于权重分配法构建判断矩阵计算用户访问行为信任值,结合自适应机制和时间衰减算法,完善信任值的更新与记录.引用按层生长决策树进行电力敏感数据访问分级,在用户认证基础上设置签密参数,引用公私钥实现访问认证信息签密.实验测试结果表明,该方法能够有效抑制恶性数据访问行为,数据加密时间开销小,平均时间开销低于1.4s内1200条,访问控制失误率低于5%,整体控制效果达到了理想标准.

关键词：零信任安全电力敏感数据敏感数据访问访问控制权重分配法

Robust H_(∞)path tracking control of autonomous vehicles with delay and actuator saturation

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Journal of Control and Decision 2022年第1期9卷 45-57页

作者： Changfang Chen Minglei Shu yuanyuan Yang Tianlei Gao Lipan bian Shandong Artificial Intelligence Institute Qilu University of Technology(Shandong Academy of Sciences)JinanPeople’s Republic of China Shandong Computer Science Center(National Supercomputer Center in Jinan) Qilu University of Technology(Shandong Academy of Sciences)JinanPeople’s Republic of China

The path tracking control problem is investigated in this paper for autonomous vehicles(AVs)with time-varying input delay and actuator saturation.Based on the Lyapunov-Krasovskii function and the characteristic of the saturation nonlinearity,a robust H_(∞)state-feedback path tracking controller is presented,and the corresponding control gain can be obtained by solving the linear matrix inequalities(LMIs).The asymptotic stability and prescribed H_(∞)performance conditions are studied for the closed-loop control system.To reduce the cost of control system,a static robust H_(∞)output-feedback controller is also proposed.In addition,the uncertainty effects of the cornering stiffness and external disturbances are included to improve the robustness of the control scheme.Simulation results are given to verify the effectiveness of the proposed theoretical results.

关键词： Path tracking robust H_(∞)control time delay actuator saturation uncertainties

复发性口腔溃疡患儿血清IRF5、sTREM-1变化及对复发的预测价值

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国际检验医学杂志 2024年第7期45卷 824-827,836页

作者：黄岩王明丽边玉婷刘元元石家庄市妇幼保健院口腔科河北石家庄050000 石家庄市第二医院口腔科河北石家庄050000

目的探讨复发性口腔溃疡患儿血清干扰素调节因子5(IRF5)、可溶性髓样细胞触发受体1(sTREM-1)水平变化及其对复发的预测价值。方法选取石家庄市妇幼保健院于2021年7月至2022年12月收治的146例复发性口腔溃疡患儿为观察组,并根据3个月内... 详细信息

目的探讨复发性口腔溃疡患儿血清干扰素调节因子5(IRF5)、可溶性髓样细胞触发受体1(sTREM-1)水平变化及其对复发的预测价值。方法选取石家庄市妇幼保健院于2021年7月至2022年12月收治的146例复发性口腔溃疡患儿为观察组,并根据3个月内是否复发分为复发组(n=45)和未复发组(n=101)。另选取同期138例健康志愿者作为对照组。采用实时荧光定量PCR(qPCR)检测血清IRF5 mRNA表达水平,酶联免疫吸附试验(ELISA)检测血清sTREM-1、白细胞介素(IL)-6和IL-10表达水平,Pearson分析法分析复发性口腔溃疡患儿血清IRF5和sTREM-1水平与IL-6和IL-10水平的相关性,受试者工作特征(ROC)曲线分析血清IRF5和sTREM-1水平对复发性口腔溃疡患儿复发的预测价值。结果与对照组比较,观察组血清IRF5水平明显降低(P<0.05),sTREM-1、IL-6和IL-10水平明显升高(P<0.05);Pearson分析结果显示,复发性口腔溃疡患儿血清IRF5与IL-6、IL-10水平呈负相关(r=-0.531、-0.462,P<0.05),血清sTREM-1水平与IL-6、IL-10水平呈正相关(r=0.435、0.480,P<0.05);与未复发组比较,复发组患儿血清IRF5水平明显降低(P<0.05),sTREM-1水平明显升高(P<0.05)。ROC曲线分析结果显示,血清IRF5水平单独预测复发性口腔溃疡患儿复发的曲线下面积(AUC)为0.823,最佳cut-off值为0.85,灵敏度和特异度分别为75.56%、84.16%;血清sTREM-1水平单独预测复发性口腔溃疡患儿复发的AUC为0.833,灵敏度和特异度分别为68.89%、88.12%,最佳cut-off值为84.08 pg/mL;二者联合预测复发性口腔溃疡患儿复发的灵敏度和特异度分别为88.89%、82.18%,AUC为0.915,显著高于IRF5单独预测的AUC(Z=2.455,P=0.014)和sTREM-1单独预测的AUC(Z=2.790,P=0.005)。结论复发性口腔溃疡患儿血清IRF5水平较低、sTREM-1水平较高,二者联合对复发性口腔溃疡患儿再复发具有较高的预测价值。

关键词：复发性口腔溃疡干扰素调节因子5 可溶性髓样细胞触发受体1