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Exosomal circular RNAs inglioma:coexistenceof opportunitiesand challenges forapplication

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Chinese Medical Journal 2022年第13期135卷 1528-1530页

作者： Xiaoyong Chen Jinyuan Chen Yue Chen Honghai You yuanxiang lin Zanyi Wu Dezhi Kang Chenyu Ding Department of Neurosurgery Neurosurgical Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujianChina Department of Ophthalmology The First Affiliated HospitalFujian Medical UniversityFuzhouFujianChina The Graduate School of Fujian Medical University FuzhouFujianChina Fujian Provincial Key Laboratory of Precision Medicine for Cancer The First Affiliated HospitalFujan Medical UniversityFuzhouFujianChina Key Laboratory of Radiation Biology of Fujian Higher Education Instions The First Affiliated HospitalFujian Medical UniversitFuzhouFujianChina Fujian Provincial Insttutes of Brain Disorders and Brain Sciences FuzhouFujianChina Fujian Provincial Clinical Research Center for Neurological Diseases FuzhouFujianChina.

Glioma is the most common primary tumor in the central nervous system.With the help of intercellular communication,glioma cells have the ability to survive in the tumor microenvironment(TME)and make it more suitable.

关键词： glioma tumor circular

Safety and feasibility of curved lead simultaneously implanted into pedunculopontine nucleus and subthalamic nucleus

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Chinese Medical Journal 2022年第20期135卷 2509-2511页

作者： Wei Wang Xiaoyong Chen Deyuan Chen Yue Chen Lianghong Yu yuanxiang lin Dezhi Kang Xiangrong Chen Chenyu Ding Department of Neurosurgery The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325000China Department of Neurosurgery Neurosurgical Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian 350005China Department of Pathology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325000China Department of Neurosurgery The Second Affiliated Hospital of Fujian Medical UniversityQuanzhouFujian 362000China

To the Editor:Combined nuclei stimulation may have a synergistic effect on controlling the symptoms of nervous system diseases and improving quality of life.[1]However,increasing of leads may increase costs and complications.[2]Therefore,our study aims to investigate the safety and feasibility of the single curved lead,which can simultaneously reach both subthalamic nucleus(STN)and pedunculopontine nucleus(PPN).

关键词： curved simultaneous synergistic

Endoscopically controlled surgery with open hemilaminectomy for the treatment of intradural extramedullary tumors:an operative technique and short-term outcomes of 20 consecutive cases

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Chinese Neurosurgical Journal 2021年第2期7卷 89-97页

作者： Xiaorong Yan Huiqing Wang Cai Li yuanxiang lin lin lin Shinong Zhu Chenyang Wang Zhangya lin Changzhen Jiang Dezhi Kang Neurosurgery Department The First Affiliated Hospital of Fujian Medical University20#Chazhong RoadFuzhou CityFujian ProvinceChina Neurosurgery Department The First Affiliated Hospital of University of South ChinaHengyang CityHunan ProvinceChina Operation Room The First Affiliated Hospital of Fujian Medical UniversityFuzhou CityFujian ProvinceChina Neurosurgery Department Jinjiang Hospital Jinnan Branch CourtsJinjiang CityFujian ProvinceChina

Background:To present a surgical technique for the treatment of intradural extramedullary(IDEM)tumors by using endoscopically controlled surgery with open hemilaminectomy technique.Methods:In this study,20 patients with 22 IDEM tumors were enrolled.An endoscopically controlled surgery with open hemilaminectomy was employed to remove the tumors.Data related to clinical symptoms and medical images before and after surgery were collected for perioperative evaluation and follow-up analysis.Results:All the tumors in 20 patients were well removed.The clinical symptoms were significantly reduced in all the patients as well.The short-term follow-up data showed that there was no tumor recurrence or spinal deformity.Conclusion:The endoscopically controlled surgery with open hemilaminectomy technique provided favorable exposure and satisfactory resection to the IDEM tumors.It may be an effective surgical method for treating IDEM tumors.Larger samples and longer follow-up data are needed to verify its long-term effectiveness.

关键词： Endoscopically controlled surgery Open hemilaminectomy Intradural extramedullary tumors

高频振荡对局灶性皮质发育不良Ⅱ型所致癫痫中的定位诊断价值

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中华医学杂志 2024年第8期104卷 614-617页

作者：梅珍林元相姚培森王丰黄小芬林涵胡雪群林云清高琳康德智福建医科大学附属第一医院神经外科福州350005 福建省脑重大疾病与脑科学研究院福州350005 福建省神经系统疾病临床医学研究中心福州350005 福建医科大学附属第一医院滨海院区国家区域医疗中心神经外科福州350005

回顾性分析2020年11月至2023年2月于福建医科大学附属第一医院神经外科行立体脑电图(SEEG)植入的9例局灶性皮质发育不良(FCD)Ⅱ型所致癫痫患者,分析高频振荡(HFO)出现的部位、时间、频率,比较HFO与发作间期、发作前、发作期波形相关性。... 详细信息

回顾性分析2020年11月至2023年2月于福建医科大学附属第一医院神经外科行立体脑电图(SEEG)植入的9例局灶性皮质发育不良(FCD)Ⅱ型所致癫痫患者,分析高频振荡(HFO)出现的部位、时间、频率,比较HFO与发作间期、发作前、发作期波形相关性。9例患者SEEG发作间期、发作期均记录到80~500 Hz HFO,其中6例患者记录到250~500 Hz快速涟波(FR)。手术切除发作起始区和FR发放电极,术后随访2年以上,5例为EngelⅠ。发作前6例患者SEEG呈持续性放电。持续性放电分布指数与发作频率呈正相关。发作期四型发作起始模式均出现80~500 Hz HFO。6例发作前为持续性放电并重叠HFO患者,手术切除发作起始区和FR发放电极,5例EngelⅠ。FCDⅡ型放电波形复杂、放电指数高,和HFO关系密切。与棘波相比HFO出现电极范围更为局限,发作前HFO发生率显著增高,与发作起始区相关性强,HFO与棘波同时出现比单独出现定位诊断价值更高,能有效提高手术疗效。

关键词：癫痫局灶性皮质发育不良脑电图高频振荡

Solitary Langerhans cell histiocytosis of frontal lobe: a case report and literature review

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Chinese Journal of Cancer Research 2014年第2期26卷 211-214页

作者： Shanshan Cai Sheng Zhang Xueyong Liu yuanxiang lin Chunlin Wu Yupeng Chen Jianping Hu Xingfu Wang Department of Pathology the Second Affiliated Hospital of Fujian Medical University Department of Pathology the First Affiliated Hospital of Fujian Medical University Department of Neurosurgery the First Affiliated Hospital of Fujian Medical University Department of Radiology the First Affiliated Hospital of Fujian Medical University

The brain parenchymal Langerhans cell histiocytosis （LCH） without systemic disease or lytic skull lesions is extremely rare. We report a 23-year-old male presenting with new onset 1 hour seizure with loss of consciousness 20 days prior to admission, and recurrent seizure 2 weeks later. Brain magnetic resonance imaging （MRI） showed an irregularly mass with enhancement involving the right frontal lobe. Microscopically, the lesion was characterized by sheets of Langerhans cells in addition to reactive inflammatory elements. Immunohistochemically, Langerhans cells were positive for Langerin, CDla and S-100 protein. The patient received no chemotherapy or radiotherapy after surgery. After 24 months of follow-up, no recurrence or other systemic lesions were observed. Although there is no standard treatment for solitary cerebral LCH, the prognosis generally appears to be good.

关键词： Langerhans cell histiocytosis （LCH） histiocytosis immunohistochemistry pathology

Anatomy and surgery of pure neuroendoscopic infratentorial supracerebellar approach for resection of pineal region tumor

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Chinese Neurosurgical Journal 2018年第3期4卷 133-138页

作者： Yuanlong Zhang Dezhi Kang Changzhen Jiang Xiaorong Yan Zhangya lin yuanxiang lin Xiyue Wu Chenyang Wang Department of Neurosurgery The First Affiliated Hospital Of Fujian Medical UniversityFuzhou 350004China

Background: The pineal region tumors are surrounded by important structures. Neuroendoscopy has been increasingly used at home and abroad. This study is to simulate pure neuroendoscopic infratentorial supracerebellar approach for resection of pineal region tumor from the cadaveric head, and discuss the advantages and safety through this corridor. Methods: The anatomical structure for resection of pineal region tumor was visualized through pure neuroendoscopic infratentorial supracerebellar approach in three cadaveric heads. Three cases with pineal region tumors were retrospectively analyzed and summarized between June 2017 and December 2017. All cases were operated through pure neuroendoscopic infratentorial supracerebellar approach in the first affiliated hospital of Fujian medical university. Results: The anatomical structures of pineal region can be completely visualized by pure neuroendoscopic infratentorial supracerebellar corridor in the cadaveric head. Among the three cases, the first case was total resection, the second case was subtotal resection and the last case was partial resection. The postoperative pathology revealed cavernous hemangioma, germinoma and yolk sac tumor, respectively. The patients were followed-up for 1-6 months and had normal life.The KPS (karnofsky performance status) score was 100. Conclusion: The anatomical structure of the pineal region can be completely visualized and the tumor can be safely removed through pure neuroendoscopic infratentorial supracerebellar approach.

关键词： Neuroendoscopy Infratentorial supracerebellar approach Surgery Anatomy Pineal region tumor

Synaptic plasticity effects on FeCl_2-induced post-traumatic epilepsy onset in the rat

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Neural Regeneration Research 2010年第18期5卷 1373-1377页

作者： yuanxiang lin Feng Wang Ruxiang Xu Xiaodan Jiang Dezhi Kang Yiquan Ke Mouxuan Du Lishuang Xu Department of Neurosurgery First Affiliated Hospital Fujian Medical University Fuzhou 350005 Fujian Province China Department of Neurosurgery Zhujiang Hospital Southern Medical University Guangzhou 510282 Guangdong Province China

Studies have confirmed that iron induces epilepsy onset, and iron ion-induced epilepsy in anima models closely resembles the clinical situation. Models of post-traumatic epilepsy （PTE） were established by intracortical injection of FeCl2 using stereotactic techniques. Electron microscopy revealed neuronal degeneration, with shrinkage of the neuronal soma, hyperplasia of rough endoplasmic reticulum, ribosomal detachment from the endoplasmic reticulum, and vacuolar degeneration of glial cells in the right frontal lobe of FeCl2-induced PTE rats. With prolonged time injuries became more severe and neuronal apoptosis was observed. Synapses in the hippocampal neuropil significantly increased （primarily type I/excitatory synapses） at day 14 following injury. Type II synapses （inhibitory synapse） were observed in the rat hippocampus at day 30. Cortical neuronal degeneration, apoptosis, glial cell proliferation, and ultrastructural hippocampal changes, in particular changes in type of neuronal synapse, play an important role in PTE onset.

关键词： post-traumatic epilepsy animal model ferrous chloride synapse synaptic plasticity electron microscope electric wire neurodegenerative diseases neural regeneration

基于压裂液自发吸入模型的页岩气压裂液滤失定量预测

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天然气工业 2024年第2期44卷 92-98页

作者：王琳琳蔺小博冷静怡周长静马占国肖元相中国石油大学(北京)安全与海洋工程学院中国石油长庆油田公司油气工艺研究院巴黎高科路桥学院

非常规油气资源开发常使用水力压裂技术提高单井产量,然而压裂现场数据表明,大量压裂液会滞留在地层中导致压裂液的返排率较低,将对储层和地下水环境造成一定影响。为进一步研究压裂液滤失机理并准确预测压裂液滤失量,首先建立了由毛细... 详细信息

非常规油气资源开发常使用水力压裂技术提高单井产量,然而压裂现场数据表明,大量压裂液会滞留在地层中导致压裂液的返排率较低,将对储层和地下水环境造成一定影响。为进一步研究压裂液滤失机理并准确预测压裂液滤失量,首先建立了由毛细管力作用引起的压裂液自发吸入模型,然后对压裂液滤失量进行定量计算,并在现场进行了验证。最后,引入无量纲吸入率参数分析了控制压裂液滤失的关键因素。研究结果表明:(1)页岩气水平井压裂施工中大约50%~95%的压裂液通过基质吸入,压裂液吸入量仅与吸入率参数、裂缝面积和吸收时间有关;(2)当润湿相黏度与非润湿相黏度之比超过阈值时,吸入率参数主要由岩石的孔径分布参数决定,流体黏度的影响非常有限;(3)当孔径分布参数介于0.5~0.7时,吸入率参数达到相对较高的值,即更多的压裂液被吸收到地层中;(4)当润湿相黏度与非润湿相黏度之比大于10,孔径分布参数小于0.8时,优化后的自吸模型具有较大的适用性;(5)由毛细管力机理引起的压裂液滤失量与实际储层观察到的滤失量相近,可认为页岩储层有足够的存储滤失液的能力,不会影响地下水层中的饮用水。结论认为,建立的压裂液自发吸入模型,能够准确预测页岩气水平井压裂液滤失量,为非常规油气的生产及环境保护提供了技术支撑。

关键词：页岩气藏毛细管力滤失自发吸入吸入率参数流体黏度孔径分布参数

Three-dimensional printing technology for treatment of intracranial aneurysm

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Chinese Neurosurgical Journal 2016年第3期2卷 -页

作者： Yin Kang LiangHong Yu Tao Xu ShuFa Zheng PeiSen Yao Man Liu yuanxiang lin Department of Neurosurgery The First Affiliated Hospital Fujian Medical University Fuzhou 350005 Fujian Province China Bio-Manufacturing Center Department of Mechanical Engineering Tsinghua University Beijing 100084China Medprin Regenerative Medical Technologies Company Limited Guangzhou 510000 Guangdong Province China

The development of three-dimensional (3D) printing technology provides a new method for surgical treatment, but currently there are few reports on its application in the treatment of aneurysm. The aim of the present study was to explore the materials and methods of fabricating 3D printed individual aneurysm model and its value in the treatment of intracranial aneurysm. Twenty-four patients with intracranial aneurysm diagnosed by CTA who had undergone operation in our hospital were analyzed retrospectively. CTA Data collected at the time of surgery was used for reconstruction. Soft Mimics 17.0 was used to reconstruct the thin layer CTA scan data into 3D image and the final data was sent to the 3D printer for fabricating the model. We compared the proposed 3D printed model-based preoperative plan and the actual approach used in the surgery based on CTA data to evaluate the value of the 3D printed model in preoperative planning, and picked out the materials which were more suitable for the clinic. Twenty-four aneurysm models with high degree of reality were fabricated successfully with 3D-printing technology. The patients’ blood vessels, skulls and aneurysms were printed into the reality model at a ratio of 1:1. It is reported that the soft material-based, 3D printed vascular and aneurysm model more closely resembled the characteristics of the real blood vessels, thus provides a better simulation compared to the plaster-based model. Compared with the original operation plan, 3D printed model could be used for pre-operative aneurysm clip selection, and provide more intuitive information in selection of operational approach. 3D printed model can be used as an operational physical model to design operative schemes, choose the best operative paths and select suitable aneurysm clips by its high simulation degree and individualized characteristics. The model is helpful for surgical planning, especially for the preoperative plan of treating refractory multiple aneurysms and giant aneurysms.

关键词： 3D printed model Intracranial aneurysm Operation design