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人工智能分析系统对需氧菌性阴道炎的判读方法初探

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四川大学学报（医学版） 2024年第2期55卷 461-468页

作者：邺琳玲于凡胡正强王霞唐袁婷四川大学华西第二医院检验科成都610041 出生缺陷与相关妇儿疾病教育部重点实验室(四川大学) 成都610041

目的开发基于深度学习的人工智能阴道分泌物分析系统,评估自动化镜检对需氧菌性阴道炎(aerobic vaginitis,AV)临床诊断的准确性。方法选取2020年1月–2021年12月就诊于四川大学华西第二医院妇产科3769例患者的阴道分泌物,以人工镜检结... 详细信息

目的开发基于深度学习的人工智能阴道分泌物分析系统,评估自动化镜检对需氧菌性阴道炎(aerobic vaginitis,AV)临床诊断的准确性。方法选取2020年1月–2021年12月就诊于四川大学华西第二医院妇产科3769例患者的阴道分泌物,以人工镜检结果为对照,通过Python Scikit-learn script开发出能识别含中毒颗粒白细胞和基底旁上皮细胞(parabasal epitheliocytes,PBC)的人工智能自动化分析软件(linear kernel SVM algorithm),并利用乳杆菌和AV常见分离菌的标准菌株重新设置细菌分级参数。以人工镜检结果为对照,得到人工智能判断AV评分中各项目各分值之间的受试者工作特征(receiver operating characteristic,ROC)曲线和cut-off值,从而设定出自动化判读AV的参数,初步建立AV自动化分析评分方法。结果共收集到3769份阴道分泌物标本。人工智能识别AV共有5个参数,每个参数有3种程度。乳杆菌与AV常见菌的直径分界值为1.5μm,乳杆菌的自动化判断参数是长径≥1.5μm∶<1.5μm细菌的比值,分界值是2.5和0.5;白细胞(white blood cell,WBC)的自动化判断参数中,WBC绝对数量的分界值是10~3μL^(-1),WBC/上皮细胞的比值分界值是10;含中毒颗粒白细胞的自动化判断参数是含中毒颗粒WBC/WBC比值,分界值是1%和15%;背景菌落的自动化判断参数是<1.5μm,细菌分界值是5×10^(3)μL^(-1)和3×10^(4)μL^(-1),PBC的自动化判断参数是PBC/上皮细胞的比值,分界值是1%和10%。自动化镜检与人工镜检的一致率为92.5%,200例标本中评分一致的有185例,不一致有15例。结论本研究开发的人工智能AV识别软件,其建立的阴道分泌物AV自动化镜检评分方法,检测结果与人工镜检具有较好的一致性,可较为客观、敏感、高效完成临床检验,并降低人工镜检工作负荷。

关键词：需氧性阴道炎人工智能自动化分析

光催化降解苯酚污染物的电化学监测——推荐一个分析化学综合实验

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大学化学 2024年第6期39卷 326-333页

作者：张宏波唐意红张素霞李原婷上海应用技术大学化学与环境工程学院上海201418

针对目前高校开展的分析化学实验教学内容单一,侧重常规分析方法以及仪器基本原理介绍等问题,将综合性实验教学项目引入到教学中,能够增强学生独立探索、主动思考和分析问题的能力。本文设计了基于纳米TiO2光催化剂催化降解苯酚的综合... 详细信息

针对目前高校开展的分析化学实验教学内容单一,侧重常规分析方法以及仪器基本原理介绍等问题,将综合性实验教学项目引入到教学中,能够增强学生独立探索、主动思考和分析问题的能力。本文设计了基于纳米TiO2光催化剂催化降解苯酚的综合性实验方案,涉及光催化降解和电化学监测的原理,以及光催化降解和电化学装置的搭建等。

关键词：分析化学实验光催化降解电化学监测苯酚含量差示脉冲伏安法

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Multi-Layer Synthesis of HighlyStructured Texture

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Wuhan University Journal of Natural Sciences 2012年第4期17卷 302-308页

作者： tang Li YU Rongwei GU yuanting YUAN Jie DU Gong School of Computer Science and Engineering ChangshuInstitute of Technology Changshu 215500 Jiangsu China State Key Laboratary of Software Engineering WuhanUniversity Wuhan 430072 Hubei China Key Laboratory of Aerospace Information Security andTrust Computing Ministry of Education Wuhan 430072 HubeiChina Institute of Software Chinese Academy of Sciences Beijing100080 Beijing China

In this paper, a novel concept of multilayer synthesis and a general framework for texture synthesis method are presented. Within this framework, we first decompose the texture into the supposed pattern layer and material layer in the frequency domain by an E-texton extracting algorithm, then manipulate and extend them respectively according to their own personalities, and finally merge the newly synthesized pattern layer and material layer again to generate the final output. Experiment results show that our method not only greatly improves the synthesis quality for those cases that single-layer synthesis cannot handle well but also provides an ability of achieving various special synthesis effects.

关键词： texture synthesis texture layer multilayer synthesis

Room-Temperature Reversibleσ-Dimerization of a Phenalenyl Radical

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Chinese Journal of Chemistry 2022年第14期40卷 1655-1661页

作者： Xue Dong Quanchun Sun Zhongtao Feng Huapeng Ruan Shuxuan tang Min Liu Yue Zhao yuanting Su Xinping Wang State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic MaterialsSchool of Chemistry and Chemical EngineeringCollaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjingJiangsu 21023China Cllege of Chemistry Chemical Engineering and Materials ScienceSoochow UniversitySuzhouiangsu 215123China

Phenalenyl derivatives have been of tremendous interest due to their reversible dimerization in response to the external stimuli such as ***,most of PLY derivatives only show the reversibility dependent on ***,we report a unique PLY-based radical anionic salt with reversibleσ-dimerization controlled by solvent rather than *** structure and reversibility of this PLY anion system have been spectroscopically,crystallographically,and theoretically *** molecule exists mainly as theσ-dimer form of K2[σ-12]in toluene,while it can be broken into the monomeric radical anion 1•–by re-dissolving in ***,when THF is replaced with toluene,radical 1•–could beσ-dimerized back *** calculations reveal that the potassium ions are necessary for the formation of theσ-dimer and the solvent polarity controls theσ-dimerization by regulating the presence of K+.

关键词： σ-Dimerization Solvent effects Reversible dimerization PLY Radicals

电化学聚合法制备分子印迹电极用于饮料中兴奋剂的检测——对“电聚合制备导电高分子”实验的改进

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大学化学 2024年第1期39卷 229-238页

作者：李原婷杨韵涵王俊刚唐意红张素霞韩生上海应用技术大学化学与环境工程学院上海201418

以大学化学实验中“电聚合制备导电高分子”为基础,融入分子印迹聚合物与食品安全元素,成功将简单的任务式制备实验,改进为集分子印迹导电聚合物制备、性能表征及饮料中兴奋剂的高选择性检测应用为一体的综合性实验。改进后实验内容丰... 详细信息

以大学化学实验中“电聚合制备导电高分子”为基础,融入分子印迹聚合物与食品安全元素,成功将简单的任务式制备实验,改进为集分子印迹导电聚合物制备、性能表征及饮料中兴奋剂的高选择性检测应用为一体的综合性实验。改进后实验内容丰富有趣,贴近现实,引入前沿分析技术,有助于学生综合技能的提升和科学思维的培养。

关键词：综合性实验实验教学改进电化学聚合表面增强拉曼光谱

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Potential for natural and enhanced attenuation of sulphanilamide in a contaminated chalk aquifer

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Journal of Environmental Sciences 2017年第12期29卷 39-48页

作者： karen A.Bennett Simon D.Kelly Xiangyu tang Brian J.Reid School of Environmental Sciences University of East AngliaNorwich Research ParkNorwich NR4 7TJUK Food and Environmental Protection Laboratory International Atomic Energy Agency1400 ViennaAustria Key Laboratory of Mountain Surface Processes and Ecological Regulation Institute of Mountain Hazards and EnvironmentChinese Academyof SciencesChengdu 610041China

Understanding antibiotic biodegradation is important to the appreciation of their fate and removal from the environment. In this research an Isotope Ratio Mass Spectrometry（IRMS）method was developed to evaluate the extent of biodegradation of the antibiotic,sulphanilamide, in contaminated groundwater. Results indicted an enrichment in δ^（13）C of8.44‰ from-26.56（at the contaminant source） to-18.12‰（300 m downfield of the source）.These results confirm reductions in sulphanilamide concentrations（from 650 to 10 mg/L）across the contaminant plume to be attributable to biodegradation（56%） vs. other natural attenuation processes, such as dilution or dispersion（42%）. To understand the controls on sulphanilamide degradation ex-situ microcosms assessed the influence of sulphanilamide concentration, redox conditions and an alternative carbon source. Results indicated, high levels of anaerobic capacity（~50% mineralisation） to degrade sulphanilamide under high（263 mg/L）, moderate（10 mg/L） and low（0.02 mg/L） substrate concentrations. The addition of electron acceptors; nitrate and sulphate, did not significantly enhance the capacity of the groundwater to anaerobically biodegrade sulphanilamide. Interestingly, where alternative carbon sources were present, the addition of nitrate and sulphate inhibited sulphanilamide biodegradation. These results suggest, under in-situ conditions, when a preferential carbon source was available for biodegradation, sulphanilamide could be acting as a nitrogen and/or sulphur source. These findings are important as they highlight sulphanilamide being used as a carbon and a putative nitrogen and sulphur source, under prevailing iron reducing conditions.

关键词： Antibiotics Sulphonamide Groundwater contamination Biodegradation Stable isotope fractionation IRMS

Clinical features and outcome of 15 patients with recurrent endometrial cancer or atypical endometrial hyperplasia received primary fertility-sparing therapy followed by hysterectomy

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Gynecology and Obstetrics Clinical Medicine 2021年第1期1卷 44-48页

作者： yuanting Li Yiqin Wang Yijiao He Rong Zhou Huiru tang Lijiang Xu Mian He Weili Li Chunlin Chen Weifeng Zhang Jianliu Wang Department of Gynecology and Obstetrics Peking University People's HospitalBeijingChina Department of Gynecology and Obstetrics Peking University Shenzhen HospitalShenzhenChina Department of Gynecology and Obstetrics The First People's Hospital of FoshanGuangdongChina Department of Gynecology and Obstetrics The First Affiliated HospitalSun Yat-sen UniversityGuangdongChina Department of Gynecology and Obstetrics Nanfang HospitalGuangdongChina Department of Gynecology and Obstetrics Ningbo Women&Children's HospitalZhejiangChina

Objective To investigate the clinical features and outcome of recurrent endometrial cancer(EC)or atypical endometrial hyperplasia(AEH)patients who underwent hysterectomy after fertility-sparing *** Clinical data was retrospectively collected for 15 recurrent endometrial cancer or atypical endometrial hyperplasia patients who underwent hysterectomy in six hospitals from 2003 to *** to the indicators of hysterectomy,patients were divided into four groups:7 patients who underwent direct hyesterectomy after the first relapse,4 due to re-treatment failure,1 after full term live birth,and 3 because of multiple *** coexisting conditions,regimen and outcome of fertility-sparing therapy,pre-and post-operative pathological results,and prognosis were ***(1)Fertility-spraring treatment was given to a total of 15 eligible patients,including 6 with EC and 9 with *** time interval from remission to recurrence was 12 months(range 3–92).Oral progestin-based medicine was the main fertility-sparing therapy in both primary treatment and re-treatment after ***(6/8)patients received progestin combined with gonadotrophin releasing hormone agonist or metformin in three re-treatment groups.(2)Nine patients underwent hysterectomy and 6 staging *** patients had pathological upgrade after ***(5/10)EC patients had superficial myometrial invasion in postoperative *** patients showed no evidence of disease in the median follow-up of 17 months(range 3–118).(3)Among seven patients who failed to re-treatment and had multiple recurrence,six were overweight/obesity and six had insulin *** of these patients had synchronous ovarian cancer in the postoperative *** For the patients with recurrent EC or AEH after primary fertility-sparing therapy,overweight/obesity and insulin resistance might be the risk factors for re-treatment *** is recommended when patients ha

关键词： Endometrial cancer Atypical endometrial hyperplasia Fertility-sparing Recurrence Hysterectomy

Machine learning enables polymer cloud-point engineering via inverse design

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npj Computational Materials 2019年第1期5卷 523-528页

作者： Jatin N.Kumar Qianxiao Li karen Y.T.tang Tonio Buonassisi Anibal L.Gonzalez-Oyarce Jun Ye Institute of Materials Research&Engineering 2 Fusionopolis Way#08-03Singapore 138634Singapore Institute of High-Performance Computing 1 Fusionopolis Way#16-16Singapore 138632Singapore Massachussets Institute of Technology CambridgeMA 02139USA

Inverse design is an outstanding challenge in disordered systems with multiple length scales such as polymers,particularly when designing polymers with desired phase *** we demonstrate high-accuracy tuning of poly(2-oxazoline)cloud point via machine *** a design space of four repeating units and a range of molecular masses,we achieve an accuracy of 4℃ root mean squared error(RMSE)in a temperature range of 24–90℃,employing gradient boosting with decision *** RMSE is>3x better than linear and polynomial *** perform inverse design via particle-swarm optimization,predicting and synthesizing 17 polymers with constrained design at 4 target cloud points from 37 to 80℃.Our approach challenges the status quo in polymer design with a machine learning algorithm,that is capable of fast and systematic discovery of new polymers.

关键词： inverse polymer enable

Use of microbial fuel cells to monitor current production in Qi-deficient liver cells

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Journal of Traditional Chinese Medicine 2016年第2期36卷 231-237页

作者： karen Poon Liang Lexin Xu Chang Wang Ruihua Program of Food Science and Technology Division of Science and Technology Beijing Normal University-Hong Kong Baptist University United International College Program of Food Science and Technology Division of Science and Technology Beijing Normal University–Hong Kong Baptist University United International College Department of Chemistry HongKong Baptist University Hong Kong SAR Department of Gastroenterology Shenzhen Hospital of Southern Medical University

OBJECTIVE:To monitor current production in Qi-deficient liver cells,and to study how cellular proton leakage might affect electric current ***:Cells were placed in an microbial fuel cells(MFC)anode and the electric current was ***-affecting chemicals,2,4-dinitrophenol(DNP)and resveratrol(RVT),were used to induce proton leakage in cells and their effect on current production ***-7 breast cancer cells exhibited higher proton leakage relative tonormal liver cells.A mouse model for Qi-deficiency was prepared according to the Methodology of Animal Experiment in Chinese *** Qi-tonics Buzhongyiqi tang(BZYQT),which is used to treat the Qi-deficiency condition,was applied to Qi-deficient liver cells to examine how current production was ***:Adding either DNP or RVT to normal liver cells increased current ***-7 cells that possessed high proton leakage were also found to produce higher currents than normal liver *** current production,lower cellular glucose content,and lower adenosine triphosphate(ATP)production rate were found in Qi-deficient liver cells,in which the use of DNP or RVT further increased current *** use of BZYQT to treat Qi-deficient liver cells decreased current production,counteracted the action of DNP,and also improved cellular glucose ***:High electric current production was found in liver cells with high cellular proton *** current responses to both mitochondria-affecting chemicals,DNP and RVT,appeared to indicate proper mitochondrial *** high proton leakage detected in Qi-deficient liver cells might have caused high energy losses,which served to explain the observed lower cellular glucose content and ATP production rate than in normal *** results might also explain the exhibited syndromes of low energy and fatigue in Qi-deficient *** leakage,induced by DNP or the Qi-deficient condition,was possibly caused

关键词： Qi deficiency Hepatocytes Bioelectric energy sources Electric current Proton leakage 2 4-Dinitrophenol Resveratrol Oxidative phosphorylation