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A spatiotemporal deep learning method for excavation-induced wall deflections

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第8期16卷 3327-3338页

作者： yuanqin tao Shaoxiang Zeng Honglei Sun Yuanqiang Cai Jinzhang Zhang Xiaodong Pan College of Civil Engineering Zhejiang University of TechnologyHangzhou310023China Ministry of Education(MOE)Key Laboratory of Soft Soils and Geoenvironmental Engineering(SSGeo) Zhejiang UniversityHangzhou310058China Key Laboratory of Geotechnical and Underground Engineering of Ministry of Education and Department of Geotechnical Engineering Tongji UniversityShanghai200092China

Data-driven approaches such as neural networks are increasingly used for deep excavations due to the growing amount of available monitoring data in practical ***,most neural network models only use the data from a single monitoring point and neglect the spatial relationships between multiple monitoring ***,most models lack flexibility in providing predictions for multiple days after monitoring *** study proposes a sequence-to-sequence(seq2seq)two-dimensional(2D)convolutional long short-term memory neural network(S2SCL2D)for predicting the spatiotemporal wall deflections induced by deep *** model utilizes the data from all monitoring points on the entire wall and extracts spatiotemporal features from data by combining the 2D convolutional layers and long short-term memory(LSTM)*** S2SCL2D model achieves a long-term prediction of wall deflections through a recursive seq2seq *** excavation depth,which has a significant impact on wall deflections,is also considered using a feature fusion *** excavation project in Hangzhou,China,is used to illustrate the proposed *** results demonstrate that the S2SCL2D model has superior prediction accuracy and robustness than that of the LSTM and S2SCL1D(one-dimensional)*** prediction model demonstrates a strong generalizability when applied to an adjacent *** on the long-term prediction results,practitioners can plan and allocate resources in advance to address the potential engineering issues.

关键词： Braced excavation Wall deflections Deep learning Convolutional layer Long short-term memory(LSTM) Sequence to sequence(seq2seq)

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开挖引起的隧道位移动态多目标优化反演预测

上海交通大学学报 2022年第12期56卷 1688-1699页

作者：何维孙宏磊陶袁钦蔡袁强浙江大学建筑工程学院杭州310058 浙江工业大学土木工程学院杭州310004

控制基坑开挖对邻近既有隧道的扰动对设计与施工至关重要.基于多目标优化方法,融合基坑开挖中的多类型监测数据,反演识别关键土体参数,量化修正隧道位移的时间效应.同时,为提高动态代理模型的优化效率,提出一种基于自适应加点准则的动... 详细信息

控制基坑开挖对邻近既有隧道的扰动对设计与施工至关重要.基于多目标优化方法,融合基坑开挖中的多类型监测数据,反演识别关键土体参数,量化修正隧道位移的时间效应.同时,为提高动态代理模型的优化效率,提出一种基于自适应加点准则的动态多目标优化(DMO-AIC)方法.该方法考虑了工程优化中动态代理模型的计算冗余,设计了自适应加点判别策略,能够自主识别寻优路径上代理模型的无效更新.结果表明,该方法在保证算法寻优性能和收敛速度的同时,显著减少了训练代理模型所需的数值模型调用次数,有利于动态代理模型在工程优化中的应用.虚拟数值算例结果表明,DMO-AIC能考虑挡墙侧移、隧道位移等多目标响应并同时对其进行更新.将DMO-AIC方法应用于上海外滩596基坑工程,合理更新了时间效应,准确预测了基坑分步开挖引起的既有隧道竖向位移.

关键词：动态多目标优化代理模型自适应加点准则基坑隧道时间效应

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基于集合卡尔曼滤波的海洋土孔隙率预测研究

工业建筑 2023年第6期53卷 37-42页

作者：汪明元张国潘孙珏徐陶袁钦中国电建集团华东勘测设计研究院有限公司杭州311122 深圳市盛业建筑科技集团有限公司广东深圳518026 浙江工业大学土木工程学院杭州310014

正确评估海洋土的物理力学性质是保障海洋工程安全的关键。基于集合卡尔曼滤波结合波阻抗测量数据和波阻抗-孔隙率转换式,提出了一种海洋土孔隙率的概率预测及不确定性量化的方法。它可同时考虑转换模型和状态转移的不确定性,提供孔隙... 详细信息

正确评估海洋土的物理力学性质是保障海洋工程安全的关键。基于集合卡尔曼滤波结合波阻抗测量数据和波阻抗-孔隙率转换式,提出了一种海洋土孔隙率的概率预测及不确定性量化的方法。它可同时考虑转换模型和状态转移的不确定性,提供孔隙率沿深度的取值及其不确定性。首先基于先验信息生成海洋土孔隙率估计的初始集合;然后通过由多传感器岩心记录仪取样测量的波阻抗数据和概率转换模型,对海洋土孔隙率进行预测和更新;最后分析转换模型误差、初始集合和观测数据量对孔隙率估计的影响,通过工程实例的验证,表明该方法可有效地估计海洋土孔隙率随深度的空间分布,并量化不确定性。

关键词：概率分析集合卡尔曼滤波海洋土孔隙率波阻抗

Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

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Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian Ding Chun Chen Heng Zhao Bin Dai Lei Ye tao Song Shuai Huang Jia Wang tao You Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2

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汽轮发电机氢气系统运行及维护

贵州电力技术 2009年第8期12卷 54-54页

作者：陶远钦纳雍发电总厂 553001

针对一厂4×300MW汽轮发电机组氢气纯度不合格及漏氢严重的问题，从设备结构及工作原理进行分析，并对运行方式进行调整，取得了明显的效果。

关键词：氢气纯度漏氢密封油

Preparation of FeCoNi medium entropy alloy from Fe^(3+)-Co^(2+)-Ni^(2+)solution system

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 92-101页

作者： Zongyou Cheng Qing Zhao Mengjie tao Jijun Du Xingxi Huang Chengjun Liu Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China Engineering Research Center of Frontier Technologies for Low-carbon Steelmaking(Ministry of Education) Shenyang 110819China

In recent years,medium entropy alloys have become a research hotspot due to their excellent physical and chemical *** controlling reasonable elemental composition and processing parameters,the medium entropy alloys can exhibit similar properties to high entropy alloys and have lower *** this paper,a FeCoNi medium entropy alloy precursor was prepared via sol-gel and coprecipitation methods,respectively,and FeCoNi medium entropy alloys were prepared by carbothermal and hydrogen *** phases and magnetic properties of FeCoNi medium entropy alloy were *** showed that FeCoNi medium entropy alloy was produced by carbothermal and hydrogen reduction at 1500℃.Some carbon was detected in the FeCoNi medium entropy alloy prepared by carbothermal *** alloy prepared by hydrogen reduction was uniform and showed a relatively high ***,the hydrogen reduction product exhibited better saturation magnetization and lower coercivity.

关键词： medium entropy alloy sol-gel co-precipitation carbothermal hydrogen reduction

Targeted gene sequencing and bioinformatics analysis of patients with gallbladder neuroendocrine carcinoma:A case report

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 239-251页

作者： Yun-Chuan Yang Zhi-tao Chen Da-Long Wan Hui Tang Mu-Lin Liu Department of Medical College Jinan UniversityGuangzhou 510000Guangdong ProvinceChina Department of General Surgery The First Affiliated Hospital of Bengbu Medical UniversityBengbu 233000Anhui ProvinceChina Department of Hepatobiliary Surgery Shulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Department of Pathology The First Affiliated Hospital of Medical School of Zhejiang UniversityHangzhou 310000Zhejiang ProvinceChina

BACKGROUND Gallbladder neuroendocrine carcinoma(NEC)represents a subtype of gallbladder malignancies characterized by a low incidence,aggressive nature,and poor *** its clinical severity,the genetic alterations,mechanisms,and signaling pathways underlying gallbladder NEC remain *** SUMMARY This case study presents a rare instance of primary gallbladder NEC in a 73-year-old female patient,who underwent a radical cholecystectomy with hepatic hilar lymphadenectomy and resection of liver segments IV-B and *** gene sequencing and bioinformatics analysis tools,including STRING,GeneMANIA,Metascape,TRRUST,Sangerbox,cBioPortal and GSCA,were used to analyze the biological functions and features of mutated genes in gallbladder *** mutations(APC,ARID2,IFNA6,KEAP1,RB1,SMAD4,TP53,BTK,GATA1,GNAS,and PRDM3)were identified,and the tumor mutation burden was determined to be 9.52 muts/Mb via targeted gene sequencing.A protein-protein interaction network showed significant interactions among the twelve mutated *** Ontology and Kyoto Encyclopedia of Genes and Genomes analyses were used to assess mutation functions and *** results revealed 40 tumor-related pathways.A key regulatory factor for gallbladder NEC-related genes was identified,and its biological functions and features were compared with those of gallbladder *** Gallbladder NEC requires standardized *** with other gallbladder carcinomas revealed clinical phenotypes,molecular alterations,functional characteristics,and enriched pathways.

关键词： Gallbladder neuroendocrine carcinoma Targeted-gene sequencing Bioinformatics analysis case report Immunocytochemistry Case report

Spatial transcriptomics combined with single-nucleus RNA sequencing reveals glial cell heterogeneity in the human spinal cord

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Neural Regeneration Research 2025年第11期20卷 3302-3316页

作者： Yali Chen Yiyong Wei Jin Liu tao Zhu Cheng Zhou Donghang Zhang Department of Anesthesiology West China HospitalSichuan UniversityChengduSichuan ProvinceChina Laboratory of Anesthesia and Critical Care Medicine National-Local Joint Engineering Research Center of Translational Medicine of AnesthesiologyWest China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Anesthesiology Longgang District Maternity&Child Healthcare Hospital of Shenzhen City(Longgang Maternity and Child Institute of Shantou University Medical College)ShenzhenGuangdong ProvinceChina Department of Anesthesiology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

Glial cells play crucial roles in regulating physiological and pathological functions,including sensation,the response to infection and acute injury,and chronic neurodegenerative *** cells include astrocytes,microglia,and oligodendrocytes in the central nervous system,and satellite glial cells and Schwann cells in the peripheral nervous *** the greater understanding of glial cell types and functional heterogeneity achieved through single-cell and single-nucleus RNA sequencing in animal models,few studies have investigated the transcriptomic profiles of glial cells in the human spinal ***,we used high-throughput single-nucleus RNA sequencing and spatial transcriptomics to map the cellular and molecular heterogeneity of astrocytes,microglia,and oligodendrocytes in the human spinal *** explore the conservation and divergence across species,we compared these findings with those from *** the human spinal cord,astrocytes,microglia,and oligodendrocytes were each divided into six distinct transcriptomic *** the mouse spinal cord,astrocytes,microglia,and oligodendrocytes were divided into five,four,and five distinct transcriptomic subclusters,*** comparative results revealed substantial heterogeneity in all glial cell types between humans and ***,we detected sex differences in gene expression in human spinal cord glial ***,in all astrocyte subtypes,the levels of NEAT1 and CHI3L1 were higher in males than in females,whereas the levels of CST3 were lower in males than in *** all microglial subtypes,all differentially expressed genes were located on the sex *** addition to sex-specific gene differences,the levels of MT-ND4,MT2A,MT-ATP6,MT-CO3,MT-ND2,MT-ND3,and MT-CO_(2) in all spinal cord oligodendrocyte subtypes were higher in females than in ***,the present dataset extensively characterizes glial cell heterogeneity and offers a valuable resource for explo

关键词： astrocyte glial cell human microglia oligodendrocyte sex differentiation single-nucleus RNA sequencing spatial transcriptomics species variation spinal cord

Cholesterol metabolism: physiological versus pathological aspects in intracerebral hemorrhage

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Neural Regeneration Research 2025年第4期20卷 1015-1030页

作者： Ruoyu Huang Qiuyu Pang Lexin Zheng Jiaxi Lin Hanxi Li Lingbo Wan tao Wang Department of Forensic Science School of Basic Medicine and Biological SciencesSuzhou Medicine College of Soochow UniversitySuzhouJiangsu ProvinceChina

Cholesterol is an important component of plasma membranes and participates in many basic life functions,such as the maintenance of cell membrane stability,the synthesis of steroid hormones,and *** plays a key role in the establishment and maintenance of the central nervous *** brain contains 20%of the whole body’s cholesterol,80%of which is located within myelin.A huge number of processes(e.g.,the sterol regulatory element-binding protein pathway and liver X receptor pathway)participate in the regulation of cholesterol metabolism in the brain via mechanisms that include cholesterol biosynthesis,intracellular transport,and *** brain injuries or diseases involving crosstalk among the processes above can affect normal cholesterol metabolism to induce detrimental ***,we hypothesized that cholesterol-related molecules and pathways can serve as therapeutic targets for central nervous system *** hemorrhage is the most severe hemorrhagic stroke subtype,with high mortality and *** cholesterol levels are associated with the risk of intracerebral ***,secondary pathological changes after intracerebral hemorrhage are associated with cholesterol metabolism dysregulation,such as neuroinflammation,demyelination,and multiple types of programmed cell *** cholesterol accumulation in the brain has been found after intracerebral *** this paper,we review normal cholesterol metabolism in the central nervous system,the mechanisms known to participate in the disturbance of cholesterol metabolism after intracerebral hemorrhage,and the links between cholesterol metabolism and cell *** also review several possible and constructive therapeutic targets identified based on cholesterol metabolism to provide cholesterol-based perspectives and a reference for those interested in the treatment of intracerebral hemorrhage.

关键词： cell death cholesterol metabolism intracerebral hemorrhage myelination therapeutic target