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Development and validation of novel inflammatory response-related gene signature for sepsis prognosis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2022年第12期23卷 1028-1041页

作者： Shuai JIANG Wenyuan ZHANG yuanqiang lu Department of Emergency Medicine the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China Zhejiang Provincial Key Laboratory for Diagnosis and Treatment of Aging and Physic-Chemical Injury Diseases Hangzhou 310003China Department of Anesthesiology and Intensive Care the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China

Due to the low specificity and sensitivity of biomarkers in sepsis diagnostics,the prognosis of sepsis patient outcomes still relies on the assessment of clinical symptoms.Inflammatory response is crucial to sepsis onset and progression;however,the significance of inflammatory response-related genes(IRRGs)in sepsis prognosis is uncertain.This study developed an IRRG-based signature for sepsis prognosis and immunological function.The Gene Expression Omnibus(GEO)database was retrieved for two sepsis microarray datasets,GSE64457 and GSE69528,followed by gene set enrichment analysis(GSEA)comparing sepsis and healthy samples.A predictive signature for IRRGs was created using least absolute shrinkage and selection operator(LASSO).To confirm the efficacy and reliability of the new prognostic signature,Cox regression,Kaplan-Meier(K-M)survival,and receiver operating characteristic(ROC)curve analyses were performed.Subsequently,we employed the GSE95233 dataset to independently validate the prognostic signature.A single-sample GSEA(ssGSEA)was conducted to quantify the immune cell enrichment score and immune-related pathway activity.We found that more gene sets were enriched in the inflammatory response in sepsis patient samples than in healthy patient samples,as determined by GSEA.The signature of nine IRRGs permitted the patients to be classified into two risk categories.Patients in the low-risk group showed significantly better 28-d survival than those in the high-risk group.ROC curve analysis corroborated the predictive capacity of the signature,with the area under the curve(AUC)for 28-d survival reaching 0.866.Meanwhile,the ss GSEA showed that the two risk groups had different immune states.The validation set and external dataset showed that the signature was clinically predictive.In conclusion,a signature consisting of nine IRRGs can be utilized to predict prognosis and influence the immunological status of sepsis patients.Thus,intervention based on these IRRGs may become a therapeutic option in the future.

关键词： Gene signature Inflammatory response-related gene(IRRG) Prognosis Immune function Sepsis

Perforation of the esophagus:an overlooked cause of chest pain as a complication of esophageal foreign bodies

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第5期24卷 455-457页

作者： Chengfan QIN Yunmei YANG yuanqiang lu Department of Geriatric and Emergency Medicine the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Key Laboratory for Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases of Zhejiang Province Hangzhou 310003China

Chest pain is one of the most common complaints in the emergency department.Diseases of the heart,aorta,lungs,esophagus,stomach,mediastinum,pleura,and abdominal viscera can all cause chest discomfort(Gulati et al.,202... 详细信息

关键词： esophagus pain

Inflammatory granuloma of the trachea: a rare case with Epstin-Barr virus infection

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第6期24卷 539-542页

作者： Zhaodi WANG Xuan lu Yunmei YANG yuanqiang lu DepartmentofGeriatricandEmergency Medicine theFirst Affiliated Hospital.Zhejiang University Schoolof MedicineHangzhou310003 China Key Laboratoryfor Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases of Zhejiang Province Hangzhou310003.China

Epstein-Barr virus(EBV),a double-stranded DNA virus with an envelope,is a ubiquitous pathogen that is prevalent in humans,although most people who contract it do not develop symptoms(Kerr,2019).While the primary cells EBV attacks are epithelial cells and B lymphocytes,its target range expands to a variety of cell types in immunodeficient hosts.Serological change occurs in 90%of infected patients.Therefore,immunoglobulin M(IgM)and IgG,serologically reactive to viral capsid antigens,are reliable biomarkers for the detection of acute and chronic EBV infections(Cohen,2000).Symptoms of EBV infection vary according to age and immune status.

关键词： infection acute granuloma

Isolated superior mesenteric artery rupture caused by abdominal trauma

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2022年第12期23卷 1065-1068页

作者： Ping WANG Congying SONG yuanqiang lu Department of Emergency Medicine the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China The Key Laboratory for Diagnosis and Treatment of Aging and Physicochemical Injury Diseases of Zhejiang Province Hangzhou 310003China

The superior mesenteric artery(SMA)is one of the visceral branches of the abdominal aorta.It has multiple branches to supply blood and nutrition to the intestinal segment,and these form an anastomosis with each other.SMA injuries are usually classified as major visceral artery injuries,and have an incidence oflude intra-abdominal bleeding and peritoneal irritation.The compromised blood supply can lead to intestinal ischemia and perforation.These injuries are often not diagnosed in time and have significant mortality rates of 25%-68%due to the lack of specific features(Maithel et al.,2020).Not only that,but patients with less severe trauma or no visible damage on initial examination may still have clinically significant intra-abdominal injuries(Nishijima et al.,2012).Emergency departments often encounter multiple cases that require urgent diagnosis and treatment(Li et al.,2021;Zhang et al.,2021;Zhou et al.,2021),and therefore,it is imperative to diagnose and manage these rare injuries expeditiously.

关键词： trauma rupture diagnosis

Uncovering the potential pathological mechanism of acute pancreatitis in patients with COVID-19 by bioinformatics methods

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World Journal of Emergency Medicine 2023年第5期14卷 397-401页

作者： Zhaodi Wang Ping Wang Xuan lu Congying Song Shuai Jiang Li Li yuanqiang lu Department of Nursing the First Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310003China Department of Geriatric and Emergency medicine the First Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310003China Key Laboratory for Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases of Zhejiang Province Hangzhou 310003China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has posed a serious challenge to emergency departments that usually encounter emergencies and severe diseases.[1-5]Angiotensin-converting enzyme 2(ACE2),a protein that interacts with the viral spike protein(s),allows SARS-CoV-2 to penetrate epithelial cells.[6]There is mounting evidence that suggests that the digestive system may also be affected.[7]An observational study described potential patterns of pancreatic injury(elevated amylase and lipase)in patients with coronavirus disease 2019(COVID-19).[8]Additionally,sporadic case reports have described secondary pancreatitis in patients with SARS-CoV-2 infection and presented imaging evidence.[9]Moreover,a previous study showed that COVID-19 patients not only have a higher risk of developing acute pancreatitis(AP),but also have a significantly higher mortality than those without COVID-19.[10]Using bioinformatics analysis,it may be possible to reveal how COVID-19 and AP are related.In this study,two RNA-seq datasets of SARS-CoV-2 and AP were selected for analysis.

关键词： patients pancreatitis acute

Development and validation of a predictive nomogram for sarcopenia among older people in China

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Chinese Medical Journal 2023年第6期136卷 752-754页

作者： Yichen Yang Congying Song Qin Zhang Caihong He Yunmei Yang yuanqiang lu Department of Geriatric and Emergency Medicine The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiang 310003China Key Laboratory of Diagnosis and Treatment of Aging and Physic-Chemical Injury Diseases of Zhejiang Province The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiang 310003China

To the Editor:Sarcopenia is defined as age-related loss of skeletal musclemass and strength,with an incidence of5%to 13%in persons aged>60 years.[1]Sarcopenia is considered a major contributor of frailty in the elderly,and frailty is reported to be associated withpoor outcomes of older people.Sarcopenia can also increase the risk of falls and fractures.

关键词： skeletal elderly incidence

Peripheral nerve injury in patients exposed to n-hexane:an analysis of eight cases

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2021年第3期22卷 248-252页

作者： Xiaping ZHANG Yaling TONG yuanqiang lu Department of Emergency Medicine the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou310003China Zhejiang Provincial Key Laboratory for Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou310003China

Poisoning is often characterized by the acute onset,rapid progress,or specific manifestations of pathological symptoms,such as pulmonary fibrosis due to paraquat poisoning or high mortality arising from dinitrophenol intoxication (Jiang et al.,2016;Wang et al.,2017;Feng et al.,2018;lu,2018;Xu and lu,2019).Unlike general poisoning,however,the manifestation of n-hexane intoxication is subacute,and its clinical symptoms are dormant,and thus the provision of a timely and correct diagnosis is often difficult.

关键词： al. diagnosis mortality

基于精品课程建设的混合式教学模式在留学生急诊医学中的应用探索

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全科医学临床与教育 2024年第6期22卷 533-536页

作者：陆远强冯梦晓浙江大学医学院附属第一医院急诊科、全省理化与增龄损伤性疾病诊治研究重点实验室浙江杭州310003

目的探索基于精品课程建设的混合式教学模式在留学生急诊医学中的应用效果。方法选择2017级和2018级临床医学专业本科留学生为研究对象,其中72名2017级留学生设为对照组,70名2018级留学生设为实验组。对照组采用传统灌输式线上教学模式... 详细信息

目的探索基于精品课程建设的混合式教学模式在留学生急诊医学中的应用效果。方法选择2017级和2018级临床医学专业本科留学生为研究对象,其中72名2017级留学生设为对照组,70名2018级留学生设为实验组。对照组采用传统灌输式线上教学模式,实验组采用基于精品课程建设的混合式教学模式。课程结束后,比较两组留学生的理论考核成绩、期末总成绩和教学满意度情况。结果实验组留学生的理论考核成绩以及期末总成绩均明显高于对照组,差异均有统计学意义(t=-2.42,Z=-2.25,P均<0.05)。实验组留学生对混合教学模式的满意度明显高于对照组,差异有统计学意义(u=5.08,P<0.05)。结论基于精品课程建设的混合式教学模式在留学生急诊医学教学中具有显著的优越性,可提高学生的考核成绩和课程满意度。为提升留学生教学质量,打造在华留学生急诊医学精品课程奠定一定的基础。

关键词：急诊医学留学生混合式教学精品课程

Promoting rapid development of Chinese minimally invasive medicine journals

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Laparoscopic, Endoscopic and Robotic Surgery 2019年第2期2卷 47-49页

作者： Li Ma Xiaojun He yuanqiang lu Editorial Department of Chinese Journal of Critical Care Medicine the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Editorial Department of Chinese Journal ofEmergencyMedicine the Second Affiliated HospitalZhejiangUniversity School ofMedicineHangzhou 310009China

In recent years,the development of Chinese scientific journals does not match the scientific development in China,especially in the field of minimally invasive surgery medicine.Scientific journals of minimally invasive medicine in China face competition not only from other traditional journals at home and abroad,but also from new media.Journals of minimally invasive medicine should be more creative,find innovative business solutions,attract professional manuscripts,and even incentivize people to contribute to projects.By doing so,we can constantly improve journals'influence,transmission,guidance and credibility in step with the pace of rapid advances in technology.

关键词： Minimally invasive medicine Scientific journal Development