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中国东中西部城市群高质量发展评价及比较研究

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区域经济评论 2021年第6期 148-156页

作者：王元亮河南省社会科学院郑州450002

从经济发展、科技创新、生态可持续和社会民生维度构建东中西部城市群高质量发展评价指标体系,综合运用AHP-熵权法和TOPSIS法对长三角、中原、关中三大城市群进行实证分析。研究结果表明:2010—2020年,我国城市群高质量发展水平稳步提高... 详细信息

从经济发展、科技创新、生态可持续和社会民生维度构建东中西部城市群高质量发展评价指标体系,综合运用AHP-熵权法和TOPSIS法对长三角、中原、关中三大城市群进行实证分析。研究结果表明:2010—2020年,我国城市群高质量发展水平稳步提高,呈现由西向东的梯度上升态势,三大城市群之间高质量发展水平差异较大,高质量发展水平越高的城市群结构特征越显著,三大城市群子指数与高质量发展指数大体一致,但也具有一定的不均衡性,城市群内部核心城市与周边城市形成较为明显的发展落差。未来,应从立足发展阶段着力补齐短板,创新驱动产业结构升级,推动资源要素流通和区域联动,以都市圈为抓手支撑城市群高质量发展,提高生态环境保护治理水平等方面推动三大城市群高质量发展。

关键词：城市群高质量发展评价比较 TOPSIS法

国家中心城市建设背景下郑州市综合承载能力评价研究

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生态经济 2019年第2期35卷 114-117,154页

作者：王元亮河南省社会科学院科研处河南郑州450002

文章在系统分析城市综合承载能力评价研究进展的基础上,构建了郑州市综合承载能力评价指标体系和城市综合承载能力仿真模型。综合运用主成分分析方法和系统动力学分析了2003—2025年郑州市综合承载能力。结果显示:2003—2016年,郑州市... 详细信息

文章在系统分析城市综合承载能力评价研究进展的基础上,构建了郑州市综合承载能力评价指标体系和城市综合承载能力仿真模型。综合运用主成分分析方法和系统动力学分析了2003—2025年郑州市综合承载能力。结果显示:2003—2016年,郑州市综合承载能力指数呈现先下降后上升的总体趋势,到2016年处在略微盈余状态。2017—2025年,设定的4种方案中,协调发展型发展方案基本能够满足郑州市建设国家中心城市主要指标的需要,但同时必须兼顾环境保护型发展方案以提高城市综合承载能力,实现郑州市的可持续发展。最后提出转变城市发展模式、优化城市空间格局、完善交通基础设施等郑州市加快国家中心城市建设的对策建议。

关键词：城市综合承载能力系统动力学仿真预测郑州市

CRABP2 regulates infiltration of cancer-associated fibroblasts and immune response in melanoma

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Oncology Research 2024年第2期32卷 261-272页

作者： SHUANGSHUANG ZENG XI CHEN QIAOLI YI ABHIMANYU THAKUR HUI YANG yuanliang YAN SHAO LIU Department of Pharmacy Xiangya HospitalCentral South UniversityChangsha410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha410008China Pritzker School of Molecular Engineering Ben May Department for Cancer ResearchUniversity of ChicagoChicagoILUSA Department of Pathology The Second Affiliated Hospital of Shandong First Medical UniversityTaian271000China

Finding biomarkers for immunotherapy is an urgent issue in cancer *** retinoic acid-binding protein 2(CRABP2)is a controversial factor in the occurrence and development of human ***,there is limited research on the relationship between CRABP2 and immunotherapy *** study found that negative correlations of CRABP2 and immune checkpoint markers(PD-1,PD-L1,and CTLA-4)were observed in breast invasive carcinoma(BRCA),skin cutaneous melanoma(SKCM),stomach adenocarcinoma(STAD)and testicular germ cell tumors(TGCT).In particular,in SKCM patients who were treated with PD-1 inhibitors,high levels of CRABP2 predicted poor ***,CRABP2 expression was elevated in cancer-associated fibroblasts(CAFs)at the single-cell *** expression of CRABP2 was positively correlated with markers of CAFs,such as MFAP5,PDPN,ITGA11,PDGFRα/βand THY1 in *** validate the tumor-promoting effect of CRABP2 in vivo,SKCM xenograft mice models with CRABP2 overexpression have been *** models showed an increase in tumor weight and *** analysis indicated that CRABP2 may be involved in immunerelated pathways of SKCM,such as extracellular matrix(ECM)receptor interaction and epithelial-mesenchymal transition(EMT).The study suggests that CRABP2 may regulate immunotherapy in SKCM patients by influencing infiltration of *** conclusion,this study provides new insights into the role of CRABP2 in immunotherapy *** findings suggest that CRABP2 may be a promising biomarker for PD-1 inhibitors in SKCM *** research is needed to confirm these findings and to explore the clinical implications of CRABP2 in immunotherapy.

关键词： CRABP2 Melanoma PD-1 Cancer-associated fibroblasts Immune infiltration

Research on Broadband RF Chip for High-precision GNSS Application

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Research on Broadband RF Chip for High-precision GNSS Applic...

第十一届中国卫星导航年会

作者： Ji Guo Kunmei Cao Xiaowei Cui Weiguang Gao yuanliang wang Kun Jiang Beijing Institute of Tracking and Telecommunications Technology Tsinghua University ByteDance Ltd.

Satellite navigation system concerns the national economy and people’s livelihood. Especially, the applications of high-precision GNSS have an increasingly important impact on people’s daily life. Hig

关键词： High-precision GNSS Broadband RF Chip Development Route

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丙交酯的合成与聚合

化工新型材料 2005年第4期33卷 20-21,19页

作者：朱久进王远亮重庆大学生物工程学院生物力学与组织工程教育部重点实验室重庆400044

丙交酯是由乳酸合成聚乳酸的中间体,采用新型La Ti复合氧化物催化乳酸合成丙交酯,粗丙交酯经乙酸乙酯纯化后,差热分析仪测得其熔点为126 4℃,纯化后的丙交酯在一定条件下,经辛酸亚锡引发,开环聚合成聚乳酸,并用红外光谱和差热分析仪对... 详细信息

丙交酯是由乳酸合成聚乳酸的中间体,采用新型La Ti复合氧化物催化乳酸合成丙交酯,粗丙交酯经乙酸乙酯纯化后,差热分析仪测得其熔点为126 4℃,纯化后的丙交酯在一定条件下,经辛酸亚锡引发,开环聚合成聚乳酸,并用红外光谱和差热分析仪对聚乳酸进行了表征。

关键词：丙交酯合成差热分析仪聚合复合氧化物聚乳酸乙酸乙酯辛酸亚锡红外光谱中间体纯化

CGG repeat expansion in LOC642361/NUTM2B-AS1 typically presents as oculopharyngodistal myopathy

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Journal of Genetics and Genomics 2024年第2期51卷 184-196页

作者： Yan Shi Chunyan Cao Yiheng Zeng yuanliang Ding Long Chen Fuze Zheng Xuejiao Chen Fanggui Zhou Xiefeng Yang Jinjing Li Liuqing Xu Guorong Xu Minting Lin Hiroyuki Ishiura Shoji Tsuji Ning wang Zhiqiang wang Wan-Jin Chen Kang Yang Department of Neurology and Institute of Neurology of First Affiliated Hospital Institute of NeuroscienceFujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhouFujian 350005China Department of Neurology National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian 350212China The First Affiliated Hospital College of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan 471000China Department of Neurology Zhangzhou Municipal Hospital of Fujian Province and Zhangzhou Affiliated Hospital of Fujian Medical UniversityZhangzhouFujian 363000China Department of Neurology Jian'ou Municipal Hospital of Fujian ProvinceJian'ouFujian 353100China Department of Radiology First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian 350005China Department of Neurology Graduate School of MedicineThe University of TokyoTokyo 113-8655Japan Department of Neurology Okayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama 700-8558Japan Institute of Medical Genomics International University of Health and WelfareChiba 286-0048Japan

CGG repeat expansions in LOC642361/NUTM2B-AS1 have recently been identified as a cause of oculopharyngeal myopathy with ***,since only three patients from a single family were reported,it remains unknown whether their clinicopathological features are typical for CGG repeat expansions in LOC642361/***,using repeat-primed-polymerase chain reaction and long-read sequencing,we identify 12 individuals from 3 unrelated families with CGG repeat expansions in LOC642361/NUTM2B-AS1,typically presenting with oculopharyngodistal *** CGG repeat expansions range from 161 to 669 repeat *** of the patients present with ptosis,restricted eye movements,dysphagia,dysarthria,and diffuse limb muscle *** one patient shows T2-weighted hyperintensity in the cerebellar white matter surrounding the deep cerebellar nuclei on brain magnetic resonance *** biopsies from three patients show a myopathic pattern and rimmed *** of muscle biopsies suggest that CGG repeat expansions in LOC642361/NUTM2B-AS1 may deleteriously affect aggrephagic capacity,suggesting that RNA toxicity and mitochondrial dysfunction may contribute to *** study thus expands the phenotypic spectrum for the CGG repeat expansion of LOC642361/NUTM2B-AS1 and indicates that this genetic variant typically manifests as oculopharyngodistal myopathy with chronic myopathic changes with rimmed vacuoles and filamentous intranuclear inclusions in muscle fibers.

关键词： Oculopharyngeal myopathy with leukoencephalopathy Oculopharyngodistal myopathy CGG repeat expansion Rimmed vacuoles

Multi-omics analysis reveals the pivotal role of phytohormone homeostasis in regulating maize grain water content

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The Crop Journal 2024年第4期12卷 1081-1092页

作者： yuanliang Liu Manman Li Jianju Liu Suining Deng Yan Zhang Yuanfeng Xia Baoshen Liu Mingliang Xu State Key Laboratory of Plant Environmental Resilience/College of Agronomy and Biotechnology/National Maize Improvement Center/Center for Crop Functional Genomics and Molecular Breeding China Agricultural UniversityBeijing 100193China College of Agronomy/State Key Laboratory of Crop Biology Shandong Agricultural UniversityTai’an 271018ShandongChina Institute of Agricultural Biotechnology Jilin Academy of Agricultural SciencesGongzhuling 136100JilinChina Maize Research Institute Jilin Academy of Agricultural SciencesGongzhuling 136100JilinChina

Grain water content(GWC)is a key determinant for mechanical harvesting of maize(Zea mays).In our previous research,we identified a quantitative trait locus,qGWC1,associated with GWC in ***,we examined near-isogenic lines(NILs)NILL and NILH that differed at the qGWC1 *** GWC in NILL was primarily attributed to reduced grain water weight(GWW)and smaller fresh grain size,rather than the accumulation of dry *** difference in GWC between the NILs became more pronounced approximately 35 d after pollination(DAP),arising from a faster dehydration rate in *** an integrated analysis of the transcriptome,proteome,and metabolome,coupled with an examination of hormones and their derivatives,we detected a marked decrease in JA,along with an increase in cytokinin,storage forms of IAA(IAA-Glu,IAA-ASP),and IAA precursor IPA in immature NILL *** kernel development,genes associated with sucrose synthases,starch biosynthesis,and zein production in NILL,exhibited an initial up-regulation followed by a gradual down-regulation,compared to those in *** discovery highlights the crucial role of phytohormone homeostasis and genes related to kernel development in balancing GWC and dry matter accumulation in maize kernels.

关键词： Grain water content Maize kernel Phytohormone homeostasis

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聚乳酸材料的仿生修饰研究进展

材料导报 2009年第23期23卷 39-42页

作者：周熙云王远亮重庆大学生物工程学院生物材料与仿生工程研究中心生物流变科学与技术教育部重点实验室重庆400030

聚乳酸是生物可降解、生物相容性材料,但由于存在亲水性差、缺乏细胞识别位点等缺陷,限制了其在生物医学工程中的应用。模拟细胞与基质相互作用的特点以及细胞外基质的特性,通过表面修饰、本体改性和复合加工的方法在聚乳酸中引入蛋白... 详细信息

聚乳酸是生物可降解、生物相容性材料,但由于存在亲水性差、缺乏细胞识别位点等缺陷,限制了其在生物医学工程中的应用。模拟细胞与基质相互作用的特点以及细胞外基质的特性,通过表面修饰、本体改性和复合加工的方法在聚乳酸中引入蛋白胶原、活性肽、多糖以及羟基磷灰石等生物活性分子,实现聚乳酸的仿生修饰,能够有效提高聚乳酸材料的生物学功能。综述了利用这些生物活性分子对聚乳酸进行仿生修饰的研究进展。

关键词：聚乳酸仿生表面修饰本体改性复合

棉布支架固定化米根霉联产果胶酶及用于处理烟梗

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化工进展 2016年第5期35卷 1494-1501页

作者：何源郑羽西潘君王远亮生物流变科学与技术教育部重点实验室生物材料与仿生工程中心重庆大学生物工程学院重庆400044

利用果胶酶处理烟梗纤维生产乳酸等对环境友好,而应用新的发酵组合方式和优化发酵条件是提高产酶量,降低成本的有效途径。本文采用实验室研发的棉布支架固定化米根霉细胞的技术,优化了底物为果胶或烟梗的发酵产果胶酶的培养条件,还优化... 详细信息

利用果胶酶处理烟梗纤维生产乳酸等对环境友好,而应用新的发酵组合方式和优化发酵条件是提高产酶量,降低成本的有效途径。本文采用实验室研发的棉布支架固定化米根霉细胞的技术,优化了底物为果胶或烟梗的发酵产果胶酶的培养条件,还优化了处理烟梗果胶的条件。底物为果胶的最佳产酶条件为：转速190r/min,装液量50m L/250m L,发酵温度30℃,初始p H值5,初始孢子浓度0.75×10^6个/m L。底物为烟梗的最佳产酶条件为：初始p H值4.6、初始孢子浓度0.5×10^6个/m L等。在优化处理烟梗果胶的条件下,固定化米根霉产果胶酶连续法比游离的果胶酶法降解烟梗果胶的效果好,果胶降解率提高18.5%,达到74.1%。棉布支架固定化米根霉利用果胶发酵产果胶酶量较高,利用烟梗发酵脱胶效果较好。

关键词：米根霉果胶酶固定化生物脱胶烟梗