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还原条件下非对称钳形PNN钴配合物的反应性研究

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化学学报 2024年第5期82卷 471-476页

作者：陈元金黄大江石向辉席振峰魏俊年北京大学化学与分子工程学院、北京分子科学国家研究中心、生物有机与分子工程教育部重点实验室北京100871

本工作报道了还原条件下,非对称钳形钴配合物PNNCoCl(1)(PNN:[6-(^(t)Bu_(2)PN)C_(5)H_(3)N-2-(3-Mes)C_(3)H_(2)N_(2)])和有机分子的反应性.利用PNNCoCl、还原剂与异腈或一氧化碳反应,实现了异腈和一氧化碳配位一价钴配合物2和3的合成.通过更换还原剂,实现了偶氮苯C—H、N=N键的选择性断裂反应.当使用石墨钾作为还原剂时,PNNCoCl(1)与偶氮苯在四氢呋喃中反应,得到偶氮苯C—H键断裂产物5;而当使用KHBEt_(3)作为还原剂时,PNNCoCl与偶氮苯反应,则能得到偶氮苯N=N键断裂产物PNNCoNHPh(6).此外,PNNCoCl(1)还可以与卡宾或邻苯醌反应,得到了相应配合物4和7.这些配合物均通过了X射线衍射、元素分析、红外光谱和溶液相磁化率测试等表征.

关键词：钳形配体钴配合物小分子活化低价金属配合物

Bioinspired Surfaces Derived from Acoustic Waves for On-Demand Droplet Manipulations

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Research 2024年第3期2023卷 613-620页

作者： Zhuhao Wu Lingyu Sun Hanxu chen yuanjin Zhao Department of Rheumatology and Immunology Nanjing Drum Tower HospitalSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhouZhejiang 325001China Chemistry and Biomedicine Innovation Center Nanjing UniversityNanjing 210023China.

The controllable manipulation and transfer of droplets are fundamental in a wide range of chemical reactions and even life processes. Herein, we present a novel, universal, and straightforward acoustic approach to fabricating biomimetic surfaces for on-demand droplet manipulations like many natural creatures. Based on the capillary waves induced by surface acoustic waves, various polymer films could be deformed into pre-designed structures, such as parallel grooves and grid-like patterns. These structured and functionalized surfaces exhibit impressive ability in droplet transportation and water collection, respectively. Besides these static surfaces, the tunability of acoustics could also endow polymer surfaces with dynamic controllability for droplet manipulations, including programming wettability, mitigating droplet evaporation, and accelerating chemical reactions. Our approach is capable of achieving universal surface manufacturing and droplet manipulation simultaneously, which simplifies the fabrication process and eliminates the need for additional chemical modifications. Thus, we believe that our acoustic-derived surfaces and technologies could provide a unique perspective for various applications, including microreactor integration, biochemical reaction control, tissue engineering, and so on.

关键词： straight eliminate acoustics

Engineered stem cells by emerging biomedical stratagems

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Science Bulletin 2024年第2期69卷 248-279页

作者： Jinglin Wang Xiaoxuan Zhang Hanxu chen Haozhen Ren Min Zhou yuanjin Zhao Department of Vascular Surgery.Nanjing Drum Tower Hospital Affliated Hospital of Medical SchoolNanjing UniversityNanjing 210008China Division of Hepatobiliary Surgery and Transplantation Surgery Department of General SurgeryNanjing Drum Tower HospitalSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Shenzhen Research Institute Southeast UniversityShenzhen 518038China

Stem cell therapy holds immense potential as a viable treatment for a widespread range of intractable *** the safety of stem cell transplantation having been demonstrated in numerous clinical trials,various kinds of stem cells are currently utilized in medical *** the achievements,the therapeutic benefits of stem cells for diseases are limited,and the data of clinical researches are *** optimize tthe effectiveness of stem cells,engineering approaches have been developed to enhance their inherent abilities and impart them with new functionalities,paving the way for the next generation of stem cell *** review offers a detailed analysis of engineered stem cells,including their clinical applications and potential for future *** begin by briefly introducing the recent advances in the production of stem cells(induced pluripotent stem cells(ipsCs),embryonic stem cells(ESCs),mesenchymal stem cells(MSCs)and hematopoietic stem cells(HSCs).Furthermore,we present the latest developments of engineered strategies in stem cells,including engineered methods in molecular biology and biomaterial fields,and their application in biomedical ***,we summarize the current obstacles and suggest future prospects for engineered stem cells in clinical translations and biomedical applications.

关键词： Stem cells Genetic modification Biomaterials Microfluidics Organ-on-a-chip Bioprinting

Spatial tumor biopsy with fluorescence PCR microneedle array

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The Innovation 2024年第1期5卷 26-32页

作者： Xiaoxuan Zhang Guopu chen Yu Wang yuanjin Zhao Department of Rheumatology and Immunology Nanjing Drum Tower HospitalSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325001China Chemistry and Biomedicine Innovation Center Nanjing UniversityNanjing 210023China

Biopsy is the gold standard for tumor diagnosis,as this technology provides highly detailed and reliable information on tumorigenesis and *** the discrete wettability of desert beetles,in this study,a fluorescence polymerase chain reaction(F-PCR)microneedle array(MNA)platform is developed for efficient spatial tumor *** MNA is fabricated by the coupled strategies of bottom-up self-assembly and top-down photolithography;it comprises a hydrophobic silica nanoparticle-assembled substrate and graphene aerogel-hydrogel hybrid microneedle *** from the hydrophilicity and absorption capacity of its graphene hybrid microneedle peaks,MNA can easily penetrate tissue specimens and collect tumor nucleic acid biomarkers *** addition,because of the discrete wettability of the platform,both tissue fluids and PCR liquids can be easily removed from the substrate,and each microneedle peak is similar to an independent island for directly conducting F-PCR reactions for tumor marker *** on these advantages,the F-PCR-MNA platform is demonstrated to be ideal for detecting DNA biomarkers of lung carcinoma in standard solutions,mouse tissue samples,and clinical specimens,thus indicating its practical potential as an innovative tumor biopsy system.

关键词： needle biopsy diagnosis

Synthesis of pyrimidines from dinitrogen and carbon

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National Science Review 2022年第12期9卷 220-226页

作者： Xianghui Shi Qianru Wang Chao Qin Li-Jun Wu yuanjin chen Gao-Xiang Wang Yongli Cai Wenbo Gao Teng He Junnian Wei Jianping Guo Ping chen Zhenfeng Xi Beijing National Laboratory for Molecular Sciences(BNLMS) Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationCollege of ChemistryPeking University Dalian Institute of Chemical Physics Chinese Academy of Sciences University of Chinese Academy of Sciences State Key Laboratory of Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences

The element nitrogen and nitrogenous compounds are vital to *** synthesis of nitrogen-containing compounds using dinitrogen as the nitrogen source,not through ammonia,is of great interest and great value but remains a grand ***,we describe a strategy to realize this transformation by combining the heterogeneous approach with the homogeneous *** N2molecule was first fixed with carbon and LiH through a one-pot heterogeneous process,forming Li2CN2as an ’activated’nitrogen source with high *** subsequent homogeneous treatments of Li2CN2to construct the organic synthon carbodiimide and the RNA/DNA building block pyrimidines were *** using15N2as the feedstock,their corresponding15N-labeled carbodiimide and pyrimidines were readily *** homogeneous-heterogeneous synergy strategy will open a new chapter for N2transformation.

关键词： dinitrogen transformation nitrogen fixation N-C bond formation homogeneous-heterogeneous synergy strategy 15n-labeled pyrimidines

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赤芍抗炎活性的物质基础及作用机制研究进展

中医药信息 2024年第2期41卷 87-93页

作者：倪嘉挺袁旭曹庆宇庞成国陈元金韩华董培良黑龙江中医药大学黑龙江哈尔滨150040 黑龙江中医药大学中医药研究院黑龙江哈尔滨150040

炎症是生物组织受到某种刺激,如外伤、感染等损伤因子的刺激所发生的一种以防御反应为主的基本病理过程,炎症的发展可能导致局部组织的变异和增生,从而进一步加速疾病发展。赤芍作为常用的中药材之一,具有清热凉血,散瘀止痛的功效。笔... 详细信息

炎症是生物组织受到某种刺激,如外伤、感染等损伤因子的刺激所发生的一种以防御反应为主的基本病理过程,炎症的发展可能导致局部组织的变异和增生,从而进一步加速疾病发展。赤芍作为常用的中药材之一,具有清热凉血,散瘀止痛的功效。笔者通过综述近期国内外关于赤芍抗炎活性的物质基础及其作用机制的相关文献,发现赤芍中的萜类、挥发油、酚酸、黄酮类、鞣质等多种化学成分通过AMPK、MAPK、NF-κB、STAT6和HO-1信号通路发挥抗炎作用,从而治疗结肠炎、关节炎、乳腺炎和角膜炎等相关炎症疾病。

关键词：赤芍抗炎物质基础作用机制综述

Deformation monitoring of long-span railway bridges based on SBAS-InSAR technology

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Geodesy and Geodynamics 2024年第2期15卷 122-132页

作者： Lv Zhou Xinyi Li yuanjin Pan Jun Ma cheng Wang Anping Shi Yukai chen College of Geomatics and Geoinformation Guilin University of TechnologyGuilin 541004China Hubei Luo Jia Laboratory Wuhan 430079China Ecological Spatiotemporal Big Data Perception Service Laboratory Guilin 541004China School of Geodesy and Geomatics Wuhan UniversityWuhan 430079China China Railway Siyuan Survey and Design Group Co. Ltd.Wuhan 430063China

The deformation monitoring of long-span railway bridges is significant to ensure the safety of human life and *** interferometric synthetic aperture radar(In SAR)technology has the advantage of high accuracy in bridge deformation *** study monitored the deformation of the Ganjiang Super Bridge based on the small baseline subsets(SBAS)In SAR technology and Sentinel-1A *** analyzed the deformation results combined with bridge structure,temperature,and riverbed sediment *** results are as follows:(1)The Ganjiang Super Bridge area is stable overall,with deformation rates ranging from-15.6 mm/yr to 10.7 mm/yr(2)The settlement of the Ganjiang Super Bridge deck gradually increases from the bridge tower toward the main span,which conforms to the typical deformation pattern of a cable-stayed bridge.(3)The sediment scouring from the riverbed cause the serious settlement on the bridge’s east side compared with that on the west side.(4)The bridge deformation negatively correlates with temperature,with a faster settlement at a higher temperature and a slow rebound trend at a lower *** study findings can provide scientific data support for the health monitoring of long-span railway bridges.

关键词： SBAS-InSAR Long-span railway bridge Deformation monitoring Bridge structure Time series deformation

积极心理资本在医学生线上学习投入度和自我导向学习能力间的中介效应

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中国高等医学教育 2024年第4期 52-54页

作者：张红陈元金程玲万籽山马玉凤唐惠艳何佳琪连学敏天津天狮学院医学院天津301700 海南省第三卫生学校海南琼海571400 天津医科大学总医院天津300052

目的:探讨积极心理资本在民办高校医学生线上学习投入度和自我导向学习能力的中介效应。方法:整群抽取天津市某民办高校医学院在线学习的学生进行问卷调查,回收有效问卷483份。采用Pearson相关分析探究积极心理资本、学习投入度和自我... 详细信息

目的:探讨积极心理资本在民办高校医学生线上学习投入度和自我导向学习能力的中介效应。方法:整群抽取天津市某民办高校医学院在线学习的学生进行问卷调查,回收有效问卷483份。采用Pearson相关分析探究积极心理资本、学习投入度和自我导向学习能力的关系,并拟合结构方程模型。结果:医学生学习投入度总分和各维度得分与积极心理资本得分、自我导向学习能力得分均呈正相关关系(r=0.253~0.824,P<0.01)。SEM结果显示,积极心理资本、自我导向学习能力对学习投入度的路径系数分别为β=0.844、β=0.426(P均<0.01);Bootstrap检验显示,积极心理资本在自我导向学习能力与学习投入度之间起部分中介作用(P<0.01)。结论:自我导向学习能力及积极心理资本均能正向预测民办高校医学生的线上学习投入度,且自我导向学习能力通过积极心理资本的中介作用影响学习投入度。

关键词：线上学习学习投入度自我导向学习能力积极心理资本中介效应

葛根芩连汤加味保留灌肠结合综合护理治疗湿热型溃疡性结肠炎

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光明中医 2016年第23期31卷 3506-3507页

作者：陈源金江西省赣州市南康区第一人民医院急诊科赣州341400

目的对葛根芩连汤加味保留灌肠治疗湿热型溃疡性结肠炎的护理措施和护理效果进行分析与探究。方法选取我院75例经过葛根芩连汤加味保留灌肠治疗湿热型溃疡性结肠炎患者作为研究对象,其入院时间均在2013年4月—2014年7月期间,用计算机随... 详细信息

目的对葛根芩连汤加味保留灌肠治疗湿热型溃疡性结肠炎的护理措施和护理效果进行分析与探究。方法选取我院75例经过葛根芩连汤加味保留灌肠治疗湿热型溃疡性结肠炎患者作为研究对象,其入院时间均在2013年4月—2014年7月期间,用计算机随机分组的方式将以上患者分为2组,分别为试验组与对照组,其中试验组有38例患者,对照组有37例患者,其中给予对照组患者常规护理,试验组患者则在常规护理的基础上实施综合护理,对两组患者护理前后的中医症状评分进行分析对比。结果试验组患者护理前的中医症状评分与对照组护理前对比无明显差异,P>0.05,护理后试验组患者的中医症状评分明显较对照组低,P<0.05。结论对葛根芩连汤加味保留灌肠治疗的湿热型溃疡性结肠炎患者实施综合护理的临床效果显著,值得在临床中进一步推广实施。

关键词：葛根芩连汤灌肠湿热型溃疡性结肠炎护理措施