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坍塌地层钻孔护壁与过溶洞钻孔隔离技术

江西煤炭科技 2009年第2期 78-79页

作者：孙远进温建丰红波皖北煤电集团安徽含山238100

0 引言2008年3月皖北煤电集团石膏矿I22回风巷迎头发生特大溃水.水害治理方案是沿I22巷道中轴面施工1#、2#、3#、5#地面注浆孔建造人工堵水塞并封闭溃破口.经过地面注浆,10000 m3/h以上的溃水和2000 m3/h动流量终被制服,堵水率为100%,... 详细信息

0 引言2008年3月皖北煤电集团石膏矿I22回风巷迎头发生特大溃水.水害治理方案是沿I22巷道中轴面施工1#、2#、3#、5#地面注浆孔建造人工堵水塞并封闭溃破口.经过地面注浆,10000 m3/h以上的溃水和2000 m3/h动流量终被制服,堵水率为100%,静水压恢复至4.1MPa.本文介绍4个注浆孔(平均透巷深度412 m)在钻探过程中严重塌孔和溶洞致使钻探轨迹偏离的处理技术.

关键词：隔离技术钻孔护壁溶洞地层坍塌地面注浆治理方案注浆孔

Biomimetic Gland Models with Engineered Stratagems

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Research 2024年第2期2023卷 583-612页

作者： Xiang Lin Lingyu sun Minhui Lu yuanjin Zhao Department of Rheumatology and Immunology Nanjng Drum Tower HospitalSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhouZhejiang 325001China Southeast University Shenzhen Research Institute Shenzhen 518071China

As extensively distributed tissues throughout the human body,glands play a critical role in various physiological ***,the construction of biomimetic gland models in vitro has aroused great interest in multiple *** the biological field,the researchers focus on optimizing the cell sources and culture techniques to reconstruct the specific structures and functions of glands,such as the emergence of organoid *** the perspective of biomedical engineering,the generation of biomimetic gland models depends on the combination of engineered scaffolds and microfluidics,to mimic the in vivo environment of glandular *** engineered stratagems endowed gland models with more biomimetic features,as well as a wide range of application *** this review,we first describe the biomimetic strategies for constructing different in vitro gland models,focusing on the role of microfluidics in promoting the structure and function development of biomimetic *** summarizing several common in vitro models of endocrine and exocrine glands,the applications of gland models in disease modelling,drug screening,regenerative medicine,and personalized medicine are ***,we conclude the current challenges and our perspective of these biomimetic gland models.

关键词： endowed constructing strata

Hierarchical Spinning of Janus Textiles with Anisotropic Wettability for Wound Healing

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Research 2024年第1期2023卷 97-105页

作者： Han Zhang Lingyu sun Jiahui Guo yuanjin Zhao Department of Rheumatology and Immunology Nanjing Drum Tower HospitalSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjingJiangsu 210096China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhouZhejiang 325001China

Wound healing and tissue repair are recognized as basic human health problems *** to accelerate the reparative process are focused on developing functional wound ***,we present novel Janus textiles with anisotropic wettability from hierarchical microfluidic spinning for wound *** hydrophilic hydrogel microfibers from microfluidics are woven into textiles for freeze-drying treatment,followed by the deposition of electrostatic spinning nanofibers composed of hydrophobic polylactic acid(PLA)and silver *** electrospun nanofiber layer can be well coupled with the hydrogel microfiber layer to generate Janus textiles with anisotropic wettability due to the roughness of the hydrogel textile surface and the incomplete evaporation of PLA solution when reaching the *** wound treatment with the hydrophobic PLA side contacting the wound surface,the wound exudate can be pumped from the hydrophobic to the hydrophilic side based on the wettability differential derived drainage *** this process,the hydrophobic side of the Janus textile can prevent excess fluid from infiltrating the wound again,preventing excessive moisture and preserving the breathability of the *** addition,the silver nanoparticles contained in the hydrophobic nanofibers could impart the textiles with good antibacterial effect,which further promote the wound healing *** features indicate that the described Janus fiber textile has great application potential in the field of wound treatment.

关键词： silver spinning healing

Microfluidic Generation of Multicomponent Soft Biomaterials

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Engineering 2022年第6期8卷 128-143页

作者： Yuetong Wang Luoran Shang yuanjin Zhao Lingyun sun Department of Rheumatology and Immunology Nanjing Drum Tower Hospital&School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China School of Food Science and Pharmaceutical Engineering Nanjing Normal UniversityNanjing 210046China Shanghai Xuhui Central Hospital&Zhongshan-Xuhui Hospital&Shanghai Key Laboratory of Medical Epigenetics&International Co-Laboratory of Medical Epigenetics and Metabolism of Ministry of Science and Technology Institutes of Biomedical SciencesFudan UniversityShanghai 200032China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)&Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325001China

Soft biomaterials hold great potential for a plethora of biomedical applications because of their deforma-bility,biodegradability,biocompatibility,high bioactivity,and low *** soft bio-materials are particularly attractive as a way of accommodating components made of different materials and generating combinative *** technology has emerged as an outstanding tool in generating multicomponent materials with elaborate structures and constituents,in that it can manipu-late multiphasic flows precisely on the micron *** recent decades,much progress has been achieved in the microfluidic fabrication of multicomponent soft biomaterials with finely defined physicochemical properties capable of controllable therapeutics delivery,three-dimensional(3D)cell culture,flexible devices and wearable electronics,and biosensing for *** the paper,we summarize current pro-gress in multicomponent soft biomaterials derived from microfluidics and emphasize their applications in biomedical *** also provide an outlook of the remaining challenges and future trends in this field.

关键词： Soft biomaterial Microfluidics Multicomponent Microparticle Microfiber

Bioinspired Surfaces Derived from Acoustic Waves for On-Demand Droplet Manipulations

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Research 2024年第3期2023卷 613-620页

作者： Zhuhao Wu Lingyu sun Hanxu Chen yuanjin Zhao Department of Rheumatology and Immunology Nanjing Drum Tower HospitalSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhouZhejiang 325001China Chemistry and Biomedicine Innovation Center Nanjing UniversityNanjing 210023China.

The controllable manipulation and transfer of droplets are fundamental in a wide range of chemical reactions and even life processes. Herein, we present a novel, universal, and straightforward acoustic approach to fabricating biomimetic surfaces for on-demand droplet manipulations like many natural creatures. Based on the capillary waves induced by surface acoustic waves, various polymer films could be deformed into pre-designed structures, such as parallel grooves and grid-like patterns. These structured and functionalized surfaces exhibit impressive ability in droplet transportation and water collection, respectively. Besides these static surfaces, the tunability of acoustics could also endow polymer surfaces with dynamic controllability for droplet manipulations, including programming wettability, mitigating droplet evaporation, and accelerating chemical reactions. Our approach is capable of achieving universal surface manufacturing and droplet manipulation simultaneously, which simplifies the fabrication process and eliminates the need for additional chemical modifications. Thus, we believe that our acoustic-derived surfaces and technologies could provide a unique perspective for various applications, including microreactor integration, biochemical reaction control, tissue engineering, and so on.

关键词： straight eliminate acoustics

Biomass Microcapsules with Stem Cell Encapsulation for Bone Repair

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Nano-Micro Letters 2022年第1期14卷 95-106页

作者： Lei Yang Yuxiao Liu Lingyu sun Cheng Zhao Guopu Chen yuanjin Zhao Department of Rheumatology and Immunology The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008People’s Republic of China Wenzhou Institute University of Chinese Academy of SciencesWenzhou 325001ZhejiangPeople’s Republic of China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou 325001ZhejiangPeople’s Republic of China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096People’s Republic of China

Bone defects caused by trauma,tumor,or osteoarthritis remain challenging due to the lack of effective treatments in *** cell transplantation has emerged as an alternative approach for bone repair and attracted widespread attention owing to its excellent biological activities and therapy *** attempts to develop this therapeutic approach focus on the generation of effective cell delivery vehicles,since the shortcomings of direct injection of stem cells into target ***,we developed a novel core-shell microcapsule with a stem cell-laden core and a biomass shell by using all-aqueous phase microfluidic electrospray *** designed core-shell microcapsules showed a high cell viability during the culture *** addition,the animal experiments exhibited that stem cell-laden core-shell microcapsules have good biocompatibility and therapeutic effect for bone *** study indicated that the core-shell biomass microcapsules generated by microfluidic electrospray have promising potential in tissue engineering and regenerative medicine.

关键词： Microcapsule Bone repair Stem cell therapy Microfluidics Electrospray

Bio-Inspired Screwed Conduits from the Microfluidic Rope-Coiling Effect for Microvessels and Bronchioles

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Engineering 2024年第10期41卷 172-178页

作者： Rui Liu Jiahui Guo Bin Kong Yunru Yu yuanjin Zhao Lingyun sun Department of Rheumatology and Immunology Institute of Translational MedicineNanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210002China Department of Rheumatology and Immunology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China

Tubular microfibers have recently attracted extensive interest for applications in tissue ***,the fabrication of tubular fibers with intricate hierarchical structures remains a major ***,we present a novel one-step microfluidic spinning method to generate bio-inspired screwed conduits(BSCs).Based on the microfluidic rope-coiling effect,a viscous hydrogel precursor is first curved into a helix stream in the channel,and then consecutively packed as a hollow structured stream and gelated into a screwed conduit(SC)via ionic and covalent *** taking advantage of the excellent fluid-controlling ability of microfluidics,various tubes with diverse structures are fabricated via simple control over fluid velocities and multiple microfluidic device *** perfusability and permeability results,as well as the encapsulation and culture of human umbilical vein endothelial cells(HUVECs),human pulmonary alveolar epithelial cells(HPAs),and myogenic cells(C2C12),demonstrate that these SCs have good perfusability and permeability and the ability to induce the formation of functional *** features support the uniqueness and potential applications of these BSCs as biomimetic blood vessels and bronchiole tissues in combination with tissue microstructures,with likely application possibilities in biomedical engineering.

关键词： Bio-inspired Microfluidics Microfiber Tissue engineering Bronchiole Vessel

Microfluidic generation of barcodes with in situ synthesized perovskite quantum dot encapsulation

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Science China Chemistry 2021年第9期64卷 1540-1546页

作者： Feika Bian Lingyu sun Yu Wang Dagan Zhang Zhiyang Li yuanjin Zhao Department of Clinical Laboratory Institute of Translational MedicineThe Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing210008China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing210096China

Perovskite quantum dots(PQDs)are new class of optoelectronic materials,which have been widely studied for their extraordinary physical *** to develop these materials are tending to make their fabrication much controllable and extend their values in different ***,we present a novel strategy for one-step in situ synthesis of PQD-encapsulated barcode particles with the assistance of microfluidic *** changing the halide ratio in perovskite precursor solutions that emulsified in microfluidic devices,a series of PQDs with different colors have been successfully fabricated,which made them ideal materials as *** of the stable encapsulation of ethyleneglycol dimethacrylate(EGDMA)resin,the PQD-encapsulated barcode particles were with no cytotoxicity and could be *** was demonstrated for the first time that the PQD-encapsutated barcode particles by microfluidics were valuable for multiplex biomolecular encoding and *** features indicate that the PQD-encapsutated barcode particles by microfluidics are ideal for many practical applications and have a broad prospect in biomedical field.

关键词： microfluidics droplet perovskite quantum dot barcode Janus

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MXene-Integrated Microneedle Patches with Innate Molecule Encapsulation for Wound Healing

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Research 2021年第1期2021卷 1236-1244页

作者： Lingyu sun Lu Fan Feika Bian Guopu Chen Yuetong Wang yuanjin Zhao Department of Rheumatology and Immunology The Affiliated Drum Tower Hospital of Nanjing University Medical School210008 NanjingChina State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China

Wound healing is a complex physiological process that involves coordinated phases such as inflammation and *** to promote the healing process tend to construct an effective delivery system based on different drugs and *** this paper,we propose novel MXene-integrated microneedle patches with adenosine encapsulation for wound *** to the dynamic covalent bonding capacity of boronate molecules with adenosine,3-(acrylamido)phenylboronic acid-(PBA-)integrated polyethylene glycol diacrylate(PEGDA)hydrogel is utilized as the host material of microneedle *** from photothermal conversion capacity of MXene,the release of loaded adenosine could be accelerated under NIR irradiation for maintaining the activation signal around injury *** vitro cell experiments proved the effect of MXene-integrated microneedle patches with adenosine encapsulation in enhancing *** applied for treating animal models,it is demonstrated that the microneedle patches efficiently promote angiogenesis,which is conductive to wound *** features make the proposed microneedle patch potential for finding applications in wound healing and other biomedical fields.

关键词： materials boron bonding