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Microbiota in colorectal cancer related to liver metastasis

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Chinese Journal of Cancer Research 2024年第1期36卷 17-24页

作者： Peijun Wei Weiming Han Zitong Zhang Xue tian Chen Yang Qiaoxuan Wang Weihao Xie Ying Liu yuanhong Gao Hui Chang Department of Radiation Oncology State Key Laboratory of Oncology in South ChinaGuangzhou 510060China Guangdong Provincial Clinical Research Center for Cancer Guangzhou 510060China Sun Yat-sen University Cancer Center Guangzhou 510060China Department of Pediatric Oncology State Key Laboratory of Oncology in South ChinaGuangzhou 510060China

The prevalence of colorectal cancer(CRC) is increasing annually and metastasis is the principal cause of death in patients with CRC, with the liver being the most frequently affected site. Many studies have shown a strong interplay between the gut flora, particularly Fusobacterium nucleatum(F. nucleatum), Escherichia coli, and Bacteroides fragilis, and the development of gut tumors. Some strains can induce gut inflammation and produce toxins that directly harm gut epithelial cells, ultimately accelerating the onset and progression of CRC. However,little clinical evidence exists on the specific interplay between the gut microflora and colorectal cancer liver metastasis(CRLM). Some research showed the existence of viable F. nucleatum in distant metastasis of ***, gut microbiota products, such as lipopolysaccharides, sodium butyrate, and protein cathepsin K, were also found to affect the development of CRC. This article summarizes the mechanism and research status of the interplay between gut microflora and CRLM, discusses the importance of gut microflora in the treatment of CRLM, and proposes a new approach to understanding the mechanism of CRLM and potential treatments for the microbiome. It is anticipated that the gut microbiota will be a formidable therapeutic and prophylactic tool for treating and preventing CRLM.

关键词： Gut microbiota liver metastasis colorectal cancer

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羊肚菌的营养成分、功能和加工的研究进展

食品工业科技 2024年第9期45卷 419-428页

作者：田金凤尚远宏肖宗妮攀枝花学院基础医学院四川攀枝花617000

羊肚菌是一种食药兼用菌,含有丰富的蛋白质、多糖、膳食纤维和有机酸等营养成分,具有免疫调节、抗氧化、抗炎、抗肿瘤、抗疲劳和降血糖等功能,可加工成保健品、休闲食品、饮品以及调味品等产品。本文综述了近十年来羊肚菌营养成分、功... 详细信息

羊肚菌是一种食药兼用菌,含有丰富的蛋白质、多糖、膳食纤维和有机酸等营养成分,具有免疫调节、抗氧化、抗炎、抗肿瘤、抗疲劳和降血糖等功能,可加工成保健品、休闲食品、饮品以及调味品等产品。本文综述了近十年来羊肚菌营养成分、功能以及产品加工等方面的研究现状,旨在引导羊肚菌产业向科学与健康的方向发展。

关键词：羊肚菌营养成分功能产品

Evolution of a Late Pleistocene palaeolake in Dali Nor area of southeastern Inner Mongolia Plateau,China

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Geoscience Frontiers 2018年第1期9卷 223-237页

作者： yuanhong Lan Mingzhong tian Xujiao Zhang Xuefeng Wen Chunjing Kang School of Earth Sciences and Resources China University of Geosciences(Beijing)29 Xueyuan RoadBeijing 100083China College of Agriculture Guizhou UniversityGuiyang 550025China The Fourth Geological Exploration Institute of Henan Geology and Mineral Bureau Zhengzhou 450001China

Lithological,geochronological,granulometric,and scanning electron microscope(SEM)analyses of eight lacustrine outcrops indicate the existence of a large palaeolake in Dali Nor area during 149-24.6 ka(MIS5-3)and a small one in upstream of the Xilamulun River during 12.96-11.69 *** large palaeolake recorded its highest water level above 1300 m during the MIS3 and covered the whole Dali Nor basin and upstream of the Xilamulun River within an area of about 3000 km^***,the small palaeolake with a highest water level above 1200 m,covered an area of about 600 km^*** the reconstruction of palaeolake areas,this study also looked into the evolutionary process of the palaeolake during the Late *** data provide insights on the timing of appearance of the large palaeolakes and a better understanding of the mechanism responsible for variations in the environment conditions of dry lands in middle latitudes.

关键词： Late Pleistocene High lake level Dali Nor area Palaeolake

Heterogeneous kinetics of the OH-initiated degradation of fenthion and parathion

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Journal of Environmental Sciences 2023年第11期133卷 161-170页

作者： yuanhong Shang Yongchun Liu Jinfeng tian Changgeng Liu Xuejun Zhu Jun Wang Dandan Chen Wei Tao School of Biological and Chemical Engineering Panzhihua UniversityPanzhihua 617000China Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical TechnologyBeijing 100029China Medical College Panzhihua UniversityPanzhihua 617000China Key Laboratory of Green Chemistry of Sichuan Institutes of Higher Education Sichuan University of Science&EngineeringZigong 643000China

Fenthion and parathion are two representative kinds of organophosphorus pesticides and widely used in *** are directly or indirectly released into the atmosphere by spraying or volatilization ***,their heterogeneous reactivity toward OH radicals has not yet been well ***,this work investigated the heterogeneous kinetics of the OH-initiated degradation of surface-bound fenthion and parathion using a flow *** results showed that OH radicals played an important role in the atmospheric degradation of fenthion and *** average rate constants were(7.20±0.77)×10^(-12) and(10.40±0.60)×10^(−12) cm^(3)/(mol·sec)at a relative humidity(RH)and temperature of 35% and 20℃,respectively,suggesting that they have relatively short lifetimes in the *** addition,a negative RH dependence and a positive temperature dependence of the rate constants were *** Arrhenius expressions of fenthion and parathion were k_(2)=(1.34±0.48)×10^(-9) exp[-(1432.59±105.29)/T]and k_(2)=(1.96±1.38)×10^(-9) exp[-(1619.98±222.02)/T],respectively,and their overall activation energy was estimated to be(11.88±0.87)and(13.48±1.83)kJ/*** experimental results will update the kinetic data of fenthion and parathion in the atmosphere and be helpful to further understand their atmospheric transportation processes.

关键词： Organophosphorus pesticide Heterogeneous kinetics Fenthion Parathion OH radicals

Effect of fluxes on synthesis and luminescence properties of BaSi_2O_2N_2:Eu^(2+) oxynitride phosphors

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Journal of Rare Earths 2018年第3期36卷 225-230页

作者： Jiansheng Huang Ronghui Liu yuanhong Liu Yunshen Hu Guantong Chen Chunpei Yan Junhang tian Bin Hu National Engineering Research Center for Rare Earth Materials General Research Institute for Nonferrous Metals Grirem Advanced Materials Co. Ltd.

Eu^2＋ activated BaSi2 O2 N2 oxynitride bluish-green phosphor was synthesized adopting conventional high-temperature solid-state reaction method, in which BaF2, Na2 CO3 and NH4 Cl were used as the *** phase formation, size distribution and microscopic morphology were characterized to investigate the influence of adding fluxes on photo luminescence properties. The results indicate that with the addition of BaF2 flux, the particle morphology becomes regular and size distribution narrows and the phase purity of BaSi2 O2 N2：Eu^2＋ phosphor can be improved effectively. The photoluminescence intensity of BaSi2 O2 N2：Eu^2＋ phosphor with BaF2 as flux gets enhanced obviously, which is much higher than that of Na2 CO3, NH4 Cl and without flux. The optimum content of BaF2 flux is 4 wt%, and the maximum photoluminescence intensity of the BaSi2 O2 N2：Eu^2＋ phosphor prepared with BaF2 flux rises to 141%,meanwhile, the phosphors with BaF2 flux exhibits low thermal quenching. The results indicate that the BaSi2 O2 N2：Eu^2＋ is sort of promising bluish-green phosphor for application in full-spectra LED.

关键词： BaSi2O2N2 Oxynitride phosphor Flux Thermal stability Rare earths

Broadband near-infrared luminescence and energy transfer of Cr^(3+),Ce^(3+) co-doped Ca_(2)LuHf_(2)Al_(3)O_(12) phosphors

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Journal of Rare Earths 2021年第3期39卷 269-276,I0002页

作者： Jinpin Wu Weidong Zhuang Ronghui Liu yuanhong Liu Tongyu Gao Chunpei Yan Min Cao Junhang tian Xiaoxia Chen National Engineering Research Center for Rare Earth Materials GRINM Croup Co.Ltd.Beijing 100088China GRIREM Advanced Materials Co. Ltd.Beijing 100088China General Research Institute for Nonferrous Metals Beijing 100088China Jiangxi Province Key Laboratory of Polymer Micro/Nano Manufacturing and Devices School of ChemistryBiology and Materials ScienceEast China University of TechnologyNanchang 330046China

Broadband near-infrared phosphors are highly desirable for food *** Ca_(2)LuHf_(2)Al_(3)O_(12):Cr^(3+)(CLHA:Cr^(3+)) and Ca_(2)LuHf_(2)Al_(3)O_(12):Ce^(3+),Cr^(3+)(CLHA:Ce^(3+),Cr^(^(3+))) phosphors were synthesized by the conventional high-temperature solid state *** CLHA:Cr^(3+)phosphor,with a good thermal stability,shows a red shift owing to radiation reabsorption and non-radiative transition with increasing Cr^(3+)*** co-doped sample,the emission intensity of Cr^(3+)can be enhanced by three times due to the energy transfer from Ce^(3+)to Cr^(3+),which can be evidenced by a significant overlap between the PLE of Cr^(3+)single-doped phosphor and the PL of Ce^(3+)single-doped *** addition,the mechanism of energy transfer is identified as a quadrupole-quadrupole interaction according to decay Lifetime and Dexter’s energy transfer *** broadband NIR emission peaked at 775 nm of CLHA:Cr^(3+),Ce^(3+)phosphor shows a bright prospect in nondestructive quality-control analysis systems for food.

关键词： Broadband near-infrared Energy transfer Garnet phosphor Rare earths

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隧道钢筋混凝土防开裂施工技术

北方建筑 2024年第2期9卷 108-112页

作者：贺榃清高兵田勇胡远宏侯永祺吉林建筑大学土木工程学院吉林长春130118

由于现有的防开裂施工技术混凝土限制膨胀率高、强度低、裂缝现象严重,为此,开展隧道钢筋混凝土防开裂施工技术研究。在隧道开挖前,搭建复拱钢架支护,运用喷射混凝土填塞缝隙。固结注浆初支围岩,形成环向保护壳。隧道开挖后,洞内反向填... 详细信息

由于现有的防开裂施工技术混凝土限制膨胀率高、强度低、裂缝现象严重,为此,开展隧道钢筋混凝土防开裂施工技术研究。在隧道开挖前,搭建复拱钢架支护,运用喷射混凝土填塞缝隙。固结注浆初支围岩,形成环向保护壳。隧道开挖后,洞内反向填充,防止坍塌部位变形破坏,并喷射混凝土修复施工面。运用逐榀环形掏槽预留核心土开挖,将填充材料填入裂缝中,提升混凝土衬砌承载能力。在施工过程中,用防水砂浆整平裂缝表面,定期养护。隧道竣工后,对裂缝衬砌断面进行安全性分析和等级判定。测试结果表明,在隧道施工28 d时,混凝土强度为45 MPa,限制膨胀率为0.045%,符合预期施工效果,裂缝现象得到较好缓解。

关键词：隧道钢筋混凝土防开裂施工衬砌断面

多酚、黄酮功能性成分导向的草果种质资源评价

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热带作物学报 2024年第5期45卷 915-927页

作者：胡一凡高晓余苏俊宇安梅杨林霞杨绍兵田洋范源洪云南农业大学农学与生物技术学院云南昆明650201 云南农业大学食品科学技术学院云南昆明650201 云南省农科院药用植物研究所云南昆明650201 食药同源资源开发与利用教育部工程研究中心云南昆明650201 云南省高原特色农业产业研究院云南昆明650201 云南省芳香生物工程技术研究中心云南昆明650201

草果是一种富含多酚和黄酮的药食同源作物。功能性草果资源的研究评价是育种利用和产业化开发的核心。本研究旨在草果资源的通便活性成分多酚、黄酮含量及抗氧化活性差异分析,进行草果种质资源的筛选评价,探讨成分积累的可能因素。对来... 详细信息

草果是一种富含多酚和黄酮的药食同源作物。功能性草果资源的研究评价是育种利用和产业化开发的核心。本研究旨在草果资源的通便活性成分多酚、黄酮含量及抗氧化活性差异分析,进行草果种质资源的筛选评价,探讨成分积累的可能因素。对来自老挝、缅甸,我国四川、广西、云南的57份草果资源,采用福林酚法、NaNO_(2)-Al(NO_(3))_(3)-NaOH比色法分别测定草果水提物的多酚、黄酮含量和DPPH自由基清除能力,分析多酚和黄酮含量与DPPH自由基清除能力、地理因子之间的相关性。结果表明:采用广靶代谢组学检测草果水提物的组分构成,检测出草果水提物中含量最高的为黄酮(46.34%)和多酚(15.98%);通过小肠墨汁推进实验验证草果水提物具有润肠通便功效;纺锤形草果资源的多酚和黄酮含量高于椭圆形果和圆形果,国外和我国云南怒江的草果资源的黄酮含量高于其他地区种质;草果多酚、黄酮含量与DPPH自由基清除能力、海拔高度呈显著正相关(P0.05)呈负相关,因此推测草果多酚和黄酮的积累可能与温度、光照、紫外线、土壤水分有关。以多酚和黄酮含量作为评价指标,将草果资源分为3个等级,利用该方法筛选到优良草果资源为我国云南怒江种质GS-3、GS-10和国外种质MDL-1、MGK-2。研究结果可为草果质量等级评价体系的建立提供分析方法,不但可以指导草果资源的考察和收集,而且可为草果资源的育种研究和新产品开发利用提供科学依据。

关键词：草果多酚黄酮 DPPH自由基清除能力种质资源评价

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Blue-emitting Sr_(1-x)Ca_(x)Lu_(2)O_(4):Ce^(3+) phosphors for high CRI white LEDs

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Journal of Rare Earths 2021年第6期39卷 627-633,I0001页

作者： Yipeng Zhou Yunsheng Hu Ronghui Liu yuanhong Liu Weidong Zhuang Min Cao Tongyu Gao Junhang tian Yanfeng Li Guantong Chen National Engineering Research Center for Rare Earth Materials GRINM Group Co.Ltd.Beijing100088China CRIREM Advanced Materials Co. Ltd.Beijing 100088China General Research Institute for Nonferrous Metals Beijing 100088China

A broadband blue-emitting Sr_(1-x)Ca_(x)Lu_(2)O_(4):Ce^(3+)(x=0-0.2) phospho rs were synthesized,which can be used for near-UV pumped white light-emitting diodes(w-LEDs).The crystal structures,photoluminescence pro perties,external quantum efficiency,the rmal stability and application perfo rmance of Sr_(1-x)Ca_(x)Lu_(2)O_(4):Ce^(3+),by partially substituting Sr^(2+) with Ca^(2+)(x=0-0.2),were studied by various analytical *** the Ca/Sr ratio of Sr_(1-x)Ca_(x)Lu_(2)O_(4):Ce^(3+) gradually increases,the emission peak of Sr_(1-x)Ca_(x)Lu_(2)O_(4):Ce^(3+) red-shiftes from 459 to 465 nm,corrected external quantum efficiency increases from 31.8% to 42.9%,and the thermal stability is also *** mechanism of the changes of the photoluminescence emission and excitation spectra,external quantum efficiency and thermal stability properties was also investigated in *** addition,a w-LED was fabricated by using SrLu_(2)O_(4):Ce^(3+)(blue),β-sialon:Eu^(2+)(green) and(Sr,Ca)AlSiN_(3):Eu^(2+)(red) phosphors combined with a 405 nm near-UV LED chip,and its color rendering index(CRI) reaches *** Sr_(0.8)Ca_(0.2)Lu_(2)O_(4):Ce^(3+) is applied as blue phosphor to substitute SrLu_(2)O_(4):Ce^(3+),the obtained w-LED devices have high luminous efficiency,and CRI greater than *** re sults show that the Sr_(1-x)Ca_(x)Lu_(2)O_(4):Ce^(3+) can be potential blue phosphors for n-UV pumped high CRI w-LEDs application.

关键词： n-UV pumped w-LED Blue phosphor Red shift Excellent thermal stability High color rendering index Rare earths