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Exsolutions of Diopside and Magnetite in Olivine from Mantle Dunite,Luobusa Ophiolite,Tibet,China

Acta Geologica Sinica(English Edition) 2008年第2期82卷 377-384页

作者： REN Yufeng CHEN Fangyuan YANG Jingsui gao yuanhong Key Laboratory of Continental Dynamics of the Ministry of Land and Resources Institute of Geology CAGS Beijing 100037

The exsolutious of diopside and magnetite occur as intergrowth and orient within olivine from the mantle dunite, Luobusa ophiolite, Tibet. The dunite is very fresh with a mineral assemblage of olivine （〉95%）＋ chromite （1%-4%）＋ diopside （〈1%）. Two types of olivine are found in thin sections： one （Fo = 94） is coarse-grained, elongated with development of kink bands, wavy extinction and irregular margins; and the other （Fo = 96） is fine-grained and poly-angied. Some of the olivine grains contain minor Ca, Cr and Ni. Besides the exsolutions in olivine, three micron-size inclusions are also discovered. Analyzed through energy dispersive system （EDS） with unitary analytical method, the average compositions of the inclusions are： Na20, 3.12%-3.84%; MgO, 19.51%-23.79%; Al2O3, 9.33%-11.31%; SiO2, 44.89%-46.29%; CaO, 11.46%-12.90%; Cr2O3, 0.74%-2.29%; FeO, 4.26%- 5.27%, which is quite similar to those of amphibole. Diopside is anhedral f＇dling between olivines, or as micro-inclusions oriented in olivines. Chromite appears euhedral distributed between olivines, sometimes with apparent compositional zone. From core to rim of the chromite, Fe content increases and Cr decreases; and A! and Mg drop greatly on the rim. There is always incomplete magnetite zone around the chromite. Compared with the nodular chromite in the same section, the euhedral chromite has higher Fe3O4 and lower MgCr2O4 and MgAI2O4 end member contents, which means it formed under higher oxygen fugacity environment. With a geothermometer estimation, the equilibrium crystalline temperature is 820℃-960℃ for olivine and nodular chromite, 630℃-770℃ for olivine and euhedral chromite, and 350℃-550℃ for olivine and exsoluted magnetite, showing that the exsolutions occurred late at low temperature. Thus we propose that previously depleted mantle harzburgite reacted with the melt containing Na, Al and Ca, and produced an olivine solid solution added with Na^＋, Al^3＋, Ca^2＋, Fe^3＋, Cr^3＋. With temperature decreasing, t

关键词： diopside magnetite exsolution olivine dunite ophiolite Luobusa Tibet

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Antarctic krill peptides improve scopolamine-induced memory impairment in mice

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Food Bioscience 2022年第5期49卷 999-1009页

作者： Jingru Zheng yuanhong gao Jie Ding Na Sun Songyi Lin National Engineering Research Center of Seafood School of Food Science and TechnologyDalian Polytechnic UniversityDalian116034PR China Collaborative Innovation Center of Seafood Deep Processing Dalian Polytechnic UniversityDalian116034PR China

The study aims to investigate the repair effects of Ser-Ser-Asp-Ala-Phe-Phe-Pro-Phe-Arg(SSDAFFPFR)and Ser-Asn-Val-Phe-Asp-Met-Phe(SNVFDMF)peptides on scopolamine-caused memory impairment in *** experiments have revealed that Antarctic krill peptides can ameliorate scopolamine caused memory impairment by changing the behavior of *** comparison with the scopolamine group,the two peptides at a dose of 40 mg/kg could improve memory *** serum SOD activity(82.82±0.19 vs 79.47±2.42 U/mg prot)and hippocampal ACh level(101.46±3.23 vs 99.85±7.13μg/mg prot)of SSDAFFPFR were higher than those of *** AChE activity(0.20±0.03 vs 0.53±0.02 U/mg prot),hippocampal MDA level(1.56±0.01 vs 1.63±0.05 nmol/mg prot)and the serum MDA level(3.38±0.24 vs 3.88±0.21 nmol/mg prot)was lower than that of *** state of mouse hippocampal cells was further observed by a microscopic imaging *** addition,western blot analysis showed that SSDAFFPFR could significantly inhibit the expression of Bax,caspase-3,and p53,and promote the expression of BCL-XL,CREB,and BDNF,thus protecting hippocampal neurons in *** conclusion,the Antarctic krill peptide can repair scopolamine-induced memory impairment in mice.

关键词： Antarctic krill Bioactive peptide Hippocampus Memory impairment Scopolamine mouse model Protein expression level

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Colorectal cancer, radiotherapy and gut microbiota

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Chinese Journal of Cancer Research 2019年第1期31卷 212-222页

作者： Shu Zhang Qiaoxuan Wang Chengjing Zhou Kai Chen Hui Chang Weiwei Xiao yuanhong gao Department of Radiation Oncology Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou 510060China

Colorectal cancer is closely related to inflammation and immune response. Radiotherapy, as a major treatment for colorectal cancer, plays a central role in cancer control. Inflammation caused by ionizing radiation can exert either anti-or pro-tumorigenic effects. Additionally, radiotherapy can elicit an anti-tumor response not only in radiation of target lesions but also in radiation of remote lesions. However, the immune mechanism underlying this effect has not been thoroughly elucidated yet. The combination therapeutic regimen of radiotherapy with other therapeutic methods, including chemotherapy and immunotherapy, has been applied in clinical practice. Meanwhile, radiation toxicity and radiosensitivity have long been problems that affect a patient's quality of life and *** have found that the abovementioned problems are closely associated with gut microbiota. Here we discuss the impact of immune response induced by radiotherapy on tumor regression and the impact of intestinal flora on the consequent clinical efficacy.

关键词： Colorectal cancer intestinal microbiota inflammation immune system radiotherapy tumorinfiltrating lymphocytes(TILs)

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Microbiota in colorectal cancer related to liver metastasis

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Chinese Journal of Cancer Research 2024年第1期36卷 17-24页

作者： Peijun Wei Weiming Han Zitong Zhang Xue Tian Chen Yang Qiaoxuan Wang Weihao Xie Ying Liu yuanhong gao Hui Chang Department of Radiation Oncology State Key Laboratory of Oncology in South ChinaGuangzhou 510060China Guangdong Provincial Clinical Research Center for Cancer Guangzhou 510060China Sun Yat-sen University Cancer Center Guangzhou 510060China Department of Pediatric Oncology State Key Laboratory of Oncology in South ChinaGuangzhou 510060China

The prevalence of colorectal cancer(CRC) is increasing annually and metastasis is the principal cause of death in patients with CRC, with the liver being the most frequently affected site. Many studies have shown a strong interplay between the gut flora, particularly Fusobacterium nucleatum(F. nucleatum), Escherichia coli, and Bacteroides fragilis, and the development of gut tumors. Some strains can induce gut inflammation and produce toxins that directly harm gut epithelial cells, ultimately accelerating the onset and progression of CRC. However,little clinical evidence exists on the specific interplay between the gut microflora and colorectal cancer liver metastasis(CRLM). Some research showed the existence of viable F. nucleatum in distant metastasis of ***, gut microbiota products, such as lipopolysaccharides, sodium butyrate, and protein cathepsin K, were also found to affect the development of CRC. This article summarizes the mechanism and research status of the interplay between gut microflora and CRLM, discusses the importance of gut microflora in the treatment of CRLM, and proposes a new approach to understanding the mechanism of CRLM and potential treatments for the microbiome. It is anticipated that the gut microbiota will be a formidable therapeutic and prophylactic tool for treating and preventing CRLM.

关键词： Gut microbiota liver metastasis colorectal cancer

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Cycle number of neoadjuvant chemotherapy might influence survival of patients with T1-4N2-3M0 nasopharyngeal carcinoma

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Chinese Journal of Cancer Research 2018年第1期30卷 51-60页

作者： Jiawang Wei Huixia Feng Weiwei Xiao Qiaoxuan Wang Bo Qiu Shiliang Liu Meiling Deng Lixia Lu Hui Chang yuanhong gao Department of Radiation Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oneology in South ChinaCollaborativeInnovation Center of Cancer MedicineGuangzhou 510060China

Objective： Stage N2-3 nasopharyngeal carcinoma（NPC） shows a high risk of distant metastasis, which will finally cause death. This study aimed to evaluate the impact of neoadjuvant chemotherapy（NACT） of various cycles before radical radiotherapy on distant metastasis and survival of patients with stage N2-3 ***： In this study, a total of 1,164 consecutive patients with non-metastatic N2-3 NPC were recruited and prospectively observed. Then 231 patients who received NACT of 4 cycles（NACT=4 group） were matched 1：2：1 to 462 patients treated with NACT of 2 cycles（NACT=2 group） and 231 patients treated without NACT（NACT=0 group）, according to age, histological subtype, N stage and NACT regimen. Five candidate variables（sex, T stage, concurrent chemotherapy, intensity-modulated radiation therapy and cycle number of NACT） were analyzed for their association with patients＇ ***： After matching, the overall survival（OS）, disease-free survival（DFS）, local-recurrence-free survival（RFS） and distant-metastasis-free survival（MFS） of the NACT=4 group（89.2%, 81.0%, 83.3% and 84.8%,respectively） were better than those of the NACT=2 group（83.3%, 72.5%, 81.2% and 77.9%, respectively） and the NACT=0 group（74.0%, 63.2%, 74.0% and 68.8%, respectively）. In multivariate analysis, the cycle number of NACT maintained statistical significance on the OS, DFS, RFS and MFS（all P〈0.05）.Conclusions： For N2-3 NPC, cycle number of NACT appeared to be an independent factor associated with an improvement of survival.

关键词： Neoadjuvant chemotherapy nasopharyngeal carcinoma cycle number distant metastasis survival

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Total mesorectal excision with or without preoperative chemoradiotherapy for resectable mid/low rectal cancer: a long-term analysis of a prospective, single-center, randomized trial

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Cancer Communications 2018年第1期38卷 773-782页

作者： Fulong Wang Wenhua Fan Jianhong Peng Zhenhai Lu Zhizhong Pan Liren Li yuanhong gao Hui Li Gong Chen Xiaojun Wu Peirong Ding Zhifan Zeng Desen Wan Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhou 510060GuangdongP.R.China Department of Colorectal Surgery Sun Yat-sen University Cancer Center651 Dongfeng Road EastGuangzhou 510060GuangdongP.R.China Department of Radiation Oncology Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Department of Gynecological Oncology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510060GuangdongP.R.China

Background:The preliminary results of our phase II randomized trial reported comparable functional sphincter pres-ervation rates and short-term survival outcomes between patients undergoing total mesorectal excision(TME)with or without preoperative concurrent chemoradiotherapy(CCRT).We now report the long-term results after a median follow-up of 71 ***:Between March 23,2008 and August 2,2012,192 patients with T3-T4 or node-positive,resectable,mid/low rectal adenocarcinoma were randomly assigned to receive TME with or without preoperative *** following endpoints were assessed:cumulative rates of local recurrence and distant metastasis,disease-free survival(DFS),and overall survival(OS).Results:The data of 184 eligible patients were analyzed:94 patients in the TME group and 90 patients in the CCRT+TME *** the whole cohort,the 5-year DFS and OS rates were 84.8%and 85.1%,*** 5-year DFS rates were 85.2%in the CCRT+TME group and 84.3%in the TME group(P=0.969),and the 5-year OS rates were 83.5%in the CCRT+TME group and 86.5%in the TME group(P=0.719).The 5-year cumulative rates of local recur-rence were 6.3%and 5.0%(P=0.681),and the 5-year cumulative rates of distant metastasis were 15.0%and 15.7%(P=0.881)in the CCRT+TME and TME groups,*** significant improvements in 5-year DFS and OS were observed with CCRT by subgroup ***:Both treatment strategies yielded similar long-term outcomes.A selective policy towards preoperative CCRT is thus recommended for rectal cancer patients if high-quality TME surgery and enhanced chemotherapy can be performed.

关键词： Rectal cancer Total mesorectal excision Chemoradiotherapy Long-term outcomes Phase II randomized trial

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文化资本与地位获得对浙江某市私营企业主子女上向流动的个案分析

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社会 2007年第1期27卷 120-140页

作者：高虹远美国芝加哥伊力诺斯大学社会学系

本文通过个案,分析探索转型期的私营企业主是如何看待“向上流动”的。被访的私营企业主依据文化资本把自己归入社会中下层,他们期望并力图使子代通过教育进入体制,从而实现向上流动。而他们的子代在进入体制失败后无奈地“子承父业”,... 详细信息

本文通过个案,分析探索转型期的私营企业主是如何看待“向上流动”的。被访的私营企业主依据文化资本把自己归入社会中下层,他们期望并力图使子代通过教育进入体制,从而实现向上流动。而他们的子代在进入体制失败后无奈地“子承父业”,没有实现他们所认同的向上流动。文中重点分析了文化资本在私营企业主自我定位和其子代谋求向上流动过程中的影响。正是这些源于制度与文化的影响使私营企业主认同积累文化资本才是实现向上流动的唯一途径。

关键词：文化资本上向社会流动经济资本

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Outcomes and toxicities of immune checkpoint inhibitors in colorectal cancer:a real-world retrospective analysis

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Cancer Communications 2021年第9期41卷 921-924页

作者： Chengjing Zhou Ting Jiang Rongzhen Li Yan Yuan Weihao Xie Xiaoxue Huang Qiaoxuan Wang Hui Chang Gong Chen Yuhong Li Zhifan Zeng Weiwei Xiao yuanhong gao Department of Radiation Oncology State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Colorectal Surgery State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Medical Oncology State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China

Dear Editor,Colorectal cancer(CRC)is a common cancer in China and worldwide[1-2].Immune checkpoint blockade(ICB)has been proven effective for DNA mismatch repairdeficient(dMMR)/microsatellite instability-high(MSIH)CRC[3-10]but not for mismatch repair-proficient(pMMR)/microsatellite stable(MSS)CRC in clinical trials[3].No published data on the real-world application of ICB in CRC exist,and thus,whether the response to ICB in unselected patients is similar to that in patients from published trials remains unclear.

关键词： cancer colorectal clinical

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Zircon SHRIMP U-Pb dating of granites from Dulan and the chronological framework of the North Qaidam UHP belt, NW China

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Science China Earth Sciences 2014年第10期57卷 2945-2965页

作者： WU CaiLai gao yuanhong LI ZhaoLi LEI Min QIN HaiPeng LI MinZe LIU ChunHua Ronald B FROST Paul T ROBINSON Joseph L WOODEN State Key Laboratory of Continental Tectonics and Dynamics Institute of Geology Chinese Academy of Geological Sciences University of Wyoming Department of Earth and Environmental Sciences Stanford University

Zircon SHRIMP dating of granites from Dulan,east segment of North Qaidam UHP belt shows that they are 406.6±3.5 Ma for Yematan-E,407.3±4.3 and 397±6 Ma for Balijiehatan-W,404.5±4.0 and 397.0±3.7 Ma for Shuiwenzhan-N,380.5±5.0 Ma for Shuiwenzhan-S,382.5±3.6 and 372.5±2.8 Ma for *** granites from Dulan represent the products of the third and fourth periods of Paleozoic magmatism in North ***,the granitoids with metalumious to weak peratuminous are quartz diorite,granodiorite,and granite in composition and mainly belong to calc-alkaline series,a few samples to calc or alkali-calc *** third period of granites is a rock association of granodiorite+granite,with initial 87Sr/86Sr ratios from 0.7082 to 0.7110 and T2DM model ages from 1.41–1.90 Ga;and the fourth period of granites is a rock association of quartz diorite+granodiorite+granite,with initial 87Sr/86Sr ratios from 0.7072 to 0.7091 and T2DM model ages from 1.07–1.38 ***,the third period of granites has higher initial 87Sr/86Sr ratios and T2DM model *** the contrary,the fourth period of granites has Nd(t)values from 0.6 to-3.0,higher than that of the third granite with Nd(t)values-3.2 ***,the data comparison indicates that the third granites may derive from Paleo-proterzoic continental crust with mantle material whereas the fourth granites may derive from the Meso-proterzoic basalt crust with continental *** with regional geology,we thought that the third granites were formed relative to plate exhumation and the fourth granites to delamination of the lithospheric mantle.

关键词： granite zircon SHRIMP U-Pb dating Dulan

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Dosimetric Comparison of Volumetric Modulated Arc Therapy (VMAT), 5F Intensity Modulated Radiotherapy (IMRT) and 3D Conformal Radiotherapy (3DCRT) in Rectal Carcinoma Receiving Neoadjuvant Chemoradiotherapy

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2015年第1期4卷 54-63页

作者： Ge Wen Jinshan Zhang Feng Chi Li Chen Sijuan Huang Shaoqing Niu yuanhong gao Bixiu Wen Yujing Zhang Department of Radiation Oncology Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in Southern China Collaborative Innovation Center of Cancer Medicine Guangzhou China Department of Radiation Oncology The Third Affiliated Hospital of Guangzhou Medical University Guangzhou China Department of Radiation Oncology The First Affiliated Hospital Sun Yat-sen University Guangzhou China

Objective: To investigate better dosimetric distribution of volumetric modulated arc therapy (VMAT) vs. 5F intensity modulated radiotherapy (IMRT) and 3D conformal radiotherapy (3DCRT) in patients with locally advanced rectal cancer (LARC) when treated with neoadjuvant chemoradiotherapy. Methods: 3D-CRT, 5F-IMRT and VMAT plans for preoperative radiotherapy were 66011designed in 12 patients with locally advanced rectal cancer. The conformity index (CI) and homogeneity index (HI) in target volume, and the dose and volume of the organs at risk (OAR) irradiated including small bowel, bladder and bilatera1 femoral heads were compared among the three plans. Results: The CI for planning target volume (PTV) 2 and HI for PTV1 of VMRT and 5F-IMRT were superior to 3D-CRT. The CI of VMAT, 5F-IMRT and 3D-CRT plans were 0.71, 0.69 and 0.62 (p = 0.011 and p = 0.019, respectively). The HI of the VMAT and 5F-IMRT plans were both 1.04 and 3D-CRT planning was 1.06 (p = 0.022 and p = 0.006, respectively). The V35 - V45 of small bowel in VMAT were significantly less than in 5F-IMRT and 3D-CRT. V35 was 47.0, 56.4, and 72.8 cm3 for VMAT, 5F-IMRT, and 3D-CRT (p = 0.021 and p = 0.034, respectively), while V40 was 30.5, 35.5, 45.1 cm3 (p = 0.024 and p = 0.032, respectively) and V45 was 15.1, 18.1, 30.0 cm3 (p = 0.033 and p = 0.032, respectively). The D5, V30 and V50 of bladder in 3D-CRT were less than in VMAT and 5F-IMRT planning (p = 0.034, 0.004, 0.002 and p = 0.027, 0.003, 0.002, respectively). The Dmean of left femoral head in VMAT and 5F-IMRT were less than in 3D-CRT planning (p = 0.028 and p = 0.022, respectively) and the Dmean, V30 of right femoral head in VMAT and 5F-IMRT were better than in 3D-CRT planning (p = 0.044, 0.036 and p = 0.023, 0.028, respectively). Conclusions: Dosimetric analyses demonstrated that IMRT is superior to 3D-CRT in the conformity and homogeneity of dose distribution to the target volume, and provide a better protection to OARs sparing in patients with locall

关键词： Rectal Cancer Preoperative Radiotherapy Dosimetry Conformity Index Homogeneity Index

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