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Application of machine learning models in groundwater quality assessment and prediction:progress and challenges

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Frontiers of Environmental Science & Engineering 2024年第3期18卷 25-55页

作者： Yanpeng Huang Chao Wang yuanhao Wang Guangfeng Lyu Sijie Lin Weijiang liu Haobo Niu Qing Hu School of Environment Harbin Institute of TechnologyHarbin 150090China School of Environmental Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Engineering Innovation Center of SUSTech(Beijing) Southern University of Science and TechnologyBeijing 100083China Technical Center for Soil Agriculture and Rural Ecology and EnvironmentMinistry of Ecology and EnvironmentBeijing 100012China Chinese Academy of Environmental Planning Beijing 100043China

Groundwater quality assessment and prediction(GQAP)is vital for protecting groundwater resources.Traditional GQAP methods can not adequately capture the complex relationships among attributes and have the disadvantage of being computationally demanding.Recently,the application of machine learning(ML)in GAQP(GQAPxML)has been widely studied due to ML’s reliability and efficiency.While many GQAPxML publications exist,a thorough review is missing.This review provides a comprehensive summary of the development of ML applications in the field of GQAP.First,the workflow of ML modeling is briefly introduced,as are data preparation,model development,model evaluation,and model application.Second,299 publications related to the topic are filtered,mainly through ML modeling.Subsequently,many aspects of GQAPxML,such as publication trends,the spatial distribution of study areas,the size of data sets,and ML algorithms,are discussed from a bibliometric perspective.In addition,we review in detail the well-established applications and recent findings for several subtopics,including groundwater quality assessment,groundwater quality modeling using groundwater quality parameters,groundwater quality spatial mapping,probability estimation of exceeding the groundwater quality threshold,groundwater quality temporal prediction,and the hybrid use of ML and physics-based models.Finally,the development of GQAPxML is explored from three perspectives:data collection and preprocessing,model building and evaluation,and the broadening of model applications.This review provides a reference for environmental scientists to better understand GQAPxML and promotes the development of innovative methods and improvements in modeling quality.

关键词： Groundwater quality assessment Groundwater quality prediction Machine learning Groundwater modeling

Genetic Insights into Glycine’s Protective Role Against CAD—European and East Asia,2015 and 2020

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China CDC weekly 2024年第9期6卷 168-172,I0003-I0008页

作者： Jiaying Yu Zhuolin Zhu Ting Wang yuanhao Wei Lianjie Huang Qianru Zhang Yuting Zhang Yiran Wang Guiyou liu Xiang Shu Rennan Feng Department of Nutrition and Food Hygiene School of Public HealthHarbin Medical UniversityHarbin CityHeilongjiang ProvinceChina Key Laboratory of Precision Nutrition and Health of Ministry of Education School of Public HealthHarbin Medical UniversityHarbin CityHeilongjiang ProvinceChina Songyang County Center for Disease Prevention and Control Songyang CityZhejiang Province China Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer CenterNew York CityNYUSA

Introduction:The purpose of this study is to examine the potential causal relationship between levels of circulating glycine and coronary artery disease(CAD)using a two-step Mendelian randomization(MR)analysis.Methods:We analyzed data from genome-wide association studies(GWAS)conducted on European and East Asian populations.To assess the causal effects of circulating glycine levels on the risk of CAD.We used the inverse-variance weighting(IVW),weighted median(WM),MR-Egger,and Mendelian Randomization Pleiotropy RESidual Sum and Outlier(MR-PRESSO)methods.Furthermore,we conducted mediation analysis to investigate the contribution of blood pressure and other cardiovascular disease-related traits.Results:The two-step Mendelian randomization analysis revealed that higher levels of glycine in the blood were associated with a reduced risk of CAD in Europeans[odds ratio(OR)=0.84,95%confidence interval(CI):0.72,−0.98;P=0.029]and East Asians:(OR=0.76,95%CI:0.66,−0.89;P=3.57×10−4).Sensitivity analysis confirmed the robustness of these findings.Additionally,our results suggest that about 6.06%of the observed causal effect is mediated through genetically predicted systolic blood pressure(SBP)in the European population.Discussion:Our results contribute to the current knowledge regarding the involvement of glycine in the progression of CAD,and provide valuable methodological insights for the prevention and treatment of this condition.

关键词： CAD prevention involvement

Responses of flood peaks to land use and landscape patterns under extreme rainstorms in small catchments-A case study of the rainstorm of Typhoon Lekima in Shandong,China

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International Soil and Water Conservation Research 2022年第2期10卷 228-239页

作者： yuanhao liu Jianqiao Han Juying Jiao Baoyuan liu Wenyan Ge Qingbin Pan Fei Wang Institute of Soil and Water Conservation Northwest A&F UniversityYangling712100Shaanxi ProvinceChina Key Laboratory of the Loess Plateau Soil Erosion and Water Loss Process and Control Ministry of Water ResourcesZhengzhou450003Henan ProvinceChina Institute of Soil and Water Conservation Chinese Academy of Sciences and Ministry of Water ResourcesYangling712100Shaanxi ProvinceChina China Institute of Water Resources and Hydropower Resea

Investigations of the formation mechanisms of flood peaks in small catchments facilitate flood prediction and disaster prevention under extreme rainstorms.However,there have been few studies on the re-sponses of flood peaks to land use landscape patterns using field surveys during extreme rainstorm events.Based on field data from 17 small catchments near the rainstorm center of Typhoon Lekima,7 landscape indices were chosen.The flood peak and its sensitivity to the land use landscape were investigated by combining remote sensing interpretation and related analysis.The conclusions are as follows:(1)The peak discharge of the small catchment was 2.36e56.50 m3/s,the peak modulus was 8.00 e48.89 m3/(s$km2),and the flood index K ranged from 3.61 to 4.55.(2)Under similar rainfall conditions,the flood peak modulus,K and the proportion of sloping cropland had significantly positive correlations(p<0.05).The flood peak modulus was significantly negatively correlated with the proportion of forest-grassland and terrace(p<0.05),and K and the proportion of forest-grassland and terraced land exhibited a negative correlation.(3)The flood peak modulus and K were positively correlated with the landscape fragmentation.(4)The sensitivities of small catchments to floods were evaluated to be moderate compared to K values from other studies.The ability of small catchments to cope with extreme rain-storms can be improved by increasing the areas of forest-grassland,and terraces and reducing landscape fragmentation.Our results could be applied to provide a basis for land use planning and support for the response against disasters caused by extreme floods.

关键词： Extreme rainstorm Flood peak intensity Flood peak sensitivity Land use Landscape pattern

The light and hypoxia induced gene ZmPORB1 determines tocopherol content in the maize kernel

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Science China(Life Sciences) 2024年第3期67卷 435-448页

作者： Nannan liu yuanhao Du Shijuan Yan Wei Chen Min Deng Shutu Xu Hong Wang Wei Zhan Wenjie Huang Yan Yin Xiaohong Yang Qiao Zhao Alisdair R.Fernie Jianbing Yan National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070China Hubei Hongshan Laboratory Wuhan 430070China Agro-biological Gene Research Center Guangdong Academy of Agricultural SciencesGuangzhou 510640China College of Agronomy Hunan Agricultural UniversityChangsha 410128China College of Agronomy Northwest A&F UniversityXi'an 710000China State Key Laboratory of North China Crop Improvement and Regulation Hebei Sub-center of National Maize Improvement Center of ChinaCollege of AgronomyHebei Agricultural UniversityBaoding 071001China College of Life Sciences South-Central Minzu UniversityWuhan 430070China Plant Science Facility of the Institute of Botany Chinese Academy of SciencesBeijing 100093China National Maize Improvement Center of China Beijing Key Laboratory of Crop Genetic ImprovementChina Agricultural UniversityBeijing 100093China Shenzhen Key Laboratory of Synthetic Genomics Guangdong Provincial Key Laboratory of Synthetic GenomicsShenzhen Institute of Synthetic BiologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Max Planck Institute of Molecular Plant Physiology Potsdam-Golm 14476Germany

Tocopherol is an important lipid-soluble antioxidant beneficial for both human health and plant growth. Here, we fine mapped a major QTLqVE1 affecting γ-tocopherol content in maize kernel, positionally cloned and confirmed the underlying gene ZmPORB1(por1), as a protochlorophyllide oxidoreductase. A 13.7 kb insertion reduced the tocopherol and chlorophyll content, and the photosynthetic activity by repressing ZmPORB1 expression in embryos of NIL-K22, but did not affect the levels of the tocopherol precursors HGA(homogentisic acid)and PMP(phytyl monophosphate). Furthermore, ZmPORB1 is inducible by low oxygen and light, thereby involved in the hypoxia response in developing embryos. Concurrent with natural hypoxia in embryos, the redox state has been changed with NO increasing and H_(2)O_(2) decreasing, which lowered γ-tocopherol content via scavenging reactive nitrogen species. In conclusion, we proposed that the lower lightharvesting chlorophyll content weakened embryo photosynthesis, leading to fewer oxygen supplies and consequently diverse hypoxic responses including an elevated γ-tocopherol consumption. Our findings shed light on the mechanism for fine-tuning endogenous oxygen concentration in the maize embryo through a novel feedback pathway involving the light and low oxygen regulation of ZmPORB1 expression and chlorophyll content.

关键词： maize tocopherol hypoxia photosynthesis ZmPORB1

Balancing efficacy and safety of doxorubicin-loaded albumin nanoparticles utilizing pH-sensitive doxorubicin-fatty acid prodrugs

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Nano Research 2024年第6期17卷 5491-5500页

作者： yuanhao Yu Shiyi Zuo Jiaxuan Song Lingxiao Li Tian liu Jiayu Guo Yaqiao Li Danping Wang Qi Lu Helin Wang Dun Zhou Zhonggui He Xiaohong liu Bingjun Sun Jin Sun School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China Department of Pharmacy The First Affiliated Hospital of Jinzhou Medical UniversityJinzhou 121001China Joint International Research Laboratory of Intelligent Drug Delivery Systems Ministry of EducationShenyang 110016China

Albumin nanoparticles(ANPs)offer unique advantages for antitumor drug delivery system,including non-immunogenicity and inherent tumor-targeting capacity.At present,only a few products,such as ABRAXANE®and FYARRO™,have been approved for clinical applications.The poor affinity of doxorubicin(DOX)for albumin,coupled with its numerous severe adverse reactions,poses challenges in the fabrication of desirable albumin nanoparticles loaded with DOX.In this study,we developed prodrugs by conjugating fatty acids of varying lengths with DOX.Our aim was to investigate the balance between efficacy and safety through the selection of appropriate modules.We synthesized five pH-sensitive doxorubicin-fatty acid prodrugs.Compared to free DOX,all DOX prodrug ANPs exhibited a uniform size distribution with desirable sizes of 150 nm.Additionally,DOX prodrugs with hydrazone bonds remained intact in blood circulation while releasing DOX within tumor cells.Significantly,the characteristics of prodrug ANPs were considerably influenced by the length of fatty acids,impacting their in vivo pharmacokinetics,antitumor effectiveness and tumor accumulation.This research offers a detailed understanding of the length of fatty acid influence on DOX-fatty acid prodrug-based ANPs,and it builds a good platform for creating ANPs which prioritize high drug loading,high efficiency,and minimal side effects.

关键词： fatty acid prodrug albumin doxorubicin pH-sensitive bond nanomedicines

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基于等效模型的砖石古塔有限元模型修正方法

振动与冲击 2024年第3期43卷 105-109页

作者：杨庆山张源浩刘纲王晖重庆大学土木工程学院重庆400045

针对砖石古塔实体有限元模型节点众多导致修正效率低下问题,提出了一种将实体模型和杆系模型相结合的有限元模型快速修正方法。基于古塔结构的测试输出信号,使用随机子空间法识别了塔的自振频率。使用整体连续式方法建立了ABAQUS有限元... 详细信息

针对砖石古塔实体有限元模型节点众多导致修正效率低下问题,提出了一种将实体模型和杆系模型相结合的有限元模型快速修正方法。基于古塔结构的测试输出信号,使用随机子空间法识别了塔的自振频率。使用整体连续式方法建立了ABAQUS有限元模型,基于实测结果,使用萤火虫算法修正了塔的弹性模量、密度。修正后的有限元模型的计算结果与实测结果对比,能够较好吻合,说明修正后的模型可靠,可以作为后续抗震性能分析的基础。

关键词：砖石古塔有限元模型模型修正等效模型萤火虫算法

Lymph node metastasis in cancer progression: molecular mechanisms, clinical significance and therapeutic interventions

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Signal Transduction and Targeted Therapy 2023年第10期8卷 4783-4815页

作者： Haoran Ji Chuang Hu Xuhui Yang yuanhao liu Guangyu Ji Shengfang Ge Xiansong Wang Mingsong Wang Department of Thoracic Surgery Shanghai Key Laboratory of Tissue EngineeringShanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai 20o011China Department of Ophthalmology Shanghai Key Laboratory of Orbital Diseases and Ocular OncologyShanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

dissemination to distant sites through a series of mechanisms,and it has been proved that lymph node metastasis(LNM)is an essential prognostic indicator in many different types of cancer.

关键词： metastasis cancer. Lymph

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分布式相参雷达相参效率及相参景深研究

系统工程与电子技术 2024年第5期46卷 1573-1582页

作者：王元昊王宏强刘兴华曾旸杨琪国防科技大学电子科学学院湖南长沙410073 军事科学院军事科学信息研究中心北京100142 电子信息系统复杂电磁环境效应国家重点实验室河南洛阳471003

分布式相参雷达(distributed coherent aperture radar,DCAR)所发射信号仅能在感兴趣点处完全相参叠加,在一定发射相参效率约束下,因相参位置失配会出现能量弥散现象。对此,定义“相参景深”用以描述该能量弥散现象,并给出相参景深形成... 详细信息

分布式相参雷达(distributed coherent aperture radar,DCAR)所发射信号仅能在感兴趣点处完全相参叠加,在一定发射相参效率约束下,因相参位置失配会出现能量弥散现象。对此,定义“相参景深”用以描述该能量弥散现象,并给出相参景深形成原因,指出其有界性和周期性特征,分析其影响因素,以具象化和定量化的方式揭示发射相参效率空间分布规律,可有效支撑DCAR发射信号参数和阵列构型选择等工程实践。最后,以多节点单元雷达的DCAR设计仿真实验,证明了所提方法的有效性。

关键词：分布式相参雷达发射相参效率相参景深分布式发射波束形成

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人源脑类器官模型在孤独症相关神经发育缺陷研究中的应用与进展

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中国细胞生物学学报 2024年第4期46卷 846-857页

作者：王源浩张栩韩晓刘妍南京医科大学生殖医学与子代健康全国重点实验室南京211166 南京医科大学药学院南京211166

孤独症谱系障碍(autism spectrum disorder,ASD)是一种以社交障碍及刻板行为为核心症状的神经发育疾病。其受遗传和环境等多种因素影响,病因复杂、患者异质性极高,这给疾病机制研究和治疗靶点的研究造成了阻碍。3D人脑类器官是由多能干... 详细信息

孤独症谱系障碍(autism spectrum disorder,ASD)是一种以社交障碍及刻板行为为核心症状的神经发育疾病。其受遗传和环境等多种因素影响,病因复杂、患者异质性极高,这给疾病机制研究和治疗靶点的研究造成了阻碍。3D人脑类器官是由多能干细胞(pluripotent stem cell,PSCs)经悬浮培养及诱导分化后自组织形成的器官样三维组织,其可携带患者完整的遗传信息,可在体外模拟胚胎的早期脑发育过程并反映病理过程。脑类器官是研究孤独症谱系障碍的理想模型与平台,该文将对近年来人脑类器官在孤独症研究中的进展与成果作综述。

关键词：孤独症谱系障碍诱导多能干细胞人脑类器官神经发育