检索结果-南通市图书馆

Efficient Construction of a Polyaniline-coated DNA Nanoparticle for Photothermal Therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2023年第6期39卷 884-890页

作者： AQIB Raja Muhammad YANG Changping WU Xiaohui wang yuang FAN Jing SHANG Yingxu LIU Jianbing DING Baoquan CAS Key Laboratory of Nanosystem and Hierarchical Fabrication National Center for NanoScience and TechnologyBeijing 100190P.R.China University of Chinese Academy of Sciences Beijing 100049P.R.China School of Materials Science and Engineering Henan Institute of Advanced TechnologyZhengzhou UniversityZhengzhou 450001P.R.China

Photothermal therapy is a direct and non-invasive therapeutic ***,we report a general strategy for the construction of polyaniline-coated DNA nanoparticles for efficient photothermal *** our design,two G4/hemin-based DNAzymes are precisely organized in a DNA template to mimic the function of horseradish peroxidase(HRP)for the catalytic oxidation of *** polymerization,the polyaniline-coated DNA nanoparticles(PANI/DNA NPs)can be efficiently obtained as the photothermal agent to elicit a pronounced photothermal *** cellular uptake,the noticeable photothermal effect from 808 nm laser irradiation can achieve an efficient proliferation inhibition of tumor *** rationally developed photothermal agent based on DNA template-assisted polymerization presents a new avenue for the development of photothermal therapy.

关键词： Nucleic acid nanostructure Self-assembly Polymeriza-tion Polyaniline Photothermal therapy

Chemically modified DNA nanostructures for drug delivery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Innovation 2022年第2期3卷 38-48页

作者： yuang wang Xuehe Lu Xiaohui Wu Yan Li Wantao Tang Changping Yang Jianbing Liu Baoquan Ding School of Materials Science and Engineering Henan Institute of Advanced TechnologyZhengzhou UniversityZhengzhou 450001China CAS Key Laboratory of Nanosystemand Hierarchical Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Based on predictable,complementary base pairing,DNA can be artificially pre-designed into versatile DNA nanostructures of well-defined shapes and *** excellent addressability and biocompatibility,DNA nanostructures have been widely employed in biomedical research,such as biosensing,bio-imaging,and drug *** the development of the chemical biology of nucleic acid.

关键词： DNA versatile pairing

Long and Covalently Conjugated Branched DNA Structures for in Situ Gelation in Vivo

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CCS Chemistry 2023年第9期5卷 2125-2139页

作者： Xuehe Lu Hong wang Ruofan Chen Tiantian Wu Xiaohui Wu Yingxu Shang yuang wang Wantao Tang Dongsheng Liu Jianbing Liu Baoquan Ding CAS Key Laboratory of Nanosystem and Hierarchical Fabrication National Center for Nanoscience and TechnologyBeijing 100190 School of Materials Science and Engineering Henan Institute of Advanced TechnologyZhengzhou UniversityZhengzhou 450001 Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology Department of ChemistryTsinghua UniversityBeijing 100084 University of Chinese Academy of Sciences Beijing 100049

DNA nanotechnology has been widely employed for biomedical ***,most DNA nanomaterials rely on noncovalent complementary base pairing of short single-stranded DNA ***,we describe a general strategy to construct a long and covalently conjugated branched DNA structure for fast and in situ gelation in *** our design,a short and covalently conjugated branched DNA structure can normally be employed as the DNA primer in the terminal deoxynucleotidyl transferase-dependent enzymatic polymerization *** enzymatic extension,the DNA aptamer-modified branched DNA structures with the sequences of poly T or poly A can immediately coassemble for in situ encapsulation of the target protein and tumor *** fast and in situ gelation system can function in a murine model of local tumor recurrence for targeting residual tumor cells to achieve long-term drug release for efficient tumor inhibition in *** rationally developed DNA self-assembly strategy provides a new avenue for the development of multifunctional DNA nanomaterials.

关键词： DNA material self-assembly nucleic acidmodification DNA polymerization in situ gelation

Metabolic reprogramming: a new option for the treatment of spinal cord injury

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第4期20卷 1042-1057页

作者： Jiangjie Chen Jinyang Chen Chao Yu Kaishun Xia Biao Yang Ronghao wang Yi Li Kesi Shi yuang Zhang Haibin Xu Xuesong Zhang Jingkai wang Qixin Chen Chengzhen Liang Department of Orthopedics The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang ProvinceChina Orthopedics Research Institute of Zhejiang University Zhejiang UniversityHangzhouZhejiang ProvinceChina Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province HangzhouZhejiang ProvinceChina Clinical Research Center of Motor System Disease of Zhejiang Province HangzhouZhejiang ProvinceChina Qiandongnan Prefecture People’s Hospital KailiGuizhou ProvinceChina Department of Orthopedics Fourth Medical CenterChinese PLA General HospitalBeijingChina

Spinal cord injuries impose a notably economic burden on society,mainly because of the severe after-effects they *** the ongoing development of various therapies for spinal cord injuries,their effectiveness remains ***,a deeper understanding of metabolism has opened up a new therapeutic opportunity in the form of metabolic *** this review,we explore the metabolic changes that occur during spinal cord injuries,their consequences,and the therapeutic tools available for metabolic *** spinal cord metabolism is characterized by independent cellular metabolism and intercellular metabolic ***,spinal cord injury results in metabolic disorders that include disturbances in glucose metabolism,lipid metabolism,and mitochondrial *** metabolic disturbances lead to corresponding pathological changes,including the failure of axonal regeneration,the accumulation of scarring,and the activation of *** rescue spinal cord injury at the metabolic level,potential metabolic reprogramming approaches have emerged,including replenishing metabolic substrates,reconstituting metabolic couplings,and targeting mitochondrial therapies to alter cell *** available evidence suggests that metabolic reprogramming holds great promise as a next-generation approach for the treatment of spinal cord *** further advance the metabolic treatment of the spinal cord injury,future efforts should focus on a deeper understanding of neurometabolism,the development of more advanced metabolomics technologies,and the design of highly effective metabolic interventions.

关键词： axons glycolysis metabolic reprogramming metabolism mitochondria neural regeneration neuroprotection oxidative phosphorylation spinal cord injury therapy

在线全文

学校读者我要写书评

暂无评论

首阳山电厂200MW汽轮机可调式汽封应用

中国电力 2000年第4期33卷 4-6页

作者：王源景许顺祥首阳山电厂

论述汽轮机可调式汽封的工作原理及其结构，经过首阳山电厂，２００ＭＷ汽轮机可调式汽封的运行实践，证明它对于汽轮机安全、经济运行，防止大轴弯曲等恶性事故的发生起重要作用。

关键词：汽轮机可调式汽封汽道汽封电厂

在线全文

学校读者我要写书评

暂无评论

邓小平对十三届四中全会以来我国发展的贡献

南昌大学学报（人文社会科学版） 2005年第1期36卷 11-16页

作者：郭秋光王员南昌大学法学院社会学系江西南昌330029 江西师范大学政治与行政管理学院江西南昌330027

邓小平作为改革开放总设计师,对十三届四中全会以来我国社会发展作出了历史性贡献。他对世纪之交世界格局作出了科学的判断,提出了正确的外交战略方针;他强调解放思想、实事求是,不断坚持理论创新;他反复强调必须始终坚持党的基本路线... 详细信息

邓小平作为改革开放总设计师,对十三届四中全会以来我国社会发展作出了历史性贡献。他对世纪之交世界格局作出了科学的判断,提出了正确的外交战略方针;他强调解放思想、实事求是,不断坚持理论创新;他反复强调必须始终坚持党的基本路线不动摇;他围绕“什么是社会主义、怎样建设社会主义”这一首要的、基本的理论问题进行了全面阐述;他致力维护以江泽民为核心的第三代中央领导集体。这就为十三届四中全会以来我国社会发展争取了和平的国际环境,奠定了思想基础和政治基础,提供了直接的理论指导和强有力的组织保障。

关键词：十三届四中全会党的基本路线外交战略世界格局政治基础和平江泽民中国社会发展组织保障

砾岩油藏流动单元研究——以克拉玛依油田二中西区八道湾组为例

在线全文

学校读者我要写书评

暂无评论

新疆石油地质 2009年第1期30卷 96-99页

作者：何辉彭仕宓黄述旺张华中国地质大学北京100083 中国石油大学北京102249 中国石油吉林油田分公司勘探开发研究院吉林松原138001

针对克拉玛依油田二中西区八道湾组砾岩油藏高含水开发期的特点,提出了砾岩油藏流动单元定量划分方法。通过对取心井参数优选,采用聚类分析的方法将储集层流动单元划分为4种类型,建立了各类流动单元的数学判别函数进行判别分析,对非取... 详细信息

针对克拉玛依油田二中西区八道湾组砾岩油藏高含水开发期的特点,提出了砾岩油藏流动单元定量划分方法。通过对取心井参数优选,采用聚类分析的方法将储集层流动单元划分为4种类型,建立了各类流动单元的数学判别函数进行判别分析,对非取心井进行了流动单元划分,并应用序贯指示模拟方法建立了流动单元三维地质模型,更加准确地反映了地下流体的流动特征,为预测剩余油分布规律、油田后期开发调整及提高采收率提供了重要的地质依据。

关键词：砾岩油藏流动单元聚类分析剩余油克拉玛依油田

基于2008年CHAMP卫星地磁总强度数据分析中国及邻区地磁异常特征

在线全文

学校读者我要写书评

暂无评论

地震研究 2017年第3期40卷 399-403页

作者：王粲袁洁浩王振东中国地震局地球物理研究所北京100081 USGS

CHAMP卫星10年的观测任务提供了大量高精度的地磁观测数据。利用2008年CHAMP卫星地磁总强度F观测数据,通过地磁指数及地方时阈值为参数选取地磁活动较为平静期间的卫星观测资料,并利用地磁参考模型去除主磁场和外源场成分,获得了中国及... 详细信息

CHAMP卫星10年的观测任务提供了大量高精度的地磁观测数据。利用2008年CHAMP卫星地磁总强度F观测数据,通过地磁指数及地方时阈值为参数选取地磁活动较为平静期间的卫星观测资料,并利用地磁参考模型去除主磁场和外源场成分,获得了中国及邻区地磁异常分布。结果表明:卫星磁异常的分布特征与地质构造有较好的对应关系,塔里木盆地、四川盆地、松辽盆地、印度地台及华北平原部分地区表现为正磁异常,青藏高原和阿尔泰造山带地区表现为负磁异常。

关键词：岩石圈磁场 CHAMP卫星地磁总强度:卫星磁异常地质构造

基于图形-背景理论的《夜归鹿门歌》认知诗学解读

在线全文

学校读者我要写书评

暂无评论

安徽工业大学学报（社会科学版） 2014年第6期31卷 69-70页

作者：王亚磊王媛媛广东财经大学外语学院广东广州510000

唐代诗人孟浩然的《夜归鹿门歌》,通过环境、人物、动静场景的对比,图形-背景随着环境对比而不断改变,诗人用朴实自然的语言表现了内心感受,凸显了诗人对悠然自得、清闲脱俗的生活的追求及赞美之情。

关键词：《夜归鹿门歌》认知诗学图形-背景理论主题意境