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Cucurbit[7]uril as a Broad-Spectrum Antiviral Agent against Diverse RNA Viruses

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Virologica Sinica 2021年第5期36卷 1165-1176页

作者： Jia Quan Xiangjun Zhang yuanfu ding Shengke Li Yang Qiu Ruibing Wang Xi Zhou State Key Laboratory of Virology College of Life SciencesWuhan UniversityWuhan 430072China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 999078China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China

The emergence and re-emergence of RNA virus outbreaks highlight the urgent need for the development of broadspectrum *** are positively-charged small molecules required for the infectivity of a wide range of RNA viruses,therefore may become good antiviral ***[7]uril(CB[7]),a synthetic macrocyclic molecule,which can bind with amine-based organic compounds with high affinity,has been shown to regulate bioactive molecules through competitive *** this study,we tested the antiviral activity of CB[7]against diverse RNA viruses,including a panel of enteroviruses(*** enterovirus A71,coxsackievirus A16,coxsackievirus B3,and echovirus 11),some flaviviruses(*** virus and Zika virus),and an alphavirus representative Semliki forest ***[7]can inhibit virus replications in a variety of cell lines,and its mechanism of action is through the competitive binding with *** findings not only for the first time provide evidence that CB[7]can be a promising broad-spectrum antiviral agent,but more importantly,offer a novel therapeutic strategy to fight against RNA viruses by supramolecular sequestration of polyamines.

关键词： Cucurbit(CB) RNA viruses Broad-spectrum antiviral activity

Polysaccharide-based supramolecular drug delivery systems mediated via host-guest interactions of cucurbiturils

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Chinese Chemical Letters 2021年第3期32卷 949-953页

作者： Yiyun Gao Yan Gao yuanfu ding Huaping Tan Aihua Zou Shengke Li School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China Shanghai Key Laboratory of Functional Materials Chemistry State Key Laboratory of Bioreactor Engineering and Institute of Applied ChemistrySchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Quality Research in Chinese Medicine.Institute of Chinese Medical Sciences.University of Macao.Macao.China College of Chemistry and Materials Science Shanghai Normal University.Shanghai 200234China

With excellent biocompatibility and biodegradability,natural polysaccharides and their derivative s have exhibited great potential in constructing drug delivery ve hicles for tissue engineering and ***[n]uril(CB[n])-mediated reversible crosslinking of polysaccharides possess intrinsic stimuliresponsiveness towards competitive guests and have been extensively investigated to fabricate various particles and hydrogels for multiple stimuli-re sponsive drug release by incorpo ration with other stimuli including photo,redox,and *** host-guest interactions between CB[6]and aliphatic diamines,functional tags covalently connected with CB[6]can be readily anchored into polysaccharidebased hydrogels,realizing multiple *** rheological prope rty and drug release profile of polysaccharide-based supramolecular hydrogels can be facilely tuned through CB[8]-mediated dyna mic homo or hetero crosslinking of polysaccharides and/or other *** this review,we introduce and summarize recent progress regarding polysaccharide-based supramolecular drug delivery systems mediated via host-guest interactions of CB[6]and CB[8],covering both bulk hydrogels and particular *** the end,possible utilization of CB[7]-based host-guest interactions in constructing polysaccharide-based drug delivery systems and future perspectives of this research direction are also discussed.

关键词： Cucurbit[n]uril Host-guest interaction Polysaccharides Hydrogel Drug delivery Tissue engineering

Supramolecular Vesicles Based on Gold Nanorods for Precise Control of Gene Therapy and Deferred Photothermal Therapy

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CCS Chemistry 2022年第5期4卷 1745-1757页

作者： Ludan Yue Kuikun Yang Jianwen Wei Mengze Xu Chen Sun yuanfu ding Zhen Yuan Shu Wang Ruibing Wang State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao SAR 999078 Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190 Cancer Center Faculty of Health Sciences and Center for Cognitive and Brain SciencesUniversity of MacaoTaipaMacao SAR 999078

In spite of being a promising therapeutic modality,gene therapy has limited clinical applications,mostly due to the lack of spatiotemporal resolution and inadequate ***,we present a facile strategy to remotely control intracellular gene expression by using gold nanorod-(Au NR)derived,host-guest interaction-mediated supramolecular vesicles as a gene carrier and photothermal *** pulsed laser irradiation,mild photothermal conditions dissociate supramolecular vesicles to release gene and simultaneously activate heat shock protein-70 promoter(Hsp70)for spatiotemporally initiating gene expression inside cancer ***,upon introducing a polymeric guest species specifically into cancer cells,the dissociated Au NRs functionalized with macrocyclic host molecules could re-aggregate rapidly in cells to retard exocytosis of these NRs,thereby allowing deferred photothermal therapy to enhance the overall therapeutic outcome.

关键词： supramolecular vesicles host-guest chemistry self-assembly photothermal therapy inducible gene therapy

Polarization-controlled dual resonant lattice Kerker effects

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Nano Research 2023年第2期16卷 3195-3200页

作者： Lei Xiong Xueqian Zhao Xiang Du Shuai Chen yuanfu Lu Hongwei ding Guangyuan Li School of Information Science and Engineering Yunnan UniversityKunming 650500China CAS Key Laboratory of Human-Machine Intelligence-Synergy Systems Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China School of Computer Electronic and InformationGuangxi UniversityNanning 530004China College of Physics and Electronic Technology Anhui Normal UniversityWuhu 241000China Tianjin H-Chip Technology Group Corporation Tianjin 300467China SIAT Branch Shenzhen Institute of Artificial Intelligence and Robotics for SocietyShenzhen 518055China

The generalized Kerker effects have attracted increasing interests in recent years due to their abilities to manipulate the far-field properties of ***,the dual-polarized generalized Kerker effect enabling different tailoring of orthogonally-polarized electromagnetic waves has not yet been ***,we demonstrate polarization-controlled dual resonant lattice Kerker effects in periodic silicon *** varying the incident angle,the electric dipole and magnetic dipole surface lattice resonances can spectrally overlap,causing zero reflectance and unitary transmittance,i.e.,the resonant lattice Kerker *** incident angle for achieving this effect can be tuned differently for s-and p-polarizations over large regions by varying the nanodisk size or the lattice *** proposed dual-polarized resonant lattice Kerker effects open up avenues for polarization-controlled manipulation of the phase and wavefront of light with metasurfaces.

关键词： Kerker effect surface lattice resonances dual-polarized silicon metasurface

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装配式建筑施工质量与安全风险评价研究

建筑经济 2019年第9期40卷 80-84页

作者：丁彦田元福海南大学土木建筑工程学院

在系统分析装配式建筑施工过程中可能存在的质量与安全风险因素的基础上,针对具体装配式建筑项目通过检查打分的方式,运用层次分析法及ABC分类法,对项目存在的风险因素进行分类排序评价,期望帮助各级项目管理人员全面辨识装配式建筑风... 详细信息

在系统分析装配式建筑施工过程中可能存在的质量与安全风险因素的基础上,针对具体装配式建筑项目通过检查打分的方式,运用层次分析法及ABC分类法,对项目存在的风险因素进行分类排序评价,期望帮助各级项目管理人员全面辨识装配式建筑风险因素,区分重点风险,提高项目风险管控效果。

关键词：装配式建筑施工质量安全层次分析法 ABC分类法风险评价

MoC掺杂钌基合金无籽晶阻挡层微结构及热稳定性研究

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金属学报 2017年第1期53卷 31-37页

作者：邹建雄刘波林黎蔚任丁焦国华鲁远甫徐可为四川大学原子核科学技术研究所教育部辐射物理及技术重点实验室成都610064 中国科学院深圳先进技术研究院深圳518055 西安交通大学金属材料强度国家重点实验室西安710049

采用磁控共溅射Ru和MoC靶制备非晶RuMoC薄膜。用四探针仪(FPPT)、X射线光电子能谱仪(XPS)、高分辨率透射电镜(HRTEM)和小角掠射X射线衍射仪(GIXRD)表征不同掺杂组分RuMoC薄膜和不同温度退火态Cu/RuMoC/p-SiOC∶H/Si多层膜系的方块电阻... 详细信息

采用磁控共溅射Ru和MoC靶制备非晶RuMoC薄膜。用四探针仪(FPPT)、X射线光电子能谱仪(XPS)、高分辨率透射电镜(HRTEM)和小角掠射X射线衍射仪(GIXRD)表征不同掺杂组分RuMoC薄膜和不同温度退火态Cu/RuMoC/p-SiOC∶H/Si多层膜系的方块电阻、成分和微观结构。结果表明,通过调控Ru膜中掺入Mo和C元素的含量能够实现RuMoC合金薄膜微结构设计及抑制膜体残余氧含量,且当MoC和Ru靶的溅射功率比为0.5时获得的RuMoCII薄膜综合性能最佳;500℃退火态RuMoC II薄膜中C-Mo和C-Ru化学键均未出现大量断裂,两者协同作用抑制了RuMoC薄膜再结晶和膜体氧含量升高,是Cu/RuMoCII/p-SiOC∶H/Si多层膜系具有高温热稳定性和优异电学性能的主要机制。

关键词：非晶RuMoC 无籽晶阻挡层热稳定性铜互连

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中西医结合治疗晚期胰腺癌重度疼痛疗效观察

山东中医杂志 2016年第6期35卷 532-534页

作者：丁铌齐元富李慧杰山东中医药大学山东济南250355 山东中医药大学附属医院山东济南250011

目的 :观察中西医结合治疗晚期胰腺癌重度疼痛的临床疗效。方法 :28例晚期胰腺癌患者按随机数字表法分为治疗组和对照组各14例。对照组给予盐酸羟考酮缓释片和盐酸吗啡注射液控制癌痛,治疗组在对照组的基础上加入中医治疗,两组均以14 d... 详细信息

目的 :观察中西医结合治疗晚期胰腺癌重度疼痛的临床疗效。方法 :28例晚期胰腺癌患者按随机数字表法分为治疗组和对照组各14例。对照组给予盐酸羟考酮缓释片和盐酸吗啡注射液控制癌痛,治疗组在对照组的基础上加入中医治疗,两组均以14 d为1个观察周期。14 d后根据两组治疗前后疼痛数字量表(NRS)评分变化判定疗效。结果:治疗后两组NRS评分较治疗前均显著降低,差异有统计学意义(P=0.000);治疗组治疗后NRS评分低于对照组,差异有统计学意义(P=0.014);治疗组总有效率100%,对照组64.29%,治疗组疗效优于对照组,差异有统计学意义(P=0.041)。结论:中西医结合治疗晚期胰腺癌重度疼痛疗效确切。

关键词：中西医结合胰腺癌癌性疼痛疗效观察

不同贮藏温度条件下南酸枣果实色泽和质地的变化

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经济林研究 2021年第4期39卷 239-245页

作者：高阳巴元富李宏宇丁菲吴南生何利人宜春学院生命科学与资源环境学院江西宜春336000 江西农业大学南酸枣研究所江西南昌330045 江西农业大学职业师范学院江西南昌330045 江西农业大学林学院江西南昌330045 崇义县绿之蓝林业有限公司江西赣州341000

【目的】为南酸枣果实的贮藏提供参考。【方法】以成熟的南酸枣果实为试验材料,将其分别放置于5、10、15和20℃(常温)条件下贮藏,使用色彩色差计测定果皮色泽,采用质构仪质地多面分析法测定贮藏期间果肉的质地参数,探讨不同贮藏温度条... 详细信息

【目的】为南酸枣果实的贮藏提供参考。【方法】以成熟的南酸枣果实为试验材料,将其分别放置于5、10、15和20℃(常温)条件下贮藏,使用色彩色差计测定果皮色泽,采用质构仪质地多面分析法测定贮藏期间果肉的质地参数,探讨不同贮藏温度条件下南酸枣果实贮藏期间果皮色泽和果肉质地的变化,并使用SPSS软件对各指标进行相关性分析。【结果】在贮藏期间,南酸枣果皮L^(*)值、b^(*)值、C^(*)值和H^(*)值逐渐降低,a^(*)值逐渐升高,果实硬度随贮藏时长延长逐渐降低,果实弹性、内聚性和回复性整体呈增加的变化趋势,咀嚼性呈先升高、后下降的变化趋势。相关性分析结果表明,南酸枣果皮颜色与果实质地间存在显著相关性。与常温贮藏相比,低温冷藏能够有效延缓南酸枣果皮L^(*)值、b^(*)值、C^(*)值、H^(*)值和果实硬度的下降,抑制果皮a^(*)值的升高,同时提高南酸枣果实的采后弹性、内聚性和回复性,其中,5℃条件下冷藏效果最佳。在贮藏末期,5℃条件下贮藏果实的L^(*)值、b^(*)值、C^(*)值和H^(*)值均高于其他处理组,且显著高于20℃条件下贮藏的果实,a^(*)值低于其他处理,并且5℃条件下贮藏的南酸枣果实硬度、弹性、内聚性和回复性均维持在较高水平。【结论】低温贮藏能有效延缓南酸枣果实贮藏期间果皮颜色和果实质地的劣变,提高果皮品质。在5、10、15和20℃贮藏条件中,以5℃低温条件下冷藏效果最佳。

关键词：贮藏温度南酸枣色泽质地

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氧含量对碳钢TU48在高温水中的低周疲劳寿命和表面腐蚀产物状态的影响

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中国腐蚀与防护学报 2005年第3期25卷 167-170页

作者：王雷明钟义兵朱小明夏元复石秀强丁亚平徐雪莲南京大学物理系南京210093 上海核工程研究设计院上海200233

对TU48碳钢在不同溶解氧浓度的水溶液中进行了低周腐蚀疲劳,结合俄歇电子能谱(AES)和M ssbauer谱分析其表面的腐蚀产物.结果表明,随着水中溶解氧含量的增加,碳钢的腐蚀疲劳断裂时间变短,碳钢表面形成的腐蚀产物的成分也有很大的变化,Fe... 详细信息

对TU48碳钢在不同溶解氧浓度的水溶液中进行了低周腐蚀疲劳,结合俄歇电子能谱(AES)和M ssbauer谱分析其表面的腐蚀产物.结果表明,随着水中溶解氧含量的增加,碳钢的腐蚀疲劳断裂时间变短,碳钢表面形成的腐蚀产物的成分也有很大的变化,Fe3O4减少,而γ-Fe2O3含量增多;在含氧量很低的条件下,腐蚀还生成α-Fe2O3和铁的氢氧化物.

关键词：穆斯堡尔谱学俄歇电子能谱碳钢氧化膜